专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050020825A1 Process for the production of 2'-branched nucleosides 有权
标题翻译：生产2'-支链核苷的方法
公开(公告)号：US20050020825A1
公开(公告)日：2005-01-27
申请号：US10735408
申请日：2003-12-12
申请人： Richard Storer , Adel Moussa , Narayan Chaudhuri , Frank Waligora
发明人： Richard Storer , Adel Moussa , Narayan Chaudhuri , Frank Waligora
IPC分类号： A61K31/7072 , C07H20060101 , C07H1/00 , C07H7/02 , C07H19/00 , C07H19/048 , C07H19/06 , C07H19/067 , C07H19/16 , C07H19/22
CPC分类号： C07H1/00 , C07H7/02 , C07H19/06 , C07H19/16 , Y02P20/55
摘要： The present invention provides an improved process for preparing β-D and β-L 2′-C-methyl-nucleosides and 2′-C-methyl-3′-O-ester nucleosides.
摘要翻译：本发明提供了制备β-D和β-L 2'-C-甲基 - 核苷和2'-C-甲基-3'-O-酯核苷的改进方法。

2. 发明申请

US20050059632A1 Synthesis of beta-L-2'-deoxy nucleosides 审中-公开
标题翻译： β-L-2'-脱氧核苷的合成
公开(公告)号：US20050059632A1
公开(公告)日：2005-03-17
申请号：US10882893
申请日：2004-06-30
申请人： Richard Storer , Adel Moussa , Jingyang Wang , Narayan Chaudhuri , Steven Mathieu , Alistair Stewart
发明人： Richard Storer , Adel Moussa , Jingyang Wang , Narayan Chaudhuri , Steven Mathieu , Alistair Stewart
IPC分类号： A61K31/7072 , A61K31/7076 , C07H13/08 , C07H19/00 , C07H19/048 , C07H19/073 , C07H19/22 , C12Q20060101
CPC分类号： C07H19/09 , C07H9/04 , C07H9/06 , C07H13/04 , C07H13/08 , C07H15/203 , C07H19/06 , C07H19/073 , Y02P20/55
摘要： An improved process for the preparation of 2′-modified nucleosides and 2′-deoxy-nucleosides, such as, β-L-2′-deoxy-thymidine (LdT), is provided. In particular, the improved process is directed to the synthesis of a 2′-deoxynucleoside that may utilize different starting materials but that proceeds via a chloro-sugar intermediate or via a 2,2′-anhydro-1-furanosyl-nucleobase intermediate. Where an 2,2′-anhydro-1-furanosyl base intermediate is utilized, a reducing agent, such as Red-Al, and a sequestering agent, such as 15-crown-5 ether, that cause an intramolecular displacement reaction and formation of the desired nucleoside product in good yields are employed. An alternative process of the present invention utilizes a 2,2′-anhydro-1-furanosyl base intermediate without a sequestering agent to afford 2′-deoxynucleosides in good yields. The compounds made according to the present invention may be used as intermediates in the preparation of other nucleoside analogues, or may be used directly as antiviral and/or antineoplastic agents.
摘要翻译：提供了用于制备2'-修饰的核苷和2'-脱氧核苷的改进方法，例如β-L-2'-脱氧胸苷（LdT）。特别地，改进的方法涉及可以利用不同起始原料但通过氯糖中间体或通过2,2'-脱水-1-呋喃糖基 - 核碱基中间体进行的2'-脱氧核苷的合成。当使用2,2'-脱水-1-呋喃糖基碱中间体时，可以使用诸如Red-Al的还原剂和诸如15-冠醚5的多价螯合剂，其引起分子内置换反应和形成使用所需的产率良好的核苷产物。本发明的另一种方法是利用不含螯合剂的2,2'-脱水-1-呋喃糖基碱中间产物得到2'-脱氧核苷。根据本发明制备的化合物可以用作制备其它核苷类似物的中间体，或者可以直接用作抗病毒和/或抗肿瘤剂。

