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1. 发明授权

US06665557B1 Sprectroscopic and time-resolved optical methods and apparatus for imaging objects in turbed media 失效
标题翻译：用于在混浊介质中成像物体的分光学和时间分辨的光学方法和装置
公开(公告)号：US06665557B1
公开(公告)日：2003-12-16
申请号：US09597505
申请日：2000-06-20
申请人： Robert R. Alfano , Swapan Kumar Gayen , Manuel E. Zevallos
发明人： Robert R. Alfano , Swapan Kumar Gayen , Manuel E. Zevallos
IPC分类号： A61B600
CPC分类号： A61B5/0091 , A61B5/4312
摘要： Method and apparatus for imaging objects in turbid media. In one embodiment, the method comprises illuminating at least a portion of the turbid medium with substantially monochromatic light of at least two wavelengths in the 600-1500 nm spectral range. A first of the at least two wavelengths is equal to a resonance wavelength for an optical property of an object in the illuminated portion of the turbid medium but is not equal to a resonance wavelength for the turbid medium. A second of the at least two wavelengths is not equal to a resonance wavelength for either the object or the turbid medium. Light emergent from the turbid medium following each of the foregoing illuminations comprises a ballistic component, a snake component and a diffuse component. A direct shadowgram image may be obtained by preferentially passing from the emergent light, following each illumination. the ballistic and snake components thereof and detecting the preferentially passed light. Alternatively, an inverse reconstruction image may be obtained by determining, following each illumination, the intensity of the diffuse component at a plurality of points in time and then using these pluralities of intensity determinations and a mathematical inversion algorithm to form an image of the object in the turbid medium. An image of the object with higher contrast and better quality may be obtained by using the ratio or difference of the images recorded with resonant light and non-resonant light.
摘要翻译：用于在浑浊介质中成像物体的方法和装置。在一个实施例中，该方法包括以600-1500nm光谱范围内的至少两个波长的基本上单色的光照亮混浊介质的至少一部分。至少两个波长中的第一个等于混浊介质的照射部分中的物体的光学性质的共振波长，但不等于混浊介质的共振波长。至少两个波长中的第二个不等于物体或混浊介质的共振波长。每个前述照明后从混浊介质出射的光包括弹道组件，蛇组件和漫射分量。可以在每个照明之后优先通过出射光获得直接阴影图像。弹道和蛇组件，并检测优先通过的光。或者，可以通过在每个照明之后确定多个时间点上的漫射分量的强度，然后使用这些多个强度确定和数学反演算法来形成对象的图像，来获得反重建图像混浊介质。通过使用用共振光和非共振光记录的图像的比率或差异可以获得具有较高对比度和更好质量的对象的图像。

2. 发明授权

US07826878B2 Optical tomography using independent component analysis for detection and localization of targets in turbid media 有权
标题翻译：使用独立分量分析进行光学层析成像，用于浑浊介质中目标的检测和定位
公开(公告)号：US07826878B2
公开(公告)日：2010-11-02
申请号：US11296831
申请日：2005-12-07
申请人： Robert R. Alfano , Min Xu , Mohammed Alrubaiee , Swapan Kumar Gayen
发明人： Robert R. Alfano , Min Xu , Mohammed Alrubaiee , Swapan Kumar Gayen
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/0066
摘要： Disclosed is a system and a method for detecting the presence of one or more objects in a turbid medium, the method including: illuminating at least a portion of the turbid medium with incident light having at least one wavelength which interacts with the one or more objects contained in the turbid medium differently than the incident light interacts with the turbid medium; measuring light that emerges from the turbid medium; and detecting and locating the one or more objects using Independent Component Analysis (ICA) of the emergent light from the turbid medium. The present invention is useful for medical applications, such as for finding and locating, a tumor(s) in body organs, or excised tissues. Moreover, the present invention can be used to locate objects in obscuring medium, such as, mines in shallow coastal water, a plane in fog, military targets under fog, smoke or cloud cover.
摘要翻译：公开了一种用于检测混浊介质中一个或多个物体的存在的系统和方法，所述方法包括：用具有至少一个波长的入射光照射混浊介质的至少一部分，该入射光与一个或多个物体相互作用不同于入射光与混浊介质相互作用的混浊介质; 测量从混浊介质中出来的光; 以及使用来自混浊介质的出射光的独立分量分析（ICA）来检测和定位一个或多个物体。本发明可用于医学应用，例如用于发现和定位体内器官或切除组织中的肿瘤。此外，本发明可以用于定位在浅色海岸水中的矿井，雾中的矿井，雾中的军事目标，烟雾或云层等模糊介质中的物体。

