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1. 发明申请

US20060051878A1 Nano-sized optical fluorescence labels and uses thereof 失效
公开(公告)号：US20060051878A1
公开(公告)日：2006-03-09
申请号：US10519267
申请日：2003-06-27
申请人： Robert Dickson , Jie Zheng
发明人： Robert Dickson , Jie Zheng
IPC分类号： G01N33/543
CPC分类号： B82Y15/00 , G01N33/582 , G01N33/588 , Y10S436/805
摘要： A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a peptide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster and/or the generation of the dendrimer, and wherein said emission is used to provide information about a biological state.

2. 发明授权

US10336896B2 One-pot synthesis of highly mechanical and recoverable double-network hydrogels 有权
公开(公告)号：US10336896B2
公开(公告)日：2019-07-02
申请号：US14787041
申请日：2014-04-23
申请人： Jie Zheng , Qiang Chen , Chao Zhao
发明人： Jie Zheng , Qiang Chen , Chao Zhao
IPC分类号： C12C11/02 , C08L33/26 , C08B37/00 , C08L5/12 , C08J3/075 , C08L5/00
摘要： A method of forming a hybrid physically and chemically cross-linked double-network hydrogel with highly recoverable and mechanical properties in a single-pot synthesis is provided. The method comprises the steps of combining the hydrogel precursor reactants into a single pot. The hydrogel precursor reactants include water; a polysaccharide; a methacrylate monomer; an ultraviolet initiator; and a chemical crosslinker. Next the hydrogel precursor reactants are heated to a temperature higher than the melting point of the polysaccharide and this temperature is retained until the polysaccharide is in a sol state. Then the single-pot is cooled to a temperature lower than the gelation point of the polysaccharide and this temperature is retained to form a first network. Thereafter, photo-initiated polymerization of the methacrylate monomer occurs via the ultraviolet initiator to form the second network.

3. 发明申请

US20160083574A1 ONE-POT SYNTHESIS OF HIGHLY MECHANICAL AND RECOVERABLE DOUBLE-NETWORK HYDROGELS 审中-公开
标题翻译：高效机械和可恢复的双网络水合物的一步法合成
公开(公告)号：US20160083574A1
公开(公告)日：2016-03-24
申请号：US14787041
申请日：2014-04-23
申请人： Jie Zheng , Qiang Chen , Chao Zhao
发明人： Jie Zheng , Qiang Chen , Chao Zhao
IPC分类号： C08L33/26 , C08L5/12
CPC分类号： C08L33/26 , C08B37/0039 , C08J3/075 , C08J2305/12 , C08J2333/26 , C08J2405/12 , C08J2433/26 , C08L5/00 , C08L5/12 , C08L33/10
摘要： A method of forming a hybrid physically and chemically cross-linked double-network hydrogel with highly recoverable and mechanical properties in a single-pot synthesis is provided. The method comprises the steps of combining the hydrogel precursor reactants into a single pot. The hydrogel precursor reactants include water; a polysaccharide; a methacrylate monomer; an ultraviolet initiator; and a chemical crosslinker. Next the hydrogel precursor reactants are heated to a temperature higher than the melting point of the polysaccharide and this temperature is retained until the polysaccharide is in a sol state. Then the single-pot is cooled to a temperature lower than the gelation point of the polysaccharide and this temperature is retained to form a first network. Thereafter, photo-initiated polymerization of the methacrylate monomer occurs via the ultraviolet initiator to form the second network.
摘要翻译：提供了在单锅合成中形成具有高可回收和机械性质的杂化物理和化学交联双网络水凝胶的方法。该方法包括以下步骤：将水凝胶前体反应物合并成单个罐。水凝胶前体反应物包括水; 多糖; 甲基丙烯酸酯单体; 紫外线引发剂; 和化学交联剂。接下来将水凝胶前体反应物加热到高于多糖的熔点的温度，并保持该温度，直到多糖处于溶胶状态。然后将单釜冷却至低于多糖的凝胶化点的温度，并保持该温度以形成第一网络。此后，通过紫外线引发剂发生甲基丙烯酸酯单体的光引发聚合以形成第二网络。

4. 发明授权

US08936665B2 Diamond metal composite 有权
标题翻译：钻石金属复合材料
公开(公告)号：US08936665B2
公开(公告)日：2015-01-20
申请号：US12741318
申请日：2008-10-30
申请人： Jie Zheng
发明人： Jie Zheng
IPC分类号： C22C26/00 , B01J3/06 , C09K3/14 , C22C47/08
CPC分类号： B22F3/1007 , B01J3/065 , B01J2203/062 , B01J2203/0655 , B22F3/1035 , B22F2999/00 , C09K3/1436 , C22C47/08 , Y10T428/12049 , B22F2201/10 , B22F2201/20
摘要： The present invention relates to a method for producing diamond-metal composites comprising mixing diamond particles with metal-filler particles forming a diamond/metal-filler mixture, forming a green body of the diamond/metal-filler mixture, optionally green machining the green body to a work piece before or after pre-sintering by heating the green body to a temperature ≦500° C., infiltrating the green body or the work piece with one or more wetting elements or infiltrating the green body or the work piece with one or more wetting alloys, which infiltration step being carried out under vacuum or in an inert gas atmosphere at a pressure ≦200 Bar. The invention relates further to a green body, a diamond metal composite, and use of the diamond metal composite.
摘要翻译：本发明涉及一种生产金刚石 - 金属复合材料的方法，包括将金刚石颗粒与形成金刚石/金属 - 填料混合物的金属 - 填料颗粒混合，形成金刚石/金属 - 填料混合物的生坯，任选地绿色加工生坯通过将生坯体加热至温度<500℃而在预烧结之前或之后的工件; 500℃，用一种或多种润湿元件渗透生坯或工件，或者用一个或多个润湿元件浸入生坯或工件或更多润湿合金，该渗透步骤在真空下或在惰性气体气氛中在压力为200巴下进行。本发明进一步涉及生坯，金刚石金属复合材料和金刚石金属复合材料的用途。

