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    • 3. 发明授权
    • Process of crosslinking PVP
    • 交联PVP的方法
    • US5236993A
    • 1993-08-17
    • US945453
    • 1992-09-16
    • Robert B. LoginJenn S. ShihJui-Chang Chuang
    • Robert B. LoginJenn S. ShihJui-Chang Chuang
    • C08F8/00C08F8/08C08F8/32
    • C08F8/08C08F8/02C08F8/44C08F2800/20C08F2810/20C08F2810/50
    • A method of crosslinking polyvinylpyrrolidone (PVP) at a predetermined pH which comprises (a) providing a tertiary amino-functional PVP as a starting material, (b) condensing said starting material with a predetermined amount of epichlorohydrin to form an epichlorohydrin-functional PVP copolymer, and, if less than an equivalent of epichlorohydrin in use, unreacted starting material, (c) acidifying the resultant copolymer to form a solution of a storage stable glycidyl quat intermediate, and (d) increasing the pH of the solution to above 7 to convert the glycidyl quat into a glycidyl epoxide, and (e) crosslinking the glycidyl epoxide with free amine group on the copolymer or as added amine functional PVP copolymer to form a crosslinked PVP polymer.
    • 一种在预定pH下交联聚乙烯吡咯烷酮(PVP)的方法,其包括(a)提供叔氨基官能的PVP作为原料,(b)将所述原料与预定量的表氯醇缩合以形成表氯醇官能的PVP共聚物 ,如果在使用中少于当量的表氯醇,未反应的原料,(c)酸化所得共聚物以形成储存稳定的缩水甘油基季铵盐中间体的溶液,和(d)将溶液的pH提高至7以上 将缩水甘油基季铵转化为缩水甘油基环氧化物,和(e)在共聚物上或作为加成的胺官能化PVP共聚物使游离胺基交联缩水甘油基环氧化物以形成交联的PVP聚合物。
    • 4. 发明授权
    • Method of crosslinking PVP
    • 交联PVP的方法
    • US5219950A
    • 1993-06-15
    • US945565
    • 1992-09-16
    • Robert B. LoginJenn S. ShihJui-Chang Chuang
    • Robert B. LoginJenn S. ShihJui-Chang Chuang
    • C08F8/00
    • C08F8/00
    • The method of crosslinking polyvinylpyrrolidone (PVP) which comprises: copolymerizing vinyl pyrrolidone (VP) and an aminoalkene, a hydroxyalkene, or an aminoalkyl acrylamide or methacrylamide, to provide a crosslinkable, functional PVP copolymer as a starting material; then (a) condensing predetermined amounts of the starting material and a haloacetal under basic conditions to form a stable, crosslinkable PVP copolymer intermediate containing an acetal group as a functional appendant on the PVP polymer backbone; (b) acidifying the basic solution to hydrolyze the acetal group to an aldehyde group, and (c) crosslinking the aldehyde-functional PVP copolymer with the amine group of the amine-functional PVP copolymer, present on the polymer as free amine after step (a), or as added amine-functional copolymer to the reaction mixture, under basic conditions.
