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1. 发明申请

US20160194376A1 HEMATOPOIETIC CELL SELECTIN LIGAND POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20160194376A1
公开(公告)日：2016-07-07
申请号：US14875250
申请日：2015-10-05
申请人： Robert SACKSTEIN
发明人： Robert SACKSTEIN
IPC分类号： C07K14/705
CPC分类号： C07K14/70585
摘要： The invention feature methods and compositions for treating inflammatory disorders, hematopoietic disorders and non-hematopoietic disorders (e.g., non-hematopoietic cancers) and for isolating cells (e.g., stem cells) in a mammal.

2. 发明申请

US20140199316A1 METHODS OF TREATING COMPLICATIONS AND DISORDERS ASSOCIATED WITH G-CSF ADMINISTRATION 审中-公开
标题翻译：治疗与G-CSF给药相关的并发症和疾病的方法
公开(公告)号：US20140199316A1
公开(公告)日：2014-07-17
申请号：US14163192
申请日：2014-01-24
申请人： Robert SACKSTEIN
发明人： Robert SACKSTEIN
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505
摘要： The present embodiments relate to novel uses of MPO inhibitors and inhibitors of MPO and E-selectin binding. In some embodiments, methods are provided for treating G-CSF-induced vascular complications and associate tissue injury comprising administering to a subject in need thereof a compound that inhibits E-selectin receptor/ligand interaction or inhibits MPO activity. The inhibitors may be administered in conjunction with G-CSF therapy. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics (including aptamers) and organic compounds (e.g., glycomimetics).
摘要翻译：本实施方案涉及MPO抑制剂和MPO和E-选择蛋白结合抑制剂的新用途。在一些实施方案中，提供了用于治疗G-CSF诱导的血管并发症和关联组织损伤的方法，包括向有需要的受试者施用抑制E-选择蛋白受体/配体相互作用或抑制MPO活性的化合物。抑制剂可以与G-CSF治疗联合施用。抑制剂包括抗体分子，以及同源物，类似物和其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物（包括适体）和有机化合物（例如，糖模拟物）。

3. 发明申请

US20160201033A1 HEMATOPOIETIC CELL E-SELECTIN/L-SELECTIN LIGAND POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译： HEMATOPOIETIC CELL E-SELECTIN / L-SELECTIN LIGAND POLYPEPTIDES及其使用方法
公开(公告)号：US20160201033A1
公开(公告)日：2016-07-14
申请号：US14599211
申请日：2015-01-16
申请人： Robert SACKSTEIN
发明人： Robert SACKSTEIN
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61K2035/124 , C07K14/70585 , C12N2501/59 , C12N2501/599 , C12N2501/724 , C12N2501/90
摘要： The invention feature methods and compositions for treating hematopoietic disorders, inflammatory conditions, and cancer and providing stem cell therapy in a mammal.
摘要翻译：本发明的特征在于用于治疗造血障碍，炎性病症和癌症并在哺乳动物中提供干细胞治疗的方法和组合物。

4. 发明申请

US20210087541A1 COMPOSITIONS AND METHODS FOR MODIFYING CELL SURFACE GLYCANS 有权
公开(公告)号：US20210087541A1
公开(公告)日：2021-03-25
申请号：US16870576
申请日：2020-05-08
申请人： Robert Sackstein
发明人： Robert SACKSTEIN
IPC分类号： C12N9/10 , C12N5/00 , C12N5/0775 , C12N5/0797 , A61K35/28 , A61K35/30
摘要： Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.

5. 发明申请

US20180127731A1 COMPOSITIONS AND METHODS FOR MODIFYING CELL SURFACE GLYCANS 审中-公开
公开(公告)号：US20180127731A1
公开(公告)日：2018-05-10
申请号：US15864975
申请日：2018-01-08
申请人： Robert Sackstein
发明人： Robert SACKSTEIN
IPC分类号： C12N9/10 , A61K35/30 , C12N5/0797 , A61K35/28 , C12N5/0775 , C12N5/00
CPC分类号： C12N9/1051 , A61K35/28 , A61K35/30 , C12N5/0006 , C12N5/0623 , C12N5/0663 , C12N2500/10 , C12N2500/14 , C12N2500/16 , C12N2500/22 , C12N2500/34 , C12N2501/58 , C12N2501/59 , C12N2501/70 , C12N2506/1369
摘要： Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.

6. 发明申请

US20150259654A1 COMPOSITIONS AND METHODS FOR MODIFYING CELL SURFACE GLYCANS 审中-公开
标题翻译：用于修饰细胞表面甘油的组合物和方法
公开(公告)号：US20150259654A1
公开(公告)日：2015-09-17
申请号：US14487290
申请日：2014-09-16
申请人： Robert SACKSTEIN
发明人： Robert SACKSTEIN
IPC分类号： C12N9/10 , C12N5/0775 , C12N5/00 , C12N5/0797 , A61K35/30 , A61K35/28
CPC分类号： C12N9/1051 , A61K35/28 , A61K35/30 , C12N5/0006 , C12N5/0623 , C12N5/0663 , C12N2500/10 , C12N2500/14 , C12N2500/16 , C12N2500/22 , C12N2500/34 , C12N2501/58 , C12N2501/59 , C12N2501/70 , C12N2506/1369
摘要： Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.
摘要翻译：本文提供了用于修饰聚糖（例如活细胞或细胞颗粒表面上表达的聚糖）的方法和组合物。

7. 发明申请

US20140170120A1 CYTOKINE INDUCTION OF SELECTIN LIGANDS ON CELLS 审中-公开
标题翻译：细胞因子诱导细胞上的选择配体
公开(公告)号：US20140170120A1
公开(公告)日：2014-06-19
申请号：US14159358
申请日：2014-01-20
申请人： Robert SACKSTEIN
发明人： Robert SACKSTEIN
IPC分类号： A61K35/14
CPC分类号： A61K35/15 , A61K38/1709 , A61K38/193 , A61K38/20 , A61K38/202 , A61K2035/124 , C07K16/2854 , C07K2317/76 , C12N5/0634 , C12N5/0669 , C12N2501/22
摘要： Methods and compositions for treating cells with cytokines are provided herein.
摘要翻译：本文提供了用细胞因子处理细胞的方法和组合物。

8. 发明申请

US20130224217A1 METHODS OF TREATING COMPLICATIONS AND DISORDERS ASSOCIATED WITH G-CSF ADMINISTRATION 有权
标题翻译：治疗与G-CSF给药相关的并发症和疾病的方法
公开(公告)号：US20130224217A1
公开(公告)日：2013-08-29
申请号：US13465691
申请日：2012-05-07
申请人： Robert SACKSTEIN
发明人： Robert SACKSTEIN
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505
摘要： The present embodiments relate to novel uses of MPO inhibitors and inhibitors of MPO and E-selectin binding. In some embodiments, methods are provided for treating G-CSF-induced vascular complications and associate tissue injury comprising administering to a subject in need thereof a compound that inhibits E-selectin receptor/ligand interaction or inhibits MPO activity. The inhibitors may be administered in conjunction with G-CSF therapy. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics (including aptamers) and organic compounds (e.g., glycomimetics).
摘要翻译：本实施方案涉及MPO抑制剂和MPO和E-选择蛋白结合抑制剂的新用途。在一些实施方案中，提供了用于治疗G-CSF诱导的血管并发症和关联组织损伤的方法，包括向有需要的受试者施用抑制E-选择蛋白受体/配体相互作用或抑制MPO活性的化合物。抑制剂可以与G-CSF治疗联合施用。抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物（包括适体）和有机化合物（例如，糖模拟物）。

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