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1. 发明授权

US06340744B1 Reagent system and method for increasing the luminescence of lanthanide(III) macrocyclic complexes 失效
标题翻译：用于增加镧系元素（III）大环络合物发光的试剂体系和方法
公开(公告)号：US06340744B1
公开(公告)日：2002-01-22
申请号：US09484670
申请日：2000-01-18
申请人： Robert C. Leif , Lidia Vallarino
发明人： Robert C. Leif , Lidia Vallarino
IPC分类号： A61K4900
CPC分类号： C07D471/18 , G01N33/582 , Y10S435/96 , Y10S435/968
摘要： Disclosed are a spectrofluorimetrically detectable luminescent composition and processes for enhancing the luminescence of one or more lanthanide-containing macrocycles. The luminescent composition comprises a micelle-producing amount of at least one surfactant, at least one energy transfer acceptor lanthanide element macrocycle compound having an emission spectrum peak in the range from 500 to 950 nanometers, and a luminescence-enhancing amount of at least one energy transfer donor compound of yttrium or a 3-valent lanthanide element having atomic number 59-71, provided that the lanthanide element of said macrocycle compound and the lanthanide element of said energy transfer donor compound are not identical. The addition of gadolinium(III) in the presence of other solutes to both the prototype and the difunctionalized europium, samarium, and terbium macrocyclic complexes, which were taught in our U.S. Pat. Nos. 5,373,093 and 5,696,240, enhances their luminescence. Similar enhancements of luminescence also results for the mono-functionalized europium, samarium, and terbium macrocyclic complexes, which were taught in our U.S. Pat. No. 5,696,240. The enhanced luminescence afforded by the composition enables the detection and/or quantitation of many analytes in low concentrations without the use of expensive, complicated time-gated detection systems.
摘要翻译：公开了分光荧光测定的发光组合物和用于增强一种或多种含镧系元素的大环化合物的发光的方法。发光组合物包含胶束产生量的至少一种表面活性剂，至少一种能量转移受体镧系元素大环化合物，其发射光谱峰值在500至950纳米的范围内，以及至少一种能量的发光增强量转移钇的供体化合物或原子序数为59-71的3价镧系元素，条件是所述大环化合物的镧系元素和所述能量转移给体化合物的镧系元素不相同。在其他溶质存在下，将钆（III）添加到原型和双官能化铕，钐和铽大环络合物中，这在我们的美国专利中已被教导。第5,373,093和第5,696,240号，增强了它们的发光。对于单官能化的铕，钐和铽大环复合物，发光的类似增强也得到了结果，这在我们的美国专利中被教导。第5,696,240号。由组合物提供的增强的发光使得能够以低浓度检测和/或定量许多分析物，而不需要使用昂贵，复杂的时间门控检测系统。

2. 发明申请

US20160290998A1 REAGENT SYSTEM AND METHOD FOR MODIFYING THE LUMINESCENCE OF LANTHANIDE (III) MACROCYCLIC COMPLEXES 审中-公开
标题翻译：试剂系统及其修饰方法（III）大分子复合物
公开(公告)号：US20160290998A1
公开(公告)日：2016-10-06
申请号：US14526248
申请日：2014-10-28
申请人： Robert C. Leif , Sean Yang , Lidia Vallarino
发明人： Robert C. Leif , Sean Yang , Lidia Vallarino
IPC分类号： G01N33/542 , G01N21/64 , C12Q1/68 , G01N33/58
CPC分类号： G01N33/542 , C12Q1/6818 , G01N21/6428 , G01N21/6458 , G01N33/582 , G01N2021/6441 , G01N2458/40
摘要： A spectrofluorimetrically detectable luminescent composition consists essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.
摘要翻译：分光荧光检测发光组合物基本上由至少一种发射光谱最大值在300至2000纳米范围内的能量转移受体镧系元素（III）络合物组成，以及至少一种能量转移供体的增亮量，该能量转移受体选自的荧光团，发光体，有机化合物，有机离子的盐，金属离子，金属离子络合物或其组合。这种能量转移供体增强至少一种能量转移受体镧系元素（III）络合物的发光，条件是任何能量转移供体的发射光谱与其能量转移受体镧系元素（III）络合物的发射光谱不同; 并且这样的能量转移供体可以溶解在具有与水的蒸发速率至少一样大的溶剂中的单一溶液。

