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1. 发明授权

US4128637A Process for producing thymosin 失效
标题翻译：生产胸腺素的方法
公开(公告)号：US4128637A
公开(公告)日：1978-12-05
申请号：US809083
申请日：1977-06-23
申请人： Robert Naylor , Howard F. Coyer
发明人： Robert Naylor , Howard F. Coyer
IPC分类号： C07K14/575 , A61K35/26 , A61K35/56 , A61K37/24
CPC分类号： C07K14/57581 , Y10S530/837
摘要： Thymosin is produced by an improved process in which thymus glands are coarse ground, extracted in saline solution which is filtered and the filtrate or extract is injected with steam for a brief period of time to denature undesired proteins without denaturing the thymosin, whereby a precipitate is formed which is separated by filtration. The filtrate is concentrated and cooled and crude thymosin is precipitated by adding the concentrate to acetone.
摘要翻译：胸腺素通过改进的方法生产，其中胸腺是粗磨的，在盐水溶液中提取，过滤，滤液或提取物用蒸汽注射短时间以使不需要的蛋白质变性，而不会使胸腺素变性，由此沉淀物形成，通过过滤分离。将滤液浓缩并冷却，通过将浓缩物加入到丙酮中来沉淀粗制胸腺素。

2. 发明授权

US5110824A Method of treating disorders of cognitive function with substituted benzamides 失效
标题翻译：用替代苯甲胺处理认知功能障碍的方法
公开(公告)号：US5110824A
公开(公告)日：1992-05-05
申请号：US507753
申请日：1990-04-12
申请人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Renee Gardaix-Luthereau , Brenda Costall , Robert Naylor
发明人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Renee Gardaix-Luthereau , Brenda Costall , Robert Naylor
IPC分类号： C07D233/50 , A61K31/415 , A61K31/42 , A61K31/421 , A61P25/28 , C07D263/28 , C07D403/12
CPC分类号： A61K31/42 , A61K31/415
摘要： The invention relates to the use of benzamide derivatives of the formula: ##STR1## in which: A is a diethylaminoethyl group or a group of the formula II: ##STR2## where R is a C.sub.1 -C.sub.3 alkyl, allyl, cyclopropylmethyl or cyclohexenylmethyl group,X is a chlorine or bromine atom, andZ is --NH-- or --O-- with the following condition: when Z is --O--, A is a diethylaminoethyl group, and their pharmacologically acceptable salts for the preparation of medicinal products which are useful in the treatment and prevention of disorders of the cognitive function.
摘要翻译：本发明涉及下式的苯甲酰胺衍生物的用途：其中：A是二乙基氨基乙基或式II的基团：其中R是C 1 -C 3烷基，烯丙基，环丙基甲基或环己烯基甲基，X为氯或溴原子，Z为-NH-或-O-，具有以下条件：当Z为-O-时，A为二乙基氨基乙基，其药理学上可接受的盐为制备可用于治疗和预防认知功能障碍的药用产品。

3. 发明授权

US5116857A Method of increasing gastrointestinal motility with substituted benzamides 失效
标题翻译：用替代苯甲酸增加胃肠动力学的方法
公开(公告)号：US5116857A
公开(公告)日：1992-05-26
申请号：US450422
申请日：1989-12-14
申请人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Brenda Costall , Robert Naylor , Renee Gardaix-Luthereau
发明人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Brenda Costall , Robert Naylor , Renee Gardaix-Luthereau
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/625 , A61P1/14 , C07D233/50 , C07D263/28 , C07D277/18 , C07D277/20 , C07D277/42
CPC分类号： A61K31/425 , A61K31/415 , A61K31/42 , C07D233/50 , C07D263/28 , C07D277/18
摘要： The present invention relates to the use of substituted benzamides of formula (1): ##STR1## in which: A is linear or branched C.sub.1 -C.sub.3 alkyl; allyl or diethylaminoethyl;R.sub.1 is hydrogen or methyl, andZ-- is --NH--, --O-- or --S--,and of their pharmacologically acceptable salts for modifying gastric motility.
摘要翻译：本发明涉及式（1）的取代苯甲酰胺的用途：其中：A是直链或支链C 1 -C 3烷基; 烯丙基或二乙基氨基乙基; R1是氢或甲基，Z-是-NH-，-O-或-S-，以及它们用于改善胃动力的药理学上可接受的盐。

4. 发明授权

US5141949A Method of providing anxiolytic and antipsychotic treatment 失效
标题翻译：提供抗焦虑和抗精神病药物治疗方法
公开(公告)号：US5141949A
公开(公告)日：1992-08-25
申请号：US785803
申请日：1991-10-31
申请人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Brenda Costall , Robert Naylor , Renee Gardaix-Luthereau
发明人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Brenda Costall , Robert Naylor , Renee Gardaix-Luthereau
IPC分类号： A61K31/415 , A61P25/18 , A61P25/20 , C07D233/50
CPC分类号： A61K31/415 , Y10S514/81 , Y10S514/811 , Y10S514/812
摘要： Anxiolytic and antipsychotic treatment is provided to patients by administering therapeutically effective amounts of N-[2-(diethylamino)-ethyl]-2-methoxy-4-[(1-H-4,5-dihydro-2-imidazolyl)-amino]-5-chlorobenzamide, or a pharmaceutically acceptable salt thereof.
摘要翻译：通过给予治疗有效量的N- [2-（二乙基氨基） - 乙基] -2-甲氧基-4 - [（1-H-4,5-二氢-2-咪唑基） - 氨基 ] -5-氯苯甲酰胺或其药学上可接受的盐。

