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1. 发明申请

US20050222384A1 Par-2-activating peptide derivative and pharmaceutical composition using the same 失效
标题翻译：对二激活肽衍生物和使用其的药物组合物
公开(公告)号：US20050222384A1
公开(公告)日：2005-10-06
申请号：US10517803
申请日：2003-06-10
申请人： Robert Ramage , Robin Plevin , Kevin Shaw , Lu Jiang , Louise Young , Alan Harvey , Pu Wang , Toru Kanke , Junichi Kawagoe , Mototsugu Kabeya
发明人： Robert Ramage , Robin Plevin , Kevin Shaw , Lu Jiang , Louise Young , Alan Harvey , Pu Wang , Toru Kanke , Junichi Kawagoe , Mototsugu Kabeya
IPC分类号： A61K38/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/12 , A61P1/14 , A61P27/02 , A61P27/04 , A61P43/00 , C07K7/06 , C07K14/705 , A61K38/08 , C07K5/06
CPC分类号： C07K14/705 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH2)n—CO—NH-Leu-Ile-Gly-AA1-AA2-CO—R (I) wherein Z represents an aryl group which may or may not have a substituent or a heteroaryl group which may or may not have a substituent; n represents 0, 1 or 2: AA1-AA2 represents Lys-Val or Arg-Leu; and R represents —OH or —NH2, and relates to a pharmaceutical composition comprising a peptide derivative represented by the general formula (I) or a salt thereof, and a pharmaceutically acceptable carrier thereof.
摘要翻译：本发明涉及由通式（I）表示的肽衍生物或其盐：Z-（CH 2 CH 2）n -CO-NH-Leu-Ile 其中Z表示可以具有或可以不具有取代基的芳基或可以不具有取代基的芳基或可以具有取代基的杂芳基，可能没有取代基; n表示0,1或2：AA 1 -A 2 2表示Lys-Val或Arg-Leu; 并且R表示-OH或-NH 2，并且涉及包含由通式（I）表示的肽衍生物或其盐及其药学上可接受的载体的药物组合物。

2. 发明授权

US07541339B2 Par-2-activating peptide derivative and pharmaceutical composition using the same 失效
标题翻译：对二激活肽衍生物和使用其的药物组合物
公开(公告)号：US07541339B2
公开(公告)日：2009-06-02
申请号：US10517803
申请日：2003-06-10
申请人： Robert Ramage , Robin Plevin , Kevin Thomas Shaw , Lu Jiang , Louise Claire Young , Alan Lang Harvey , Pu Wang , Toru Kanke , Junichi Kawagoe , Mototsugu Kabeya
发明人： Robert Ramage , Robin Plevin , Kevin Thomas Shaw , Lu Jiang , Louise Claire Young , Alan Lang Harvey , Pu Wang , Toru Kanke , Junichi Kawagoe , Mototsugu Kabeya
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： C07K14/705 , A61K38/00 , C07K7/06
摘要： The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH2)n—CO—NH-Leu-Ile-Gly-AA1-AA2-CO—R (I) wherein Z represents an aryl group which may or may not have a substituent or a heteroaryl group which may or may not have a substituent; n represents 0, 1 or 2: AA1-AA2 represents Lys-Val or Arg-Leu; and R represents —OH or —NH2, and relates to a pharmaceutical composition comprising a peptide derivative represented by the general formula (I) or a salt thereof, and a pharmaceutically acceptable carrier thereof. The peptide derivative is useful as a prophylactic and therapeutic agent of dysfunction of masticatory, dysphagia, dysgeusia, ozostomia, intra-oral cavity dysphoria, intra-oral cavity infections, intra-oral cavity inflammations, dry eye, ectocornea detachment, keratitis, corneal ulcer, conjunctivitis, stomach ulcer, duodenal ulcer, gastritis, diarrhea, enteritis or Sjogren's syndrome.
摘要翻译：本发明涉及由通式（I）表示的肽衍生物或其盐：Z-（CH2）n-CO-NH-Leu-Ile-Gly-AA1-AA2-CO-R（Ⅰ）其中Z 表示可以具有也可以不具有取代基的芳基或可以具有取代基的杂芳基; n表示0,1或2：AA1-AA2表示Lys-Val或Arg-Leu; 和R表示-OH或-NH 2，并且涉及包含由通式（I）表示的肽衍生物或其盐及其药学上可接受的载体的药物组合物。肽衍生物可用作咀嚼，吞咽困难，发重症，口臭，口腔内烦躁，口腔内感染，口腔内炎症，干眼症，异位角脱落，角膜炎，角膜溃疡功能障碍的预防和治疗剂，结膜炎，胃溃疡，十二指肠溃疡，胃炎，腹泻，肠炎或干燥综合征。

