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1. 发明授权

US07205159B2 Diagnostic testing process and apparatus 有权
公开(公告)号：US07205159B2
公开(公告)日：2007-04-17
申请号：US10487052
申请日：2002-08-20
申请人： Robert Alan Cole , Andrew John Sloane , William Samuel Hunter
发明人： Robert Alan Cole , Andrew John Sloane , William Samuel Hunter
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.

2. 发明授权

US07875435B2 Diagnostic testing process 有权
标题翻译：诊断测试过程
公开(公告)号：US07875435B2
公开(公告)日：2011-01-25
申请号：US10497925
申请日：2002-12-12
申请人： David Ian Marlborough , Andrew John Sloane , Robert Alan Cole , William Samuel Hunter
发明人： David Ian Marlborough , Andrew John Sloane , Robert Alan Cole , William Samuel Hunter
IPC分类号： G01N33/554
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/807 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterized by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为结合胶体金或荧光标记的一种或多种抗体）已知结合特定蛋白质可以结合在一起所需的时间段。此预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与承载捕获分析物的膜接触，从而允许流体从孵育室通过捕获膜转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

3. 发明授权

US08067246B2 Diagnostic testing process 有权
标题翻译：诊断测试过程
公开(公告)号：US08067246B2
公开(公告)日：2011-11-29
申请号：US12874675
申请日：2010-09-02
申请人： David Ian Marlborough , Andrew John Sloane , Robert Alan Cole , William Samuel Hunter
发明人： David Ian Marlborough , Andrew John Sloane , Robert Alan Cole , William Samuel Hunter
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/807 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analyzed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus o permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为结合胶体金或荧光标记的一种或多种抗体）已知结合特定蛋白质可以结合在一起所需的时间段。此预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与携带捕获分析物的膜接触，从而允许流体通过捕获膜从孵育室转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

4. 发明申请

US20100323369A1 Diagnostic Testing Process 有权
标题翻译：诊断测试过程
公开(公告)号：US20100323369A1
公开(公告)日：2010-12-23
申请号：US12874675
申请日：2010-09-02
申请人： David Ian Marlborough , Andrew John Sloane , Robert Alan Cole , William Samuel Hunter
发明人： David Ian Marlborough , Andrew John Sloane , Robert Alan Cole , William Samuel Hunter
IPC分类号： G01N33/53 , G01N30/00 , C12M1/34 , G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/807 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus o permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译：公开了一种用于流过测定过程的方法和装置。该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为结合胶体金或荧光标记的一种或多种抗体）已知结合特定蛋白质可以结合在一起所需的时间段。此预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与携带捕获分析物的膜接触，从而允许流体通过捕获膜从孵育室转移。在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。

5. 发明申请

US20090061450A1 SYSTEM AND METHOD FOR DIAGNOSIS OF INFECTIOUS DISEASES 审中-公开
标题翻译：感染性疾病诊断系统及方法
公开(公告)号：US20090061450A1
公开(公告)日：2009-03-05
申请号：US12203715
申请日：2008-09-03
申请人： William Samuel Hunter
发明人： William Samuel Hunter
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502715 , B01L3/5029 , B01L7/52 , B01L2200/0689 , B01L2200/10 , B01L2300/0867 , B01L2300/087 , B01L2300/1827 , B01L2400/0475 , B01L2400/0622
摘要： A biosafe apparatus is disclosed for assay and diagnosis of respiratory pathogens comprising a nasal sampling device, a single entry, disposable microfluidic cartridge for target nucleic acid amplification, and an instrument with on-board assay control platform and target detection means.
摘要翻译：公开了用于呼吸道病原体的测定和诊断的生物安全装置，其包括鼻取样装置，用于靶核酸扩增的单入口，一次性微流体盒，以及具有板载测定控制平台和目标检测装置的仪器。

6. 发明申请

US20120135511A1 PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM 有权
标题翻译：便携式高增益荧光检测系统
公开(公告)号：US20120135511A1
公开(公告)日：2012-05-31
申请号：US13191120
申请日：2011-07-26
申请人： C. Frederick Battrell , Troy D. Daiber , William Samuel Hunter
发明人： C. Frederick Battrell , Troy D. Daiber , William Samuel Hunter
IPC分类号： C12M1/40
CPC分类号： G01N21/6456 , B01L7/52 , C12M23/16 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N2201/0245
摘要： Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are shown to be improved by use of a heating block with reflective mirror face in intimate contact with a thermo-optical window enclosing the liquid sample.
摘要翻译：公开了一种用于液体样品中的荧光测定的紧凑型微处理器控制仪器，该仪器具有用于接收微流控盒的对接舱的浮动台和具有用于控制源LED的放射性嵌入式微处理器的扫描检测器头，发射信号放大和在检测器头内的隔离，低噪声，高增益环境中进行滤波。多个光通道可并入扫描头。在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。通过使用具有与包围液体样品的热光学窗口紧密接触的反射镜面的加热块，可以改善扫描期间对气泡干扰的灵敏度和抗性。