5. 发明申请

US20140283597A1 Sensor Device Having Plural Resistance Change Type Sensors and Method of Using the Same 有权
标题翻译：具有多个电阻变化型传感器的传感器装置及其使用方法
公开(公告)号：US20140283597A1
公开(公告)日：2014-09-25
申请号：US14224223
申请日：2014-03-25
申请人： Jie Zheng , Ryo Ito , Kenji Kanazawa , Osamu Takahashi
发明人： Jie Zheng , Ryo Ito , Kenji Kanazawa , Osamu Takahashi
IPC分类号： G01N27/12 , G03G15/00
CPC分类号： G03G21/203 , G01N27/121 , G03G2215/00084
摘要： To detect humidity, used are a first series connection circuit connecting a thermistor and a fixed resistor via a node, a second series connection circuit connecting a resistance change type humidity sensor and the thermistor via the node, and a third series connection circuit connecting the humidity sensor and the fixed resistor via the node. A predetermined voltage is applied across the first circuit to detect a first voltage indicating temperature through the node, and secondly across the second circuit to detect a second voltage indicating a first humidity through the node, and finally across the third circuit to detect a third voltage indicating a second humidity through the node. Then, the first voltage is compared with a reference voltage and judgment is made, based on a comparison result, to determine which of the second voltage and the third voltage is relevant to use as a basis for outputting the humidity as detected.
摘要翻译：为了检测湿度，使用的是通过节点连接热敏电阻和固定电阻器的第一串联连接电路，经由节点连接电阻变化型湿度传感器和热敏电阻的第二串联连接电路和连接湿度的第三串联连接电路传感器和固定电阻通过节点。在第一电路两端施加预定电压以检测通过该节点的指示温度的第一电压，其次跨越第二电路检测指示通过节点的第一湿度的第二电压，最后跨越第三电路检测第三电压表示通过节点的第二湿度。然后，将第一电压与参考电压进行比较，并且基于比较结果进行判断，以确定第二电压和第三电压中的哪一个与用作输出检测到的湿度的基础相关。

6. 发明申请

US20140064449A1 METHOD AND APPARATUS FOR DETERMINING TREATMENT MARGIN OF TARGET AREA 有权
标题翻译：用于确定目标区域治疗标准的方法和装置
公开(公告)号：US20140064449A1
公开(公告)日：2014-03-06
申请号：US14013188
申请日：2013-08-29
申请人： Xiang Deng , Jie Zheng
发明人： Xiang Deng , Jie Zheng
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B6/032 , A61B6/4441 , A61B6/463 , A61B6/5217 , A61B6/5235
摘要： Disclosed is a method and apparatus for determining a tumor ablation margin. The method includes acquiring an angiography image before tumor ablation and an angiography image after tumor ablation when tumor ablation is performed, registering the angiography image before tumor ablation and the angiography image after tumor ablation, and determining the tumor ablation margin according to the relative positions of the tumor area in the angiography image before tumor ablation and the ablation area in the angiography image after tumor ablation after registration. Using an embodiment, one directly determines the tumor ablation margin during tumor ablation, thus improving the efficiency and success rate of tumor ablation.
摘要翻译：公开了一种用于确定肿瘤消融边缘的方法和装置。该方法包括在进行肿瘤消融术前获取肿瘤消融前的血管造影图像和肿瘤消融后的血管造影图像，在肿瘤消融前记录血管造影图像和肿瘤消融后的血管造影图像，并根据相对位置确定肿瘤消融边缘肿瘤消融前血管造影图像中的肿瘤区域和注射后肿瘤消融后血管造影图像中的消融区域。使用一个实施例，在肿瘤消融期间直接确定肿瘤消融边缘，从而提高肿瘤消融的效率和成功率。