3. 发明授权

US07598373B2 Process for the production of 2-C-methyl-D-ribonolactone 有权
标题翻译：制备2-C-甲基-D-核糖内酯的方法
公开(公告)号：US07598373B2
公开(公告)日：2009-10-06
申请号：US10735408
申请日：2003-12-12
申请人： Richard Storer , Adel M. Moussa , Narayan Chaudhuri , Frank Waligora
发明人： Richard Storer , Adel M. Moussa , Narayan Chaudhuri , Frank Waligora
IPC分类号： C07H1/00 , C07H3/10
CPC分类号： C07H1/00 , C07H7/02 , C07H19/06 , C07H19/16 , Y02P20/55
摘要： The present invention provides an improved process for preparing 2-C-methyl-D-ribonolactone.
摘要翻译：本发明提供了制备2-C-甲基-D-核糖内酯的改进方法。

4. 发明授权

US07365090B2 Substituted phenylindoles for the treatment of HIV 有权
标题翻译：用于治疗HIV的取代的苯基吲哚
公开(公告)号：US07365090B2
公开(公告)日：2008-04-29
申请号：US10637949
申请日：2003-08-07
申请人： Marino Artico , Paolo LaColla , Romano Silvestri , Adel Moussa , Jean-Pierre Sommadossi , Richard Storer
发明人： Marino Artico , Paolo LaColla , Romano Silvestri , Adel Moussa , Jean-Pierre Sommadossi , Richard Storer
IPC分类号： A61K31/405 , C07D209/14
CPC分类号： C07D403/04 , C07D209/42 , C07D403/12
摘要： This invention is in the area of phenylindoles that are useful for the treatment of HIV infection, and, in particular, phenylindoles that exhibit significant activity against resistant strains of HIV. The phenylindoles have at least two substituents other than hydrogen on the benzo ring of the indole function, preferably at the 4′ and 5′, 5′ and 6′ or the 5′ and 7′ positions, optionally in combination with disubstitution at positions 3″ and 5″ on the phenyl ring of the compound, and carboxamide containing moieties at position-2 on the indole group of the compound. Methyl is a preferred group for substitution on the phenyl ring. Preferred substituents for the benzo ring of the indole function include but are not limited to chlorine, fluorine, bromine, iodine, CF3, methoxy, CN, and NO2.
摘要翻译：本发明在可用于治疗HIV感染的苯基吲哚的区域中，特别是对抗HIV抗性菌株显示出显着活性的苯基吲哚。苯吲哚在吲哚官能团的苯并环上具有至少两个除氢之外的取代基，优选在4'和5'，5'和6'或5'和7'位置，任选地与3位的取代基组合 “和5”，化合物的吲哚基上的位置-2的含羧酰胺的部分。甲基是在苯环上取代的优选基团。吲哚官能团的苯并环的优选取代基包括但不限于氯，氟，溴，碘，CF 3，甲氧基，CN和NO 2。

5. 发明申请

US20050004357A1 Industrially scalable nucleoside synthesis 失效
标题翻译：工业可扩展的核苷合成
公开(公告)号：US20050004357A1
公开(公告)日：2005-01-06
申请号：US10833925
申请日：2004-04-28
申请人： Adel Moussa , Jing Wang , Richard Storer
发明人： Adel Moussa , Jing Wang , Richard Storer
IPC分类号： A61K20060101 , C07H19/00 , C07H19/04 , C07H19/048 , C07H19/22
CPC分类号： C07H19/073
摘要： An industrially scalable two-step process for preparing a β-L-2′-deoxy-nucleoside that results in a predominance of the β- over the γ-anomeric form of the compound is described. An optional third step may be used to prepare 3′-prodrugs of desirable β-L-2′-deoxy-nucleosides for the delivery of these pharmaceuticals effective for treating viral diseases. The synthetic process is applicable in particular to the formation of β-L-2′-deoxy-cytidine, a pharmaceutically acceptable salt or prodrug thereof. The process can provide a relatively uncontaminated product that may require no further isolation or purification, thereby making the synthesis easily scalable for industrial manufacture.
摘要翻译：描述了一种用于制备β-L-2'-脱氧核苷的工业可扩展的两步法，其导致β-位于化合物的γ-异头体形式之上。可选的第三步可用于制备所需的β-L-2'-脱氧核苷的3'-前药，用于递送有效治疗病毒性疾病的这些药物。合成方法特别适用于形成β-L-2'-脱氧胞苷，其药学上可接受的盐或前药。该方法可以提供可能不需要进一步分离或纯化的相对未污染的产品，从而使合成容易扩展到工业制造。