    • 交联聚乙烯吡咯烷酮(PVP)的方法,其包括:使乙烯基吡咯烷酮(VP)和氨基链烯烃,羟基亚烷基或氨基烷基丙烯酰胺或甲基丙烯酰胺共聚,得到可交联的官能化PVP共聚物作为原料; 然后(a)在碱性条件下冷凝预定量的原料和卤代缩醛,以形成在PVP聚合物主链上含有缩醛基作为官能基的稳定的可交联PVP共聚物中间体; (b)将碱性溶液酸化以将缩醛基水解成醛基,和(c)将醛官能的PVP共聚物与胺官能化PVP共聚物的胺基交联,作为游离胺在步骤之后存在于聚合物上 a)或作为添加的胺官能共聚物在反应混合物中。
    • 6. 发明授权
    • Method of making crosslinked PVP
    • 制备交联PVP的方法
    • US5362830A
    • 1994-11-08
    • US122834
    • 1993-09-15
    • Jui-Chang ChuangJenn S. ShihRobert B. Login
    • Jui-Chang ChuangJenn S. ShihRobert B. Login
    • C08F8/00C08F226/10C08F224/00C08K5/05C08L39/06
    • C08F226/10C08F8/00C08F2800/20C08F2810/20
    • Crosslinkable copolymers of (a) 80-99% by wt. vinylpyrrolidone (VP) and 1-20% by wt. of a tertiary-amine-containing polymerizable monomer, e.g. vinylimidazole (VI) or 4-vinylpyridine (VPy), and (b) 80-99% by wt. VP and 1-20% by wt. of an epoxide-containing polymerizable monomer, e.g. allyl glycidyl ether (AGE) or glycidyl acrylate (GA), are reacted in solution, e.g. water, alcohol, or mixtures thereof, at a predetermined temperature, e.g. 50.degree.-70.degree. C., in a wt. ratio (solids basis) of (a):(b) of about 2:1 to 1:2, preferably about 1:1, in a solution concentration of about 10-30% of each, to provide a crosslinked PVP product, in gel form, suitable for use as an electrolead on a conductive foilbacking, or for bandages and wound dressings, and as a controlled release media for pharmaceuticals.
    • (a)80-99重量%的可交联共聚物 乙烯基吡咯烷酮(VP)和1-20重量% 的含叔胺的可聚合单体,例如。 乙烯基咪唑(VI)或4-乙烯基吡啶(VPy),和(b)80-99重量% VP和1-20重量% 的含环氧化物的可聚合单体,例如 烯丙基缩水甘油醚(AGE)或丙烯酸缩水甘油酯(GA)在溶液中反应。 水,醇或其混合物,例如在预定温度下。 50℃-70℃, (a):(b)的比例(固体基准)为约2:1至1:2,优选约1:1,溶液浓度为约10-30%,以提供交联的PVP产物, 凝胶形式,适合用作导电箔片上的电泳,或用于绷带和伤口敷料,以及用作药物的控释介质。
    • 7. 发明授权
    • Method of making crosslinked PVP
    • 制备交联PVP的方法
    • US5283305A
    • 1994-02-01
    • US966489
    • 1992-10-26
    • Jui-Chang ChuangJenn S. ShihRobert B. Login
    • Jui-Chang ChuangJenn S. ShihRobert B. Login
    • C08F8/00C08F226/10C08F226/06
    • C08F226/10C08F8/00C08F2800/20C08F2810/20
    • Crosslinkable copolymers of (a) 80-99% by wt. vinylpyrrolidone (VP) and 1-20% by wt. of a tertiary-amine-containing polymerizable monomer, e.g. vinylimidazole (VI) or 4-vinylpyridine (VPy), and (b) 80-99% by wt. VP and 1-20% by wt. of an epoxide-containing polymerizable monomer, e.g. allyl glycidyl ether (AGE) or glycidyl acrylate (GA), are reacted in solution, e.g. water, alcohol, or mixtures thereof, at a predetermined temperature, e.g. 50.degree.-70.degree. C., in a wt. ratio (solids basis) of (a):(b) of about 2:1 to 1:2, preferably about 1:1, in a solution concentration of about 10-30% of each, to provide a crosslinked PVP product, in gel form, suitable for use as an electrolead on a conductive foilbacking, or for bandages and wound dressings, and as a controlled release media for pharmaceuticals.
    • (a)80-99重量%的可交联共聚物 乙烯基吡咯烷酮(VP)和1-20重量% 的含叔胺的可聚合单体,例如。 乙烯基咪唑(VI)或4-乙烯基吡啶(VPy),和(b)80-99重量% VP和1-20重量% 的含环氧化物的可聚合单体,例如 烯丙基缩水甘油醚(AGE)或丙烯酸缩水甘油酯(GA)在溶液中反应。 水,醇或其混合物,例如在预定温度下。 50摄氏度-70摄氏度。 (a):(b)的比例(固体基准)为约2:1至1:2,优选约1:1,溶液浓度为约10-30%,以提供交联的PVP产物, 凝胶形式,适合用作导电箔片上的电泳,或用于绷带和伤口敷料,以及用作药物的控释介质。