7. 发明申请

US20090312253A1 Methods of effecting Wnt signaling through Dkk structural analysis 有权
标题翻译：通过Dkk结构分析实现Wnt信号传导的方法
公开(公告)号：US20090312253A1
公开(公告)日：2009-12-17
申请号：US12454758
申请日：2009-05-22
申请人： Jie Zheng
发明人： Jie Zheng
IPC分类号： A61K38/16 , C07K14/00 , C12N5/00 , C12N5/08 , G01N33/53 , C12Q1/68 , A61P35/00 , A61P25/28 , A61P19/08 , A61P19/02 , A61P25/18 , A61P35/02
CPC分类号： C07K14/705 , A61K31/00 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/32 , G01N33/5041 , G01N33/68 , G01N2333/495 , G01N2333/705 , A61K2300/00
摘要： Compositions and methods related to Wnt signaling regulation by Dickkopf (Dkk) polypeptides and Wnt-related diseases are disclosed. For example, compounds that bind a Dkk or LRP polypeptide are disclosed. Compounds that disrupt binding of a Dkk polypeptide to an LRP polypeptide are also disclosed. Methods for using the described compounds and compositions are also disclosed.
摘要翻译：公开了与Dickkopf（Dkk）多肽和Wnt相关疾病的Wnt信号调节有关的组合物和方法。例如，公开了结合Dkk或LRP多肽的化合物。还公开了破坏Dkk多肽与LRP多肽的结合的化合物。还公开了使用所述化合物和组合物的方法。

8. 发明授权

US07611907B2 Nano-sized optical fluorescence labels and uses thereof 失效
标题翻译：纳米尺寸的光学荧光标记及其用途
公开(公告)号：US07611907B2
公开(公告)日：2009-11-03
申请号：US10519267
申请日：2003-06-27
申请人： Robert Martin Dickson , Jie Zheng
发明人： Robert Martin Dickson , Jie Zheng
IPC分类号： G01N33/553
CPC分类号： B82Y15/00 , G01N33/582 , G01N33/588 , Y10S436/805
摘要： A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a peptide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster and/or the generation of the dendrimer, and wherein said emission is used to provide information about a biological state.
摘要翻译：公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。贵金属纳米团簇优选被树枝状聚合物或肽包封。封装的贵金属纳米团簇具有特征光谱发射，其中所述光谱发射通过控制封装材料的性质而变化，例如通过控制纳米簇的尺寸和/或树枝状聚合物的产生，并且其中使用所述发射提供有关生物状态的信息。

9. 发明申请

US20080118912A1 Raman-Enhancing, and Non-Linear Optically Active Nano-Sized Optical Labels and Uses Thereof 审中-公开
标题翻译：拉曼增强和非线性光学活性纳米尺寸光学标签及其用途
公开(公告)号：US20080118912A1
公开(公告)日：2008-05-22
申请号：US10598722
申请日：2005-03-10
申请人： Robert Martin Dickson , Jie Zheng , Lynn Anne Capadona , Jeffrey Thomas Petty , Sandeep Ajit Patel , Marcus Weck
发明人： Robert Martin Dickson , Jie Zheng , Lynn Anne Capadona , Jeffrey Thomas Petty , Sandeep Ajit Patel , Marcus Weck
IPC分类号： G01N33/543 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/588 , A61K49/0065 , A61K49/0067 , A61K49/0093 , B82Y15/00 , G01N33/532 , G01N33/54346 , G01N33/5436 , G01N33/582 , Y10T436/107497
摘要： A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer, a peptide, a small organic or inorganic molecule, or an oligonucleotide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster, the generation of a dendrimer, the incorporation of a functional group, and wherein said emission is used to provide information about a biological state. The emission is selected from the group consisting of nanocluster fluorescence, multiphoton excited nanocluster fluorescence, Stokes or Anti-Stokes Raman emission from the encapsulating material, and second harmonic generation.
摘要翻译：公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。在某些实施方案中，贵金属纳米簇被树枝状聚合物，肽，小有机或无机分子或寡核苷酸包封。封装的贵金属纳米团簇具有特征光谱发射，其中通过控制封装材料的性质来改变所述光谱发射，例如通过控制纳米簇的尺寸，树枝状聚合物的产生，官能团的结合，和其中所述发射用于提供关于生物学状态的信息。发射选自纳米团簇荧光，多光子激发纳米团簇荧光，来自封装材料的斯托克斯或反斯托克斯拉曼发射以及二次谐波产生。

10. 发明申请

US20050247773A1 Template-based information extraction system and method 审中-公开
标题翻译：基于模板的信息提取系统和方法
公开(公告)号：US20050247773A1
公开(公告)日：2005-11-10
申请号：US10839146
申请日：2004-05-06
申请人： Jack Hoang , Jie Zheng
发明人： Jack Hoang , Jie Zheng
IPC分类号： G06F3/12 , G06F15/12 , G06F17/00 , G06F17/30
CPC分类号： G06Q20/209 , G06F16/258 , G06Q20/0453 , G07G5/00
摘要： A system and method for extracting and processing text information from a receipt signal generated for output by a printer using a template, comprising the steps of: receiving the template; parsing the receipt signal using the template into at least one receipt information item; and storing the at least one receipt information item into a database.
摘要翻译：一种用于从由打印机使用模板生成的收据信号中提取和处理文本信息的系统和方法，包括以下步骤：接收模板; 使用所述模板将接收信号解析为至少一个接收信息项; 以及将所述至少一个收据信息项存储到数据库中。

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