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1. 发明申请

US20090024047A1 DEVICES AND METHODS FOR RESPIRATION THERAPY 审中-公开
标题翻译：用于呼吸治疗的装置和方法
公开(公告)号：US20090024047A1
公开(公告)日：2009-01-22
申请号：US11780861
申请日：2007-07-20
申请人： Robert D. Shipley , Rodney W. Salo
发明人： Robert D. Shipley , Rodney W. Salo
IPC分类号： A61B5/08 , A61B5/00 , A61F2/02
CPC分类号： A61N1/3601 , A61B5/0031 , A61B5/0816 , A61B5/113 , G06Q50/24
摘要： Embodiments of the invention are related to devices and methods for respiration therapy, amongst other things. In an embodiment, the invention includes a system for providing respiration therapy to a patient, including an implantable device comprising a chronically implanted respiration sensor, the respiration sensor configured to generate a signal indicative of respiration rate of the patient; and an external interface device in communication with the implantable device, the external interface device comprising an output device and configured to deliver respiration therapy to the patient, the respiration therapy comprising one or more breathing prompts generated by the output device. In an embodiment, the invention includes a method for providing respiration therapy to a patient. In an embodiment, the invention includes a method of monitoring a heart failure patient for decompensation events. Other aspects and embodiments are provided herein.
摘要翻译：除了别的以外，本发明的实施例涉及用于呼吸治疗的装置和方法。在一个实施例中，本发明包括用于向患者提供呼吸治疗的系统，包括可植入装置，其包括长期植入的呼吸传感器，所述呼吸传感器被配置为产生指示患者呼吸速率的信号; 以及与所述可植入装置通信的外部接口装置，所述外部接口装置包括输出装置并且被配置为向所述患者递送呼吸治疗，所述呼吸治疗包括由所述输出装置产生的一个或多个呼吸提示。在一个实施例中，本发明包括用于向患者提供呼吸治疗的方法。在一个实施例中，本发明包括监测失败患者的失代偿事件的方法。本文提供了其它方面和实施例。

2. 发明授权

US08731677B2 Myocardium conditioning using myocardial and parasympathetic stimulation 有权
标题翻译：心肌调理使用心肌和副交感神经刺激
公开(公告)号：US08731677B2
公开(公告)日：2014-05-20
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

3. 发明授权

US08046070B2 Pre-excitation pacing for treatment of hypertension 有权
标题翻译：预激励起搏治疗高血压
公开(公告)号：US08046070B2
公开(公告)日：2011-10-25
申请号：US11557202
申请日：2006-11-07
申请人： Rodney W. Salo , Robert Shipley
发明人： Rodney W. Salo , Robert Shipley
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36564
摘要： Described herein are methods and apparatus for treating hypertension with electrical pre-excitation pacing therapy. Electrical pre-excitation of a hypertrophic region advances the timing of the regional contraction and reduces its contribution to the overall contraction. Such pre-excitation pacing therapy may be beneficial to hypertensive patients with an abnormal distribution of ventricular wall stress/strain.
摘要翻译：本文描述了用电预激发起步疗法治疗高血压的方法和装置。增生区域的电预激发促进了区域收缩的时机，并减少了其对整体收缩的贡献。这种预激励起搏治疗可能有益于心室壁应力/应变异常分布的高血压患者。

4. 发明授权

US08046069B2 Method and apparatus for control of cardiac therapy using non-invasive hemodynamic sensor 有权
标题翻译：使用非侵入性血液动力学传感器控制心脏治疗的方法和装置
公开(公告)号：US08046069B2
公开(公告)日：2011-10-25
申请号：US11315032
申请日：2005-12-22
申请人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
发明人： Andrew P. Kramer , Joseph M. Pastore , Jeffrey E. Stahmann , Rodney W. Salo , Jesse W. Hartley
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译：心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。

