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1. 发明授权

US06194182B1 Magnetically oriented tissue-equivalent and biopolymer tubes 失效
标题翻译：磁性取向组织等效和生物聚合物管
公开(公告)号：US06194182B1
公开(公告)日：2001-02-27
申请号：US09103063
申请日：1998-06-23
申请人： Robert T. Tranquillo , Daniel L. Mooradian , Timothy Samuel Girton , Stefano Guido
发明人： Robert T. Tranquillo , Daniel L. Mooradian , Timothy Samuel Girton , Stefano Guido
IPC分类号： C12N1100
CPC分类号： A61L27/24 , A61L27/507 , A61L2430/32
摘要： Tissue-equivalent and biopolymer tubes include fibrils which are oriented by a magnetic field. These oriented fibrils provide enhanced mechanical properties to the tissue-equivalent and biopolymer tubes. One such tissue-equivalent tube includes a body of collagen with mammalian tissue cells interspersed therein. The collagen fibrils are circumferentially oriented within the tubular body by a magnetic field, thereby inducing circumferential orientation of the cells. Methods of making magnetically oriented tissue-equivalent tubes and biopolymer tubes are also disclosed.
摘要翻译：组织等价物和生物聚合物管包括通过磁场取向的原纤维。这些取向的原纤维为组织等效生物聚合物管提供增强的机械性能。一个这样的组织等效管包括胶原蛋白体，其中分散有哺乳动物组织细胞。胶原原纤维通过磁场沿圆周方向定向在管状体内，从而引起细胞周向取向。还公开了制备磁性取向的组织等效管和生物聚合物管的方法。

2. 发明授权

US6057137A Tissue-equivalent rods containing aligned collagen fibrils and schwann cells 失效
标题翻译：组织等效棒包含对齐的胶原纤维和雪旺氏细胞
公开(公告)号：US6057137A
公开(公告)日：2000-05-02
申请号：US725916
申请日：1996-10-04
申请人： Robert T. Tranquillo , Daniel L. Mooradian , Timothy Sanuel Girton , Stefano Guido
发明人： Robert T. Tranquillo , Daniel L. Mooradian , Timothy Sanuel Girton , Stefano Guido
IPC分类号： A61B17/00 , A61B17/11 , A61F2/06 , A61L27/24 , A61L27/50 , A61L31/00 , A61L31/04 , C12N11/00 , A61F2/04
CPC分类号： A61L27/507 , A61B17/1128 , A61F2/06 , A61L27/24 , A61L31/005 , A61L31/044 , A61B2017/00004 , A61L2430/32
摘要： Tissue-equivalent and biopolymer tubes and rods include fibrils which are oriented (aligned) by a magnetic field. These oriented fibrils provide enhanced mechanical and cell guidance properties to the tissue-equivalent and biopolymer tubes. One such tissue-equivalent tube includes a body of collagen gel with mammalian tissue cells interspersed therein. The collagen fibrils are circumferentially oriented within the tubular body by a magnetic field, thereby inducing circumferential orientation of the cells. One such biopolymer rod includes collagen fibrils longitudinally oriented along the rod axis by a magnetic field that guides invasion of cells. Methods of making magnetically oriented tissue-equivalent and biopolymer tubes and rods are also disclosed.
摘要翻译：组织等价物和生物聚合物管和棒包括通过磁场取向（对齐）的原纤维。这些取向的原纤维为组织等效和生物聚合物管提供增强的机械和细胞引导性能。一个这样的组织等效管包括胶原凝胶体，其中分散有哺乳动物组织细胞。胶原原纤维通过磁场沿圆周方向定向在管状体内，从而引起细胞周向取向。一种这样的生物聚合物棒包括通过引导细胞侵入的磁场沿着杆轴纵向取向的胶原原纤维。还公开了制备磁取向组织等效生物聚合物管和棒的方法。

