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1. 发明授权

US06548740B1 Methods for creating transgenic animals 有权
标题翻译：创建转基因动物的方法
公开(公告)号：US06548740B1
公开(公告)日：2003-04-15
申请号：US09502264
申请日：2000-02-11
申请人： Robert D. Bremel , Anthony W.S. Chan , Jane C. Burns
发明人： Robert D. Bremel , Anthony W.S. Chan , Jane C. Burns
IPC分类号： C12N1500
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K14/005 , C12N15/8509 , C12N15/86 , C12N2730/10122 , C12N2740/13043 , C12N2740/13051
摘要： The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
摘要翻译：本发明提供用于产生转基因非人动物的改进的方法和组合物。本发明允许通过将感染性逆转录病毒显微注射到卵的periviteline空间中将外源核酸序列引入未受精卵的基因组（例如，预成熟卵母细胞和预受精卵母细胞）中。本发明的方法提供了转基因动物的生产效率的提高，其中产生动物的速率降低，这是为了转基因的存在而镶嵌的。

2. 发明授权

US07138562B2 Transgenic animals 有权
公开(公告)号：US07138562B2
公开(公告)日：2006-11-21
申请号：US09907859
申请日：2001-07-18
申请人： Robert D. Bremel , Anthony W. S. Chan , Jane C. Burns
发明人： Robert D. Bremel , Anthony W. S. Chan , Jane C. Burns
IPC分类号： C12N15/00 , A01K67/00 , A01K67/033
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K14/005 , C12N15/8509 , C12N15/86 , C12N2730/10122 , C12N2740/13043 , C12N2740/13051
摘要： The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.

3. 发明授权

US06291740B1 Transgenic animals 失效
标题翻译：转基因动物
公开(公告)号：US06291740B1
公开(公告)日：2001-09-18
申请号：US09329749
申请日：1999-06-10
申请人： Robert D. Bremel , Anthony W. S. Chan , Jane C. Burns
发明人： Robert D. Bremel , Anthony W. S. Chan , Jane C. Burns
IPC分类号： C12N1500
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C07K14/005 , C12N15/8509 , C12N15/86 , C12N2730/10122 , C12N2740/13043 , C12N2740/13051
摘要： The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.
摘要翻译：本发明提供用于产生转基因非人动物的改进的方法和组合物。本发明允许通过将感染性逆转录病毒显微注射到卵的periviteline空间中将外源核酸序列引入未受精卵的基因组（例如，预成熟卵母细胞和预受精卵母细胞）中。本发明的方法提供了转基因动物的生产效率的提高，其中产生动物的速率降低，这是为了转基因的存在而镶嵌的。

4. 发明授权

US6080912A Methods for creating transgenic animals 失效
公开(公告)号：US6080912A
公开(公告)日：2000-06-27
申请号：US821984
申请日：1997-03-20
申请人： Robert D. Bremel , Anthony W. S. Chan , Jane C. Burns
发明人： Robert D. Bremel , Anthony W. S. Chan , Jane C. Burns
IPC分类号： A01K67/027 , C07K14/02 , C12N5/02 , C12N15/85 , C12N15/867 , C12N15/00
CPC分类号： A01K67/0275 , C07K14/005 , C12N15/8509 , C12N15/86 , A01K2217/05 , A01K2227/101 , A01K2267/01 , A01K2267/02 , C12N2730/10122 , C12N2740/13043 , C12N2740/13051
摘要： The present invention provides improved methods and compositions for the generation of transgenic non-human animals. The present invention permits the introduction of exogenous nucleic acid sequences into the genome of unfertilized eggs (e.g., pre-maturation oocytes and pre-fertilization oocytes) by microinjection of infectious retrovirus into the perivitelline space of the egg. The methods of the present invention provide an increased efficiency of production of transgenic animals with a reduced rate of generating animals which are mosaic for the presence of the transgene.

5. 发明申请

US20080267943A1 Innate Immune Receptor Directed Biocides 审中-公开
标题翻译：先天免疫受体导向杀生物剂
公开(公告)号：US20080267943A1
公开(公告)日：2008-10-30
申请号：US11875343
申请日：2007-10-19
申请人： Michael Imboden , Jane Homan , Robert D. Bremel
发明人： Michael Imboden , Jane Homan , Robert D. Bremel
IPC分类号： A61K38/43 , A61K38/00 , C12N5/06 , C12N15/00 , A01K67/027 , A61P31/00 , A23L3/3463
CPC分类号： A01N63/04 , A01N63/00 , A01N63/02 , A01N65/00 , C07K16/00 , C07K16/20 , C07K2317/52 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/55 , C07K2319/735
摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.
摘要翻译：本发明涉及编码新单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体及其使用和生产方法。特别地，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如，免疫球蛋白或先天免疫系统受体分子）和杀生物剂（例如杀菌酶）的融合蛋白的方法。文化。本发明还涉及在医疗保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法，牛肉屠体处理）。本发明还涉及在农业，医药，国防等不同领域的多种诊断应用中使用包含微生物靶向分子和杀生物剂的融合蛋白的方法。

