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1. 发明授权

US06890346B2 Apparatus and method for debilitating or killing microorganisms within the body 失效
标题翻译：用于使身体内的微生物衰弱或杀死的装置和方法
公开(公告)号：US06890346B2
公开(公告)日：2005-05-10
申请号：US10119976
申请日：2002-04-09
申请人： Robert A. Ganz , Hans L. Melgaard
发明人： Robert A. Ganz , Hans L. Melgaard
IPC分类号： A61L2/12 , A61B17/22 , A61B18/00 , A61B18/22 , A61B18/24 , A61M36/04 , A61N5/04 , A61N5/06 , A61N5/10 , H01J35/32 , A61N5/00
CPC分类号： A61N5/0601 , A61B18/24 , A61B2017/22051 , A61B2018/00982 , A61B2018/2261 , A61N5/1001 , A61N2005/0609 , A61N2005/0651 , A61N2005/0654 , A61N2005/0661 , H01J35/32 , H01J2235/164
摘要： A surgical apparatus has a body portion that includes a shaft terminating in a distal head or tip for directing light radiation from the apparatus onto the lining of a body cavity for treating an ailment in a body cavity of a patient as for example a gastrointestinal ailment of a patient such as gastritis, gastric ulcer, duodenal ulcer, gastric cancer, gastric lymphoma, ulcerative colitis, or Crohn's disease as well as for treating diseases of the circulatory system, urogenital systems and other body cavities. During use, the shaft of the apparatus is inserted into a body cavity, e.g., stomach or colon, of the patient to place the distal tip of the shaft in the desired position. The body cavity of the patient is then irradiated with light radiation so as to kill or debilitate microorganisms lining the body cavity without serious destruction of the body tissue of the patient to thereby improve or alleviate one or more of the symptoms of the ailment. A probiotic comprising innocuous bacteria can be administered to the patient to reestablish the growth of normal microbial flora when treating the gastrointestinal tract.
摘要翻译：手术装置具有主体部分，该主体部分包括终止于远侧头部或尖端的轴，用于将来自该装置的光辐射引导到体腔的衬里上，用于治疗患者的体腔中的疾病，例如胃肠道疾病诸如胃炎，胃溃疡，十二指肠溃疡，胃癌，胃淋巴瘤，溃疡性结肠炎或克罗恩病的患者，以及用于治疗循环系统，泌尿生殖系统和其他体腔的疾病。在使用期间，将装置的轴插入到患者的体腔（例如胃或结肠）中，以将轴的远侧末端放置在期望的位置。然后用光辐射照射患者的体腔，以便杀死或破坏体腔内的微生物，而不会严重破坏患者的身体组织，从而改善或减轻疾病的一种或多种症状。可以向患者施用包含无害细菌的益生菌以在治疗胃肠道时重新建立正常微生物菌群的生长。

2. 发明申请

US20180344993A1 BLOCKAGE CLEARING DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：US20180344993A1
公开(公告)日：2018-12-06
申请号：US15995105
申请日：2018-05-31
申请人： Robert A. Ganz , Mark Anders Rydell , Travis Sessions , Steven Berhow , Doug Wahnschaffe , Michael W. Augustine
发明人： Robert A. Ganz , Mark Anders Rydell , Travis Sessions , Steven Berhow , Doug Wahnschaffe , Michael W. Augustine
IPC分类号： A61M25/10 , A61B17/22
摘要： A system for clearing a blockage from a lumen of a patient, such as an impacted food bolus, can include a catheter that includes a distal end for insertion into the lumen of the patient. The catheter further includes a proximal end for coupling with a suction source at a position external to the patient. The catheter further includes a lumen extending through the proximal and distal ends. The system can include a cutting tip for cutting a morsel from the bolus as suction is applied to the bolus via the lumen of the catheter. The system can also include a positioning element that transitions from an undeployed state to a deployed state, which is expanded relative to the undeployed state. The positioning element can contact the esophagus to space the cutting tip from the esophagus when in the deployed state.

