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1. 发明申请

US20080262197A1 METHODS AND MATERIALS FOR TREATING INFLAMMATORY CONDITIONS 审中-公开
标题翻译：用于治疗炎症症状的方法和材料
公开(公告)号：US20080262197A1
公开(公告)日：2008-10-23
申请号：US12099332
申请日：2008-04-08
申请人： Rikard Holmdahl , Lars T. Hellman
发明人： Rikard Holmdahl , Lars T. Hellman
IPC分类号： C07K14/47
CPC分类号： C07K14/472 , A61K39/0008 , A61K39/001 , C07K2319/24 , C07K2319/50 , Y10S530/806
摘要： The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5a. For example, the methods and materials described herein can be used to reduce the effects of C5a within a mammal by reducing the amount of total and receptor bound C5a in the mammal.
摘要翻译：本发明提供了治疗炎性病症的方法和材料。具体地说，本发明提供多肽，分离的核酸，宿主细胞和可用于在哺乳动物中针对抗原如C5或C5a诱导抗体应答的方法。例如，本文所述的方法和材料可用于通过减少哺乳动物中总的和受体结合的C5a的量来减少哺乳动物内C5a的作用。

2. 发明授权

US07361742B2 Methods and materials for treating inflammatory conditions 失效
标题翻译：治疗炎症的方法和材料
公开(公告)号：US07361742B2
公开(公告)日：2008-04-22
申请号：US10724662
申请日：2003-12-01
申请人： Rikard Holmdahl , Lars T. Hellman
发明人： Rikard Holmdahl , Lars T. Hellman
IPC分类号： C07K19/00
CPC分类号： C07K14/472 , A61K39/0008 , A61K39/001 , C07K2319/24 , C07K2319/50 , Y10S530/806
摘要： The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5a. For example, the methods and materials described herein can be used to reduce the effects of C5a within a mammal by reducing the amount of total and receptor bound C5a in the mammal.
摘要翻译：本发明提供了治疗炎性病症的方法和材料。具体地说，本发明提供多肽，分离的核酸，宿主细胞和可用于在哺乳动物中针对抗原如C5或C5a诱导抗体应答的方法。例如，本文所述的方法和材料可用于通过减少哺乳动物中总的和受体结合的C5a的量来减少哺乳动物内C5a的作用。

3. 发明申请

US20090191268A1 ALLERGY VACCINES 审中-公开
标题翻译：过敏疫苗
公开(公告)号：US20090191268A1
公开(公告)日：2009-07-30
申请号：US12327868
申请日：2008-12-04
申请人： Lars T. Hellman , Stefan Persson , Asa Jansson
发明人： Lars T. Hellman , Stefan Persson , Asa Jansson
IPC分类号： A61K9/10 , A61K39/395
CPC分类号： A61K39/39566 , A61K38/00 , A61K39/00 , C07K14/705 , C07K16/00 , C07K16/4291 , C07K2317/24 , C07K2317/52
摘要： The invention provides methods and materials related to vaccines against self polypeptides. For example, the invention provides compositions containing chimeric IgE polypeptides and adjuvants.
摘要翻译：本发明提供了与针对自身多肽的疫苗相关的方法和材料。例如，本发明提供含有嵌合IgE多肽和佐剂的组合物。

4. 发明授权

US07459158B2 Immunogenic polypeptides for inducing anti-self IgE responses 失效
标题翻译：用于诱导抗自身IgE反应的免疫原性多肽
公开(公告)号：US07459158B2
公开(公告)日：2008-12-02
申请号：US10176664
申请日：2002-06-19
申请人： Lars T. Hellman
发明人： Lars T. Hellman
IPC分类号： A61K39/00 , C12P21/08
CPC分类号： C07K16/4291 , A61K39/395 , A61K2039/505 , A61K2300/00
摘要： The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically, the invention relates to methods and materials that can be used to vaccinate a mammal against specific self or non-self antigens. For example, the methods and materials described herein can be used to reduce the effects of IgE antibodies within a mammal by reducing the amount of total and receptor bound IgE antibodies in the mammal. In addition, the invention provides vaccine conjugates, immunogenic polypeptides, nucleic acid molecules that encode immunogenic polypeptides, host cells containing the nucleic acid molecules that encode immunogenic polypeptides, and methods for making vaccine conjugates and immunogenic polypeptides as well as nucleic acid molecules that encode immunogenic polypeptides. Further, the invention provides an IgE vaccine that induces an anti-self IgE response in a mammal.
摘要翻译：本发明涉及涉及各种疾病如感染和IgE相关疾病的治疗和预防的方法和材料。具体地，本发明涉及可用于针对特定自身或非自身抗原接种哺乳动物的方法和材料。例如，本文所述的方法和材料可用于通过减少哺乳动物中总的和受体结合的IgE抗体的量来减少哺乳动物内IgE抗体的作用。此外，本发明提供疫苗缀合物，免疫原性多肽，编码免疫原性多肽的核酸分子，含有编码免疫原性多肽的核酸分子的宿主细胞，以及用于制备疫苗缀合物和免疫原性多肽的方法以及编码免疫原性的核酸分子多肽。此外，本发明提供了在哺乳动物中诱导抗自身IgE应答的IgE疫苗。