3. 发明授权

US06750005B2 Reagent system and method for increasing the luminescence of lanthanide(III) macrocyclic complexes 失效
标题翻译：用于增加镧系元素（III）大环络合物发光的试剂体系和方法
公开(公告)号：US06750005B2
公开(公告)日：2004-06-15
申请号：US10010597
申请日：2001-12-06
申请人： Robert C. Leif , Lidia Vallarino
发明人： Robert C. Leif , Lidia Vallarino
IPC分类号： C12Q100
CPC分类号： C07D471/18 , G01N33/582 , Y10S435/96 , Y10S435/968
摘要： Disclosed are a spectrofluorimetrically detectable luminescent composition and processes for enhancing the luminescence of one or more lanthanide-containing macrocycles. The luminescent composition comprises a micelle-producing amount of at least one surfactant, at least one energy transfer acceptor lanthanide element macrocycle compound having an emission spectrum peak in the range from 500 to 950 nanometers, and a luminescence-enhancing amount of at least one energy transfer donor compound of yttrium or a 3-valent lanthanide element having atomic number 59-71, provided that the lanthanide element of said macrocycle compound and the lanthanide element of said energy transfer donor compound are not identical. The addition of gadolinium(III) in the presence of other solutes to both the prototype and the di-functionalized europium, samarium, and terbium macrocyclic complexes, which were taught in our U.S. Pat. Nos. 5,373,093 and 5,696,240, enhances their luminescence. Similar enhancements of luminescence also results for the mono-functionalized europium, samarium, and terbium macrocyclic complexes, which were taught in our U.S. Pat. No. 5,696,240. The enhanced luminescence afforded by the composition enables the detection and/or quantitation of many analytes in low concentrations without the use of expensive, complicated time-gated detection systems.
摘要翻译：公开了分光荧光测定的发光组合物和用于增强一种或多种含镧系元素的大环化合物的发光的方法。发光组合物包含胶束产生量的至少一种表面活性剂，至少一种能量转移受体镧系元素大环化合物，其发射光谱峰值在500至950纳米的范围内，以及至少一种能量的发光增强量转移钇的供体化合物或原子序数为59-71的3价镧系元素，条件是所述大环化合物的镧系元素和所述能量转移给体化合物的镧系元素不相同。在其他溶质存在下，将钆（III）添加到原型和二官能化的铕，钐和铽大环络合物中，这在我们的美国专利No. 第5,373,093和第5,696,240号，增强了它们的发光。对于单官能化的铕，钐和铽大环复合物，发光的类似增强也得到了结果，这在我们的美国专利中被教导。第5,696,240号。由组合物提供的增强的发光使得能够以低浓度检测和/或定量许多分析物，而不需要使用昂贵，复杂的时间门控检测系统。

4. 发明授权

US08916692B2 Reagent system and method for modifying the luminescence of lanthanide(III) macrocyclic complexes 有权
标题翻译：用于改变镧系元素（III）大环络合物发光的试剂体系和方法
公开(公告)号：US08916692B2
公开(公告)日：2014-12-23
申请号：US10578355
申请日：2004-11-08
申请人： Robert C. Leif , Sean Yang , Lidia Vallarino
发明人： Robert C. Leif , Sean Yang , Lidia Vallarino
IPC分类号： C07F5/00 , G01N21/64 , G01N33/533 , A61B5/00
CPC分类号： G01N33/533 , G01N21/6428 , G01N2021/6441
摘要： Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.
摘要翻译：公开了一种分光荧光测定的发光组合物，其基本上由至少一种发射光谱最大值在300至2000纳米的能量转移受体镧系元素（III）络合物组成，并且增亮量的至少一种能量转移给体选自由荧光团，荧光体，有机化合物，有机离子的盐，金属离子，金属离子络合物或其组合组成的组。这种能量转移供体增强至少一种能量转移受体镧系元素（III）络合物的发光，条件是任何能量转移供体的发射光谱与其能量转移受体镧系元素（III）络合物的发射光谱不同; 并且这样的能量转移供体可以溶解在具有与水的蒸发速率至少一样大的溶剂中的单一溶液。

