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1. 发明授权

US5998374A Clavaspirins 失效
标题翻译：克拉霉素
公开(公告)号：US5998374A
公开(公告)日：1999-12-07
申请号：US808277
申请日：1997-02-28
申请人： Robert I. Lehrer , In-Hee Lee , Chengquan Zhao
发明人： Robert I. Lehrer , In-Hee Lee , Chengquan Zhao
IPC分类号： A61K38/00 , A61P43/00 , C07K14/435 , C12N15/12 , A61K38/17
CPC分类号： C07K14/43504 , A61K38/00
摘要： Novel microbial peptides called clavaspirins are of the formula (SEQ ID NO:1)X'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 U.sub.6 U.sub.7 X.sub.8 X.sub.9 B.sub.10 X'.sub.11 X.sub.12 U.sub.13 B.sub.14 X.sub.15 X.sub.16 B*.sub.17 B.sub.18 X.sub.19 U.sub.20 X.sub.21 X'.sub.22 X.sub.23 (1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof;B* is a basic or a hydrophobic amino acid residue or a modified form thereof; andU is a small amino acid residue or modified form thereof.
摘要翻译：称为克拉斯匹林的新型微生物肽具有式（SEQ ID NO：1）X'1X2B'3X4X5U6U7X8X9B10X'11X12U13B14X15X16B * 17B18X19U20X21X'22X23（1），其包括其盐，酯，酰胺和酰化形式，其中X是疏水性氨基酸残基或其修改形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式。

2. 发明授权

US6040293A Clavanins 失效
标题翻译：克拉夫人
公开(公告)号：US6040293A
公开(公告)日：2000-03-21
申请号：US810324
申请日：1997-02-28
申请人： Robert I. Lehrer , Chengquan Zhao , In-Hee Lee
发明人： Robert I. Lehrer , Chengquan Zhao , In-Hee Lee
IPC分类号： A61K38/00 , C07K14/435 , C12N1/21 , C12N15/12 , C07K14/00 , A61K37/02
CPC分类号： C07K14/43504 , A61K38/00
摘要： Novel microbial peptides called clavanins are of the formula[X'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 ]U.sub.6 B.sub.7 X.sub.8 X.sub.9 B.sub.10 B.sub.11 X.sub.12 U.sub.13 Z.sub.14 X.sub.15 X.sub.16 B*.sub.17 U.sub.18 X.sub.19 U.sub.20 B.sub.21 X.sub.22 X.sub.23 ( 1)(SEQ ID NO:1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof; andB* is a basic or a hydrophobic amino acid residue or a modified form thereof;U is a small amino acid residue or modified form thereof;Z is a polar/large amino acid residue or modified form thereof, and wherein 1-5 amino acids is deleted from the N-terminus.
摘要翻译：称为克拉维宁的新型微生物肽具有式[X'1X2B'3X4X5] U6B7X8X9B10B11X12U13Z14X15X16B * 17U18X19U20B21X22X23（1）（1）（SEQ ID NO：1），其包括其盐，酯，酰胺和酰化形式，其中X是疏水性氨基酸残基或经修饰形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式; Z是极性/大的氨基酸残基或其修饰形式，其中1-5个氨基酸从N-末端缺失。

3. 发明授权

US6010876A Clavanins 失效
标题翻译：克拉夫人
公开(公告)号：US6010876A
公开(公告)日：2000-01-04
申请号：US746160
申请日：1996-11-06
申请人： Robert I. Lehrer , Sylvia L. Harwig, deceased , Chengquan Zhao , In-Hee Lee
发明人： Robert I. Lehrer , Sylvia L. Harwig, deceased , Chengquan Zhao , In-Hee Lee
IPC分类号： A61K38/00 , C07K14/435 , C12N1/21 , C12N15/12 , C12N15/63
CPC分类号： C07K14/43504 , A61K38/00
摘要： Novel microbial peptides called clavanins are of the formulaX'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 U.sub.6 B.sub.7 X.sub.8 X.sub.9 B.sub.10 B.sub.11 X.sub.12 U.sub.13 Z.sub.14 X.sub.15 X.sub.16 B*.sub.17 U.sub.18 X.sub.19 U.sub.20 B.sub.21 X.sub.22 X.sub.23 ( 1)(SEQ ID NO: 1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof; andB* is a basic or a hydrophobic amino acid residue or a modified form thereof;U is a small amino acid residue or modified form thereof;Z is a polar/large amino acid residue or modified form thereof.
摘要翻译：称为克拉维宁的新型微生物肽具有式X'1X2B'3X4X5U6B7X8X9B10B11X12U13Z14X15X16B * 17U18X19U20B21X22X23（1）（1）（SEQ ID NO：1），其中X是疏水性氨基酸残基或其修饰形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式; Z是极性/大氨基酸残基或其修饰形式。

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