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1. 发明授权

US07084145B2 Triazole compounds useful in therapy 失效
标题翻译：用于治疗的三唑化合物
公开(公告)号：US07084145B2
公开(公告)日：2006-08-01
申请号：US10693327
申请日：2003-10-24
申请人： Robert Duncan Armour , Andrew Douglas Baxter , Justin Stephen Bryans , Kevin Neil Dack , Patrick Stephen Johnson , Russell Andrew Lewthwaite , Julie Newman , David James Rawson , Thomas Ryckmans
发明人： Robert Duncan Armour , Andrew Douglas Baxter , Justin Stephen Bryans , Kevin Neil Dack , Patrick Stephen Johnson , Russell Andrew Lewthwaite , Julie Newman , David James Rawson , Thomas Ryckmans
IPC分类号： A61K31/4965 , C07D403/00
CPC分类号： C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14
摘要： The invention provides compounds of formula (I), the pharmaceutically acceptable salts and solvates thereof, wherein A, B, R1, R2, and R7 are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof as vasopressin V1A antagonists.
摘要翻译：本发明提供式（I）化合物，其药学上可接受的盐和溶剂化物，其中A，B，R 1，R 2和R 7， / SUP>如本文所定义; 其药物组合物; 其组合; 并且其用作血管加压素V 1A拮抗剂。

2. 发明申请

US20080188478A1 Compounds Useful In Therapy 审中-公开
标题翻译：化合物可用于治疗
公开(公告)号：US20080188478A1
公开(公告)日：2008-08-07
申请号：US11912592
申请日：2006-04-18
申请人： Justin Stephen Bryans , Mark Edward Bunnage , Patrick Stephen Johnson , Helen Janet Mason , Lee Richard Roberts , Thomas Ryckmans , Alan Stobie , Toby James Underwood
发明人： Justin Stephen Bryans , Mark Edward Bunnage , Patrick Stephen Johnson , Helen Janet Mason , Lee Richard Roberts , Thomas Ryckmans , Alan Stobie , Toby James Underwood
IPC分类号： A61K31/454 , C07D401/04 , C07D471/04 , A61K31/5025 , A61P25/00 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R1 represents a group selected from H, CF3, and C1-6 alkyl (optionally substituted by C1-6 alkyloxy or triazolyl); R2 represents halo; Ring A represents a 5- or 6-membered heterocyclic ring containing at least one N atom (the ring being optionally bridged with two or more carbon atoms); R3 represents a 5- or 6-membered heterocyclic ring containing at least one atom selected from N, O or S, the heterocyclic ring being optionally substituted by one or more groups selected from C1-6 alkyl oxo or NH2, the heterocyclic ring being further optionally fused to a 5- or 6-membered aryl or heterocyclic ring containing at least one atom selected from N, O or S, the fused aryl or heterocyclic ring being substituted by one or more halo atoms; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhea.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：R 1表示选自H，CF 3 N和C 1-6的基团，（任选被C 1-6烷氧基或三唑基取代）; R 2表示卤素; 环A表示含有至少一个N原子（该环任选地与两个或多个碳原子桥连）的5-或6-元杂环; R 3表示含有至少一个选自N，O或S的原子的5元或6元杂环，杂环任选被一个或多个选自C 1〜 -6个烷基氧基或NH 2，杂环进一步任选地与含有至少一个选自N，O或S的原子的5-或6-元芳基或杂环稠合稠合的芳基或杂环被一个或多个卤素原子取代; 可用于治疗指示V1a拮抗剂的疾病，特别是痛经。

3. 发明授权

US08093400B2 Compounds useful in therapy 失效
标题翻译：化合物可用于治疗
公开(公告)号：US08093400B2
公开(公告)日：2012-01-10
申请号：US12777522
申请日：2010-05-11
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： C07D249/12 , C07D249/08 , C07D249/04 , A61K31/4196 , A61K31/4192
CPC分类号： C07D401/04 , C07D249/08 , C07D249/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的衍生物，其中变量Z，Q，环A，V，X，Y和Y'如本文所定义，以及包含这些化合物的药物组合物。式（I）化合物和包含它们的药物组合物可用于治疗指示V1a拮抗剂，特别是痛经的病症。