3. 发明申请

US20190216330A1 PHOTOACOUSTIC CATHETER AND IMAGING SYSTEM USING SAME 审中-公开
公开(公告)号：US20190216330A1
公开(公告)日：2019-07-18
申请号：US15998889
申请日：2017-02-13
申请人： JI-XIN CHENG , Pu Wang , Yingchun Cao , Jie Hui
发明人： JI-XIN CHENG , Pu Wang , Yingchun Cao , Jie Hui
IPC分类号： A61B5/00 , A61B8/00 , A61B5/02 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0066 , A61B5/02007 , A61B8/12 , A61B8/445 , A61B2560/0233 , A61M25/0067
摘要： A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45° relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45° relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.

4. 发明授权

US08730298B2 Method, device, terminal and system for switching video resolution 有权
标题翻译：用于切换视频分辨率的方法，设备，终端和系统
公开(公告)号：US08730298B2
公开(公告)日：2014-05-20
申请号：US13547752
申请日：2012-07-12
申请人： Chenchen Gu , Jing Lv , Xuecheng Luo , Peizhao Li , Pu Wang
发明人： Chenchen Gu , Jing Lv , Xuecheng Luo , Peizhao Li , Pu Wang
IPC分类号： H04N7/14
CPC分类号： H04N7/14 , H04N21/440263 , H04N21/440281 , H04N21/44209 , H04N21/4424 , H04N21/4788
摘要： A method for switching video resolution includes: confirming that a video sender and a video receiver have established a video communication connection, and obtaining an initial resolution of the video sender; confirming that bandwidth of the video communication connection and hardware of the video sender meet preset conditions, and switching the initial resolution of the video sender to a target resolution, in which the target resolution is higher than the initial resolution. After establishing video communication connections between terminals, when there are available bandwidth and hardware of the terminal using video communication, the resolution of terminal may be switched to provide a more clear video communication for terminal user, and guarantee smooth switching of resolution.
摘要翻译：用于切换视频分辨率的方法包括：确认视频发送者和视频接收者建立了视频通信连接，并获得视频发送者的初始分辨率; 确认视频发送器的视频通信连接和硬件的带宽满足预设条件，并将视频发送器的初始分辨率切换到目标分辨率，其中目标分辨率高于初始分辨率。在终端之间建立视频通信连接之后，当使用视频通信的终端可用带宽和硬件时，可以切换终端的分辨率，为终端用户提供更清晰的视频通信，并保证平滑的分辨率切换。

5. 发明授权

US08284098B2 Persymmetric parametric adaptive matched filters for detecting targets using space-time adaptive processing of radar signals 有权
标题翻译：用于使用雷达信号的空时自适应处理来检测目标的不对称参数自适应匹配滤波器
公开(公告)号：US08284098B2
公开(公告)日：2012-10-09
申请号：US12954254
申请日：2010-11-24
申请人： Zafer Sahinoglu , Pu Wang , Man-On Pun
发明人： Zafer Sahinoglu , Pu Wang , Man-On Pun
IPC分类号： G01S13/00
CPC分类号： G01S13/5244 , G01S13/5242
摘要： A method provides space-time adaptive processing (STAP) for target detection using adaptive matched filters (AMF). A generalized likelihood ratio test (GLRT) is determined where spatial and temporal correlation matrices Q and A are assumed. Then, the correlation matrices A and Q are replaced with maximum likelihood (ML) estimates obtained only from training signals subject to a persymmetric constraint.
摘要翻译：一种方法使用自适应匹配滤波器（AMF）提供用于目标检测的时空自适应处理（STAP）。在假定空间和时间相关矩阵Q和A的情况下确定广义似然比检验（GLRT）。然后，相关矩阵A和Q被替换为仅由经受不对称约束的训练信号获得的最大似然（ML）估计。