5. 发明授权

US06913749B2 Immunogenic polypeptides for inducing anti-self IgE responses 失效
标题翻译：用于诱导抗自身IgE应答的免疫原性多肽
公开(公告)号：US06913749B2
公开(公告)日：2005-07-05
申请号：US09401636
申请日：1999-09-22
申请人： Lars T. Hellman
发明人： Lars T. Hellman
IPC分类号： C12N15/09 , A61K39/395 , A61P11/06 , A61P17/04 , A61P31/04 , A61P31/10 , A61P31/12 , A61P37/06 , A61P43/00 , C07K14/47 , C07K16/42 , C12N1/15 , C12N1/19 , C12N5/10 , C12P21/08 , A61K39/00 , C07K16/46
CPC分类号： C07K16/4291 , A61K39/395 , A61K2039/505 , A61K2300/00
摘要： The invention relates to methods and materials involved in the treatment and prevention of various diseases such as infections and IgE-related diseases. Specifically, the invention relates to methods and materials that can be used to vaccinate a mammal against specific self or non-self antigens. For example, the methods and materials described herein can be used to reduce the effects of IgE antibodies within a mammal by reducing the amount of total and receptor bound IgE antibodies in the mammal. In addition, the invention provides vaccine conjugates, immunogenic polypeptides, nucleic acid molecules that encode immunogenic polypeptides, host cells containing the nucleic acid molecules that encode immunogenic polypeptides, and methods for making vaccine conjugates and immunogenic polypeptides as well as nucleic acid molecules that encode immunogenic polypeptides. Further, the invention provides an IgE vaccine that induces an anti-self IgE response in a mammal.
摘要翻译：本发明涉及涉及各种疾病如感染和IgE相关疾病的治疗和预防的方法和材料。具体地，本发明涉及可用于针对特定自身或非自身抗原接种哺乳动物的方法和材料。例如，本文所述的方法和材料可用于通过减少哺乳动物中总的和受体结合的IgE抗体的量来减少哺乳动物内IgE抗体的作用。此外，本发明提供疫苗缀合物，免疫原性多肽，编码免疫原性多肽的核酸分子，含有编码免疫原性多肽的核酸分子的宿主细胞，以及用于制备疫苗缀合物和免疫原性多肽的方法以及编码免疫原性的核酸分子多肽。此外，本发明提供了在哺乳动物中诱导抗自身IgE应答的IgE疫苗。

6. 发明授权

US5653980A Vaccine comprising part of constant region of IgE for treatment of IgE-mediated allergic reactions 失效
标题翻译：疫苗包含用于治疗IgE介导的过敏反应的IgE恒定区的一部分
公开(公告)号：US5653980A
公开(公告)日：1997-08-05
申请号：US196227
申请日：1994-03-23
申请人： Lars T. Hellman
发明人： Lars T. Hellman
IPC分类号： A61K39/00 , A61K39/385 , A61K39/39 , A61K39/395 , A61P37/08 , C07K16/42 , C07K17/02 , C12N1/21 , C12N15/09 , C12R1/19 , A61K39/44 , C12P21/08
CPC分类号： C07K16/4291 , C07K17/02 , A61K39/00 , Y10S424/80 , Y10S424/801 , Y10S424/805 , Y10S424/809 , Y10S424/81 , Y10S530/862 , Y10S530/867 , Y10S530/868
摘要： The invention relates to a vaccine, preferably for human use, against IgE-mediated allergic reactions. The vaccine contains a protein having the entire amino acid sequence of the constant CH2-CH3 domains of the epsilon chain of the IgE molecule or a structurally stable unit of said amino acid sequence, the protein optionally being coupled to one or more heterologous carrier proteins, and optionally containing an adjuvant. The vaccine is injected, with or without adjuvant, to raise the concentration of endogenous anti-IgE antibodies in the plasma of allergy subjects. In practice, the vaccine can be used against all types of IgE-mediated allergies since the antibodies are not dependent of the antigen specificity of the IgE molecule but will reduce the total IgE pool of the subject. Therefore, the vaccine is aimed at being used for treatment of subjects having different types of IgE-mediated allergies. The increased concentrations of anti-IgE antibodies reduces the free pool of antigen-specific IgE, which thereby strongly reduces the risk for an allergen-mediated release of the physiologically highly active substances which are stored or produced in connection with granula release from mast cells and basophilic leucocytes.
摘要翻译： PCT No.PCT / SE92 / 00673 Sec。 371日期1994年3月23日 102（e）日期1994年3月23日PCT提交1992年9月25日PCT公布。出版物WO93 / 05810 日期1994年4月1日本发明涉及针对IgE介导的过敏反应的优选用于人类的疫苗。疫苗含有蛋白质，其具有IgE分子的ε链的恒定CH2-CH3结构域的全部氨基酸序列或所述氨基酸序列的结构稳定的单位，所述蛋白质任选与一种或多种异源载体蛋白偶联，并任选地含有佐剂。用或不含佐剂注射疫苗以提高过敏体血浆中内源性抗IgE抗体的浓度。实际上，疫苗可以用于所有类型的IgE介导的过敏，因为抗体不依赖于IgE分子的抗原特异性，而是减少受试者的总IgE池。因此，疫苗旨在用于治疗具有不同类型的IgE介导的过敏症的受试者。抗IgE抗体的增加浓度降低了抗原特异性IgE的游离池，从而强烈地降低了与肥大细胞释放颗粒释放有关的储存或产生的生理高活性物质的过敏原介导释放的风险，嗜碱性白细胞。

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