4. 发明授权

US07442795B2 Triazole compounds useful in therapy 失效
标题翻译：用于治疗的三唑化合物
公开(公告)号：US07442795B2
公开(公告)日：2008-10-28
申请号：US11416498
申请日：2006-05-01
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Thomas Ryckmans , Alan Stobie
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Thomas Ryckmans , Alan Stobie
IPC分类号： C07D401/14 , C07D413/14
CPC分类号： C07D401/04 , C07D413/14 , C07D487/04 , C07D513/04
摘要： A compound of formula (I), or a pharmaceutically acceptable derivative, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中A，B，V，W，X，Y和Z如本文所定义; 其药物组合物; 及其用途。

5. 发明授权

US07745630B2 Triazolyl piperidine arginine vasopressin receptor modulators 失效
标题翻译：三唑基哌啶精氨酸加压素受体调节剂
公开(公告)号：US07745630B2
公开(公告)日：2010-06-29
申请号：US11009768
申请日：2004-12-10
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： A61K31/454 , C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D249/08 , C07D249/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Z, O, A, V, Y and Y′ are as defined herein; are useful for treating dysmenorreah.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：Z，O，A，V，Y和Y'如本文所定义; 对治疗dysmenorreah有用。

6. 发明申请

US20100317652A1 Compounds Useful In Therapy 失效
标题翻译：化合物可用于治疗
公开(公告)号：US20100317652A1
公开(公告)日：2010-12-16
申请号：US12777522
申请日：2010-05-11
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： A61K31/454 , C07D413/14 , C07D401/14 , C07D403/04 , C07D413/04 , A61K31/5377 , A61K31/506 , A61K31/4545 , A61K31/551 , A61K31/496 , A61P9/10 , A61P9/00 , A61P9/12 , A61P9/04 , A61P29/00 , A61P15/00 , A61P15/06
CPC分类号： C07D401/04 , C07D249/08 , C07D249/14 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable derivatives thereof wherein the variables Z, Q, Ring A, V, X, Y and Y′ are as defined herein, and pharmaceutical compositions comprising these compounds. The compounds of formula (I) and pharmaceutical compositions comprising them are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的衍生物，其中变量Z，Q，环A，V，X，Y和Y'如本文所定义，以及包含这些化合物的药物组合物。式（I）化合物和包含它们的药物组合物可用于治疗指示V1a拮抗剂，特别是痛经的病症。

