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    • 8. 发明申请
    • Microneedle Devices
    • 微针装置
    • US20080319404A1
    • 2008-12-25
    • US12095197
    • 2006-12-19
    • Mikhail L. PekurovskyMitchell A.F. Johnson
    • Mikhail L. PekurovskyMitchell A.F. Johnson
    • A61M5/32A61L31/16
    • A61M37/0015A61M2037/0038
    • Microneedles and microarrays comprising such microneedles are described. The microneedles comprise: a base; a shaft portion extending from the base to a second end distal from the base; a microblade structure extending from the second end; capillary spaces associated with the microblade structure; and a coating in the capillary spaces, the coating comprising an active component. The invention also provides a method for delivering an active component through mammalian skin, comprising: applying the medical device to mammalian skin so that the at least one microneedle is inserted through the stratum corneum and the active component is exposed to interstitial fluids; and allowing the at least one microneedle to remain inserted through the stratum corneum for a sufficient amount of time to dissolve the active component. In another aspect, the invention provides a method for applying an active component to a microneedle, comprising: providing a microneedle, comprising: a base, a shaft portion extending from the base to a second end distal from the base, a microblade structure extending from the second end, and capillary spaces associated with the microblade structure; applying a liquid coating to at least the microblade structure of the microneedle, the liquid coating comprising an active component; and drying the liquid coating to provide a dried coating of active component, the dried coating located at least within the capillary spaces of the microblade structure.
    • 描述了包括这种微针的微针和微阵列。 微针包括:基部; 轴部分,其从所述基部延伸到远离所述基部的第二端; 从第二端延伸的微刃结构; 与微刀片结构相关的毛细管空间; 以及毛细管空间中的涂层,所述涂层包含活性组分。 本发明还提供了一种通过哺乳动物皮肤递送活性成分的方法,包括:将所述医疗装置施用于哺乳动物皮肤,使得所述至少一个微针穿过所述角质层并且所述活性成分暴露于组织液; 并允许至少一个微针保持穿过角质层插入足够的时间以溶解活性成分。 另一方面,本发明提供了一种将活性成分施加到微针上的方法,包括:提供微针,其包括:基部,从所述基部延伸到远离所述基部的第二端的轴部分,从所述基部延伸的微刃结构 第二端和与微刃结构相关的毛细管空间; 将液体涂层施加到所述微针的至少微刃结构,所述液体涂层包含活性组分; 以及干燥所述液体涂层以提供活性组分的干燥涂层,所述干燥涂层至少位于所述微粉碎结构的毛细管空间内。