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    • 6. 发明授权
    • Pharmaceutical nanosuspensions for medicament administration as systems
with increased saturation solubility and rate of solution
    • 用于药物给药的药物纳米悬浮液作为具有增加的饱和溶解度和溶液速率的系统
    • US5858410A
    • 1999-01-12
    • US836305
    • 1997-06-19
    • Rainer H. MullerRobert BeckerBernd KrussKatrin Peters
    • Rainer H. MullerRobert BeckerBernd KrussKatrin Peters
    • A61K9/107A61K9/10A61K9/14A61K9/51B01F17/56B01J13/00
    • A61K9/145A61K9/0019A61K9/10
    • Provided is a drug carrier comprising particles of at least one pure active compound which is insoluble, only sparingly soluble or moderately soluble in water, aqueous media and/or organic solvents, wherein said active ingredient is solid at room temperature and has an average diameter, determined by photon correlation spectroscopy (PCS) of 10 nm to 1,000 nm, the proportion of particles larger than 5 .mu.m in the total population being less than 0.1% (number distribution determined with a Coulter counter), and, when introduced into water, aqueous media and/or organic solvents, the active compound has an increased saturation solubility and an increased rate of dissolution compared with powders of the active compound prepared using an ultrasonic probe, a ball mill or a pearl mill, the solid particles having been comminuted, without prior conversion into a melt, by using cavitation or shearing and impact forces with introduction of a high amount of energy.
    • PCT No.PCT / EP95 / 04401 Sec。 371日期:1997年6月19日 102(e)日期1997年6月19日PCT提交1995年11月9日PCT公布。 公开号WO96 / 14830 日期1996年5月23日提供了一种药物载体,其包含至少一种纯的活性化合物的颗粒,所述纯活性化合物是不溶的,仅微溶或适度溶于水,水性介质和/或有机溶剂,其中所述活性成分在室温下为固体, 通过10nm至1000nm的光子相关光谱(PCS)确定的平均直径,总体中大于5μm的颗粒的比例小于0.1%(用库尔特计数器确定的数量分布),以及当 引入水,水性介质和/或有机溶剂中,与使用超声波探针,球磨机或珍珠磨机制备的活性化合物的粉末相比,活性化合物具有增加的饱和溶解度和增加的溶解速率,固体颗粒 通过在引入大量能量的情况下使用空化或剪切和冲击力,已经粉碎,没有预先转化成熔体。
    • 9. 发明授权
    • Open-loop and/or closed-loop control system of a 3-phase power converter for the operation of an asynchronous machine
    • 用于异步机操作的三相电力转换器的开环和/或闭环控制系统
    • US08129936B2
    • 2012-03-06
    • US12447947
    • 2007-10-19
    • Robert BeckerPeter KrafkaMichael Rampe
    • Robert BeckerPeter KrafkaMichael Rampe
    • H02P27/08
    • H02P23/30H02P21/22H02P21/30
    • An open-loop and/or closed-loop control device for operating an asynchronous machine which is fed by a 3-phase power converter. The open-loop and/or closed-loop control structure has a stator flux controller and a pulse pattern generator for generating pulse signals based on mean values. An output of the stator flux controller is connected to an input of the pulse pattern generator, with the result that the pulse pattern generator can generate the pulse signals as a function of a manipulated variable which is generated by the stator flux controller. The stator flux controller is configured so as to generate the manipulated variable as a function of a desired value of the stator flux of the asynchronous machine and as a function of a desired value of the torque of the asynchronous machine. The stator flux controller has a dead-beat control response.
    • 一种用于操作由三相电源转换器馈电的异步电机的开环和/或闭环控制装置。 开环和/或闭环控制结构具有定子通量控制器和用于基于平均值产生脉冲信号的脉冲模式发生器。 定子通量控制器的输出端连接到脉冲图形发生器的输入端,结果脉冲图形发生器可以产生作为由定子通量控制器产生的操作变量的函数的脉冲信号。 定子磁通控制器被配置为根据异步电机的定子通量的期望值产生操作变量,并且作为异步电机的转矩的期望值的函数。 定子通量控制器具有死点控制响应。