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1. 发明授权

US5837150A Extracorporeal blood processing methods 失效
标题翻译：体外血液加工方法
公开(公告)号：US5837150A
公开(公告)日：1998-11-17
申请号：US484209
申请日：1995-06-07
申请人： Robert W. Langley , Brian M. Holmes , Marlene Adele Bainbridge
发明人： Robert W. Langley , Brian M. Holmes , Marlene Adele Bainbridge
IPC分类号： A61M1/36 , B04B5/04 , B04B9/08 , B01D21/26 , B04B1/00
CPC分类号： B04B9/08 , A61M1/3624 , A61M1/3639 , A61M1/3652 , A61M1/3693 , A61M1/3696 , B04B5/0442 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/505
摘要： A method for processing blood in an apheresis system is disclosed. The present invention includes selecting a packing factor for separated blood component types in the separation stage(s) of a blood processing vessel. A packing factor is a number that reflects the degree with which the blood component types are packed together in the separation stage(s) and is dependent at least upon the rotational speed and the flow rate into the blood processing vessel. The method further includes providing an apheresis system and operating it under conditions to separate the blood into a plurality of blood component types and achieve the selected packing factor.
摘要翻译：公开了一种用于处理单采血液系统中血液的方法。本发明包括在血液处理容器的分离阶段中选择分离的血液成分类型的包装因子。包装因子是反映在分离阶段中血液成分类型被包装在一起的程度的数字，并且至少依赖于转入速度和进入血液处理容器的流速。该方法还包括提供分离系统并在将血液分离成多种血液成分类型并实现所选择的包装因子的条件下操作。

2. 发明授权

US07824355B2 Methods and devices for processing blood 有权
公开(公告)号：US07824355B2
公开(公告)日：2010-11-02
申请号：US12187988
申请日：2008-08-07
申请人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
发明人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
IPC分类号： A61M37/00 , A61M1/00 , A61M5/00
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.

3. 发明申请

US20090043237A1 METHODS AND DEVICES FOR PROCESSING BLOOD 有权
标题翻译：用于处理血液的方法和装置
公开(公告)号：US20090043237A1
公开(公告)日：2009-02-12
申请号：US12187988
申请日：2008-08-07
申请人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
发明人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
IPC分类号： A61M1/14
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
摘要翻译：提出了用于血液处理的方法，装置和装置部件。特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。

4. 发明授权

US07704454B1 Methods and devices for processing blood 有权
标题翻译：处理血液的方法和装置
公开(公告)号：US07704454B1
公开(公告)日：2010-04-27
申请号：US10680950
申请日：2003-10-08
申请人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
发明人： Robert W. Langley , Thomas J. Felt , Geert Van Waeg , Marlene Adele Bainbridge
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
摘要翻译：提出了用于血液处理的方法，装置和装置部件。特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。

5. 发明授权

US07857744B2 Blood processing apparatus with flared cell capture chamber and method 有权
标题翻译：具有扩张细胞捕获室的血液处理装置及方法
公开(公告)号：US07857744B2
公开(公告)日：2010-12-28
申请号：US11765091
申请日：2007-06-19
申请人： Robert W. Langley , Linda A. Taylor , Timothy Michael Taga
发明人： Robert W. Langley , Linda A. Taylor , Timothy Michael Taga
IPC分类号： B04B7/08
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , B04B5/0442 , B04B2005/0471
摘要： A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length, the axial length being greater than the inmost maximum diameter. The cell separation chamber further comprises a separation section having a wall comprising an inward curve. A transition section between the entry section and the separation section has a wall comprising a second inward curve, the second inward curve being different from said first inward curve. The first curve may be tangent to the second curve at a first junction between the first and second curves and the second curve may be tangent to the third curve at a second junction between the second and third curves.
摘要翻译：一种用于分离血液成分的细胞分离装置，具有细胞分离室，具有具有向外扩张曲线的壁的第一入口部分，入口部分具有垂直于轴向长度的轴向长度和最大直径，轴向长度为大于最大直径。细胞分离室还包括具有包括内向曲线的壁的分离部分。进入部分和分离部分之间的过渡部分具有包括第二向内曲线的壁，第二向内曲线不同于所述第一向内曲线。第一曲线可以在第一和第二曲线之间的第一连接处与第二曲线相切，并且第二曲线可以在第二曲线和第三曲线之间的第二接点处与第三曲线相切。

