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1. 发明授权

US4922026A Acylation process to form diketones 失效
标题翻译：酰化过程形成二酮
公开(公告)号：US4922026A
公开(公告)日：1990-05-01
申请号：US290723
申请日：1988-12-27
申请人： Robert B. Baker, Jr. , R. Garth Pews , Eric W. Otterbacher , James A. Gall
发明人： Robert B. Baker, Jr. , R. Garth Pews , Eric W. Otterbacher , James A. Gall
IPC分类号： C07C45/46
CPC分类号： C07C45/46
摘要： Aromatic diketones are prepared by a process comprising contacting at least one acylatable aromatic compound and at least one aromatic diacyl halide in the presence of catalytic amounts of ferric chloride or ferric oxide at an elevated temperature and at superatmospheric conditions.
摘要翻译：通过一种方法制备芳族二酮，该方法包括在升高的温度和超大气压条件下，在催化量的氯化铁或氧化铁的存在下，使至少一种可酰化的芳族化合物和至少一种芳族二酰基卤化物接触。

2. 发明授权

US5041674A Process and intermediates for the preparation of 2,6-difluoroaniline 失效
标题翻译：制备2,6-二氟苯胺的方法和中间体
公开(公告)号：US5041674A
公开(公告)日：1991-08-20
申请号：US537975
申请日：1990-06-14
申请人： R. Garth Pews , James A. Gall
发明人： R. Garth Pews , James A. Gall
IPC分类号： C07C209/36 , C07C211/52
CPC分类号： C07C211/52 , C07C209/365
摘要： 1-Chloro-3,5-difluorobenzene is chlorinated to give 4,6-difluoro-1,2,3-trichlorobenzene which in turn is nitrated and reduced to the corresponding novel aniline, 2,6-difluoro-3,4,5-trichloroaniline. Further reduction of this aniline provides 2,6-difluoroaniline with high selectivity.
摘要翻译：氯化1-氯-3,5-二氟苯，得到4,6-二氟-1,2,3-三氯苯，然后将其硝化并还原成相应的新型苯胺，2,6-二氟-3,4,5 三氯苯胺该苯胺的进一步还原提供了高选择性的2,6-二氟苯胺。

3. 发明授权

US4937396A Preparation of 3,4-difluorobenzotrifluoride 失效
标题翻译：制备3,4-二氟三氟甲苯
公开(公告)号：US4937396A
公开(公告)日：1990-06-26
申请号：US276711
申请日：1988-11-28
申请人： R. Garth Pews , Jack C. Little , James A. Gall
发明人： R. Garth Pews , Jack C. Little , James A. Gall
IPC分类号： C07C17/20 , C07C255/50
CPC分类号： C07C255/50 , C07C17/208
摘要： 3,4-Difluorobenzotrifluoride is prepared by contacting a 3,4-dihalobenzotrifluoride with an effective amount of KF or CsF in a polar aprotic solvent at an elevated temperature under substantially anhydrous conditions. The product can be removed as it is formed or the reaction may be run at the autogenous pressures generated by the reaction mixture in a sealed reactor.
摘要翻译：通过在极性非质子溶剂中在高温下在基本上无水的条件下使3,4-二卤代三氟甲苯与有效量的KF或CsF接触来制备3,4-二氟三氟甲苯。产物可以在其形成时被除去，或者反应可以在密封反应器中由反应混合物产生的自生压力下进行。

4. 发明授权

US4940821A Preparation of fluorophenols 失效
标题翻译：氟苯酚的制备
公开(公告)号：US4940821A
公开(公告)日：1990-07-10
申请号：US325421
申请日：1989-03-20
申请人： R. Garth Pews , James A. Gall
发明人： R. Garth Pews , James A. Gall
IPC分类号： C07C37/02 , C07C39/27
CPC分类号： C07C37/02
摘要： Fluorophenols are prepared by heating a chlorofluorobenzene with water in the presence of a copper salt at a pH of from 3.0 to 6.5.

5. 发明授权

US4937397A Preparation of halofluorobenzenes 失效
标题翻译：卤代氟苯的制备
公开(公告)号：US4937397A
公开(公告)日：1990-06-26
申请号：US276713
申请日：1988-11-28
申请人： R. Garth Pews , James A. Gall
发明人： R. Garth Pews , James A. Gall
IPC分类号： C07C17/20 , C07C25/13
CPC分类号： C07C17/208
摘要： Chlorofluorobenzenes and difluorobenzenes are prepared by contacting a dichlorobenzene with an effective amount of KF or CsF in a polar aprotic solvent at an elevated temperature under substantially anhydrous conditions. The product can be removed as it is formed or the reaction may be run at the autogenous pressures generated by the reaction mixture in a sealed reactor.

