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1. 发明申请

US20090240523A1 OPTIMIZING PHARMACEUTICAL TREATMENT PLANS ACROSS MULTIPLE DIMENSIONS 失效
标题翻译：优化多维度药物治疗计划
公开(公告)号：US20090240523A1
公开(公告)日：2009-09-24
申请号：US12054074
申请日：2008-03-24
申请人： Robert R. Friedlander , Joanna Lynn Fueyo , Richard A. Hennessy , James R. Kraemer
发明人： Robert R. Friedlander , Joanna Lynn Fueyo , Richard A. Hennessy , James R. Kraemer
IPC分类号： G06Q50/00
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/3456 , G06Q10/10 , G06Q50/22 , G16H50/20 , G16H50/70
摘要： A computer implemented method for generating optimized pharmaceutical treatment plans for an individual. A set of known treatments to be used by the target individual over a future period of time is generated. An actual use of the treatments in the set of known treatments by the target individual during the future period of time is substantially certain. A set of probable treatments of the target individual is received. The actual use of the treatments in the set of probable treatments by the target individual during the future period of time is uncertain. An optimized pharmaceutical treatment plan for the target individual is generated. The optimized pharmaceutical treatment plan comprises medications and durable medical goods that are likely to be used by the target individual over the future period of time optimized over a set of dimensions associated with the set of known treatments and the set of probable treatments.
摘要翻译：一种用于为个体生成优化的药物治疗计划的计算机实施方法。产生一组目标个体在未来时间段内使用的已知治疗方法。目标个体在未来时间段内对一组已知治疗的实际使用情况基本上是确定的。收到一组目标个人的可能治疗。目标个人在未来一段时间内在一组可能治疗中的实际使用是不确定的。产生针对目标个体的优化药物治疗计划。优化的药物治疗计划包括可能由目标个体在未来时间段内被使用的药物和耐久性医疗用品，其优化于与一组已知治疗和一组可能的治疗相关联的一组尺寸。

2. 发明授权

US08121858B2 Optimizing pharmaceutical treatment plans across multiple dimensions 失效
标题翻译：优化多个维度的药物治疗计划
公开(公告)号：US08121858B2
公开(公告)日：2012-02-21
申请号：US12054074
申请日：2008-03-24
申请人： Robert R. Friedlander , Joanna Lynn Fueyo , Richard A. Hennessy , James R. Kraemer
发明人： Robert R. Friedlander , Joanna Lynn Fueyo , Richard A. Hennessy , James R. Kraemer
IPC分类号： G06Q10/00 , G06Q50/00
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/3456 , G06Q10/10 , G06Q50/22 , G16H50/20 , G16H50/70
摘要： A computer implemented method for generating optimized pharmaceutical treatment plans for an individual. A set of known treatments to be used by the target individual over a future period of time is generated. An actual use of the treatments in the set of known treatments by the target individual during the future period of time is substantially certain. A set of probable treatments of the target individual is received. The actual use of the treatments in the set of probable treatments by the target individual during the future period of time is uncertain. An optimized pharmaceutical treatment plan for the target individual is generated. The optimized pharmaceutical treatment plan comprises medications and durable medical goods that are likely to be used by the target individual over the future period of time optimized over a set of dimensions associated with the set of known treatments and the set of probable treatments.
摘要翻译：一种用于为个体生成优化的药物治疗计划的计算机实施方法。产生一组目标个体在未来时间段内使用的已知治疗方法。目标个体在未来时间段内对一组已知治疗的实际使用情况基本上是确定的。收到一组目标个人的可能治疗。目标个人在未来一段时间内在一组可能治疗中的实际使用是不确定的。产生针对目标个体的优化药物治疗计划。优化的药物治疗计划包括可能由目标个体在未来时间段内被使用的药物和耐久性医疗用品，其优化于与一组已知治疗和一组可能的治疗相关联的一组尺寸。

