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1. 发明申请

US20080200797A1 METHOD AND APPARATUS FOR ENDOBRONCHIAL DIAGNOSIS 审中-公开
标题翻译：方法和装置用于内分泌诊断
公开(公告)号：US20080200797A1
公开(公告)日：2008-08-21
申请号：US12108035
申请日：2008-04-23
申请人： Robert Kotmel , Peter Soltesz , Anthony Wondka , Rodney Perkins
发明人： Robert Kotmel , Peter Soltesz , Anthony Wondka , Rodney Perkins
IPC分类号： A61B5/087 , A61B8/14 , A61B6/00 , A61B5/055
摘要： The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance. In addition, the diseased lung compartments may be temporarily isolated and the measurement tests performed to determine the affect of the isolation on overall lung performance. As a result, the most beneficial treatment options may be selected.
摘要翻译：本发明提供用于评估单个肺隔室中肺部疾病水平的系统，方法，装置和试剂盒。肺隔室包括例如肺的子部分，例如叶，片段或子段。通过测量单个肺隔室，可以通过确定反映个体子部分或肺室的疾病参数的值来更精确地定义肺系统的疾病水平。同样，隔室也可以单独成像以提供进一步的测量信息。一旦个体隔室被表征，可以基于反映例如疾病水平或治疗需要的多个变量来比较和分级。可以通过在视觉显示器上同时显示这样的变量或图像来辅助这种比较。此外，可以在肺部作为整体或在两个肺上进行相同的测试，并且确定患病肺隔室对整体肺功能的影响。此外，可以暂时隔离患病的肺隔室，并进行测量测试以确定隔离对整体肺功能的影响。因此，可以选择最有益的治疗方案。

2. 发明申请

US20050203483A1 Methods, systems, and kits for lung volume reduction 有权
公开(公告)号：US20050203483A1
公开(公告)日：2005-09-15
申请号：US11104717
申请日：2005-04-12
申请人： Rodney Perkins , Peter Soltesz , Robert Kotmel , Anthony Wondka
发明人： Rodney Perkins , Peter Soltesz , Robert Kotmel , Anthony Wondka
IPC分类号： A61B17/00 , A61B1/00 , A61B1/005 , A61B1/267 , A61B17/12 , A61B17/28 , A61M16/04 , A61M31/00
CPC分类号： A61B17/1219 , A61B1/00165 , A61B1/005 , A61B1/0051 , A61B1/2676 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12104 , A61B17/12136 , A61B17/12159 , A61B17/12186 , A61B50/30 , A61B2017/00535 , A61B2017/1205 , A61B2017/2905 , A61B2017/2927 , A61M16/04 , A61M16/0404 , A61M16/0418 , A61M16/0459 , A61M16/0486 , A61M2016/0027 , A61M2016/0413 , A61M2025/1052 , A61M2205/058 , A61M2209/06 , A61M2210/1039
摘要： Lung volume reduction is performed in a minimally invasive manner by isolating a lung tissue segment, optionally reducing gas flow obstructions within the segment, and aspirating the segment to cause the segment to at least partially collapse. Further optionally, external pressure may be applied on the segment to assist in complete collapse. Reduction of gas flow obstructions may be achieved in a variety of ways, including over inflation of the lung, introduction of mucolytic or dilation agents, application of vibrational energy, induction of absorption atelectasis, or the like. Optionally, diagnostic procedures on the isolated lung segment may be performed, typically using the same isolation/access catheter.

3. 发明申请

US20060162731A1 Pulmonary occlusal stent delivery catheter, loading system and methods of use 审中-公开
公开(公告)号：US20060162731A1
公开(公告)日：2006-07-27
申请号：US11280530
申请日：2005-11-15
申请人： Anthony Wondka , Peter Soltesz , Robert Kotmel , Nadia Matov , Thomas Crowder
发明人： Anthony Wondka , Peter Soltesz , Robert Kotmel , Nadia Matov , Thomas Crowder
IPC分类号： A62B9/06 , A61M16/00
CPC分类号： A61B17/12104 , A61B1/012 , A61B1/2676 , A61B17/12022 , A61B17/12172 , A61B2017/00867 , A61B2017/12054 , A61B2017/12086 , A61B2017/22069
摘要： Methods, systems and devices are provided for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung and occluding various lung passageways with the use of occlusal stents. The occlusal stents are delivered with the use of an occlusal stent delivery system which is loaded with the occlusal stent with the use of an occlusal stent loading system.

4. 发明申请

US20060135947A1 Occlusal stent and methods for its use 审中-公开
标题翻译：咬合支架及其使用方法
公开(公告)号：US20060135947A1
公开(公告)日：2006-06-22
申请号：US11280592
申请日：2005-11-15
申请人： Peter Soltesz , Anthony Wondka , Jeffrey Lee , Robert Kotmel
发明人： Peter Soltesz , Anthony Wondka , Jeffrey Lee , Robert Kotmel
IPC分类号： A61M31/00
CPC分类号： A61B17/12104 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/1219 , A61B2017/00862 , A61B2017/00867
摘要： Improved methods, systems and devices for occluding body passageways, particularly lung passageways. Such occlusion is achieved with occlusal stents which are particularly suited for use in performing Endobronchial Volume Reduction (EVR) in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The present invention is likewise suitable for the treatment of bronchopleural fistula and potentially for other pulmonary diseases, such as hemoptysis and pneumothorax. The occlusal stents are delivered with the use of any suitable delivery system, particularly minimally invasive with instruments introduced through the mouth (endotracheally). A target lung tissue segment is isolated from other regions of the lung by deploying an occlusal stent into a target area of a lung passageway. A variety of different occlusal stent designs are provided to improve the performance and reliability of the delivered occlusal stent.
摘要翻译：改进的阻塞体通道的方法，系统和装置，特别是肺通道。使用特别适用于在患有慢性阻塞性肺疾病或其它需要肺部分离或肺容积减少的其他病症的患者中进行支气管扩张减少（EVR）的咬合支架实现这种阻塞。本发明同样适用于治疗支气管胸膜瘘并且可能用于其它肺部疾病，例如咯血和气胸。咬合支架使用任何合适的输送系统递送，特别是通过口腔（气管内）引入的器械具有最小的侵入性。通过将咬合支架部署到肺通道的目标区域中，从肺的其他区域分离出目标肺组织段。提供了各种不同的咬合支架设计，以改善输送的咬合支架的性能和可靠性。

