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1. 发明授权

US07498171B2 Modulation of stem and progenitor cell differentiation, assays, and uses thereof 有权
标题翻译：茎和祖细胞分化的调节，测定及其用途
公开(公告)号：US07498171B2
公开(公告)日：2009-03-03
申请号：US10411655
申请日：2003-04-11
申请人： Robert J. Hariri , David I. Stirling , Laure A. Moutouh-De Parseval , Kyle W. H. Chan
发明人： Robert J. Hariri , David I. Stirling , Laure A. Moutouh-De Parseval , Kyle W. H. Chan
IPC分类号： C12N5/00
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译：本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或用于将早期祖细胞分化成粒细胞谱系。最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。

2. 发明授权

US08889411B2 Modulation of stem and progenitor cell differentiation, assays, and uses thereof 有权
标题翻译：茎和祖细胞分化的调节，测定及其用途
公开(公告)号：US08889411B2
公开(公告)日：2014-11-18
申请号：US12396397
申请日：2009-03-02
申请人： Robert J. Hariri , David I. Stirling , Laure A. Moutouh-De Parseval , Kyle W. H. Chan
发明人： Robert J. Hariri , David I. Stirling , Laure A. Moutouh-De Parseval , Kyle W. H. Chan
IPC分类号： C12N5/00 , C12N5/0789 , C12N5/0784 , C12N5/0787 , A61K35/12
CPC分类号： A61K31/454 , A61K2035/124 , C12N5/0639 , C12N5/0642 , C12N5/0647 , C12N2501/125 , C12N2501/14 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/385 , C12N2501/70 , C12N2506/02
摘要： The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
摘要翻译：本发明涉及调节哺乳动物干细胞和祖细胞分化的方法。本发明的方法可用于调节和控制特定细胞和组织谱系中哺乳动物，特别是人干细胞的分化和成熟。本发明的方法涉及某些小有机分子在特定细胞和组织谱系中调节干细胞或祖细胞群的分化的用途，特别是涉及来源于产后胎盘的胚胎样干细胞的分化或用于将早期祖细胞分化成粒细胞谱系。最后，本发明涉及这种分化的干细胞或祖细胞在移植和其他医学治疗中的用途。

3. 发明授权

US06413720B1 Method for the affinity isolation of newly synthesized RNA 失效
标题翻译：新合成RNA亲和分离方法
公开(公告)号：US06413720B1
公开(公告)日：2002-07-02
申请号：US09228455
申请日：1999-01-11
申请人： Jose R. Pardinas , Kyle W. H. Chan
发明人： Jose R. Pardinas , Kyle W. H. Chan
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q2563/131 , C12Q2527/113
摘要： Methods are provided for the isolation of newly synthesized mRNA. Such methods involve the incorporation of biotinylated rNTP analogues into cellular mRNA, and separating biotinylated mRNA from unlabeled RNA. The methods provided herein may be used, for example, for gene discovery, drug screens and studies of the regulation of gene expression.
摘要翻译：提供了用于分离新合成的mRNA的方法。这些方法涉及将生物素化的rNTP类似物并入细胞mRNA中，并将生物素化的mRNA与未标记的RNA分离。本文提供的方法可用于例如基因发现，药物筛选和基因表达调节的研究。

4. 发明授权

US06960438B2 Method for the affinity isolation of newly synthesized RNA 失效
标题翻译：新合成RNA亲和分离方法
公开(公告)号：US06960438B2
公开(公告)日：2005-11-01
申请号：US10154517
申请日：2002-05-23
申请人： Jose R. Pardinas , Kyle W. H. Chan
发明人： Jose R. Pardinas , Kyle W. H. Chan
IPC分类号： C12N15/09 , C07K14/47 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6809 , C12Q2563/131 , C12Q2527/113
摘要： Methods are provided for the isolation of newly synthesized mRNA. Such methods involve the incorporation of biotinylated rNTP analogues into cellular mRNA, and separating biotinylated mRNA from unlabeled RNA. The methods provided herein may be used, for example, for gene discovery, drug screens and studies of the regulation of gene expression.
摘要翻译：提供了用于分离新合成的mRNA的方法。这些方法涉及将生物素化的rNTP类似物并入细胞mRNA中，并将生物素化的mRNA与未标记的RNA分离。本文提供的方法可用于例如基因发现，药物筛选和基因表达调节的研究。

5. 发明授权

US08722731B2 Furanyl compounds and the use thereof 有权
标题翻译：呋喃基化合物及其用途
公开(公告)号：US08722731B2
公开(公告)日：2014-05-13
申请号：US13702041
申请日：2011-06-07
申请人： Leah M. Fung , Kyle W. H. Chan , Cathy A. Swindlehurst
发明人： Leah M. Fung , Kyle W. H. Chan , Cathy A. Swindlehurst
IPC分类号： A61K31/343 , C07D307/40
CPC分类号： C07D307/68 , A61K31/341 , A61K45/06
摘要： Provided herein are substituted furanyl compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate eIF4E activity. In one embodiment, the compounds provided herein modulate the Hedgehog pathway activity. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.
摘要翻译：本文提供了式（I）的取代的呋喃基化合物，包含化合物的药物组合物，其制备方法及其使用方法。本文提供的化合物可用于治疗，预防和/或改善各种疾病，包括癌症和增殖性疾病。在一个实施方案中，本文提供的化合物调节eIF4E活性。在一个实施方案中，本文提供的化合物调节Hedgehog途径活性。在一个实施方案中，本文提供的化合物与外科，放射治疗，免疫治疗和/或一种或多种另外的抗癌药物结合使用以治疗，预防和/或改善癌症和增殖性疾病。

6. 发明授权

US08334307B2 Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases 有权
标题翻译：羟基吡啶酮衍生物，其药物组合物及其治疗增殖性疾病的治疗用途
公开(公告)号：US08334307B2
公开(公告)日：2012-12-18
申请号：US13269454
申请日：2011-10-07
申请人： Frank Mercurio , Kyle W. H. Chan
发明人： Frank Mercurio , Kyle W. H. Chan
IPC分类号： A61K31/4418 , C07D211/94
CPC分类号： C07D213/89
摘要： Provided herein are hydroxypyridone derivatives, for example, a compound of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
摘要翻译：本文提供羟基吡啶酮衍生物，例如式I化合物及其药物组合物。本文还提供其用于治疗，预防或改善增殖性疾病的一种或多种症状的方法。

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