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    • 5. 发明授权
    • Use of chelating agents in the treatment of atherosclerotic conditions
    • 使用螯合剂治疗动脉粥样硬化病症
    • US06310051B1
    • 2001-10-30
    • US09599861
    • 2000-06-23
    • Jan Olof Gustav KarlssonRolf Goran Gustav AnderssonAnders OlssonBo ZiedenPer JyngeTudor GriffithDerek GrantRobertson TowartHelge Refsum
    • Jan Olof Gustav KarlssonRolf Goran Gustav AnderssonAnders OlssonBo ZiedenPer JyngeTudor GriffithDerek GrantRobertson TowartHelge Refsum
    • A61K31675
    • A61K31/444A61K31/198A61K31/675Y02A50/411Y02A50/414Y10S514/824
    • The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R1 independently represents hydrogen or —CH2COR5; R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R2 independently represents a group XYR6; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7; Y represents a bond, an oxygen atom or a group NR6; R6 is a hydrogen atom, a group COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, ═R8, ═O, OP(O)(OR8)R7 and OSO3M; R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R3 represents a C1-8 alkylene group, preferably a C1-6, e.g. a C2-4 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R4 independently represents hydrogen or C1-3 alkyl; and each R9 independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl).
    • 本发明提供了双嘧磺酰氧基或氨基多羧酸类螯合剂,金属螯合物及其盐在制备用于治疗或预防人或非人动物体内的动脉粥样硬化和相关病症的治疗剂中的用途。 用于本发明方法的优选化合物是式(I)化合物或金属螯合物或其盐(其中在式(I)中,每个R 1独立地表示氢或-CH 2 COR 5; R 5表示羟基,任选羟基化的烷氧基,氨基或 烷基酰氨基;每个R 2独立地表示基团XYR 6; X表示键或任选被基团R 7取代的C 1-3亚烷基或氧代亚烷基; Y表示键,氧原子或基团NR 6; R 6是氢原子, 任选被一个或多个选自COOR8,CONR82,NR82,OR8,R8,= O,OP(O)(OR8)R7和OSO3M的基团取代的COOR8,烷基,烯基,环烷基,芳基或芳烷基; R7 羟基,任选羟基化,任选烷氧基化的烷基或氨基烷基; R 8是氢原子或任选羟基化,任选烷氧基化的烷基; M是氢原子或一当量的生理上可耐受的阳离子,例如碱金属或碱土金属阳离子 ,铵io n或有机胺阳离子,如葡甲胺离子; R 3表示C 1-8亚烷基,优选C 1-6。 C2-4亚烷基,1,2-亚环烷基或1,2-亚芳基; 每个R 4独立地表示氢或C 1-3烷基; 并且每个R 9独立地可以不存在或表示氢,烷基,羟基烷基或羧基烷基)。
    • 6. 发明授权
    • Methods and systems for predictive alerting
    • 预测警报的方法和系统
    • US09373078B1
    • 2016-06-21
    • US13453926
    • 2012-04-23
    • Anders OlssonRoman JugaiAndreas Jonsson
    • Anders OlssonRoman JugaiAndreas Jonsson
    • G06N5/04G06N5/02
    • G06Q10/107G06F17/30294G06F17/3051G06F17/30536G06N5/04G06N5/048
    • Systems and methods to provide predictive alerting are disclosed. Trends and characteristics in the data may be identified in advance of actual occurrence, with an expected event being predicted or extrapolated based on data and a predictive model associated with stored and/or incoming data. This may be done by, for example, developing a set of rules associated with the model that may then be used to trigger predictive alerts based on predicted trends. Various data and associated characteristics may be determined based on past data and/or analogous data taken from similarly modeled systems. For example, seasonal trends may be factored into the model so that a prediction is based on both a received set of data and expected seasonal (or other temporal) trends. Various other characteristics may also be used in the predictive model.