5. 发明申请

US20060264772A1 Minimally invasive determination of collateral ventilation in lungs 有权
公开(公告)号：US20060264772A1
公开(公告)日：2006-11-23
申请号：US11296951
申请日：2005-12-07
申请人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney Perkins
发明人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney Perkins
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.

6. 发明授权

US08876791B2 Collateral pathway treatment using agent entrained by aspiration flow current 有权
标题翻译：通过吸入流动电流夹带的药物的抵押途径治疗
公开(公告)号：US08876791B2
公开(公告)日：2014-11-04
申请号：US12883039
申请日：2010-09-15
申请人： Anthony Wondka , Peter Soltesz , John McCutcheon , Antony J. Fields
发明人： Anthony Wondka , Peter Soltesz , John McCutcheon , Antony J. Fields
IPC分类号： A61M31/00 , A61B17/12 , A61M25/10 , A61B17/22 , A61B17/00
CPC分类号： A61M25/10 , A61B17/12031 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B2017/00809 , A61B2017/22067 , A61M2025/1052 , A61M2210/1039
摘要： A method and system for increasing the flow resistance of collateral pathways in the lung by employing aspiration to establish an artificial convective flow current between compartments in the lung in order to entrain and deliver a clogging agent preferentially to the collateral pathways. The method may sometimes be performed after lung has been assessed for the presence of collateral pathways.
摘要翻译：一种用于通过抽吸来增加肺内侧支路径的流阻的方法和系统，以在肺间隔室之间建立人造对流流动流，以夹带并将阻塞剂优先递送至旁路。有时可以在肺已经评估了侧支通路的存在后进行该方法。

7. 发明申请

US20110087122A1 MINIMALLY INVASIVE DETERMINATION OF COLLATERAL VENTILATION IN LUNGS 有权
标题翻译：最小限度地确定肺内通气通气
公开(公告)号：US20110087122A1
公开(公告)日：2011-04-14
申请号：US12972225
申请日：2010-12-17
申请人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
发明人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
IPC分类号： A61B5/087 , A61B5/091 , A61F2/04
CPC分类号： A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
摘要翻译：提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。这种测量的实例包括但不限于流量，体积和压力。这些测量用于确定侧支通气的存在并量化此类旁路通气。

8. 发明申请

US20110220104A1 COLLATERAL PATHWAY TREATMENT USING AGENT ENTRAINED BY ASPIRATION FLOW CURRENT 有权
标题翻译：使用通过吸入流量电流进入的药剂的阴道途径治疗
公开(公告)号：US20110220104A1
公开(公告)日：2011-09-15
申请号：US12883039
申请日：2010-09-15
申请人： Anthony Wondka , Peter Soltesz , John McCutcheon , Antony J. Fields
发明人： Anthony Wondka , Peter Soltesz , John McCutcheon , Antony J. Fields
IPC分类号： A61M16/10
CPC分类号： A61M25/10 , A61B17/12031 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B2017/00809 , A61B2017/22067 , A61M2025/1052 , A61M2210/1039
摘要： A method and system for increasing the flow resistance of collateral pathways in the lung by employing aspiration to establish an artificial convective flow current between compartments in the lung in order to entrain and deliver a clogging agent preferentially to the collateral pathways. The method may sometimes be performed after lung has been assessed for the presence of collateral pathways.
摘要翻译：一种用于通过抽吸来增加肺内侧支路径的流阻的方法和系统，以在肺间隔室之间建立人造对流流动流，以夹带并将阻塞剂优先递送至旁路。有时可以在肺已经评估了侧支通路的存在后进行该方法。

9. 发明授权

US08454527B2 Minimally invasive determination of collateral ventilation in lungs 有权
标题翻译：肺部旁路通气微创测定
公开(公告)号：US08454527B2
公开(公告)日：2013-06-04
申请号：US12972225
申请日：2010-12-17
申请人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
发明人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
摘要翻译：提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。这种测量的实例包括但不限于流量，体积和压力。这些测量用于确定侧支通气的存在并量化此类旁路通气。

10. 发明授权

US07883471B2 Minimally invasive determination of collateral ventilation in lungs 有权
标题翻译：肺部旁路通气微创测定
公开(公告)号：US07883471B2
公开(公告)日：2011-02-08
申请号：US11296951
申请日：2005-12-07
申请人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
发明人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
摘要翻译：提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。这种测量的实例包括但不限于流量，体积和压力。这些测量用于确定侧支通气的存在并量化此类旁路通气。

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