6. 发明申请

US20120249361A1 Method for Detecting Targets Using Space-Time Adaptive Processing 有权
标题翻译：使用时空自适应处理检测目标的方法
公开(公告)号：US20120249361A1
公开(公告)日：2012-10-04
申请号：US13291323
申请日：2011-11-08
申请人： Zafer Sahinoglu , Man-On Pun , Pu Wang
发明人： Zafer Sahinoglu , Man-On Pun , Pu Wang
IPC分类号： G01S13/04
CPC分类号： G01S7/292 , G01S13/5244 , G01S2013/0245
摘要： A method for detecting a target in a non-homogeneous environment using a space-time adaptive processing of a radar signal includes normalizing training data of the non-homogeneous environment to produce normalized training data; determining a normalized sample covariance matrix representing the normalized training data; tracking a subspace represented by the normalized sample covariance matrix to produce a clutter subspace matrix; determining a test statistic representing a likelihood of a presence of the target in the radar signal based on the clutter subspace matrix and a steering vector; and comparing the test statistic with a threshold to detect the target.
摘要翻译：使用雷达信号的时空自适应处理来检测非均匀环境中的目标的方法包括对非均匀环境的训练数据进行归一化以产生归一化的训练数据; 确定表示归一化训练数据的归一化样本协方差矩阵; 跟踪由归一化样本协方差矩阵表示的子空间以产生杂波子空间矩阵; 基于所述杂波子空间矩阵和导向矢量，确定表示所述雷达信号中所述目标的存在的可能性的测试统计量; 并将检验统计与阈值进行比较以检测目标。

7. 发明申请

US20120281062A1 Method, Device, Terminal And System For Switching Video Resolution 有权
标题翻译：方法，设备，终端和系统用于切换视频分辨率
公开(公告)号：US20120281062A1
公开(公告)日：2012-11-08
申请号：US13547752
申请日：2012-07-12
申请人： Chenchen Gu , Jing Lv , Xuecheng Luo , Peizhao Li , Pu Wang
发明人： Chenchen Gu , Jing Lv , Xuecheng Luo , Peizhao Li , Pu Wang
IPC分类号： H04N7/14
CPC分类号： H04N7/14 , H04N21/440263 , H04N21/440281 , H04N21/44209 , H04N21/4424 , H04N21/4788
摘要： A method for switching video resolution includes: confirming that a video sender and a video receiver have established a video communication connection, and obtaining an initial resolution of the video sender; confirming that bandwidth of the video communication connection and hardware of the video sender meet preset conditions, and switching the initial resolution of the video sender to a target resolution, in which the target resolution is higher than the initial resolution. After establishing video communication connections between terminals, when there are available bandwidth and hardware of the terminal using video communication, the resolution of terminal may be switched to provide a more clear video communication for terminal user, and guarantee smooth switching of resolution.
摘要翻译：用于切换视频分辨率的方法包括：确认视频发送者和视频接收者建立了视频通信连接，并获得视频发送者的初始分辨率; 确认视频发送器的视频通信连接和硬件的带宽满足预设条件，并将视频发送器的初始分辨率切换到目标分辨率，其中目标分辨率高于初始分辨率。在终端之间建立视频通信连接之后，当使用视频通信的终端可用带宽和硬件时，可以切换终端的分辨率，为终端用户提供更清晰的视频通信，并保证平滑的分辨率切换。

8. 发明申请

US20060023758A1 Laser material, laser system and methods 审中-公开
标题翻译：激光材料，激光系统和方法
公开(公告)号：US20060023758A1
公开(公告)日：2006-02-02
申请号：US11017345
申请日：2004-12-20
申请人： Pu Wang , Peter Dekker , Justin Blows , Judith Dawes , James Piper
发明人： Pu Wang , Peter Dekker , Justin Blows , Judith Dawes , James Piper
IPC分类号： H01S3/10 , H01S3/16
CPC分类号： H01S3/109 , H01S3/1095 , H01S3/1618 , H01S3/1631 , H01S3/1638 , H01S3/1666
摘要： A nonlinear Yb:YAB laser material is disclosed. The material is capable of generating fundamental o-polarized first wavelength laser light and frequency doubled e-polarized second wavelength laser light, the material being oriented for type 1 phase matching of the first wavelength laser light. Also disclosed is a laser system. The system comprises a pumping light source emitting a pumping beam of light, a laser cavity having an input coupler operatively disposed with respect to the light source so as to couple the pumping beam of light into the cavity, and a nonlinear Yb:YAB laser material capable of lasing in response to a pumping beam of light thereby generating fundamental o-polarized first wavelength laser light and frequency doubled e-polarized second wavelength laser light, the material being oriented for type 1 phase matching of the first wavelength laser light, the first wavelength laser light being in the range of 1020-1100 nm and the second wavelength laser light being in the range of 510-550 nm. The input coupler comprises a reflector to at least partially reflect the first wavelength laser light and the second wavelength laser light into the cavity, and the laser cavity further includes an output coupler for coupling and outputting at least the second wavelength laser light from the cavity as an output laser beam. Also disclosed are methods of providing an output laser beam and methods of using the beam.
摘要翻译：公开了一种非线性Yb：YAB激光材料。该材料能够产生基本的o偏振第一波长激光和倍频e偏振第二波长激光，该材料被定向为第一波长激光的1型相位匹配。还公开了一种激光系统。该系统包括发射泵浦光束的激发光源，激光腔，其具有相对于光源可操作地设置的输入耦合器，以将泵浦光束耦合到空腔中，以及非线性Yb：YAB激光材料能够响应于泵浦光束而激光，从而产生基本的o偏振第一波长激光和倍频e偏振的第二波长激光，该材料被定向为第一波长激光的1型相位匹配，第一波长激光波长激光在1020-1100nm范围内，第二波长激光在510-550nm范围内。所述输入耦合器包括至少部分地将所述第一波长激光和所述第二波长激光反射到所述空腔中的反射器，并且所述激光腔还包括输出耦合器，用于将来自所述空腔的至少第二波长激光耦合并输出，输出激光束。还公开了提供输出激光束的方法和使用该束的方法。