3. 发明申请

US20080146897A1 Optical tomography using independent component analysis for detection and localization of targets in turbid media 有权
标题翻译：使用独立分量分析进行光学层析成像，用于浑浊介质中目标的检测和定位
公开(公告)号：US20080146897A1
公开(公告)日：2008-06-19
申请号：US11296831
申请日：2005-12-07
申请人： Robert R. Alfano , Min Xu , Mohammed Alrubaiee , Swapan Kumar Gayen
发明人： Robert R. Alfano , Min Xu , Mohammed Alrubaiee , Swapan Kumar Gayen
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/0066
摘要： Disclosed is a system and a method for detecting the presence of one or more objects in a turbid medium, the method including: illuminating at least a portion of the turbid medium with incident light having at least one wavelength which interacts with the one or more objects contained in the turbid medium differently than the incident light interacts with the turbid medium; measuring light that emerges from the turbid medium; and detecting and locating the one or more objects using Independent Component Analysis (ICA) of the emergent light from the turbid medium. The present invention is useful for medical applications, such as for finding and locating, a tumor(s) in body organs, or excised tissues. Moreover, the present invention can be used to locate objects in obscuring medium, such as, mines in shallow coastal water, a plane in fog, military targets under fog, smoke or cloud cover.
摘要翻译：公开了一种用于检测混浊介质中一个或多个物体的存在的系统和方法，所述方法包括：用具有至少一个波长的入射光照射混浊介质的至少一部分，该入射光与一个或多个物体相互作用不同于入射光与混浊介质相互作用的混浊介质; 测量从混浊介质中出来的光; 以及使用来自混浊介质的出射光的独立分量分析（ICA）来检测和定位一个或多个物体。本发明可用于医学应用，例如用于发现和定位体内器官或切除组织中的肿瘤。此外，本发明可以用于定位在浅色海岸水中的矿井，雾中的矿井，雾中的军事目标，烟雾或云层等模糊介质中的物体。

4. 发明申请

US20080132794A1 Spectral polarizing tomographic dermatoscope 审中-公开
标题翻译：光谱偏振层析成像皮肤镜
公开(公告)号：US20080132794A1
公开(公告)日：2008-06-05
申请号：US12011580
申请日：2008-01-28
申请人： Robert R. Alfano , Yury Budansky , Jingcheng Luo , Manuel E. Zevallos
发明人： Robert R. Alfano , Yury Budansky , Jingcheng Luo , Manuel E. Zevallos
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0013 , A61B5/0068 , A61B5/0073 , A61B5/0084 , A61B5/415 , A61B5/418 , A61B5/4331 , A61B5/443 , A61B5/444 , A61B5/445
摘要： An apparatus for use in examining an object, such as skin, mucosa and cervical tissues for detecting cancer and precancerous conditions therein. In one embodiment, the apparatus includes a gun-shaped housing having a handle portion and a barrel portion. The front end of the barrel portion is open, and a glass cover is mounted therein. LED's are disposed within the handle portion. A manually-operable switch for controlling actuation of the LED's is accessible on the handle portion. An optical fiber is used to transmit light from the LED's through a first polarizer in the barrel portion and then through the glass cover to illuminate a desired object. Reflected light from the object is passed through a second polarizer, which is adjustably mounted in the barrel portion and which is preferably oriented to pass depolarized light emitted from an illuminated object, and is then imaged by optics onto a CCD detector. The detector is coupled to a wireless transmitter that transmits the output from the detector to a remotely located wireless receiver.
摘要翻译：用于检查诸如皮肤，粘膜和子宫颈组织的物体以检测其中的癌症和癌前病症的装置。在一个实施例中，该装置包括具有手柄部分和镜筒部分的枪形壳体。筒部的前端开放，玻璃罩安装在其中。 LED设置在手柄部分内。用于控制LED的致动的手动操作开关可在手柄部分上进行。光纤用于通过筒部中的第一偏振器从LED透射光，然后通过玻璃盖照射所需物体。来自物体的反射光穿过第二偏振器，第二偏振器可调节地安装在镜筒部分中，并且其优选地定向成使从被照射物体发射的去偏振光通过，然后通过光学器件被成像到CCD检测器上。该检测器耦合到将检测器的输出传输到远程位置的无线接收器的无线发射器。

