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1. 发明申请

US20200016160A1 Treatment Agents for Inhibiting HIV and Cancer in HIV Infected Patients 审中-公开
公开(公告)号：US20200016160A1
公开(公告)日：2020-01-16
申请号：US16580988
申请日：2019-09-24
申请人： Robert R. Redfield , Alonso Heredia , Charles Davis , Ronald Gartenhaus , Edward A. Sausville
发明人： Robert R. Redfield , Alonso Heredia , Charles Davis , Ronald Gartenhaus , Edward A. Sausville
IPC分类号： A61K31/519 , A61K31/4745 , A61K31/501 , A61K31/5377 , A61K45/06
摘要： Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.

2. 发明授权

US11364242B2 Treatment agents for inhibiting HIV and cancer in HIV infected patients 有权
公开(公告)号：US11364242B2
公开(公告)日：2022-06-21
申请号：US16580988
申请日：2019-09-24
申请人： Robert R. Redfield , Alonso Heredia , Charles Davis , Ronald Gartenhaus , Edward A. Sausville
发明人： Robert R. Redfield , Alonso Heredia , Charles Davis , Ronald Gartenhaus , Edward A. Sausville
IPC分类号： A61K31/519 , A61K31/44 , A61K31/4745 , A61K31/501 , A61K31/5377 , A61K45/06
摘要： Methods are provided for treating HIV and cancer in a subject in need thereof by administering to the subject therapeutically effective amounts of an mTOR inhibitor. Other methods are provided for treating subjects infected with HIV by administering to the subject therapeutically effective amounts of the mTOR inhibitor INK128, GSK2126458, AZD2014 or Torin-2.

3. 发明申请

US20110117576A1 MCT-1, A HUMAN ONCOGENE 审中-公开
标题翻译： MCT-1，人类癌症
公开(公告)号：US20110117576A1
公开(公告)日：2011-05-19
申请号：US12902722
申请日：2010-10-12
申请人： Ronald Gartenhaus
发明人： Ronald Gartenhaus
IPC分类号： G01N33/566
CPC分类号： C07K14/4738 , A61K38/00 , C07K14/82
摘要： A novel gene, designated MCT-1 (for Multiple Copies in T-cell malignancy), is provided. A protein encoded by MCT-1, designated MCT-1, is also provided. Antisense oligonucleotides complementary to or homologous with a portion of MCT-1, substantially purified MCT-1, and methods of determining whether a cell is a tumor cell are also provided. The invention also includes monoclonal and polyclonal antibody preparations which bind with specificity to MCT-1. The invention further includes methods of determining whether a compound or a gene product is a modulator of MCT-1 expression, a method of reducing MCT-1 expression in a cell, and a method of conferring a growth advantage on a cell.
摘要翻译：提供了一种称为MCT-1（用于T细胞恶性肿瘤中的多拷贝）的新基因。还提供了称为MCT-1的MCT-1编码的蛋白质。还提供了与一部分MCT-1，基本上纯化的MCT-1互补或同源的反义寡核苷酸，以及确定细胞是否为肿瘤细胞的方法。本发明还包括与MCT-1特异性结合的单克隆和多克隆抗体制剂。本发明还包括确定化合物或基因产物是MCT-1表达调节剂的方法，还原细胞中MCT-1表达降低的方法以及赋予细胞生长优势的方法。

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