3. 发明授权

US5556632A Phospholipid modified non-thombogenic surface 失效
标题翻译：磷脂改性非特异性表面
公开(公告)号：US5556632A
公开(公告)日：1996-09-17
申请号：US406124
申请日：1995-03-17
申请人： Anja S. Kohler , Daniel L. Mooradian , Leo T. Furcht
发明人： Anja S. Kohler , Daniel L. Mooradian , Leo T. Furcht
IPC分类号： A61L33/00 , A61F2/02
CPC分类号： A61L33/0082 , Y10S514/822
摘要： A biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provide an improved nonthrombogenic surface relative to the substrate without the phospholipid moiety covalently attached thereto is provided. In particularly preferred embodiments, the biocompatible material has the following structure: ##STR1## wherein: R.sup.1 is a (C.sub.1 -C.sub.30)alkyl group; R.sup.2 is a (C.sub.1 -C.sub.30)alkylene group; m is 1-4; n is 1-4; and L is a divalent linking group covalently bonded to the substrate and to the phospholipid moiety.
摘要翻译：提供了一种生物相容性材料，其包含以有效提供相对于底物的改进的非凝血基因表面的量和取向共价连接于其上的磷脂部分，而磷脂部分共价连接到其上。在特别优选的实施方案中，生物相容性材料具有以下结构：其中：R 1是（C 1 -C 30）烷基; R2是（C1-C30）亚烷基; m为1-4; n为1-4; 并且L是共价键合到底物和磷脂部分的二价连接基团。

4. 发明申请

US20100234861A1 SURGICAL FASTENER BUTTRESS MATERIAL 审中-公开
标题翻译：手术紧固材料
公开(公告)号：US20100234861A1
公开(公告)日：2010-09-16
申请号：US12728993
申请日：2010-03-22
申请人： B. Nicholas Oray , Daniel L. Mooradian
发明人： B. Nicholas Oray , Daniel L. Mooradian
IPC分类号： A61B17/08 , A61B17/03 , A61B17/068
CPC分类号： A61B17/07207 , A61B17/07292
摘要： A staple line buttress material having an adhesive surface, packaged and provided in sterile, ready-to-use form. The material can be used to retrofit surgical staplers to provide an improved staple line, and with improved ease of use.
摘要翻译：具有粘合剂表面的短纤维支撑材料，被包装并以无菌的即用形式提供。该材料可用于改进外科缝合器以提供改进的缝合线，并且具有改进的易用性。

5. 发明授权

US07192400B2 Device and method for vascular monitoring 有权
标题翻译：血管监测装置及方法
公开(公告)号：US07192400B2
公开(公告)日：2007-03-20
申请号：US10279751
申请日：2002-10-24
申请人： Michael K. Campbell , William F. Kuester, III , Daniel L. Mooradian
发明人： Michael K. Campbell , William F. Kuester, III , Daniel L. Mooradian
IPC分类号： A61B5/00 , A61B5/02
CPC分类号： A61B17/11 , A61B8/06 , A61B8/08 , A61B8/12 , A61B8/4472 , A61B8/488 , A61B2017/00022 , A61B2017/1107
摘要： A vascular coupler adapted to be fixed into position upon a blood vessel and there retain and position a matable sensing device. In a preferred embodiment, the vascular coupler is an anastomotic coupler and the sensing device comprises an ultrasonic Doppler probe.
摘要翻译：适于固定在血管上的位置的血管耦合器，并且保持并定位可配置的感测装置。在优选实施例中，血管耦合器是吻合耦合器，并且感测装置包括超声多普勒探针。

6. 发明授权

US07128748B2 Circular stapler buttress combination 有权
公开(公告)号：US07128748B2
公开(公告)日：2006-10-31
申请号：US10109595
申请日：2002-03-26
申请人： Daniel L. Mooradian , B. Nicholas Oray
发明人： Daniel L. Mooradian , B. Nicholas Oray
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/115 , A61B17/07292 , A61B17/1114 , A61B17/1155 , A61B2017/00725
摘要： A combination medical device comprising a circular stapler instrument and one or more portions of preformed buttress material adapted to be stably positioned upon the staple cartridge and/or anvil components of the stapler prior or at the time of use. Positioned buttress material(s) are delivered to a tissue site where the circular stapler is actuated to connect previously severed tissue portions. The buttress material is retained and provides an improved seal between the joined tissue sections. The buttress material is made up of two regions, one of which serves primarily to secure the buttress material to the stapler prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler to form an anastomoses. Methods of use and preparation of the buttress material are also described.

