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1. 发明申请

US20070173905A1 Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress 有权
标题翻译：植入式视网膜电极阵列配置，用于最小的视网膜损伤和减少视网膜应力的方法
公开(公告)号：US20070173905A1
公开(公告)日：2007-07-26
申请号：US11728144
申请日：2007-03-23
申请人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
发明人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543
摘要： This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.
摘要翻译：本发明是一种视网膜电极阵列组件及其使用方法，其通过向操作外科医生提供视觉参考和抓握装置以及减少对视网膜和周围组织的实际和潜在损伤的创新来促进手术植入程序。

2. 发明申请

US20080058898A1 Implantable Retinal Electrode Array Configuration for Minimal Retinal Damage and Method of Reducing Retinal Stress 有权
标题翻译：植入式视网膜电极阵列配置最小视网膜损伤和减少视网膜压力的方法
公开(公告)号：US20080058898A1
公开(公告)日：2008-03-06
申请号：US11933878
申请日：2007-11-01
申请人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
发明人： Robert Greenberg , Alfred Mann , James Little , Karl-Heinz Ihrig , Brian Mech , Neil Talbot , DaoMin Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543
摘要： This invention is a retinal electrode array assembly and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means and with innovations that reduce actual and potential damage to the retina and the surrounding tissue.
摘要翻译：本发明是一种视网膜电极阵列组件及其使用方法，其通过向操作外科医生提供视觉参考和抓握装置以及减少对视网膜和周围组织的实际和潜在损伤的创新来促进手术植入程序。

3. 发明申请

US20070021787A1 Biocompatible bonding method and electronics package suitable for implantation 有权
公开(公告)号：US20070021787A1
公开(公告)日：2007-01-25
申请号：US11455028
申请日：2006-07-24
申请人： Robert Greenberg , Alfred Mann , Neil Talbot , Jerry Ok , Gaillard Nolan , Dau Zhou
发明人： Robert Greenberg , Alfred Mann , Neil Talbot , Jerry Ok , Gaillard Nolan , Dau Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/3758 , A61N1/0543 , A61N1/36046 , A61N1/375 , H01L21/563 , H01L23/49827 , H01L23/49838 , H01L23/4985 , H01L24/81 , H01L2224/0557 , H01L2224/05571 , H01L2224/05573 , H01L2224/13169 , H01L2224/13178 , H01L2224/16225 , H01L2224/16227 , H01L2224/32225 , H01L2224/73204 , H01L2224/81469 , H01L2224/81478 , H01L2224/81815 , H01L2924/00014 , H01L2924/01019 , H01L2924/01046 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/14 , H01L2924/1461 , H05K1/028 , H05K1/0306 , H05K1/09 , H05K1/111 , H05K1/113 , H05K1/115 , H05K1/189 , H05K3/10 , H05K3/188 , H05K3/305 , H05K3/321 , H05K3/328 , H05K3/3436 , H05K3/361 , H05K3/4015 , H05K3/4038 , H05K3/4084 , H05K3/423 , H05K3/4644 , H05K3/4652 , H05K3/4691 , H05K13/0469 , H05K2201/09127 , H05K2201/1028 , H05K2201/10287 , H05K2201/10295 , H05K2201/10977 , H05K2203/05 , H05K2203/06 , H05K2203/0733 , H05K2203/09 , H05K2203/107 , H05K2203/1446 , H01L2924/00 , H01L2224/05599
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.

4. 发明申请

US20090308391A1 Dry Powder Inhaler and System for Drug Delivery 有权
标题翻译：干粉吸入器和药物输送系统
公开(公告)号：US20090308391A1
公开(公告)日：2009-12-17
申请号：US12484129
申请日：2009-06-12
申请人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
发明人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
摘要翻译：提供了一种呼吸动力的干粉吸入器，药筒和肺部药物递送系统。干粉吸入器可以配备有或不带有与吸入器一起使用的单位剂量盒。吸入器和/或药筒可以具有药物递送制剂，其包含例如二酮哌嗪和活性成分，包括肽和蛋白质，例如用于治疗糖尿病和/或肥胖症的胰岛素和胰高血糖素样肽1。干粉吸入器紧凑; 可以以各种形状和尺寸，颜色提供，并且包括壳体，接口管，盒放置区域和用于打开和关闭药剂盒的机构。该设备易于制造，提供预单位单位剂量，相对易于使用，并且可重复使用或一次性使用。