3. 发明授权

US07996242B2 Automatically developing neuropsychiatric treatment plans based on neuroimage data 失效
标题翻译：基于神经图像数据自动开发神经精神治疗计划
公开(公告)号：US07996242B2
公开(公告)日：2011-08-09
申请号：US12169402
申请日：2008-07-08
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： G06Q10/00 , G06F19/00
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/325 , G06F19/3481 , G06Q50/22 , G16H10/60 , G16H50/20
摘要： A computer implemented method, apparatus, and computer program product for developing neuropsychiatric treatment plans. A treatment plan generator receives a set of diagnoses for a patient. The treatment plan generator automatically analyzes medical information in a set of electronic medical literature sources for potential therapies associated with treatment of each identified condition in the set of diagnoses. The treatment plan generator identifies the potential therapies associated with the treatment of each diagnosed condition. The treatment plan generator selects a set of recommended therapies from the potential therapies based on portions of the medical literature describing each therapy in the potential therapies and a medical history for the patient. The treatment plan generator generates a treatment plan. The treatment plan comprises the set of recommended therapies to treat each diagnosed condition in the set of diagnoses.
摘要翻译：用于开发神经精神治疗计划的计算机实现的方法，装置和计算机程序产品。治疗计划生成器接收患者的一组诊断。治疗计划生成器自动分析一组电子医学文献来源中的医疗信息，用于与该组诊断中的每个识别的病症的治疗相关联的潜在疗法。治疗计划生成器识别与每个诊断的病症的治疗相关的潜在疗法。治疗计划生成者根据描述潜在疗法中的每种治疗的医学文献的部分以及患者的病史来选择潜在疗法中的一组推荐疗法。治疗计划生成器产生治疗计划。治疗计划包括一套推荐的治疗方法，用于治疗诊断中的每一个诊断病症。

4. 发明申请

US20090316969A1 DETERMINING EFFICACY OF THERAPEUTIC INTERVENTION IN NEUROSYCHIATRIC DISEASE 失效
标题翻译：治疗神经病学治疗效果的测定
公开(公告)号：US20090316969A1
公开(公告)日：2009-12-24
申请号：US12141322
申请日：2008-06-18
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： A61B5/00 , G06F17/30
CPC分类号： G06F17/30244 , A61B5/055 , A61B5/16 , A61B6/037 , A61B6/501 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/0012 , G06T2207/20104 , G06T2207/30016 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for determining the efficacy of neuropsychiatric therapy is provided. A neuroimage mapping manager automatically compares a first set of regions of interest in a first set of scans taken at a first time to a second set of regions of interest in a second set of scans generated at a second time and identifies a set of changes in the regions of interest occurring over time. The neuroimage mapping manager searches a set of electronic medical literature sources for medical literature relevant to the set of changes in the regions of interest and identifies portions of the relevant medical literature associated with the set of changes in the regions of interest. The neuroimage mapping manager generates results comprising the set of changes in the regions of interest and a set of links to the portions of the relevant medical literature.
摘要翻译：提供了一种用于确定神经精神治疗疗效的计算机实现的方法，装置和计算机程序产品。神经图像映射管理器将在第一时间拍摄的第一组扫描中的感兴趣区域的第一组区域自动地比较在第二时间生成的第二组扫描中的感兴趣区域的第二组，并且识别一组变化感兴趣的地区随着时间的推移而发生。神经图像映射管理器搜索一组电子医学文献来源，获取与感兴趣区域中的一组变化相关的医学文献，并且识别与感兴趣区域中的一组变化相关联的相关医学文献的部分。神经图像映射管理器生成包含感兴趣区域中的一组变化的结果以及到相关医学文献部分的一组链接。

5. 发明授权

US08199982B2 Mapping of literature onto regions of interest on neurological images 失效
标题翻译：将文献映射到神经系统图像上的感兴趣区域
公开(公告)号：US08199982B2
公开(公告)日：2012-06-12
申请号：US12141316
申请日：2008-06-18
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： G06K9/00
CPC分类号： G06F19/345 , A61B5/055 , A61B6/037 , A61B6/501 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/0012 , G06T2207/20104 , G06T2207/30016 , G16H50/20 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.
摘要翻译：一种用于分析神经图像的计算机实现的方法，装置和计算机程序产品。将一组患者的脑扫描与一组基线控制扫描进行比较，以自动识别该组患者扫描中的感兴趣区域。感兴趣区域是显示潜在异常的指示的扫描区域。一组电子医学文献来源搜索与该组患者扫描相关的感兴趣区域的医学文献。相关的医学文献与将病人扫描的病人扫描中的感兴趣区域描述在该组病人扫描中的感兴趣区域的医学文献相关。产生结果。输出结果包括感兴趣区域和与相关医学文献的相关部分的一组链接。