7. 发明申请

US20080234252A1 Compounds Useful in Therapy 审中-公开
标题翻译：化合物可用于治疗
公开(公告)号：US20080234252A1
公开(公告)日：2008-09-25
申请号：US11914688
申请日：2006-05-08
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Lee Richard Roberts , Thomas Ryckmans
IPC分类号： A61K31/55 , C07D249/08 , A61K31/4196 , C07D471/02 , C07D487/02 , A61P15/00 , A61K31/519 , A61K31/437 , C07D221/20 , C07D223/16
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D403/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D498/04
摘要： Compounds of formula (I), or a pharmaceutically acceptable salt, solvate, ester or amide thereof, wherein R1 represents [CH2]n—R2. R2 represents H, C1-6 alkyloxy or Het; n represents a number selected from 0 to 6; Het represents an unsaturated heterocycle of 5 or 6 atoms containing one or more heteroatoms selected from O, N, and S; R3 represents halo; Ring A represents a 4 to 7 membered, saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from O, N, and S; Ring B represents a saturated, partially saturated, or unsaturated heterocycle of from 3 to 8 atoms containing one or more heteroatoms selected from O, N, and S, or Ring B represents a saturated or unsaturated carbocyclic ring of from 3 to 8 atoms; Ring B is optionally fused to an aryl ring and is optionally substituted with one or more groups independently selected from R4; Ring A and Ring B share at least one atom; R4 represents oxo, [CH2]m—R5 or CH—R6R7; R5 represents H, OH, C1-6 alkyloxy, COOH, or CONR8R9; m represents a number selected from 0 or 1; and R6, R7, R8 and R9 independently represent H or C1-6 alkyl; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂合物，酯或酰胺，其中R 1表示[CH 2 N] -R <2> 。 R 2表示H，C 1-6烷氧基或Het; n表示选自0〜6的数; Het表示含有一个或多个选自O，N和S的杂原子的5或6个原子的不饱和杂环; R 3表示卤素; 环A表示含有一个或多个选自O，N和S的杂原子的4至7元饱和的，部分饱和的或不饱和的杂环; 环B表示含有一个或多个选自O，N和S的杂原子的3至8个原子的饱和，部分饱和或不饱和杂环，或环B表示3至8个原子的饱和或不饱和碳环; 环B任选地与芳环稠合并且任选地被一个或多个独立地选自R 4的基团取代; 环A和环B共享至少一个原子; R 4表示氧代，[CH 2 CH 2] m -R 5或CH-R 6， 7＆lt; 7＆gt;; R 5表示H，OH，C 1-6烷氧基，COOH或CONR 8 R 9; m表示选自0或1的数字; 且R 6，R 7，R 8和R 9独立地表示H或C 1〜 6烷基; 可用于治疗指示V1a拮抗剂的疾病，特别是痛经。

8. 发明授权

US07119088B2 Triazole compounds useful in therapy 失效
标题翻译：三唑化合物可用于治疗
公开(公告)号：US07119088B2
公开(公告)日：2006-10-10
申请号：US10782285
申请日：2004-02-18
申请人： Justin Stephen Bryans , Patrick Stephen Johnson , Thomas Ryckmans , Alan Stobie
发明人： Justin Stephen Bryans , Patrick Stephen Johnson , Thomas Ryckmans , Alan Stobie
IPC分类号： A61K31/5517 , C07D487/14 , C07D498/14 , C07D513/14
CPC分类号： C07D401/04 , C07D413/14 , C07D487/04 , C07D513/04
摘要： A compound of formula (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中A，B，V，W，X，Y和Z如本文所定义; 其药物组合物; 及其用途。

9. 发明授权

US07183294B2 Indole derivatives useful for the treatment of diseases 失效
标题翻译：用于治疗疾病的吲哚衍生物
公开(公告)号：US07183294B2
公开(公告)日：2007-02-27
申请号：US10800253
申请日：2004-03-12
申请人： Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon John Mantell
发明人： Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon John Mantell
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/4045 , C07D401/12 , C07D209/14
CPC分类号： C07D209/42 , C07D401/12 , C07D417/12
摘要： The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及吲哚衍生物和制备用于制备含有这些衍生物的组合物和用途的中间体的方法。根据本发明的吲哚衍生物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

10. 发明授权

US06844362B2 Indole derivatives useful for the treatment of diseases 失效
标题翻译：用于治疗疾病的吲哚衍生物
公开(公告)号：US06844362B2
公开(公告)日：2005-01-18
申请号：US10684233
申请日：2003-10-09
申请人： Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon Mantell
发明人： Alan Daniel Brown , Justin Stephen Bryans , Mark Edward Bunnage , Paul Alan Glossop , Charlotte Alice Louise Lane , Russell Andrew Lewthwaite , Simon Mantell
IPC分类号： C07D209/42 , A61K31/404 , C07D209/04
CPC分类号： C07D209/42
摘要： The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
摘要翻译：本发明涉及吲哚衍生物和制备用于制备含有这些衍生物的组合物和用途的中间体的方法。根据本发明的吲哚衍生物可用于许多疾病，病症和病症，特别是炎症，过敏和呼吸道疾病，病症和病症。

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