5. 发明授权

US4914117A Novel benzamides, intermediates and process for the preparation and therapeutic use thereof 失效
标题翻译：新型苯甲酰胺，中间体及其制备和治疗用途的方法
公开(公告)号：US4914117A
公开(公告)日：1990-04-03
申请号：US322122
申请日：1989-03-13
申请人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Gardaix-Luthereau Renee , Brenda Costall , Robert Naylor
发明人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Gardaix-Luthereau Renee , Brenda Costall , Robert Naylor
IPC分类号： A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P1/08 , A61P25/24 , A61P25/26 , C07D233/50 , C07D263/28 , C07D277/18 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D403/12 , C07D233/50 , C07D263/28 , C07D277/18 , C07D413/12 , C07D417/12
摘要： New substituted benzamides have the general formula: ##STR1## their optical isomers and their physiologically acceptable salts. The compounds are used as activators of the central nervous system.

6. 发明授权

US08271633B2 Correlating network transactions 有权
标题翻译：关联网络交易
公开(公告)号：US08271633B2
公开(公告)日：2012-09-18
申请号：US12425183
申请日：2009-04-16
申请人： Daniel S. Pyrik , Kaynam Hedayat , Robert Naylor
发明人： Daniel S. Pyrik , Kaynam Hedayat , Robert Naylor
IPC分类号： G06F15/173
CPC分类号： H04L43/00 , H04L41/0816 , H04L41/5009
摘要： The correlating network transactions techniques include a method, an apparatus, and/or a computer program product. In some embodiments of these techniques, the method includes receiving, at a first monitor server, a first plurality of network transmissions from a first plurality of communication networks and correlating, at the first monitor server, the first plurality of network transmissions based on information associated with the first plurality of network transmissions to form a first correlated network transaction. The method further includes transmitting the first correlated network transaction from the first monitor server to a second monitor server based on a first correlation flag and correlating, at the second monitor server, the first correlated network transaction with a second network transmission based on at least one of the first correlation flag, information associated with the second network transmission, and information associated with the first correlated network transaction to form a second correlated network transaction.
摘要翻译：相关网络交易技术包括方法，装置和/或计算机程序产品。在这些技术的一些实施例中，该方法包括在第一监视服务器处接收来自第一多个通信网络的第一多个网络传输，并且在第一监视服务器处，基于相关信息关联第一多个网络传输与第一多个网络传输形成第一相关网络事务。该方法还包括基于第一相关标志将第一相关网络事务从第一监视服务器发送到第二监视服务器，并且在第二监视服务器处将第一相关网络事务与第二网络传输基于至少一个所述第一相关标志，与所述第二网络传输相关联的信息，以及与所述第一相关网络事务相关联的信息，以形成第二相关网络事务。

7. 发明申请

US20100268797A1 CORRELATING NETWORK TRANSACTIONS 有权
标题翻译：相关网络交易
公开(公告)号：US20100268797A1
公开(公告)日：2010-10-21
申请号：US12425183
申请日：2009-04-16
申请人： Daniel S. Pyrik , Kaynam Hedayat , Robert Naylor
发明人： Daniel S. Pyrik , Kaynam Hedayat , Robert Naylor
IPC分类号： G06F15/177 , G06F15/173
CPC分类号： H04L43/00 , H04L41/0816 , H04L41/5009
摘要： The correlating network transactions techniques include a method, an apparatus, and/or a computer program product. In some embodiments of these techniques, the method includes receiving, at a first monitor server, a first plurality of network transmissions from a first plurality of communication networks and correlating, at the first monitor server, the first plurality of network transmissions based on information associated with the first plurality of network transmissions to form a first correlated network transaction. The method further includes transmitting the first correlated network transaction from the first monitor server to a second monitor server based on a first correlation flag and correlating, at the second monitor server, the first correlated network transaction with a second network transmission based on at least one of the first correlation flag, information associated with the second network transmission, and information associated with the first correlated network transaction to form a second correlated network transaction.
摘要翻译：相关网络交易技术包括方法，装置和/或计算机程序产品。在这些技术的一些实施例中，该方法包括在第一监视服务器处接收来自第一多个通信网络的第一多个网络传输，并且在第一监视服务器处，基于相关信息关联第一多个网络传输与第一多个网络传输形成第一相关网络事务。该方法还包括基于第一相关标志将第一相关网络事务从第一监视服务器发送到第二监视服务器，并且在第二监视服务器处将第一相关网络事务与第二网络传输基于至少一个所述第一相关标志，与所述第二网络传输相关联的信息，以及与所述第一相关网络事务相关联的信息，以形成第二相关网络事务。

