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1. 发明授权

US5304569A Compositions and their use in lowering intraocular pressure 失效
标题翻译：组合物及其在降低眼压方面的用途
公开(公告)号：US5304569A
公开(公告)日：1994-04-19
申请号：US607398
申请日：1990-10-31
申请人： Risto Lammintausta , Arto Karjalainen , Ewen MacDonald , Arto Urtti , Raimo Virtanen , Thomas Yorio
发明人： Risto Lammintausta , Arto Karjalainen , Ewen MacDonald , Arto Urtti , Raimo Virtanen , Thomas Yorio
IPC分类号： C07D233/58 , A61K31/415 , A61P27/02 , A61P27/06
CPC分类号： A61K31/415 , Y10S514/913
摘要： Compounds of formula: ##STR1## where X is --CH.sub.2 --, --CH(CH.sub.3)--, --CHR.sub.3 --CH.sub.2 -- or --CR.sub.3 .dbd.CH-- and R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, are each H or CH.sub.3 or a stereoisomer or pharmaceutically acceptable salt thereof, and pharmaceutical compositions containing them, are useful for lowering intraocular pressure in a mammal, e.g. in the treatment of glaucoma.
摘要翻译：（*化学结构*）（I）的化合物，其中X是-CH 2 - ， - CH（CH 3） - ， - CH 3 -CH 2 - 或-CR 3 = CH-，并且R 1，R 2和R 3可以相同或不同的，各自为H或CH 3或其立体异构体或药学上可接受的盐，以及含有它们的药物组合物可用于降低哺乳动物的眼内压，例如治疗青光眼。

2. 发明授权

US5977180A Anandamide analog compositions and method of treating intraocular hypertension using same 失效
标题翻译：阿那酰胺类似物组合物和使用其治疗眼内高血压的方法
公开(公告)号：US5977180A
公开(公告)日：1999-11-02
申请号：US776268
申请日：1997-01-10
申请人： David W. Pate , Tomi Jarvinen , Kristina Jarvinen , Arto Urtti
发明人： David W. Pate , Tomi Jarvinen , Kristina Jarvinen , Arto Urtti
IPC分类号： A61K9/00 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48
CPC分类号： B82Y5/00 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48969 , A61K9/0048 , Y10S514/912 , Y10S514/913
摘要： Anandamide analogues useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.
摘要翻译： PCT No.PCT / US95 / 08226 Sec。 371日期1997年1月10日 102（e）日期1997年1月10日PCT提交1995年7月10日PCT公布。第WO96 / 01558号公报日期1996年1月25日可用于治疗眼内高血压的阿那酰胺类似物，以及包含其的眼用组合物和环糊精，以及这些化合物用于治疗眼内高血压的方法。

3. 发明授权

US5631297A Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same 失效
标题翻译：可用于治疗眼内高血压的阿那酰胺，含有其的眼用组合物及其使用方法
公开(公告)号：US5631297A
公开(公告)日：1997-05-20
申请号：US272532
申请日：1994-07-11
申请人： David W. Pate , Tomi Jarvinen , Kristiina Jarvinen , Arto Urtti
发明人： David W. Pate , Tomi Jarvinen , Kristiina Jarvinen , Arto Urtti
IPC分类号： A61K9/00 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48 , A61K31/16
CPC分类号： B82Y5/00 , A61K31/164 , A61K31/165 , A61K31/275 , A61K31/5375 , A61K47/48969 , A61K9/0048 , Y10S514/912 , Y10S514/913
摘要： Anandamides useful for the treatment of intraocular hypertension, as well as ophthalmic compositions comprising the same and a cyclodextrin, and methods of use of these compounds to treat intraocular hypertension.
摘要翻译：可用于治疗眼内高血压的阿那酰胺，以及包含其的眼用组合物和环糊精，以及这些化合物用于治疗眼内高血压的方法。

4. 发明申请

US20050131498A1 Visual stimulator 失效
标题翻译：视觉刺激器
公开(公告)号：US20050131498A1
公开(公告)日：2005-06-16
申请号：US10974866
申请日：2004-10-26
申请人： Antti Valjakka , Arto Urtti , Janne Ahonen
发明人： Antti Valjakka , Arto Urtti , Janne Ahonen
IPC分类号： A61B3/032 , A61B5/0496 , A61N1/00
CPC分类号： A61B3/0091 , A61B3/032 , A61B5/0496
摘要： The present invention relates to a visual stimulator, which comprises a light stimulation source, a regulable attenuator of light, mirrors for reflecting light and light detectors. The visual stimulator in accordance with the invention comprises a mirror chamber and a mirror tube constructed of mirrors in which the reflecting points of the mirrors form various angles with respect to each other, and which have been connected to each other such that light beams disperse from the mirror tube to the mirror chamber without hindrance regardless of the location of the object to be examined or a part of it in the mirror chamber and though the location of the object or a part of it would vary in certain limits in the mirror chamber, and that to one end of the mirror tube, viewed away from the mirror chamber a light stimulation source has been directed.
摘要翻译：本发明涉及视觉刺激器，其包括光刺激源，可调节的光衰减器，用于反射光和光检测器的反射镜。根据本发明的视觉刺激器包括镜室和由反射镜构成的镜管，其中反射镜的反射点相对于彼此形成各种角度，并且已经彼此连接，使得光束从尽管反射镜室中的物体或其一部分的位置将在某些限度内变化，但镜子管无需受检对象的位置或镜像室中的一部分即可，并且从反射镜室观察的镜管的一端已经引导了光刺激源。