7. 发明申请

US20120021422A1 METHODS FOR PROCESSING SAMPLES IN A CLOSED CONTAINER 有权
标题翻译：在封闭容器中处理样品的方法
公开(公告)号：US20120021422A1
公开(公告)日：2012-01-26
申请号：US13235922
申请日：2011-09-19
申请人： Simon Jonathon Spence , Richard Alexander Grant , Timothy Doyle Peele , William Samuel Hunter , Ashraf F. Abdelmoteleb , David Thomas Kneen , Robert Alister Neil , Simon Harris
发明人： Simon Jonathon Spence , Richard Alexander Grant , Timothy Doyle Peele , William Samuel Hunter , Ashraf F. Abdelmoteleb , David Thomas Kneen , Robert Alister Neil , Simon Harris
IPC分类号： C12Q1/68 , G01N35/00
CPC分类号： G01N35/0099 , B01L1/00 , B01L1/02 , B01L3/021 , B01L3/0293 , B01L3/5085 , B01L7/52 , B01L9/06 , B01L9/523 , B01L2200/02 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/06 , B01L2300/0838 , B01L2300/123 , B01L2400/0481 , G01L1/00 , G01N1/34 , G01N35/00732 , G01N35/00871 , G01N2021/0378 , Y10T436/11 , Y10T436/2575
摘要： A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or other sample manipulation device can be attached to the inside of the barrier, and the barrier can include an interface for a robotic arm or other device. When the barrier is sealed over the tray, the barrier separates the contents of the tray from the robot or other manipulation device. The barrier can be flexible, and allow the robotic arm to move the pipette head throughout the work area of the tray. All samples, reagents, pipette tips and other tools or devices for processing nucleic acid samples may remain within the closed compartment provided by the container during processing.
摘要翻译：用于核酸和其它样品的自动处理的系统和方法包括一个包含托盘和柔性屏障的一次性容器。阻挡件被构造成与托盘的顶部边缘密封，在密封托盘内提供封闭的无菌工作区域。移液管头和/或其他样品操纵装置可以附接到屏障的内部，并且屏障可以包括用于机器臂或其它装置的界面。当屏障被密封在托盘上时，屏障将托盘的内容物与机器人或其他操纵装置分开。障碍物可以是柔性的，并且允许机器人臂将移液管头移动到托盘的整个工作区域。用于处理核酸样品的所有样品，试剂，移液器吸头和其他工具或装置可以在处理期间保留在由容器提供的封闭隔室内。

8. 外观设计

USD486411S1 Warning device with bases 失效
标题翻译：带底座的警示装置
公开(公告)号：USD486411S1
公开(公告)日：2004-02-10
申请号：US29162535
申请日：2002-06-17
申请人： Warwick Brown , William Samuel Hunter
设计人： Warwick Brown , William Samuel Hunter

9. 外观设计

USD402383S Combined warning light and base 失效
公开(公告)号：USD402383S
公开(公告)日：1998-12-08
申请号：US77035
申请日：1997-09-24
申请人： William Samuel Hunter
设计人： William Samuel Hunter

10. 发明申请

US20130011912A1 PORTABLE HIGH GAIN FLUORESCENCE DETECTION SYSTEM 有权
标题翻译：便携式高增益荧光检测系统
公开(公告)号：US20130011912A1
公开(公告)日：2013-01-10
申请号：US13536592
申请日：2012-06-28
申请人： C. Frederick Battrell , Troy D. Daiber , William Samuel Hunter
发明人： C. Frederick Battrell , Troy D. Daiber , William Samuel Hunter
IPC分类号： C12M1/34 , G01N21/64
CPC分类号： G01N21/6456 , B01L7/52 , C12M23/16 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N2201/0245
摘要： An instrument for fluorometric assays in liquid samples is disclosed. The instrument may include multiple optical channels for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. The disclosed instrument finds utility in any number of applications, including microfluidic molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general.
摘要翻译：公开了用于液体样品中荧光测定的仪器。仪器可以包括用于监测与靶分析物相关联的第一荧光团的多个光学通道和与对照相关联的第二荧光团。所公开的仪器可用于任何数量的应用，包括基于目标核酸的PCR扩增和荧光测定的微流体分子生物学测定。

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