    • 公开了提供预测性警报的系统和方法。 数据中的趋势和特征可以在实际发生之前被识别,其中基于数据和与存储和/或输入数据相关联的预测模型预测或外推预期事件。 这可以通过例如开发与模型相关联的一组规则来完成,所述规则然后可以用于基于预测趋势触发预测警报。 可以基于从类似建模的系统获取的过去数据和/或类似数据来确定各种数据和相关特征。 例如,季节性趋势可以被分解到模型中,使得预测基于所接收的一组数据和预期的季节(或其他时间)趋势。 预测模型中也可以使用各种其他特征。
    • 7. 发明授权
    • Generation of graphical feedback in a computer system
    • 在计算机系统中生成图形反馈
    • US09213404B2
    • 2015-12-15
    • US12162694
    • 2007-01-17
    • John ElvesjöAnders OlssonJohan Sahlén
    • John ElvesjöAnders OlssonJohan Sahlén
    • G06F3/033G09G5/08G06F3/01
    • G06F3/013G06F3/017G06F3/0304G06F3/167G09G5/08
    • The present invention relates to control of a computer system, which includes a data processing unit, a display and an eye tracker adapted to register a user's gaze point with respect to the display. The data processing unit is adapted to present graphical information on the display, which includes feedback data reflecting the user's commands entered into the unit. The data processing unit is adapted to present the feedback data such that during an initial phase, the feedback data is generated based on an absolute position of the gaze point. An imaging device of the system is also adapted to register image data representing movements of a body part of the user, and to forward a representation of the image data to the data processing unit. Hence, during a phase subsequent to the initial phase, the data is instead generated based on the image data.
    • 本发明涉及一种计算机系统的控制,其包括数据处理单元,显示器和眼睛跟踪器,其适于相对于显示器注册用户的凝视点。 数据处理单元适于在显示器上呈现图形信息,其包括反映输入到该单元中的用户命令的反馈数据。 数据处理单元适于呈现反馈数据,使得在初始阶段期间,基于目视点的绝对位置产生反馈数据。 系统的成像装置还适于注册表示用户的身体部分的移动的图像数据,并将图像数据的表示转发到数据处理单元。 因此,在初始阶段之后的阶段期间,相反地,基于图像数据生成数据。
    • 8. 发明授权
    • Event collection architecture
    • 事件收集架构
    • US07680672B2
    • 2010-03-16
    • US10037674
    • 2001-10-22
    • Anders OlssonMartin Liljenback
    • Anders OlssonMartin Liljenback
    • G06F17/60
    • G06Q10/103G06Q30/02G06Q30/0601
    • The present invention relates to an event tracking server that determines event tracking information related to a user's interaction with a server device on a computer network, such as a server device for a Web site. The event tracking server determines the event tracking information by first receiving an event signal from a client device associated with the user, wherein the user used the client device to interact with the server device. The event signal includes an event ID and data that describes the user's interaction with the server device. The event tracking server then retrieves a set of instructions that correspond to the event ID included in the event signal and extracts the descriptive data from the event signal in accordance with the retrieved instructions. The retrieved data is then stored in a database. The user interaction with the server device can include various actions, such as downloading a file, placing or removing an item into or from an electronic shopping cart, purchasing an item, or using a search capability of a search engine.
    • 本发明涉及事件跟踪服务器,其确定与用户与计算机网络上的服务器设备(例如网站的服务器设备)的交互相关的事件跟踪信息。 事件跟踪服务器通过首先从与用户相关联的客户端设备接收事件信号来确定事件跟踪信息,其中用户使用客户端设备与服务器设备进行交互。 事件信号包括事件ID和描述用户与服务器设备交互的数据。 然后,事件跟踪服务器检索对应于包括在事件信号中的事件ID的一组指令,并根据检索到的指令从事件信号中提取描述数据。 然后将检索的数据存储在数据库中。 与服务器设备的用户交互可以包括各种动作,例如下载文件,将物品放入或从电子购物车放置或从电子购物车中取出物品,购买物品或使用搜索引擎的搜索能力。