5. 发明申请

US20110213436A1 METHOD AND DEVICE FOR TREATING MYOCARDIAL ISCHEMIA 有权
标题翻译：用于治疗心肌梗塞的方法和装置
公开(公告)号：US20110213436A1
公开(公告)日：2011-09-01
申请号：US13103477
申请日：2011-05-09
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

6. 发明申请

US20110144575A1 METHOD AND APPARATUS FOR MINIMIZING POST-INFARCT VENTRICULAR REMODELING 失效
标题翻译：用于最小化后腹腔镜重建的方法和装置
公开(公告)号：US20110144575A1
公开(公告)日：2011-06-16
申请号：US13034560
申请日：2011-02-24
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/365 , A61M5/00
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译：一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。这种起搏服务器可以预防或最小化梗死后重塑。

7. 发明授权

US07914452B2 Method and apparatus for controlling cardiac therapy using ultrasound transducer 有权
标题翻译：使用超声波换能器控制心脏治疗的方法和装置
公开(公告)号：US07914452B2
公开(公告)日：2011-03-29
申请号：US11539939
申请日：2006-10-10
申请人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61B8/00 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36528
摘要： A cardiac rhythm management (CRM) system provides for post-myocardial infarction (MI) therapy with closed-loop control using one or more ultrasound transducers sensing one or more ultrasound signals indicative of cardiac dimensions. Cardiac size parameters are produced using the one or more ultrasound signals to represent, for example, cardiac chamber diameter, cardiac chamber volume, cardiac wall thickness, infarct size, and degree of change in any of these parameters over time or between measurements. In various embodiments, such cardiac size parameters provide for titration, safety check, and acute optimization of the post-MI therapy.
摘要翻译：心律控制（CRM）系统通过使用一个或多个超声换能器感测一个或多个指示心脏尺寸的超声信号，通过闭环控制提供心肌梗死后心肌梗死（MI）治疗。使用一个或多个超声信号产生心脏尺寸参数，以表示例如心脏室直径，心室容积，心壁厚度，梗塞面积以及随时间或测量之间的任何这些参数的变化程度。在各种实施方案中，这种心脏尺寸参数提供滴定，安全性检查和MI后治疗的急性优化。

8. 发明授权

US07877140B2 Pressure sensing for feedback control of post-MI remodeling control pacing 有权
标题翻译：压力感应用于后MI重建控制起搏的反馈控制
公开(公告)号：US07877140B2
公开(公告)日：2011-01-25
申请号：US11220023
申请日：2005-09-06
申请人： Jeffrey E. Stahmann , Joseph M. Pastore , Andrew P. Kramer , Rodney W. Salo , Jesse W. Hartley
发明人： Jeffrey E. Stahmann , Joseph M. Pastore , Andrew P. Kramer , Rodney W. Salo , Jesse W. Hartley
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36542 , A61N1/36564 , A61N1/3684
摘要： A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an intravascular pressure measurement in order to balance the beneficial effects of stress reduction with hemodynamic compromise.
摘要翻译：描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。根据血管内压力测量调节预激发起搏，以平衡应力减少与血液动力学妥协的有益效果。

9. 发明授权

US07774057B2 Method and apparatus for device controlled gene expression for cardiac protection 有权
标题翻译：心脏保护装置控制基因表达的方法和装置
公开(公告)号：US07774057B2
公开(公告)日：2010-08-10
申请号：US11220397
申请日：2005-09-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译：基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。基因调控信号直接或间接调控基因产物的基因表达。

10. 发明授权

US07627373B2 Method and apparatus for cell and electrical therapy of living tissue 有权
标题翻译：活体组织细胞和电疗法的方法和装置
公开(公告)号：US07627373B2
公开(公告)日：2009-12-01
申请号：US10723258
申请日：2003-11-25
申请人： Steven D. Girouard , Rodney W. Salo , Bruce H. KenKnight
发明人： Steven D. Girouard , Rodney W. Salo , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译：一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。在一个应用中，可以使用植入式起搏器进行VDD模式，与内在房室延迟相比，房室延迟保持相对较短。

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