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1. 发明申请

US20070154518A1 Photoactive biocompatible coating composition 审中-公开
标题翻译：光活性生物相容性涂料组合物
公开(公告)号：US20070154518A1
公开(公告)日：2007-07-05
申请号：US11321424
申请日：2005-12-29
申请人： Robert Falotico , Jonathon Zhao
发明人： Robert Falotico , Jonathon Zhao
IPC分类号： A61F2/02 , C08F2/50 , C08B37/10 , C08G63/48
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/236 , A61L2300/41 , A61L2300/418 , A61L2300/434 , A61L2300/606
摘要： The present invention discloses a biocompatible coating composition that can be photo crosslinked when exposed to long wavelength ultraviolet light. The biocompatible coating composition comprises at least one biocompatible polymer having a photoactive moiety covalently attached thereto, and a biologically active molecule having a photoactive moiety covalently attached thereto. The photoactive moiety covalently attached to the biologically active molecule and the photoactive moiety covalently attached to the at least one biocompatible polymer are the same or different, and absorb and respond to ultraviolet light having a wavelength band of about 300 nm or above. Preferably, the photoactive moiety is a chemical moiety derived from thioxanthone. The inventive biocompatible coating composition can be applied on at least a portion of one surface of an article.
摘要翻译：本发明公开了一种生物相容性涂料组合物，当暴露于长波长紫外光下时可以进行光交联。生物相容性涂料组合物包含至少一种具有共价连接于其上的光活性部分的生物相容性聚合物和具有共价连接于其上的光活性部分的生物活性分子。共价连接到生物活性分子和共价连接到至少一种生物相容性聚合物的光活性部分的光活性部分相同或不同，并且吸收并响应波长带约为300nm或更高的紫外光。优选地，光活性部分是衍生自噻吨酮的化学部分。本发明的生物相容性涂料组合物可以施用在制品的一个表面的至少一部分上。

2. 发明申请

US20070116736A1 Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury 审中-公开
标题翻译：单独或与西罗莫司联合治疗PI3激酶抑制剂的局部血管输送，以防止血管损伤后的再狭窄
公开(公告)号：US20070116736A1
公开(公告)日：2007-05-24
申请号：US11285866
申请日：2005-11-23
申请人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61F2/02 , A61F2/82
CPC分类号： A61L27/54 , A61B2017/0641 , A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/432
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。治疗剂也可以递送到疾病部位的区域。在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药剂或化合物维持在医疗装置上，直到被输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

3. 发明申请

US20070087028A1 INTRALUMINAL DEVICES FOR THE PREVENTION AND TREATMENT OF VASCULAR DISEASE 审中-公开
标题翻译：用于预防和治疗血管疾病的内科手术
公开(公告)号：US20070087028A1
公开(公告)日：2007-04-19
申请号：US11566707
申请日：2006-12-05
申请人： Robert Falotico , Jonathon Zhao
发明人： Robert Falotico , Jonathon Zhao
IPC分类号： A61F2/06
CPC分类号： A61B17/0644 , A61B17/00491 , A61B17/0469 , A61B17/11 , A61B17/115 , A61B17/54 , A61B2017/06028 , A61F2/064 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2250/0067 , A61F2250/0068 , A61F2310/0097 , A61K31/436 , A61K31/727 , A61K45/06 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/606 , A61L2300/61 , A61K2300/00 , C08L27/12
摘要： An intralumen medical device comprising anti-inflamatory and anti-thrombotic or anti-coagulant drugs, agents or compounds may be utilized in the treatment of vascular disease. The intralumen medical device is selectively coated with the drugs, agents or compounds for local delivery, thereby increasing their effectiveness and reducing potential toxicity associated with systemic use. The selective coating is utilized to ensure that the specific drugs, agents or compounds come into contact with or are delivered to the appropriate tissues and/or fluids for maximum effectiveness.
摘要翻译：包含抗炎和抗血栓形成或抗凝血药物，药剂或化合物的脉管内医疗装置可用于治疗血管疾病。腔内医疗器械选择性地涂覆有用于局部递送的药物，试剂或化合物，从而增加其效力并降低与全身使用相关的潜在毒性。使用选择性涂层来确保特定药物，试剂或化合物与适当的组织和/或液体接触或递送至最大的有效性。

4. 发明申请

US20060104903A1 Model for evaluating the efficacy of locally applied antiproliferatives or other agents on neointimal hyperplasia, immunohistochemical and vascular cell cycle changes in balloon-injured rat carotid arteries 审中-公开
标题翻译：用于评估局部应用抗增生剂或其他药物对球囊损伤的大鼠颈动脉内膜增生，免疫组织化学和血管细胞周期变化的功效的模型
公开(公告)号：US20060104903A1
公开(公告)日：2006-05-18
申请号：US10991188
申请日：2004-11-17
申请人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Dennis Argentieri , Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61K49/00 , C12Q1/00
CPC分类号： A61K49/0008
摘要： A methodology for evaluating the efficacy of locally applied antiproliferatives and/or other therapeutic agents on neointimal hyperplasia, as well as immunohistochemical and vascular cell cycle changes, in balloon-injured rat carotid arteries may be utilized for determining the efficacy of treatments in humans.
摘要翻译：用于评估局部施用的抗增殖剂和/或其它治疗剂对新生内膜增生以及球囊损伤的大鼠颈动脉中的免疫组织化学和血管细胞周期变化的功效的方法可用于确定治疗在人中的功效。