6. 发明授权

US5091580A Process for the preparation of 2,6-difluoroaniline 失效
标题翻译： 2,6-二氟苯胺的制备方法
公开(公告)号：US5091580A
公开(公告)日：1992-02-25
申请号：US676017
申请日：1991-03-27
申请人： R. Garth Pews , James A. Gall
发明人： R. Garth Pews , James A. Gall
IPC分类号： B01J23/44 , C07B61/00 , C07C17/20 , C07C25/13 , C07C209/10 , C07C211/45 , C07C211/52
CPC分类号： C07C211/45 , C07C17/208 , C07C209/10 , C07C25/13
摘要： 2,6-Difluoroaniline is prepared from 1,2,3-trichlorobenzene by partial fluorine exchange to a mixture of 2,6-difluorochlorobenzene and 2,3-difluorochlorobenzene, amination of the chloro substituents, and separation of the desired product from the isomeric 2,3-difluoroaniline. By incorporating a selective reduction into the process immediately after the partial fluorine exchange, the undesirable 2,3-difluorochlorobenzene is converted into valuable ortho-difluorobenzene and the 2,3-difluoroaniline isomer is avoided.

7. 发明授权

US5744655A Process to make 2,3-dihalopropanols 失效
标题翻译：制备2,3-二卤丙醇的方法
公开(公告)号：US5744655A
公开(公告)日：1998-04-28
申请号：US667526
申请日：1996-06-19
申请人： P. J. Thomas , R. Garth Pews , Paul C. Vosejpka , George J. Frycek
发明人： P. J. Thomas , R. Garth Pews , Paul C. Vosejpka , George J. Frycek
IPC分类号： C07C29/141 , C07C31/36 , C07C45/35 , C07C45/63 , C07D301/26 , C07C31/34
CPC分类号： C07D301/26 , C07C29/141 , C07C45/35 , C07C45/63 , Y02P20/582
摘要： A 2,3-dihalopropanol is made by reacting 2,3-dihalopropanal with a hydrogenating agent in the presence of a transition metal-containing catalyst, under conditions such that 2,3-dihalopropanol is formed. The reaction is particularly useful as Step (3) in a process to make epihalohydrin by: (1) reacting a 3-carbon hydrocarbon with an oxidizing agent to form acrolein; (2) reacting acrolein with a molecular halogen to form 2,3-dihalopropanal; (3) reducing 2,3-dihalopropanal to form 2,3-dihalopropanol; and (4) cyclizing 2,3-dihalopropanol to make epihalohydrin. The process produces epihalohydrin using only about one mole of halogen per mole of epihalohydrin. It also uses substantially less water than existing processes.
摘要翻译：在含过渡金属的催化剂存在下，在形成2,3-二卤丙醇的条件下，通过2,3-二卤代丙醛与氢化剂反应制备2,3-二卤丙醇。在通过以下步骤制备表卤代醇的方法中，作为步骤（3）特别有用：（1）使3-碳烃与氧化剂反应形成丙烯醛; （2）使丙烯醛与分子卤素反应形成2,3-二卤代丙醛; （3）还原2,3-二卤丙醛以形成2,3-二卤丙醇; 和（4）环化2,3-二卤丙醇以制备表卤代醇。该方法使用每摩尔表卤代醇仅使用约1摩尔卤素产生表卤代醇。它还使用比现有工艺少得多的水。

8. 发明授权

US5491155A Substituted thiadiazoles, compositions containing them and their use as antimicrobial and marine antifouling agents 失效
标题翻译：取代的噻二唑，含有它们的组合物及其作为抗微生物剂和海洋防污剂的用途
公开(公告)号：US5491155A
公开(公告)日：1996-02-13
申请号：US360497
申请日：1994-12-21
申请人： Ravi B. Shankar , R. Garth Pews , Duane R. Romer
发明人： Ravi B. Shankar , R. Garth Pews , Duane R. Romer
IPC分类号： A01N43/82 , A01N43/832 , C07D285/10 , C09D5/14 , C09D5/16 , A61K31/41
CPC分类号： C07D285/10 , A01N43/82 , C09D5/14 , C09D5/1625
摘要： Substituted thiadiazoles which correspond to the formula: ##STR1## wherein X and Y each independently represents --Br, --Cl, --OCH.sub.3, --SCN, --OCH.sub.2 SCN, --SCH.sub.2 SCN, --OCH.sub.2 CH.sub.2 SCN or --SCH.sub.2 CH.sub.2 SCN, provided that at least one of X or Y represents --SCN, --OCH.sub.2 SCN, --SCH.sub.2 SCN, --OCH.sub.2 CH.sub.2 SCN or --SCH.sub.2 CH.sub.2 SCN are disclosed.These compounds have been found to exhibit antimicrobial and marine antifouling activity in industrial and commercial applications and compositions containing these compounds are so employed.
摘要翻译：对应于下式的取代的噻二唑：其中X和Y各自独立地表示-Br，-Cl，-OCH 3，-SCN，-OCH 2 SCN，-SCH 2 SCN，-OCH 2 CH 2 SCN或-SCH 2 CH 2 SCN，条件是X或 Y表示-SCN，-OCH 2 SCN，-SCH 2 SCN，-OCH 2 CH 2 SCN或-SCH 2 CH 2 SCN。已经发现这些化合物在工业和商业应用中表现出抗微生物和海洋防污性，并且使用含有这些化合物的组合物。