7. 发明申请

US20120197272A1 SURGICAL FASTENER BUTTRESS MATERIAL 审中-公开
标题翻译：手术紧固材料
公开(公告)号：US20120197272A1
公开(公告)日：2012-08-02
申请号：US13366998
申请日：2012-02-06
申请人： B. Nicholas Oray , Daniel L. Mooradian
发明人： B. Nicholas Oray , Daniel L. Mooradian
IPC分类号： A61B17/04
CPC分类号： A61B17/07207 , A61B17/07292
摘要： A staple line buttress material having an adhesive surface, packaged and provided in sterile, ready-to-use form. The material can be used to retrofit surgical staplers to provide an improved staple line, and with improved ease of use.
摘要翻译：具有粘合剂表面的短纤维支撑材料，被包装并以无菌的即用形式提供。该材料可用于改进外科缝合器以提供改进的缝合线，并且具有改进的易用性。

8. 发明授权

US07776060B2 Circular stapler buttress combination 有权
标题翻译：圆形订书机支撑组合
公开(公告)号：US07776060B2
公开(公告)日：2010-08-17
申请号：US10509216
申请日：2003-03-21
申请人： Daniel L. Mooradian , B. Nicholas Oray , William F. Kuester
发明人： Daniel L. Mooradian , B. Nicholas Oray , William F. Kuester
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/115 , A61B17/07292 , A61B17/1114 , A61B17/1155 , A61B2017/00725
摘要： A combination medical device comprising a circular stapler instrument (4) and one or more portions of preformed buttress material (16) adapted to be stably positioned upon the staple cartridge (12) and/or anvil (14) components of the stapler (4) prior or at the time of use. Positioned buttress material(s) (16) are delivered to a tissue site where the circular stapler (4) is actuated to connect previously severed tissue portions. An embodiment of the invention allows tissue portions to be joined without the use of sutures. The buttress material (16) is made up of two regions, one of which serves primarily to secure the buttress material (16) to the stapler (4) prior to actuation, and one of which serves primarily to form the improved seal. The former region is severed and discarded upon activation of the circular stapler (4) to form anastomoses, while the remaining material secures and seals the newly connected tissue. Methods of use and preparation of the buttress material (16) are also described.
摘要翻译：一种组合医疗装置，包括圆形缝合器械（4）和适于稳定地定位在钉仓（12）和/或砧座（14）上的吻合器（4）的部件的预成形支撑材料（16）的一个或多个部分，在使用前或在使用时。定位的支撑材料（16）被输送到组织部位，在那里圆形缝合器（4）被致动以连接先前切断的组织部分。本发明的一个实施例允许组织部分在不使用缝线的情况下连接。支撑材料（16）由两个区域组成，其中一个区域主要用于在推动之前将支撑材料（16）固定到订书机（4），并且其中一个主要用于形成改进的密封件。在激活圆形订书机（4）时，前一个区域被切断并丢弃，以形成吻合，而剩余的材料固定和密封新连接的组织。还描述了支撑材料（16）的使用和制备方法。