3. 发明授权

US08641711B2 Method and apparatus for gastrointestinal tract ablation for treatment of obesity 有权
标题翻译：用于治疗肥胖的胃肠道消融的方法和装置
公开(公告)号：US08641711B2
公开(公告)日：2014-02-04
申请号：US12114628
申请日：2008-05-02
申请人： Douglas Kelly , David S. Utley , Robert A. Ganz , Michael P. Wallace , Nathan Every
发明人： Douglas Kelly , David S. Utley , Robert A. Ganz , Michael P. Wallace , Nathan Every
IPC分类号： A61B18/18
CPC分类号： A61B18/04 , A61B18/1492 , A61B18/18 , A61B2018/0022 , A61B2018/0212 , A61B2018/1467
摘要： Devices and methods for ablating tissue in the wall of various organs of the gastrointestinal tract of a patient in order to cure or ameliorate metabolic pathophysiological conditions such as obesity, insulin resistance, or type 2 diabetes mellitus are provided. Ablational treatment of target areas may be fractional or partial, rendering a post-treatment portion of target tissue ablated and another portion that is substantially intact. Fractional ablation is achieved by controlling the delivery of ablational energy across the surface area being treated, and controlling the depth of energy penetration into tissue. Surface area control of energy delivery may controlled by the spatial pattern of distributed ablation elements or by the selective activation of a subset of a dense pattern of ablation elements. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.
摘要翻译：提供了用于消除患者胃肠道的各种器官的壁中的组织以便治愈或改善代谢病理生理条件如肥胖，胰岛素抵抗或2型糖尿病的装置和方法。目标区域的消融治疗可能是部分或部分，使目标组织的后处理部分消融，另一部分基本上完好无损。通过控制穿过所治疗的表面区域的消融能量的传递并控制能量渗入组织的深度来实现分数消融。能量输送的表面积控制可以由分布式消融元件的空间模式控制，或者通过选择性地激活消融元件的密集图案的子集。该装置的实施例包括跨越360度的消融电极阵列和跨越小于360度的弧的阵列。

4. 发明授权

US07933659B2 Device and method for treatment of gastroesophageal reflux disease 有权
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US07933659B2
公开(公告)日：2011-04-26
申请号：US12839112
申请日：2010-07-19
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B12/00 , A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

5. 发明授权

US06764501B2 Apparatus and method for treating atherosclerotic vascular disease through light sterilization 失效
标题翻译：通过光灭菌治疗动脉粥样硬化性血管疾病的装置和方法
公开(公告)号：US06764501B2
公开(公告)日：2004-07-20
申请号：US10119855
申请日：2002-04-09
申请人： Robert A. Ganz
发明人： Robert A. Ganz
IPC分类号： A61N500
CPC分类号： A61B18/18 , A61B2017/00243 , A61B2018/1807 , A61B2018/2211 , A61N5/0601 , A61N2005/0651
摘要： Atherosclerotic vascular disease is treated by exposing the interior of an artery or vein to visible or ultraviolet light of a selected spectrum to thereby sterilize the artery, eradicating infectious pathogens and reverse the pathogenesis of atherosclerotic artery disease. A fiber optic bundle positioned via an intra-arterial catheter is connected to an appropriate light radiation source located outside of the body during treatment. In another form, the light energy is produced by means of a light energy source located at the distal tip of the instrument shaft positioned centrally within the atherosclerotic plaque formation. In this case, the power source at the distal tip of the instrument can be a light emitting diode (LED) or a transparent tube containing a chemilumlumenescent substance for producing cool light energy within the vessel to destroy the pathogenic microorganisms in the surrounding plaque or vessel without damage to the body tissue of the patient.
摘要翻译：通过将动脉或静脉的内部暴露于所选光谱的可见光或紫外光来对动脉粥样硬化性血管疾病进行治疗，从而消灭动脉，消除感染性病原体并逆转动脉粥样硬化性动脉疾病的发病机制。通过动脉导管定位的光纤束在处理期间连接到位于身体外部的适当的光辐射源。在另一种形式中，光能通过位于设置在动脉粥样硬化斑块形成中心的器械轴的远端的光能源产生。在这种情况下，仪器的远端的电源可以是发光二极管（LED）或含有化学发光衰减物质的透明管，用于在容器内产生冷光能以破坏周围斑块或容器中的致病微生物而不损伤患者的身体组织。

6. 发明授权

US06551310B1 System and method of treating abnormal tissue in the human esophagus 有权
标题翻译：治疗人类食管异常组织的系统和方法
公开(公告)号：US06551310B1
公开(公告)日：2003-04-22
申请号：US09714344
申请日：2000-11-16
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