9. 发明申请

US20120127027A1 Persymmetric Parametric Adaptive Matched Filters for Detecting Targets Using Space-Time Adaptive Processing of Radar Signals 有权
标题翻译：用于使用雷达信号的时空自适应处理来检测目标的非对称参数自适应匹配滤波器
公开(公告)号：US20120127027A1
公开(公告)日：2012-05-24
申请号：US12954254
申请日：2010-11-24
申请人： Zafer Sahinoglu , Pu Wang , Man-On Pun
发明人： Zafer Sahinoglu , Pu Wang , Man-On Pun
IPC分类号： G01S13/00
CPC分类号： G01S13/5244 , G01S13/5242
摘要： A method provides space-time adaptive processing (STAP) for target detection using adaptive matched filters (AMF). A generalized likelihood ratio test (GLRT) is determined where spatial and temporal correlation matrices Q and A are assumed. Then, the correlation matrices A and Q are replaced with maximum likelihood (ML) estimates obtained only from training signals subject to a persymmetric constraint.
摘要翻译：一种方法使用自适应匹配滤波器（AMF）提供用于目标检测的时空自适应处理（STAP）。在假定空间和时间相关矩阵Q和A的情况下确定广义似然比检验（GLRT）。然后，相关矩阵A和Q被替换为仅由经受不对称约束的训练信号获得的最大似然（ML）估计。

10. 发明申请

US20120062409A1 METHOD FOR DETECTING TARGETS USING SPACE-TIME ADAPTIVE PROCESSING AND SHARED KNOWLEDGE OF THE ENVIRONMENT 有权
标题翻译：使用空间自适应处理和共享环境知识来检测目标的方法
公开(公告)号：US20120062409A1
公开(公告)日：2012-03-15
申请号：US12879288
申请日：2010-09-10
申请人： Man-On Pun , Zafer Sahinoglu , Pu Wang
发明人： Man-On Pun , Zafer Sahinoglu , Pu Wang
IPC分类号： G01S13/04 , G01S13/00
CPC分类号： G01S7/292 , G01S13/04
摘要： A method detects a target in a radar signal using space-time adaptive processing. A test statistic is T = max α  max λ  ∫ R  f 1  ( x 0 , x 1 , …  , x K  α , λ , R )  p  ( R )   R max λ  ∫ R  f 0  ( x 0 , x 1 , …  , x K  λ , R )  p  ( R )   R , where x0 is a test signal, xk are K training signals, α is an unknown amplitude of a target signal within the test signal, λ is a scaling factor, R is a covariance matrix of the training signals, and a function max returns a maximum values. The test statistic is compared to a threshold to determine whether the target is present, or not.
摘要翻译：一种方法使用空时自适应处理来检测雷达信号中的目标。一个测试统计量是T = max（α，max，λ）∫R f f 1（x 0，x 1，...，x Kα，λ，R） R 0 f（x 0，x 1，...，x Kλ，R）p R（R）其中x0是测试信号，xk是K个训练信号，α是未知振幅的测试信号内的目标信号，λ是缩放因子，R是训练信号的协方差矩阵，函数max返回最大值。将测试统计量与阈值进行比较，以确定目标是否存在。

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