5. 发明授权

US10433731B2 Continuous diode laser stimulated Raman gain/loss vibrational microscope 有权
公开(公告)号：US10433731B2
公开(公告)日：2019-10-08
申请号：US15243207
申请日：2016-08-22
申请人： Robert R. Alfano
发明人： Robert R. Alfano , Lingyan Shi , Yury Budansky
IPC分类号： A61B5/00 , G01N21/65
摘要： There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

6. 发明授权

US09804088B2 Spatial frequency spectrometer for and method of detection of spatial structures in materials 有权
公开(公告)号：US09804088B2
公开(公告)日：2017-10-31
申请号：US14580892
申请日：2014-12-23
申请人： Robert R. Alfano , Yang Pu
发明人： Robert R. Alfano , Yang Pu
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01N21/4788
摘要： Spatial frequency spectra from periodic, aperiodic and quasi-random structures in materials are shown and used to detect differences among objects via internal coding from the spatial frequencies. The method is applied to different grades of human tissues for a new form of histology and pathology, and to detect art forgeries and coding boxes, money and papers and gems. The randomness of material structures on surface and at depths near surface can be detected from the spatial spectrum. In tissue spectral features from normal to different stages of cancer in tissue for ex vivo and in vivo applications can be recognized by different spectral fingerprints content of the spatial frequency. Similarly, the painting for the strokes of artist is different. A new type of instrument is described to analyze materials as a Spatial Frequency Spectrometer.

7. 发明授权

US09620858B2 Compact electromagnetic-radiation antenna 有权
公开(公告)号：US09620858B2
公开(公告)日：2017-04-11
申请号：US14218864
申请日：2014-03-18
申请人： Robert R. Alfano
发明人： Robert R. Alfano , M. Yu Sharonov
IPC分类号： H01Q7/06 , H01Q7/08 , H01Q1/36
CPC分类号： H01Q7/08 , H01Q1/36 , H01Q7/06 , Y10T29/49016
摘要： A compact random media size antenna employing random magnetic and dielectrics nm to mm range size particles in polymer hosts is used to transfer E & M oscillations in 1 kHz to 900 Mhz range using a 1 cm to 1 meter length antenna. This is achieved by using small size particles and a random mean path length of E & M wavefront travel in and about a core tube of effective length matching Leff=L2/2ltr, equivalent to λ/2 for transmitting and receiving E & M radiation, where L is the physical size of the antenna, ltris the transport scattering random walk length between particles and λ is the frequency wavelength.

8. 发明申请

US20160128775A1 METHOD OF USING SUPERCONTINUUM LIGHT FOR MEDICAL AND BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：超光连接用于医疗和生物应用的方法
公开(公告)号：US20160128775A1
公开(公告)日：2016-05-12
申请号：US14996449
申请日：2016-01-15
申请人： Robert R. Alfano
发明人： Robert R. Alfano
IPC分类号： A61B18/20
CPC分类号： G02B21/0064 , A61B5/0066 , A61B18/20 , A61B2017/00508 , A61B2018/1807 , A61B2018/2065 , A61N5/0622 , A61N2005/0659 , A61N2005/067 , G01N33/4833 , G02B21/0032 , G02B21/0084 , G02F1/3515 , G02F1/3536 , G02F1/355 , G02F1/3551 , G02F1/365 , G02F2001/3528 , G06N99/002
摘要： A method and an apparatus are provided for producing SuperContinuum (SC) light for medical and biological applications is provided. Pulses are focused from a laser system into at least one of a pressurized cell and one or more fibers. A pump pulse is converted into the SC light at a specified rate of repetition. The SC light is applied at the specified rate of repetition to tissue for medical and biological applications.
摘要翻译：提供了用于生产用于医疗和生物应用的超级连续（SC）光的方法和装置。脉冲从激光系统聚焦成加压电池和一个或多个光纤中的至少一个。泵浦脉冲以指定的重复速率转换成SC光。以指定的重复速率将SC光施加到用于医疗和生物应用的组织。