9. 发明授权

US5466707A Dimercapto-1,3-dithiolo-2-one or thione maleimides, compositions containing them and their use as antimicrobial and marine antifouling agents 失效
标题翻译：二巯基-1,3-二硫代-2-酮或硫酮马来酰亚胺，含有它们的组合物及其作为抗微生物剂和海洋防污剂的用途
公开(公告)号：US5466707A
公开(公告)日：1995-11-14
申请号：US360490
申请日：1994-12-21
申请人： Weishi W. Wu , Ravi B. Shankar , Duane R. Romer , R. Garth Pews
发明人： Weishi W. Wu , Ravi B. Shankar , Duane R. Romer , R. Garth Pews
IPC分类号： A01N43/90 , C07D495/14 , C09D5/14 , C09D5/16 , A01N43/72 , C07D513/14
CPC分类号： C07D495/14 , A01N43/90 , C09D5/14 , C09D5/1625
摘要： Various 4,5-dimercapto-1,3-dithiolo-2-one or thione maleimides corresponding to the formula ##STR1## wherein R represents --H, phenyl, benzyl, phenethyl, a C.sub.1 -C.sub.10 straight or branched chain alkyl radical, a C.sub.3 -C.sub.10 cycloalkyl radical, a C.sub.1 -C.sub.10 straight or branched chain alkoxy radical, a C.sub.3 -C.sub.10 cycloalkoxy, an ester of the formula --CH.sub.2 CH.sub.2 O--C(O)--R.sup.1, wherein R.sup.1 represents a C.sub.1 -C.sub.5 straight or branched chain alkyl radical or a C.sub.3 -C.sub.5 cycloalkyl radical and Z represents oxygen or sulfur are disclosed.These compounds have been found to exhibit antimicrobial and marine antifouling activity in industrial and commercial applications and compositions containing these compounds are so employed.
摘要翻译：对应于式“IMAGE”的各种4,5-二巯基-1,3-二硫代-2-酮或硫酮马来酰亚胺，其中R表示-H，苯基，苄基，苯乙基，C1-C10直链或支链烷基， C 3 -C 10环烷基，C 1 -C 10直链或支链烷氧基，C 3 -C 10环烷氧基，式-CH 2 CH 2 O-C（O）-R 1的酯，其中R 1表示C 1 -C 5直链或支链烷基自由基或C3-C5环烷基，Z表示氧或硫。已经发现这些化合物在工业和商业应用中表现出抗微生物和海洋防污性，并且使用含有这些化合物的组合物。

10. 发明授权

US5349095A Process for preparing hydroxyalkylbenzocyclobutenes 失效
标题翻译：制备羟烷基苯并环丁烯的方法
公开(公告)号：US5349095A
公开(公告)日：1994-09-20
申请号：US982213
申请日：1992-11-25
申请人： P. J. Thomas , R. Garth Pews
发明人： P. J. Thomas , R. Garth Pews
IPC分类号： C07C29/14 , C07C33/34 , C07C45/00 , C07C45/51 , C07C49/792
CPC分类号： C07C49/792 , C07C29/14 , C07C33/34 , C07C45/004 , C07C45/513 , C07C2101/06
摘要： A process for preparing a substituted or unsubstituted 3- or 4-hydroxyalkylbenzocyclobutene compound comprises reducing a corresponding 3- or 4-formyl or ketobenzocyclobutene compound with a hydride at a temperature below that at which dimerization or oligomerization of the formyl- or ketobenzocycloutene compound or the thus-produced hydroxyalkylbenzocyclobutene compound is a significant side reaction, for a time sufficient to convert the formyl- or ketobenzocyclobutene compound to the hydroxyalkylbenzocyclobutene compound. In a two-step process, formylbenzocyclobutenes are prepared from bromobenzocyclobutenes in 90% yield or from benzocyclobutenes in a 70% yield, and then converted to hydroxymethylbenzocyclobutenes for an overall yield of about 85% from a bromobenzocyclobutene or of about 65% from a benzocyclobutene. In a two-step process, ketobenzocyclobutenes from bromobenzocyclobutene Grignard reagents and an N-alkanoyl- or N-aroyl-2-methylaziridine are converted to hydroxyalkylbenzocyclobutenes in high yields.
摘要翻译：取代或未取代的3-或4-羟基烷基苯并环丁烯化合物的方法包括在低于甲酰基或酮基苯并环丁烯化合物的二聚或低聚的温度下用氢化物还原相应的3-或4-甲酰基或酮基苯并环丁烯化合物或因此产生的羟烷基苯并环丁烯化合物是足够将甲酰基或酮基苯并环丁烯化合物转化为羟烷基苯并环丁烯化合物的显着副反应。在两步法中，甲酰基苯并环丁烯由90％产率的溴代苯并环丁烯或70％产率的苯并环丁烯制备，然后从溴代苯并环丁烯转化为羟甲基苯并环丁烯，总产率为约85％，或从苯并环丁烯转化为约65％。在两步法中，来自溴苯并环丁烯格氏试剂和N-烷酰基或N-芳酰基-2-甲基氮丙啶的酮基苯并环丁烯以高产率转化为羟基烷基苯并环丁烯。

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