6. 发明授权

US5611997A Apparatus for producing blood component products 失效
标题翻译：用于生产血液成分产品的装置
公开(公告)号：US5611997A
公开(公告)日：1997-03-18
申请号：US457840
申请日：1995-06-01
申请人： Robert W. Langley , Larry J. Dumont
发明人： Robert W. Langley , Larry J. Dumont
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , G01N33/00 , G06F15/00
CPC分类号： A61M1/385 , A61M1/02 , A61M1/303 , A61M1/3696 , A61M1/30 , A61M2205/50 , Y10T436/101666 , Y10T436/115831 , Y10T436/25 , Y10T436/25375
摘要： An apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield of the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield of the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield may be associated therewith, thereby providing a blood component product.
摘要翻译：血液成分制品的制造装置。在一个实施例中，从全血源收集多个预定类型的血液成分。使用至少两种在线产量测定技术来确定收获的血液成分的产量。一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每一种产生提供确定的产量。因此，当收集的血液成分被包装时，所确定的产量可能与之相关，从而提供血液成分产品。

7. 发明授权

US5970423A Blood component collection system with optimizer 失效
标题翻译：血液成分采集系统优化
公开(公告)号：US5970423A
公开(公告)日：1999-10-19
申请号：US928329
申请日：1997-09-12
申请人： Robert W. Langley , John J. Keller , Steven Gage Urdahl
发明人： Robert W. Langley , John J. Keller , Steven Gage Urdahl
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , A61M1/38 , G05B13/00 , G06F19/00
CPC分类号： A61M1/30 , A61M1/02 , A61M1/303 , A61M1/307 , A61M1/3603 , A61M1/3609 , A61M1/3672 , A61M1/3696 , A61M1/38 , A61M1/385 , A61M1/387 , A61M1/3643 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/12 , A61M2205/50
摘要： A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.
摘要翻译：具有优化能力的血液成分收集系统。在一个实施例中，过程参数是根据输入/配置的预定血液成分产量导出的，并且其基于至少一个过程参数的最大化。此后，使用这些导出的过程控制参数来执行血液成分收集过程。在另一个实施例中，从至少一个其它过程控制参数的最大值的输入总程序时间导出过程参数，以便在该固定时间内使血液成分产量最大化。此后，用这些导出的参数进行血液成分收集过程。