6. 发明申请

US20100010831A1 AUTOMATICALLY DETERMINING IDEAL TREATMENT PLANS FOR COMPLEX NEUROPSYCHIATRIC CONDITIONS 有权
标题翻译：自动确定复杂神经病理条件的理想治疗方案
公开(公告)号：US20100010831A1
公开(公告)日：2010-01-14
申请号：US12169329
申请日：2008-07-08
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： G06Q50/00
CPC分类号： G06F19/321 , G06F19/00 , G06F19/3481 , G06Q50/22 , G06Q50/24
摘要： A computer implemented method, apparatus, and computer program product for modifying neuropsychiatric treatment plans based on efficacy of treatment. A current treatment plan comprising a first set of therapies to treat a set of neuropsychiatric conditions and portions of the medical literature associated with the set of neuropsychiatric conditions is retrieved. A set of brain scans of the patient is analyzed to determine a set of changes over time associated with the set of neuropsychiatric conditions. The portions of the medical literature and the set of changes are analyzed to determine a patient rate of response to the treatment plan. If the patient rate of response falls below a threshold expected rate, a set of alternative treatments for the patient is identified. A modified treatment plan is generated using the set of alternative treatments.
摘要翻译：一种基于治疗效果的用于修改神经精神治疗计划的计算机实现的方法，装置和计算机程序产品。检索包括治疗一组神经精神病状的第一组疗法和与该组神经精神病学条件相关的部分医学文献的当前治疗计划。分析患者的一组脑扫描，以确定与神经精神病学条件相关联的随时间变化的一组变化。分析医学文献的一部分和一组变化，以确定患者对治疗计划的反应率。如果患者的反应率降低到阈值预期速率以下，则识别患者的一组替代治疗。使用一组替代治疗产生修改的治疗计划。

7. 发明申请

US20100010316A1 DIFFERENTIAL DIAGNOSIS OF NEUROPSYCHIATRIC CONDITIONS 有权
标题翻译：神经功能障碍的差异诊断
公开(公告)号：US20100010316A1
公开(公告)日：2010-01-14
申请号：US12169339
申请日：2008-07-08
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： A61B5/00 , G06F17/30
CPC分类号： G06T7/0012 , G06F19/00 , G06T2207/10016 , G06T2207/10072 , G06T2207/20104 , G06T2207/30016 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for generating neuropsychiatric diagnoses. Quantitative information describing diagnostic characteristics associated with a patient is generated based on an analysis of a set of patient scans. The quantitative information comprises a set of indictors associated with regions of interest in the set of scans for the patient. The set of indicators of potential neuropsychiatric conditions is compared with a set of diagnostic signatures. A diagnostic signature comprises a set of indicators of a known neuropsychiatric condition. Matching signatures are identified. A matching signature is a diagnostic signature that corresponds to at least one indicator in the set of indicators to form a set of signatures. A diagnosis associated with each signature in the set of signatures is identified to form a set of potential diagnoses. The set of potential diagnoses is presented with links to relevant portion of the medical literature.
摘要翻译：一种用于产生神经精神科诊断的计算机实现的方法，装置和计算机程序产品。基于对一组患者扫描的分析来生成描述与患者相关联的诊断特征的定量信息。定量信息包括与患者的扫描集合中的感兴趣区域相关联的一组指示符。将一组潜在神经精神病学指标与一组诊断标记进行比较。诊断签名包括已知神经精神病状的一组指标。识别匹配的签名。匹配的签名是对应于该组指示符中的至少一个指示符以形成一组签名的诊断签名。识别与该组签名中的每个签名相关联的诊断以形成一组潜在诊断。该组潜在诊断呈现与医学文献相关部分的链接。

8. 发明授权

US09390233B2 Mapping of literature onto regions of interest on neurological images 有权
标题翻译：将文献映射到神经系统图像上的感兴趣区域
公开(公告)号：US09390233B2
公开(公告)日：2016-07-12
申请号：US13452331
申请日：2012-04-20
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： G06F19/00 , A61B6/03 , A61B6/00 , G06T7/00 , A61B5/055
CPC分类号： G06F19/345 , A61B5/055 , A61B6/037 , A61B6/501 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/0012 , G06T2207/20104 , G06T2207/30016 , G16H50/20 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.
摘要翻译：一种用于分析神经图像的计算机实现的方法，装置和计算机程序产品。将一组患者的脑扫描与一组基线控制扫描进行比较，以自动识别该组患者扫描中的感兴趣区域。感兴趣区域是显示潜在异常的指示的扫描区域。一组电子医学文献来源搜索与该组患者扫描相关的感兴趣区域的医学文献。相关的医学文献与将病人扫描的病人扫描中的感兴趣区域描述在该组病人扫描中的感兴趣区域的医学文献相关。产生结果。输出结果包括感兴趣区域和与相关医学文献的相关部分的一组链接。