9. 发明授权

US5853744A Solid-phase method for attaching a biomolecule to a substrate surface with a photoreactive crosslinking agent 失效
标题翻译：用光反应性交联剂将生物分子附着到基材表面的固相方法
公开(公告)号：US5853744A
公开(公告)日：1998-12-29
申请号：US699965
申请日：1996-08-20
申请人： Daniel L. Mooradian , Gregg B. Fields
发明人： Daniel L. Mooradian , Gregg B. Fields
IPC分类号： A61L27/34 , A61L27/50 , C12N5/00 , A61F2/06 , C07K17/06 , C12N11/06
CPC分类号： C12N5/0068 , A61L27/34 , A61L27/507 , C12N2533/30 , C12N2533/50 , Y10S530/81 , Y10S530/812 , Y10S530/815 , Y10S530/816
摘要： A method for making a medical device having a biomolecule immobilized on a substrate surface is provided. The method includes: providing an immobilized biomolecule comprising a biomolecule covalently attached to a support material; attaching a photoreactive crosslinking agent to the immobilized biomolecule to form a photoreactive analog of the biomolecule; and removing the photoreactive analog of the biomolecule from the support material. The photoreactive analog of the biomolecule can then be attached to a substrate surface, such as a biomaterial that forms part of a medical device. The immobilized biomolecule may contain a peptide having an N.sup..alpha. -terminus. The photoreactive crosslinking agent is attached to the peptide at the N.sup..alpha. -terminus to form the photoreactive analog of the biomolecule. The peptide can be an adhesion peptide containing the sequence Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile. Attachment of the peptide to a substrate surface promotes cell adhesion to the surface. The photoreactive crosslinking agent can be heterobifunctional or contain two photoreactive groups. The photoreactive analog of the biomolecule is attached to the substrate surface by activating a photoreactive group of the analog such as by exposing the analog to UV radiation.
摘要翻译：提供一种制造具有固定在基板表面上的生物分子的医疗装置的方法。该方法包括：提供固定化的生物分子，其包含共价连接到载体材料上的生物分子; 将光反应性交联剂附着到固定化的生物分子上以形成生物分子的光反应性类似物; 并从载体材料中除去生物分子的光反应性类似物。然后可以将生物分子的光反应性类似物连接到基底表面，例如形成医疗装置的一部分的生物材料。固定化的生物分子可以含有具有Nα末端的肽。光反应性交联剂以Nα末端连接到肽上以形成生物分子的光反应性类似物。肽可以是含有序列Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile的粘附肽。将肽附着到基底表面促进细胞对表面的粘附。光反应性交联剂可以是异双官能的或含有两个光反应性基团。生物分子的光反应性类似物通过激活类似物的光反应性基团（例如通过将类似物暴露于紫外线辐射）而附着到基底表面。

10. 发明授权

US5711959A Biocompatible materials 失效
标题翻译：生物相容性材料
公开(公告)号：US5711959A
公开(公告)日：1998-01-27
申请号：US707954
申请日：1996-09-10
申请人： Anja S. Kohler , Daniel L. Mooradian , Leo T. Furcht
发明人： Anja S. Kohler , Daniel L. Mooradian , Leo T. Furcht
IPC分类号： A61L33/00 , A61F2/02
CPC分类号： A61L33/0082 , Y10S514/822
摘要： A biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provide an improved nonthrombogenic surface relative to the substrate without the phospholipid moiety covalently attached thereto is provided. In particularly preferred embodiments, the biocompatible material has the following structure: ##STR1## wherein: R.sup.1 is a (C.sub.1 -C.sub.30)alkyl group; R.sup.2 is a (C.sub.1 -C.sub.30)alkylene group; m is 1-4; n is 1-4; and L is a divalent linking group covalently bonded to the substrate and to the phospholipid moiety.
摘要翻译：提供了一种生物相容性材料，其包含以有效提供相对于底物的改进的非凝血基因表面的量和取向共价连接于其上的磷脂部分，而磷脂部分共价连接到其上。在特别优选的实施方案中，生物相容性材料具有以下结构：其中：R 1是（C 1 -C 30）烷基; R2是（C1-C30）亚烷基; m为1-4; n为1-4; 并且L是共价键合到底物和磷脂部分的二价连接基团。

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