8. 发明授权

US5817042A Method and apparatus for controlling concentrations in vivos and in tubing systems 失效
标题翻译：用于控制活体和管道系统中浓度的方法和装置
公开(公告)号：US5817042A
公开(公告)日：1998-10-06
申请号：US622642
申请日：1996-03-27
申请人： Robert W. Langley , Geert Van Waeg , Larry Joe Dumont
发明人： Robert W. Langley , Geert Van Waeg , Larry Joe Dumont
IPC分类号： A61M1/30 , A61M1/34 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3672 , A61M1/303 , A61M1/30 , A61M1/34 , A61M1/3693
摘要： A method and apparatus for maximizing the total amount of blood processed during an apheresis procedure by optimizing the concentration of anticoagulant in a donor/patient and the associated extracorporeal tubing set is provided. A simplified model of anticoagulant accumulation in a donor/patient's body is used to calculate an optimal anticoagulant infusion rate profile to the donor/patient during a blood processing procedure. A maximum acceptable anticoagulant concentration in the donor/patient acts as an upper limit on the rate at which anticoagulant may be infused to the donor/patient using the optimized infusion rate profile. A minimum acceptable anticoagulant level acts as a lower limit in optimally controlling the anticoagulant concentration in the extracorporeal tubing set. Both the maximum acceptable anticoagulant level in the donor/patient and the minimum acceptable anticoagulant level in the extracorporeal tubing set may be customized for a specific donor/patient thereby allowing the optimized infusion rate profile and the extracorporeal tubing set anticoagulant concentration to be customized for the specific patient.
摘要翻译：提供了一种通过优化供体/患者和相关体外管组中的抗凝血剂的浓度来最大化在分离术过程中处理的血液总量的方法和装置。供体/患者体内的抗凝血剂积聚的简化模型用于在血液处理过程中计算给予者/患者的最佳抗凝血剂输注速率曲线。供体/患者中最大可接受的抗凝血剂浓度作为使用优化的输注速率曲线将抗凝血剂注入供体/患者的速率的上限。最小可接受的抗凝血剂水平作为最佳控制体外管组中抗凝血剂浓度的下限。供体/患者中最大可接受的抗凝血剂水平和体外管组中最小可接受的抗凝血剂水平可以针对特定供体/患者定制，从而允许优化的输注速率曲线和体外管道凝固剂浓度定制为具体病人。

9. 发明申请

US20080318756A1 Blood Processing Apparatus with Flared Cell Capture Chamber and Method 有权
标题翻译：具有扩张细胞捕获室的血液处理装置和方法
公开(公告)号：US20080318756A1
公开(公告)日：2008-12-25
申请号：US11765091
申请日：2007-06-19
申请人： Robert W. Langley , Linda A. Taylor , Timothy Michael Taga
发明人： Robert W. Langley , Linda A. Taylor , Timothy Michael Taga
IPC分类号： B04B7/02 , B04B5/10 , B04B7/04
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , B04B5/0442 , B04B2005/0471
摘要： A cell separation set for separating blood components, having a cell separation chamber with a first entry section having a wall with an outwardly flared curve, the entry section having an axial length and an inmost maximum diameter perpendicular to the axial length, the axial length being greater than the inmost maximum diameter. The cell separation chamber further comprises a separation section having a wall comprising an inward curve. A transition section between the entry section and the separation section has a wall comprising a second inward curve, the second inward curve being different from said first inward curve. The first curve may be tangent to the second curve at a first junction between the first and second curves and the second curve may be tangent to the third curve at a second junction between the second and third curves.
摘要翻译：一种用于分离血液成分的细胞分离装置，具有细胞分离室，具有具有向外扩张曲线的壁的第一入口部分，入口部分具有垂直于轴向长度的轴向长度和最大直径，轴向长度为大于最大直径。细胞分离室还包括具有包括内向曲线的壁的分离部分。进入部分和分离部分之间的过渡部分具有包括第二向内曲线的壁，第二向内曲线不同于所述第一向内曲线。第一曲线可以在第一和第二曲线之间的第一连接处与第二曲线相切，并且第二曲线可以在第二曲线和第三曲线之间的第二接点处与第三曲线相切。

10. 发明授权

US5712798A Blood component collection system with optimizer 失效
公开(公告)号：US5712798A
公开(公告)日：1998-01-27
申请号：US439649
申请日：1995-05-12
申请人： Robert W. Langley , John J. Keller , Steven Gage Urdahl
发明人： Robert W. Langley , John J. Keller , Steven Gage Urdahl
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , A61M1/38 , G05B13/00
CPC分类号： A61M1/30 , A61M1/02 , A61M1/303 , A61M1/307 , A61M1/3603 , A61M1/3609 , A61M1/3672 , A61M1/3696 , A61M1/38 , A61M1/385 , A61M1/387 , A61M1/3643 , A61M1/3693 , A61M2202/0415 , A61M2202/0427 , A61M2205/12 , A61M2205/50
摘要： A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

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