8. 发明申请

US20050164803A1 Golf club and method of manufacturing 失效
标题翻译：高尔夫俱乐部及制造方法
公开(公告)号：US20050164803A1
公开(公告)日：2005-07-28
申请号：US10766400
申请日：2004-01-27
申请人： Robert Naylor , David Petersen
发明人： Robert Naylor , David Petersen
IPC分类号： A63B53/02 , B29C65/54
CPC分类号： A63B53/02 , A63B60/00
摘要： A golf club is manufactured according to a method in which a radially compliant crush sleeve is interposed between the shaft tip and hosel of the club head. The crush sleeve is fabricated from a strip of metal formed into a substantially cylindrical metallic band with a plurality of radially-extending dimples or corrugations that grip the shaft. The crush sleeve is retained either in an undercut region in the hosel bore, on a mandrel extending from the hosel, or on a pilot shaft at the tip of the golf club shaft. After the interface between the shaft and hosel is coated with an adhesive, the shaft is assembled to the hosel with the crush sleeve squeezed in between. The crush sleeve secures the shaft to the club head with sufficient rigidity to allow the adhesive to set while maintaining the appropriate axial and rotational alignment.
摘要翻译：根据一种方法制造高尔夫球杆，其中径向柔顺的挤压套筒插入在球杆头的轴尖和杆之间。挤压套筒由形成为大致圆柱形金属带的金属条制成，多个径向延伸的凹陷或波纹夹持轴。挤压套筒保持在插孔内的底切区域中，在从插鞘延伸的心轴上或在高尔夫球杆杆杆的尖端处的导向轴上。在轴和插鞘之间的界面涂覆有粘合剂之后，将轴组装到插鞘上，挤压套筒在其间挤压。挤压套筒将轴固定到球杆头上，具有足够的刚性，以允许粘合剂固定，同时保持适当的轴向和旋转对准。

9. 发明授权

US5116859A Method of providing anxiolytic and antipsychotic treatment 失效
标题翻译：提供抗炎和抗生素治疗的方法
公开(公告)号：US5116859A
公开(公告)日：1992-05-26
申请号：US207947
申请日：1988-06-17
申请人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Brenda Costall , Robert Naylor , Renee Gardaix-Luthereau
发明人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Brenda Costall , Robert Naylor , Renee Gardaix-Luthereau
IPC分类号： A61K31/415 , A61P25/18 , A61P25/20 , C07D233/50
CPC分类号： A61K31/415 , Y10S514/81 , Y10S514/811 , Y10S514/812
摘要： Anxiolytic and antipsychotic treatment is provided to patients by administering therapeutically effective amounts of N-[2-(diethylamino)-ethyl]-2-methoxy-4-[(1-H-4,5-dihydro-2-immidazolyl)-amino]-5-chlorobenzamide, or a pharmaceutically acceptable salt thereof.
摘要翻译：通过给予治疗有效量的N- [2-（二乙基氨基） - 乙基] -2-甲氧基-4 - [（1-H-4,5-二氢-2-咪唑基） - 氨基 ] -5-氯苯甲酰胺或其药学上可接受的盐。

10. 发明授权

US5086066A Method of providing anxiolytic and antipsychotic treatment with substituted benzamides 失效
标题翻译：用替代苯甲酸提供抗炎和抗菌治疗的方法
公开(公告)号：US5086066A
公开(公告)日：1992-02-04
申请号：US454015
申请日：1989-12-20
申请人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Renee Gardaix-Luthereau , Robert Naylor , Brenda Costall
发明人： Jacques Acher , Jean-Claude Monier , Jean-Paul Schmitt , Renee Gardaix-Luthereau , Robert Naylor , Brenda Costall
IPC分类号： C07D233/50 , A61K31/415 , A61K31/42 , A61K31/421 , A61P25/18 , A61P25/20 , C07D263/28 , C07D403/12 , C07D413/12
CPC分类号： A61K31/42 , A61K31/415
摘要： The present invention relates to the application of substituted benzamides of formula (I): ##STR1## in which: A is diethylaminoethyl, 1-ethyl-2-pyrrolidinylmethyl or 1-allyl-2-pyrrolidinylmethyl;R.sub.1 is hydrogen or methyl;X is chlorine or bromine;Z is --NH-- or --O-- except when Z is --NH--,R.sub.1 is hydrogen and X is chlorine, and of their pharmacologically acceptable addition salts, as anxiolytics and antipsychotics.
摘要翻译：本发明涉及式（I）的取代苯甲酰胺的应用：其中：A是二乙基氨基乙基，1-乙基-2-吡咯烷基甲基或1-烯丙基-2-吡咯烷基甲基; R1是氢或甲基; X是氯或溴; Z是-NH-或-O-，除了当Z是-NH-，R1是氢和X是氯时，以及它们的药学上可接受的加成盐作为抗焦虑剂和抗精神病药。

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