会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明申请
    • Stent Coating For Eluting Medication
    • 用于洗脱药物的支架涂层
    • US20060200231A1
    • 2006-09-07
    • US11307226
    • 2006-01-27
    • Robert O'BrienChristine Frysz
    • Robert O'BrienChristine Frysz
    • A61F2/06
    • A61L31/084A61F2/91A61F2250/0067A61F2250/0068A61L31/146A61L31/16A61L2300/108Y10T29/49885
    • A vascular stent comprising a drug-eluting outer layer of a porous sputtered columnar metal having each column capped with a biocompatible carbon-containing material is described. This is done by placing the stent over a close-fitting mandrel and rotating the assembly in a sputter flux. The result is a coating that is evenly distributed over the outward-facing side of the stent's wire mesh while preventing the sputtered columnar coating from reaching the inward facing side where a smooth hemocompatible surface is required. The stent is then removed from the mandrel, exposing all surfaces, and finally coated with a layer of carbon such as amorphous carbon or diamond-like carbon. The carbonaceous coating enhances biocompatibility without preventing elutriation of a therapeutic drug provided in the porosity formed between the columnar structures. The result is a stent that is adapted to both the hemodynamic and the immune response requirements of its vascular environment.
    • 描述了一种包含多孔溅射柱状金属的药物洗脱外层的血管支架,每个柱用生物相容性含碳材料封盖。 这通过将支架放置在紧密的心轴上并将组件旋转在溅射通量中来完成。 其结果是均匀地分布在支架的金属丝网的向外侧上的涂层,同时防止溅射的柱状涂层到达需要光滑的血液相容表面的内侧。 然后将支架从心轴移除,暴露所有表面,并最终涂覆有碳层如无定形碳或类金刚石碳。 碳质涂层增强生物相容性,而不阻止在柱状结构之间形成的孔隙中提供的治疗药物的淘析。 其结果是适应于其血管环境的血液动力学和免疫应答要求的支架。