5. 发明授权

US06183771B2 Transdermal compositions containing levosimendan 有权
标题翻译：含有左西孟旦的透皮组合物
公开(公告)号：US06183771B2
公开(公告)日：2001-02-06
申请号：US09214295
申请日：1999-03-23
申请人： Arto Urtti , Jouni Hirvonen , Lasse Lehtonen , Saila Antila
发明人： Arto Urtti , Jouni Hirvonen , Lasse Lehtonen , Saila Antila
IPC分类号： A61F1302
CPC分类号： A61K9/7023 , A61K9/0009 , A61K31/50
摘要： Transdermal administration of levosimenden or (−)-[[4-(1,4,5,6-tetahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono]propanedinitrile or a pharmaceutically acceptable salt thereof is disclosed. Transdermal preparations of levosimenden can be in the form of e.g. ointment, emulsion, lotion, solution, gel, cream, patch or transdermal delivery device including iontophoretic device.
摘要翻译：公开透皮给药左西孟旦或（ - ） - [[4-（1,4,5,6-四氢-4-甲基-6-氧代-3-哒嗪基）苯基）亚肼基]丙二腈或其药学上可接受的盐。左旋香豆素的透皮制剂可以是例如，软膏，乳液，洗剂，溶液，凝胶，霜剂，补片或透皮递送装置，包括离子电渗疗法装置。

6. 发明授权

US07596400B2 Electrode detector for monitoring biopotential on tissue 有权
标题翻译：用于监测组织上的生物潜能的电极检测器
公开(公告)号：US07596400B2
公开(公告)日：2009-09-29
申请号：US10974865
申请日：2004-10-26
申请人： Antti Valjakka , Arto Urtti , Janne Ahonen
发明人： Antti Valjakka , Arto Urtti , Janne Ahonen
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0496
CPC分类号： A61B5/0496
摘要： The present invention relates to an electrode detector, which comprises a contact electrode part adjustable to tissue, or being in touch with it and which contact electrode part is for monitoring biopotential or other physical magnitude, a conducting wire (2) attached to the contact electrode part, electroconductive material, non-electroconductive material and electronics processing the signal. The electrode detector in accordance with the invention comprises a ball-shaped or almost ball-shaped contact electrode part, monitoring biopotential or some other physical magnitude, the covering part of which contact electrode part is made of non-toxic material to tissue and some electroconductive part of which has been galvanically or capacitively or indirectly through an electronic circuitry in the contact electrode part itself connected to the electroconductive inner part of a flexible conducting wire while its covering part is made of material that is non-toxic to tissue and insulating electricity, and attaching part of which has been connected or may be connected galvanically, non-galvanically or indirectly through the electronic circuitry in the attaching part to the conducting wire of the electrode detector and which may be anchored with external attaching elements/attaching material in it or some other external attaching elements/materials near the subject to be monitored.
摘要翻译：电极检测器本发明涉及一种电极检测器，其包括可调整到组织或与之接触的接触电极部分，以及哪个接触电极部分用于监测生物电位或其他物理大小;附接到接触电极的导线（2）部分，导电材料，非导电材料和电子元件处理信号。根据本发明的电极检测器包括球形或几乎是球形的接触电极部分，监测生物电位或一些其他物理大小，其接触电极部分的覆盖部分由无毒材料制成组织，一些导电其一部分已经电流或电容性或间接地通过连接到柔性导线的导电内部的接触电极部分中的电子电路，而其覆盖部分由对组织无毒且绝缘的材料制成，并且其一部分已经连接或可以被电连接，非电流地或间接地通过附接部分中的电子电路连接到电极检测器的导线，并且其可以被固定在其中的外部附接元件/附接材料或附近受监控的其他外部附着元件/材料。

7. 发明授权

US07549749B2 Visual stimulator 失效
标题翻译：视觉刺激器
公开(公告)号：US07549749B2
公开(公告)日：2009-06-23
申请号：US10974866
申请日：2004-10-26
申请人： Antti Valjakka , Arto Urtti , Janne Ahonen
发明人： Antti Valjakka , Arto Urtti , Janne Ahonen
IPC分类号： A61B3/10 , A61B3/02
CPC分类号： A61B3/0091 , A61B3/032 , A61B5/0496
摘要： The present invention relates to a visual stimulator, which comprises a light stimulation source, a regulable attenuator of light, mirrors for reflecting light and light detectors. The visual stimulator in accordance with the invention comprises a mirror chamber and a mirror tube constructed of mirrors in which the reflecting points of the mirrors form various angles with respect to each other, and which have been connected to each other such that light beams disperse from the mirror tube to the mirror chamber without hindrance regardless of the location of the object to be examined or a part of it in the mirror chamber and though the location of the object or a part of it would vary in certain limits in the mirror chamber, and that to one end of the mirror tube, viewed away from the mirror chamber a light stimulation source has been directed.
摘要翻译：本发明涉及视觉刺激器，其包括光刺激源，可调节的光衰减器，用于反射光和光检测器的反射镜。根据本发明的视觉刺激器包括镜室和由反射镜构成的镜管，其中反射镜的反射点相对于彼此形成各种角度，并且彼此连接，使得光束从尽管反射镜室中的物体或其一部分的位置将在某些限度内变化，但镜子管无需受检对象的位置或镜像室中的一部分即可，并且从反射镜室观察的镜管的一端已经引导了光刺激源。