9. 发明授权

US08974444B2 Method for picosecond and femtosecond laser tissue welding 有权
标题翻译：皮秒和飞秒激光组织焊接方法
公开(公告)号：US08974444B2
公开(公告)日：2015-03-10
申请号：US13642746
申请日：2011-04-20
申请人： Robert R. Alfano , Vidyasagar Sriramoju
发明人： Robert R. Alfano , Vidyasagar Sriramoju
IPC分类号： A61B18/20 , A61B17/00 , A61B18/00
CPC分类号： A61B18/20 , A61B18/203 , A61B2017/00508 , A61B2018/00452
摘要： A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collagen in the tissue wound and tissue surrounding the tissue wound. The pulsed laser has a pulse width of not more than picoseconds in order of magnitude to heat tissue surrounding the tissue wound and facilitate bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. The laser wavelength is in a range of between about 800 nm to about 2,700 nm.
摘要翻译：一种用于焊接动物组织伤口的方法。该方法包括接合伤口组织的边缘并用脉冲激光照射卷绕的组织周围的组织。脉冲激光在组织伤口和围绕组织伤口的组织的水吸收带，弹性蛋白和/或胶原的范围内具有激光波长。脉冲激光器具有不超过皮秒的脉冲宽度，以加热组织周围的组织，并促进存在于围绕组织伤口的组织中的天然组织蛋白质的结合以实现组织修复。激光波长在约800nm至约2,700nm之间的范围内。

10. 发明授权

US07706862B2 Detecting human cancer through spectral optical imaging using key water absorption wavelengths 失效
标题翻译：通过使用关键吸水波长的光谱成像检测人类癌症
公开(公告)号：US07706862B2
公开(公告)日：2010-04-27
申请号：US10926556
申请日：2004-08-26
申请人： Robert R. Alfano , Jamal H. Ali , Wubao Wang , Manuel Zevallos
发明人： Robert R. Alfano , Jamal H. Ali , Wubao Wang , Manuel Zevallos
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/4381 , A61B5/7264
摘要： Spectral optical imaging at one or more key water absorption fingerprint wavelengths measures the difference in water content between a region of cancerous or precancerous tissue and a region of normal tissue. Water content is an important diagnostic parameter because cancerous and precancerous tissues have different water content than normal tissues. Key water absorption wavelengths include at least one of 980 nanometers (nm), 1195 nm, 1456 nm, 1944 nm, 2880 nm to 3360 nm, and 4720 nm. In the range of 400 nm to 6000 nm, one or more points of negligible water absorption are used as reference points for a comparison with one or more key neighboring water absorption wavelengths. Different images are generated using at least two wavelengths, including a water absorption wavelength and a negligible water absorption wavelength, to yield diagnostic information relevant for classifying a tissue region as cancerous, precancerous, or normal. The results of this comparison can be used to identify regions of cancerous tissue in organs such as the breast, cervix and prostate.
摘要翻译：一个或多个关键的吸水指纹波长的光谱成像测量癌变或癌前组织区域与正常组织区域之间的含水量差异。水含量是重要的诊断参数，因为癌和癌前组织的含水量比正常组织水分含量高。关键的吸水波长包括980纳米（nm），1195nm，1456nm，1944nm，2880nm至3360nm和4720nm中的至少一个。在400nm至6000nm的范围内，使用可忽略的吸水点的一个或多个点作为与一个或多个关键相邻吸水波长的比较的参考点。使用包括吸水波长和可忽略的吸水波长的至少两个波长产生不同的图像，以产生与将癌组织区域分类为癌，癌前或正常相关的诊断信息。该比较的结果可以用于识别器官如乳腺，子宫颈和前列腺中癌组织的区域。

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