5. 发明申请

US20050158360A1 Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送霉酚酸与雷帕霉素联合，以防止血管损伤后的再狭窄
公开(公告)号：US20050158360A1
公开(公告)日：2005-07-21
申请号：US10761032
申请日：2004-01-20
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61B17/00 , A61B17/11 , A61B17/115 , A61F2/06 , A61F2/82 , A61K31/343 , A61K31/436 , A61L31/00 , A61L31/10 , A61L31/16 , A61P7/02 , A61P9/10 , A61P9/14 , A61P41/00 , A61P43/00 , A61F2/02
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/21 , A61L2300/416 , A61L2420/08 , C08L27/16 , C08L27/20
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

6. 发明申请

US20060019691A1 Method and system for evaluating the efficacy of locally-applied anti-proliferative or other agents on neointimal hyperplasia, immunohistochemical and vascular cell cycle changes in injured or atherosclerotic rabbit central ear arteries 审中-公开
标题翻译：用于评估局部应用抗增殖剂或其他药物对受损或动脉粥样硬化兔中枢动脉内膜增生，免疫组织化学和血管细胞周期变化的功效的方法和系统
公开(公告)号：US20060019691A1
公开(公告)日：2006-01-26
申请号：US10895548
申请日：2004-07-21
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： H04Q7/20
CPC分类号： A61D1/00
摘要： A methodology for percutaneously accessing the central ear artery of a rabbit may be utilized for inducing, treating and evaluating injuries therein to determine the pathology of the injuries and the safety and efficacy of the treatment. The central ear artery of a rabbit is similar to morphology to human coronary arteries. Accordingly, the study of the central ear artery of a rabbit will provide valuable information in the biology and identification of new treatments for restenosis, atherosclerosis and vulnerable plaque.
摘要翻译：用于经皮进入兔中枢动脉的方法可用于诱导，治疗和评估其中的损伤，以确定损伤的病理以及治疗的安全性和功效。兔的中枢动脉与人冠状动脉的形态相似。因此，兔子中耳动脉的研究将为生物学提供有价值的信息，并为再狭窄，动脉粥样硬化和易损斑块的新治疗提供依据。

7. 发明申请

US20050202059A1 Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：拓扑替康与雷帕霉素组合的局部血管输送，以防止血管损伤后的再狭窄
公开(公告)号：US20050202059A1
公开(公告)日：2005-09-15
申请号：US10796397
申请日：2004-03-09
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61L31/00 , A61F2/84 , A61L27/44 , A61L27/54 , A61L31/12 , A61L31/16 , A61L33/00 , A61F2/00
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/434 , A61L2420/08 , C08L27/12 , C08L33/02
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

8. 发明申请

US20070098753A1 Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease 有权
标题翻译：局部给药雷帕霉素和西洛他唑联合用于治疗血管疾病
公开(公告)号：US20070098753A1
公开(公告)日：2007-05-03
申请号：US11260632
申请日：2005-10-27
申请人： Robert Falotico , Jonathon Zhao
发明人： Robert Falotico , Jonathon Zhao
IPC分类号： A61K31/4745 , A61F2/02
CPC分类号： A61L31/16 , A61B2017/0641 , A61L31/10 , A61L2300/416 , A61L2300/42
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。治疗剂也可以递送到疾病部位的区域。在区域递送中，液体制剂可能是期望的，以增加特定药物的功效和递送能力。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

9. 发明申请

US20050272806A1 Injectable formulations of taxanes for cad treatment 有权
公开(公告)号：US20050272806A1
公开(公告)日：2005-12-08
申请号：US10858954
申请日：2004-06-02
申请人： Robert Falotico , Jonathon Zhao
发明人： Robert Falotico , Jonathon Zhao
IPC分类号： A61K9/06 , A61F2/84 , A61K9/08 , A61K9/10 , A61K31/337 , A61K31/355 , A61K47/22 , A61K47/34 , A61L31/00 , A61M29/02 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/14 , A61P29/00 , A61P35/04 , A61P37/00 , A61P43/00
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/337 , A61K47/22
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. The drugs, agents, and/or compounds may also be utilized to treat specific diseases, including vulnerable plaque. Therapeutic agents may also be delivered to the region of a disease site. In regional delivery, liquid formulations may be desirable to increase the efficacy and deliverability of the particular drug. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices. Liquid formulations, including solutions and suspensions of the various drugs, agents and/or compounds, may be locally or regionally delivered. In each of these instances, antioxidants are utilized to prolong product integrity.

10. 发明申请

US20050182485A1 Local vascular delivery of cladribine in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：局部血管输送克拉屈滨与雷帕霉素组合，以防止血管损伤后的再狭窄
公开(公告)号：US20050182485A1
公开(公告)日：2005-08-18
申请号：US10780596
申请日：2004-02-18
申请人： Robert Falotico , Tom Parry , Jonathon Zhao
发明人： Robert Falotico , Tom Parry , Jonathon Zhao
IPC分类号： A61B17/00 , A61B17/11 , A61B17/12 , A61F2/06 , A61F2/82 , A61K31/436 , A61K31/7076 , A61L17/00 , A61L31/00 , A61L31/10 , A61L31/16 , A61L33/00 , A61L33/10 , A61P7/02 , A61P9/10 , A61F2/02
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/45 , A61L2420/08 , C08L33/02 , C08L27/12
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

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