5. 发明授权

US08048659B1 Conjugated polymer tag complexes 失效
标题翻译：共轭聚合物标签复合物
公开(公告)号：US08048659B1
公开(公告)日：2011-11-01
申请号：US10110114
申请日：2000-10-07
申请人： Robert C. Leif , Lidia Vallarino
发明人： Robert C. Leif , Lidia Vallarino
IPC分类号： G01N33/53
CPC分类号： G01N33/582 , C08F289/00 , C08F290/14 , C08F291/00 , C08L51/08 , C12Q1/37
摘要： A tagged water-soluble polymer linked to a solid support is provided and includes a solid support optionally including a spacer sequence including one or more spacer monomer units attached to the solid support; and a water-soluble polymer covalently linked to the solid support or to the spacer sequence, the water-soluble polymer including a first cleavage segment including at least one monomer unit including a selectively cleavable link to the solid support or to the spacer sequence, where cleavage of the selectively cleavable link separates the water-soluble polymer from the solid support, a second segment including at least one monomer unit selected from a monomer unit linked to a reactive functionality able to be covalently coupled to a tag or linked to a tag, a third segment including one or more monomer units linked to a reactive functionality that can form a covalent bond with an analyte-binding species or an analyte, and optionally one or more spacer monomer units provided adjacent to any segment and/or between any two segments and/or within any one or more of the second segment and the third segment.
摘要翻译：提供与固体支持物连接的标记的水溶性聚合物，并且包括固体支持物，任选地包括间隔物序列，其包括连接到固体支持物上的一个或多个间隔单体单元; 和与固体支持体或间隔物序列共价连接的水溶性聚合物，所述水溶性聚合物包括第一切割区段，所述第一切割区段包含至少一个单体单元，所述单体单元包括与所述固体支持物或所述间隔物序列的选择性可切割的连接，其中可选择性切割链节的切割将水溶性聚合物与固体支持物分开，第二部分包括至少一个单体单元，所述单体单元选自与能够共价耦合到标签或连接到标签的反应性官能团的单体单元，第三片段，其包含连接到可与分析物结合物质或分析物形成共价键的反应性官能团的一个或多个单体单元，以及任选地与任何片段相邻和/或任意两个片段之间设置的一个或多个间隔单体单元和/或在第二段和第三段中的任何一个或多个内。

6. 发明申请

US20070134160A1 Reagent system and method for modifying the luminescence of lanthanide(III) macrocyclic complexes 有权
标题翻译：用于改变镧系元素（III）大环络合物发光的试剂体系和方法
公开(公告)号：US20070134160A1
公开(公告)日：2007-06-14
申请号：US10578355
申请日：2004-11-08
申请人： Robert Leif , Sean Yang , Lidia Vallarino
发明人： Robert Leif , Sean Yang , Lidia Vallarino
IPC分类号： A61K49/00 , C07F5/00
CPC分类号： G01N33/533 , G01N21/6428 , G01N2021/6441
摘要： Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water.
摘要翻译：公开了一种分光荧光测定的发光组合物，其基本上由至少一种发射光谱最大值在300至2000纳米的能量转移受体镧系元素（III）络合物组成，并且增亮量的至少一种能量转移给体选自由荧光团，荧光体，有机化合物，有机离子的盐，金属离子，金属离子络合物或其组合组成的组。这种能量转移供体增强至少一种能量转移受体镧系元素（III）络合物的发光，条件是任何能量转移供体的发射光谱与其能量转移受体镧系元素（III）络合物的发射光谱不同; 并且这样的能量转移供体可以溶解在具有与水的蒸发速率至少一样大的溶剂中的单一溶液。

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