7. 发明申请

US20120330298A1 SYSTEM AND METHOD OF TREATING ABNORMAL TISSUE IN THE HUMAN ESOPHAGUS 审中-公开
标题翻译：在人类ESOPHAGUS中治疗异常组织的系统和方法
公开(公告)号：US20120330298A1
公开(公告)日：2012-12-27
申请号：US13530464
申请日：2012-06-22
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

8. 发明授权

US07761169B2 Device and method for treatment of gastroesophageal reflux disease 失效
标题翻译：用于治疗胃食管反流病的装置和方法
公开(公告)号：US07761169B2
公开(公告)日：2010-07-20
申请号：US12136730
申请日：2008-06-10
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.
摘要翻译：一种用于治疗胃食管反流病的下食道括约肌紧固装置，其包括插入装置，能量源和能量传递装置。插入装置通过插入体开口将能量传递装置定位在食管下括约肌附近。能量源通过插入装置产生能量并将能量传递到能量传递装置，该能量传递装置将传播的能量引导到主要由胶原蛋白组成的下部食管括约肌上。能量源以足以引起括约肌胶原加热的水平传输能量，从而导致胶原蛋白的收缩和括约肌紧缩。

9. 发明授权

US07553326B2 Method and apparatus for preventing dialysis graft intimal hyperplasia 有权
标题翻译：用于预防透析移植物内膜增生的方法和装置
公开(公告)号：US07553326B2
公开(公告)日：2009-06-30
申请号：US10994623
申请日：2004-11-22
申请人： Richard M. Sweet , Robert A. Ganz
发明人： Richard M. Sweet , Robert A. Ganz
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2250/0001 , A61L29/16 , A61L2300/416 , A61N5/0601 , Y10S623/903
摘要： To prevent intimal hyperplasia within a dialysis graft, a flexible tube comprising the dialysis graft is coated interiorly before placement with an anticarcinogen or mitosis-inhibiting agent for preventing cell division. The graft can also be irradiated with light energy by directing light into the lumen of the tube that has been grafted in place, thereby preventing or reducing dialysis graft intimal hyperplasia and reducing inflammation. The light source can be a light emitting diode (LED) or a chemical light source, i.e., a chemiluminescent substance for producing cool light energy within the graft to prevent or reduce the symptoms of GIH. When phototherapy is used, the body is exposed to light radiation at the site of the graft in sufficient amount to prevent undesired cell proliferation within the vessels, the graft, or surrounding tissue where the invention is used without detectable damage to body tissue.
摘要翻译：为了防止透析移植物中的内膜增生，包含透析移植物的柔性管在放置前涂覆有用于防止细胞分裂的抗癌剂或有丝分裂抑制剂。也可以通过将光引入已被移植到位的管的内腔中，从而防止或减少透析移植物内膜增生并减少炎症，也可以用光能照射移植物。光源可以是发光二极管（LED）或化学光源，即用于在移植物内产生冷光能的化学发光物质，以防止或减少GIH的症状。当使用光疗时，身体暴露于移植物位置处的光辐射足够的量以防止使用本发明的血管，移植物或周围组织中不期望的细胞增殖，而对身体组织无可察觉的损伤。

10. 发明授权

US07043307B1 Device and method for treatment of gastroesophageal reflux disease 失效
公开(公告)号：US07043307B1
公开(公告)日：2006-05-09
申请号：US10633820
申请日：2003-08-04
申请人： Brian D. Zelickson , Robert A. Ganz
发明人： Brian D. Zelickson , Robert A. Ganz
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B1/00082 , A61B1/018 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B2018/00011 , A61B2018/00214 , A61B2018/00553
摘要： A lower esophageal sphincter tightening device for treating gastroesophageal reflux disease which includes an insertion device, an energy source, and an energy transmitting device. The insertion device, by insertion through a body opening, positions the energy transmitting device in the proximity of the lower esophageal sphincter. The energy source generates and transmits energy via the insertion device to the energy transmitting device which directs the transmitted energy onto the lower esophageal sphincter which is comprised largely of collagen. The energy source transmits energy at a level sufficient to cause heating of the sphincter's collagen resulting in a shrinkage of the collagen and a tightening of the sphincter.

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