6. 发明授权

US07300790B2 Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins 失效
标题翻译：转基因动物表达显性阴性逆转录病毒核酸和蛋白质
公开(公告)号：US07300790B2
公开(公告)日：2007-11-27
申请号：US10764201
申请日：2004-01-23
申请人： Kurt Eakle , Thomas Hope , Eun-A Choi , Jane Homan , Robert D. Bremel
发明人： Kurt Eakle , Thomas Hope , Eun-A Choi , Jane Homan , Robert D. Bremel
IPC分类号： C12P1/00 , C12P37/04
CPC分类号： C07K14/005 , A01K2217/05 , A01K2227/101 , A01K2267/02 , A61K48/00 , C12N2740/14022 , C12N2740/14043 , C12N2830/00
摘要： The present invention relates to non-vaccinal and non-pharmacologic compositions and methods for controlling complex retroviral infections. In particular, the present invention provides transgenic animals expressing a transdominant negative Rex gene product that inhibits retroviral replication.
摘要翻译：本发明涉及用于控制复合逆转录病毒感染的非疫苗和非药物组合物和方法。特别地，本发明提供表达抑制逆转录病毒复制的显性阴性Rex基因产物的转基因动物。

7. 发明授权

US5530177A Transgenic mice producing bovine .alpha.-lactalbumin in their milk 失效
标题翻译：在其牛奶中产生牛α-乳白蛋白的转基因小鼠
公开(公告)号：US5530177A
公开(公告)日：1996-06-25
申请号：US71601
申请日：1993-06-04
申请人： Gregory T. Bleck , Robert D. Bremel
发明人： Gregory T. Bleck , Robert D. Bremel
IPC分类号： C12N15/09 , A01K67/027 , C07K14/76 , C12N15/85 , C12P21/02 , C12N5/00 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C12N15/8509 , A01K67/0275 , C07K14/76 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2267/01
摘要： The present invention relates to the use of a mammary specific .alpha.-lactalbumin regulatory sequence to assist in the production of recombinant proteins in mammals' milk. The invention also relates to the genetically engineered mammal that produces the desired recombinant product in its milk and to the products produced by the genetically engineered mammal, including the altered composition of milk and the semen which includes the desired .alpha.-lactalbumin protein DNA sequence.
摘要翻译：本发明涉及乳腺特异性α-乳白蛋白调节序列在哺乳动物乳中生产重组蛋白质的用途。本发明还涉及在其牛奶中产生所需重组产物和由遗传工程哺乳动物产生的产品的基因工程哺乳动物，包括改变的乳组合物和包含所需α-乳白蛋白DNA序列的精液。

8. 发明授权

US10706955B2 Bioinformatic processes for determination of peptide binding 有权
公开(公告)号：US10706955B2
公开(公告)日：2020-07-07
申请号：US13052733
申请日：2011-03-21
申请人： Robert D. Bremel , Jane Homan
发明人： Robert D. Bremel , Jane Homan
IPC分类号： G16B20/00 , G16B40/00
摘要： This invention relates to processes for identifying peptide and polypeptide ligands for a binding partner by using principal component analysis of amino acids to derive vectors describing amino acid subsets corresponding to peptides with known binding affinities and then using this information in a neural network modeling process to derive binding prediction equations. These binding prediction equations are then used in the analysis of subsets of amino acids from a target source to identify peptides or polypeptides ligands in the target source that have affinity for a binding partner.

9. 发明申请

US20130330335A1 BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING 审中-公开
标题翻译：用于确定肽结合的生物工艺
公开(公告)号：US20130330335A1
公开(公告)日：2013-12-12
申请号：US13052733
申请日：2011-03-21
申请人： Robert D. Bremel , Jane Homan
发明人： Robert D. Bremel , Jane Homan
IPC分类号： A61K39/395 , C07H21/04 , A61K39/00 , A61P37/04 , C07K16/00 , C07K19/00 , C12N9/96 , C12P21/00 , G01N33/53 , G01N33/569 , A61K38/02 , G06F17/10 , G06N3/08 , G06G7/58 , C07K14/00
摘要： This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
摘要翻译：本发明涉及肽结合配体的鉴定，特别涉及由微生物和哺乳动物细胞表达的表位的鉴定。本发明提供了包含表位的多肽，以及利用或使用表位开发的疫苗，抗体和诊断产物。

10. 发明申请

US20080269122A1 Antimicrobial Peptide Biocides 审中-公开
标题翻译：抗微生物肽杀菌剂
公开(公告)号：US20080269122A1
公开(公告)日：2008-10-30
申请号：US11875349
申请日：2007-10-19
申请人： Michael Imboden , Jane Homan , Robert D. Bremel
发明人： Michael Imboden , Jane Homan , Robert D. Bremel
IPC分类号： A61K38/00 , C12N15/00 , C12N5/06 , A61P31/00 , A23L3/3463
CPC分类号： A01N63/04 , A01N63/00 , A01N63/02 , A01N65/00 , C07K16/00 , C07K16/20 , C07K2317/52 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/55 , C07K2319/735
摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.
摘要翻译：本发明涉及编码新单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体及其使用和生产方法。特别地，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如，免疫球蛋白或先天免疫系统受体分子）和杀生物剂（例如杀菌酶）的融合蛋白的方法。文化。本发明还涉及在医疗保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法，牛肉屠体处理）。本发明还涉及在农业，医药，国防等不同领域的多种诊断应用中使用包含微生物靶向分子和杀生物剂的融合蛋白的方法。

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