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1. 发明授权

US5260337A Ibuprofen-muscle relaxant combinations 失效
标题翻译：布洛芬 - 肌肉松弛剂组合
公开(公告)号：US5260337A
公开(公告)日：1993-11-09
申请号：US921882
申请日：1992-07-29
申请人： Robert T. Sims , Thomas N. Gates , William Slivka
发明人： Robert T. Sims , Thomas N. Gates , William Slivka
IPC分类号： A61K31/42 , A61K31/19 , A61K31/135
CPC分类号： A61K31/00 , A61K31/42
摘要： This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the treatment of muscle spasms and associated pain, soreness and tightness of muscles in mammalian organism, said composition comprising:(i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; and(ii) an amount effective in the treatment of muscle spasms of at least one of the muscle relaxants, or a therapeutically active stereoisomer thereof, substantially free of its other stereoisomers.
摘要翻译：本发明涉及用于治疗疼痛和炎症以及治疗肌肉痉挛的药物组合物，以及哺乳动物生物体中肌肉的相关疼痛，酸痛和紧张性，所述组合物包括：（i）止痛和消炎有效量的（S） - 布洛芬或其盐，基本上不含（R） - 布洛芬; 和（ii）有效治疗基本上不含其其它立体异构体的至少一种肌肉松弛剂或其治疗活性立体异构体的肌肉痉挛的量。

2. 发明授权

US5288507A Ibuprofen antacid combinations 失效
标题翻译：布洛芬抗酸剂组合
公开(公告)号：US5288507A
公开(公告)日：1994-02-22
申请号：US921879
申请日：1992-07-29
申请人： Robert T. Sims , Thomas N. Gates , William Slivka
发明人： Robert T. Sims , Thomas N. Gates , William Slivka
IPC分类号： A61K31/19 , A61K33/00 , A61K33/08 , A61K33/10 , A61K33/12 , A61P1/04 , A61P29/00 , A61K33/06
CPC分类号： A61K33/08 , A61K33/00 , A61K33/10 , A61K33/12
摘要： This invention relates to a pharmaceutical composition for use in the treatment of pain and inflammation and the treatment of acid indigestion, sour stomach, heartburn and symptoms of upset stomach associated with these conditions in a mammalian organism, said composition comprising:(i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen;(ii) an amount effective in the treatment of acid indigestion, sour stomach and/or heartburn of at least one of the antacids; and(iii) optionally, an amount effective in treating excess gas and flatulence of an anti-gas agent.
摘要翻译：本发明涉及一种用于治疗疼痛和炎症的药物组合物，以及与哺乳动物生物体中的这些病症相关的酸痛消化不良，酸胃，胃灼热和不适胃部症状的治疗，所述组合物包含：（i）止痛剂和消炎有效量的（S） - 布洛芬或其盐，基本上不含（R） - 布洛芬; （ii）有效治疗至少一种抗酸剂的酸性消化不良，酸性胃和/或灼热的量; 和（iii）任选地，有效处理过量气体和抗气体剂的肠胃气胀的量。

3. 发明授权

US5164398A Ibuprofen-antitussive combinations 失效
标题翻译： IBUPROFEN-ANTITUSSIVE组合
公开(公告)号：US5164398A
公开(公告)日：1992-11-17
申请号：US678772
申请日：1991-04-01
申请人： Robert T. Sims , William Slivka
发明人： Robert T. Sims , William Slivka
IPC分类号： A61K31/085 , A61K31/19 , A61K31/215 , A61K31/485 , A61P11/10 , A61P11/14 , A61P25/04
CPC分类号： A61K31/19 , A61K31/485
摘要： This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the relief of cough and cold symptoms in a mammalian organism, said composition comprising:(i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; and(ii) an antitussively effective amount of at least one antitussive agent selected from codeine, hydrocodone, caramiphen, carbetapentane, or dextromethorphan, or a therapeutically active stereoisomer thereof substantially free of its other stereoisomers and optionallyiii) a therapeutically effective amount of at least one expectorant selected from guaicolsulfonate, guaifenesin, guaiacol, or terpin;or a pharamceutically acceptable salt thereof.
摘要翻译：本发明涉及用于治疗疼痛和炎症以及减轻哺乳动物生物体中咳嗽和感冒症状的药物组合物，所述组合物包含：（i）止痛和消炎有效量的（S） - 布洛芬，或其盐，基本上不含（R） - 布洛芬; 和（ii）镇咳有效量的至少一种选自可待因，氢可酮，卡拉美芬，碳代四烯或右美沙芬或其基本上不含其它立体异构体的治疗活性立体异构体的镇咳剂，并且任选地iii）治疗有效量的至少一种祛痰剂，其选自瓜氨酸磺酸盐，愈创甘油醚，愈创木酚或愈伤组织; 或其药学上可接受的盐。

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