9. 发明授权

US09198612B2 Determination of neuropsychiatric therapy mechanisms of action 有权
标题翻译：确定神经精神病治疗机制的作用
公开(公告)号：US09198612B2
公开(公告)日：2015-12-01
申请号：US12169350
申请日：2008-07-08
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： A61B5/05 , A61B5/00 , A61B6/03 , A61B6/00 , A61B5/055 , G06F19/00
CPC分类号： G06F19/321 , A61B5/055 , A61B5/411 , A61B5/417 , A61B6/037 , A61B6/501 , A61B6/56 , A61B6/563 , A61B6/566 , G06F17/30011 , G06F17/30864 , G06F19/00 , G06F19/324 , G06F19/3481 , G06K9/46 , G06K9/6215 , G06K2009/4666 , G06T7/0012 , G06T2207/10088 , G06T2207/10104 , G06T2207/30016 , G16H50/20 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product of determining mechanisms of action for therapies. A first set of brain scans for each subject in a plurality of subjects generated at a first time period and a second set of brain scans for each subject generated at a second time period are received. Each subject is diagnosed with a given condition and received a given therapy. A set of changes in the set of brain scans is identified for the each subject based on a comparison of a first set of regions of interest in the first set of scans for each subject with a second set of regions of interest in the second set of scans for each subject. A set of typical changes attributable to the given therapy is identified. A mechanism of action for the given therapy is generated based on the set of typical changes.
摘要翻译：一种计算机实现的方法，装置和计算机程序产品，用于确定治疗的作用机制。接收在第一时间段生成的多个对象中的每个受试者的第一组脑扫描和在第二时间段产生的每个对象的第二组脑扫描。每个受试者被诊断为给定的病症并接受给定的治疗。基于对于每个受试者的第一组扫描中的第一组感兴趣区域与第二组感兴趣区域中的第二组感兴趣的区域的比较，针对每个受试者识别一组脑扫描集合中的变化扫描每个主题。确定归因于给定治疗的一组典型变化。基于典型变化的集合产生给定治疗的作用机制。

10. 发明授权

US08548823B2 Automatically determining ideal treatment plans for complex neuropsychiatric conditions 有权
标题翻译：自动确定复杂神经精神病学条件的理想治疗计划
公开(公告)号：US08548823B2
公开(公告)日：2013-10-01
申请号：US12169329
申请日：2008-07-08
申请人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
发明人： Joanna Lynn Fueyo , Robert Lee Angell , Robert R. Friedlander , James R. Kraemer
IPC分类号： G06Q10/00 , G06F19/00
CPC分类号： G06F19/321 , G06F19/00 , G06F19/3481 , G06Q50/22 , G06Q50/24
摘要： A computer implemented method, apparatus, and computer program product for modifying neuropsychiatric treatment plans based on efficacy of treatment. A current treatment plan comprising a first set of therapies to treat a set of neuropsychiatric conditions and portions of the medical literature associated with the set of neuropsychiatric conditions is retrieved. A set of brain scans of the patient is analyzed to determine a set of changes over time associated with the set of neuropsychiatric conditions. The portions of the medical literature and the set of changes are analyzed to determine a patient rate of response to the treatment plan. If the patient rate of response falls below a threshold expected rate, a set of alternative treatments for the patient is identified. A modified treatment plan is generated using the set of alternative treatments.
摘要翻译：一种基于治疗效果的用于修改神经精神治疗计划的计算机实现的方法，装置和计算机程序产品。检索包括治疗一组神经精神病状的第一组疗法和与该组神经精神病学条件相关的部分医学文献的当前治疗计划。分析患者的一组脑扫描，以确定与神经精神病学条件相关联的随时间变化的一组变化。分析医学文献的一部分和一组变化，以确定患者对治疗计划的反应率。如果患者的反应率降低到阈值预期速率以下，则识别患者的一组替代治疗。使用一组替代治疗产生修改的治疗计划。

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