8. 发明申请

US20050119544A1 Electrode detector for monitoring biopotential on tissue 有权
标题翻译：用于监测组织上的生物潜能的电极检测器
公开(公告)号：US20050119544A1
公开(公告)日：2005-06-02
申请号：US10974865
申请日：2004-10-26
申请人： Antti Valjakka , Arto Urtti , Janne Ahonen
发明人： Antti Valjakka , Arto Urtti , Janne Ahonen
IPC分类号： A61B5/0496 , A61B5/04
CPC分类号： A61B5/0496
摘要： The present invention relates to an electrode detector, which comprises a contact electrode part adjustable to tissue, or being in touch with it and which contact electrode part is for monitoring biopotential or other physical magnitude, a conducting wire (2) attached to the contact electrode part, electroconductive material, non-electroconductive material and electronics processing the signal. The electrode detector in accordance with the invention comprises a ball-shaped or almost ball-shaped contact electrode part, monitoring biopotential or some other physical magnitude, the covering part of which contact electrode part is made of non-toxic material to tissue and some electroconductive part of which has been galvanically or capacitively or indirectly through an electronic circuitry in the contact electrode part itself connected to the electroconductive inner part of a flexible conducting wire while its covering part is made of material that is non-toxic to tissue and insulating electricity, and attaching part of which has been connected or may be connected galvanically, non-galvanically or indirectly through the electronic circuitry in the attaching part to the conducting wire of the electrode detector and which may be anchored with external attaching elements/attaching material in it or some other external attaching elements/materials near the subject to be monitored.
摘要翻译：电极检测器本发明涉及一种电极检测器，其包括可调整到组织或与之接触的接触电极部分，以及哪个接触电极部分用于监测生物电位或其他物理大小;附接到接触电极的导线（2）部分，导电材料，非导电材料和电子元件处理信号。根据本发明的电极检测器包括球形或几乎是球形的接触电极部分，监测生物电位或一些其他物理大小，其接触电极部分的覆盖部分由无毒材料制成组织，一些导电其一部分已经电流或电容性或间接地通过连接到柔性导线的导电内部的接触电极部分中的电子电路，而其覆盖部分由对组织无毒且绝缘的材料制成，并且其一部分已经连接或可以被电连接，非电流地或间接地通过附接部分中的电子电路连接到电极检测器的导线，并且其可以被固定在其中的外部附接元件/附接材料或附近受监控的其他外部附着元件/材料。

9. 发明授权

US5436350A Bispilocarpic acid ester derivatives and process for their preparation 失效
标题翻译：双蔗糖酯衍生物及其制备方法
公开(公告)号：US5436350A
公开(公告)日：1995-07-25
申请号：US67674
申请日：1993-05-26
申请人： Tomi Jarvinen , Pekka Peura , Pekka Suhonen , Arto Urtti , Hannu Hanhijarvi , Esko Pohjala
发明人： Tomi Jarvinen , Pekka Peura , Pekka Suhonen , Arto Urtti , Hannu Hanhijarvi , Esko Pohjala
IPC分类号： C07D233/54 , C07D405/14 , C07D233/64 , A61K31/415
CPC分类号： C07D233/64 , C07D405/14
摘要： The object of the invention are bispilocarpates useful in the treatment of glaucoma and having the formula ##STR1## wherein A) Y is hydrogen or the acyl group ##STR2## and W is the group --O--A--O--Z--Y', wherein Y' is hydrogen or the acyl group ##STR3## the groups R and R' having different meanings and may be the same or different and A is an aliphatic, aromatic or heterocyclic bridging group, and --Z--Y' is ##STR4## or B) W is OR, wherein R has the same meaning as above, Y is ##STR5## where R' has the same meaning as above, B means the same as A and Z'--OR' is ##STR6## or C) W and Y together mean ##STR7## where the symbols have the same meanings as above.
摘要翻译：本发明的目的是可用于治疗青光眼并具有下式的双眉果糖：其中A）Y是氢或酰基“IMAGE”，W是基团-OAOZ-Y'，其中Y'是氢或酰基基团可以相同或不同，A是脂族，芳族或杂环桥基，-ZY'是或B）W是OR，其中R具有与上述相同的含义，Y是< IMAGE>其中R'具有与上述相同的含义，B表示与A相同，Z'-OR'为或C）W和Y一起表示，其中符号具有与上述相同的含义。

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