5. 发明申请

US20070217640A1 Hearing Aid Design 失效
标题翻译：助听器设计
公开(公告)号：US20070217640A1
公开(公告)日：2007-09-20
申请号：US11752196
申请日：2007-05-22
申请人： Albert Maltan , Alfred Mann , James McGivern , Philip Lee
发明人： Albert Maltan , Alfred Mann , James McGivern , Philip Lee
IPC分类号： H04R25/00
CPC分类号： H04R25/505 , H04R25/554 , H04R25/558 , H04R25/60 , H04R25/65 , H04R25/658 , H04R2225/51 , H04R2225/67 , H04R2420/07
摘要： A hearing aid module is shaped for insertion into a tunnel made through the soft tissue that connects the retro-auricular space with the ear canal. The hearing aid module contains a speaker or auditory transducer, a battery or other power source powering the module, signal processing circuitry, a microphone, and a hollow tube which contains a steroid or drug. Telemetry circuitry within the module allows the signal processing circuitry to be programmed with a desired frequency response or signal processing strategy using an external programming unit. A remote control unit permits the user to make simple adjustments, such as volume and/or tone (frequency) control.
摘要翻译：助听器模块被成形为插入到通过将耳环空间与耳道连接的软组织制成的隧道中。助听器模块包含扬声器或听觉换能器，为模块供电的电池或其它电源，信号处理电路，麦克风和含有类固醇或药物的中空管。模块内的遥测电路允许使用外部编程单元对信号处理电路进行所需的频率响应或信号处理策略的编程。遥控单元允许用户进行简单的调节，例如音量和/或音调（频率）控制。

6. 发明申请

US20070066997A1 Methods and systems for placing an implanted stimulator for stimulating tissue 失效
标题翻译：放置刺激器刺激组织的方法和系统
公开(公告)号：US20070066997A1
公开(公告)日：2007-03-22
申请号：US11232540
申请日：2005-09-21
申请人： Tom He , Todd Whitehurst , Alfred Mann , Peter Johnson
发明人： Tom He , Todd Whitehurst , Alfred Mann , Peter Johnson
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/37205
摘要： Systems for providing stimulation with an implantable system control unit and for optimally positioning that system control unit include a system control unit configured to provide a stimulus to a patient with a member attached to the system control unit for pulling the system control unit into position within the patient. Methods of optimally positioning the implantable system control unit within a patient such that the system control unit is proximal to target tissue that is to be stimulated by the system control unit include threading a member through a patient's body using a needle, the member passing proximal to the target tissue and being attached to the system control unit, and pulling the system control unit into place with the member.
摘要翻译：用于用可植入系统控制单元提供刺激并且用于最佳地定位该系统控制单元的系统包括系统控制单元，该系统控制单元被配置为向患者提供具有连接到系统控制单元的构件的刺激，用于将系统控制单元牵引到患者。将可植入系统控制单元最佳地定位在患者体内的方法，使得系统控制单元靠近要由系统控制单元刺激的目标组织，包括使用针穿过患者身体的部件，目标组织并附接到系统控制单元，并且将系统控制单元拉到构件的适当位置。

7. 发明授权

US08258095B2 Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content 有权
标题翻译：通过超临界作用胰岛素控制血糖的方法，而不调整膳食含量的胰岛素剂量
公开(公告)号：US08258095B2
公开(公告)日：2012-09-04
申请号：US12539499
申请日：2009-08-11
申请人： Anders Hasager Boss , Richard Petrucci , Campbell Howard , Alfred Mann
发明人： Anders Hasager Boss , Richard Petrucci , Campbell Howard , Alfred Mann
IPC分类号： A61P3/10 , A61K38/00
CPC分类号： A61K38/28 , A61K9/0021 , A61K9/0075 , A61K47/545
摘要： Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
摘要翻译：本文公开了一种通过超快速作用的胰岛素和甘精胰岛素的组合治疗高血糖的改进方法，其包括餐前施用超级胰岛素，以及在醒来6小时内施用第一剂甘精胰岛素。

8. 发明申请

US20100035795A1 USE OF ULTRARAPID ACTING INSULIN 有权
公开(公告)号：US20100035795A1
公开(公告)日：2010-02-11
申请号：US12539499
申请日：2009-08-11
申请人： Anders Hasager Boss , Richard Petrucci , Campbell Howard , Alfred Mann
发明人： Anders Hasager Boss , Richard Petrucci , Campbell Howard , Alfred Mann
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0021 , A61K9/0075 , A61K47/545
摘要： Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.

9. 发明申请

US20090308390A1 Dry Powder Inhaler and System for Drug Delivery 有权
公开(公告)号：US20090308390A1
公开(公告)日：2009-12-17
申请号：US12484125
申请日：2009-06-12
申请人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
发明人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfield , Anthony Bryant , Tom He , Alfred Mann
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

10. 发明授权

US08636001B2 Dry powder inhaler and system for drug delivery 有权
公开(公告)号：US08636001B2
公开(公告)日：2014-01-28
申请号：US12484129
申请日：2009-06-12
申请人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfileld , Anthony Bryant , Tom He , Alfred Mann
发明人： Chad C. Smutney , P. Spencer Kinsey , Carl R. Sahi , Benoit Adamo , John M. Polidoro , Scott McLean , Dennis Overfileld , Anthony Bryant , Tom He , Alfred Mann
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61K9/0075 , A61K38/00 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K38/28 , A61K47/22 , A61M15/0021 , A61M15/0023 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0086 , A61M15/0091 , A61M2202/064 , A61M2205/6081 , A61M2206/20
摘要： A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.

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