6. 发明申请

US20050014774A1 Oxo-pyrimidine compounds 审中-公开
标题翻译：氧嘧啶化合物
公开(公告)号：US20050014774A1
公开(公告)日：2005-01-20
申请号：US10833601
申请日：2004-04-28
申请人： Richard Storer , Adel Moussa , Paolo La Colla , Marino Artico
发明人： Richard Storer , Adel Moussa , Paolo La Colla , Marino Artico
IPC分类号： A61K20060101 , A61K31/505 , A61K31/513 , C07D239/52 , C07D239/56
CPC分类号： C07D239/47 , C07D239/48 , C07D239/52 , C07D239/553
摘要： Oxo-pyrimidine compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the oxo-pyrimidine derivatives alone or in combination with other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译：描述了用于治疗逆转录病毒感染，特别是用于HIV的氧嘧啶化合物。还包括包含单独或与其它抗逆转录病毒剂组合的氧嘧啶衍生物的组合物，其制备方法和制备并入这些化合物的药物的方法。

7. 发明授权

US07595390B2 Industrially scalable nucleoside synthesis 失效
标题翻译：工业可扩展的核苷合成
公开(公告)号：US07595390B2
公开(公告)日：2009-09-29
申请号：US10833925
申请日：2004-04-28
申请人： Adel Moussa , Jing Yang Wang , Richard Storer
发明人： Adel Moussa , Jing Yang Wang , Richard Storer
IPC分类号： C07H19/073
CPC分类号： C07H19/073
摘要： An industrially scalable two-step process for preparing a β-L-2′-deoxy-nucleoside that results in a predominance of the β- over the α-anomeric form of the compound is described. An optional third step may be used to prepare 3′-prodrugs of desirable β-L-2′-deoxy-nucleosides for the delivery of these pharmaceuticals effective for treating viral diseases. The synthetic process is applicable in particular to the formation of β-L-2′-deoxy-cytidine, a pharmaceutically acceptable salt or prodrug thereof. The process can provide a relatively uncontaminated product that may require no further isolation or purification, thereby making the synthesis easily scalable for industrial manufacture.
摘要翻译：描述了一种用于制备β-L-2'-脱氧核苷的工业可扩展的两步法，其导致β-位于化合物的α-端基异构体形式的优势。可选的第三步可用于制备所需的β-L-2'-脱氧核苷的3'-前药，用于递送有效治疗病毒性疾病的这些药物。合成方法特别适用于形成β-L-2'-脱氧胞苷，其药学上可接受的盐或前药。该方法可以提供可能不需要进一步分离或纯化的相对未污染的产品，从而使合成容易扩展到工业制造。

8. 发明授权

US08044091B2 Phospho-indoles as HIV inhibitors 有权
标题翻译：磷酸吲哚作为HIV抑制剂
公开(公告)号：US08044091B2
公开(公告)日：2011-10-25
申请号：US12275510
申请日：2008-11-21
申请人： Richard Storer , Cyril Dousson , Francois-Rene Alexandre , Arlene Roland
发明人： Richard Storer , Cyril Dousson , Francois-Rene Alexandre , Arlene Roland
IPC分类号： A61K31/40 , C07F9/28
CPC分类号： C07F9/65586 , C07F9/5728 , C07F9/65583
摘要： 3-phosphoindole compounds for the treatment of retroviral infections, and particularly for HIV, are described. Also included are compositions comprising the 3-phosphoindole derivatives alone or in combination with one or more other anti-retroviral agents, processes for their preparation, and methods of manufacturing a medicament incorporating these compounds.
摘要翻译：描述了用于治疗逆转录病毒感染，特别是HIV的3-磷酸吲哚化合物。还包括包含单独的3-磷酸吲哚衍生物或与一种或多种其它抗逆转录病毒剂组合的组合物，其制备方法和制备并入这些化合物的药物的方法。

9. 发明申请

US20110195932A1 Drug Combinations for the Treatment of Duchenne Muscular Dystrophy 有权
标题翻译：药物组合治疗杜氏肌营养不良症
公开(公告)号：US20110195932A1
公开(公告)日：2011-08-11
申请号：US12600242
申请日：2008-08-01
申请人： Graham Michael Wynne , Stephen Paul Wren , Peter David Johnson , Paul Damien Price , Olivier De Moor , Gary Nugent , Richard Storer , Richard Joseph Pye , Colin Richard Dorgan
发明人： Graham Michael Wynne , Stephen Paul Wren , Peter David Johnson , Paul Damien Price , Olivier De Moor , Gary Nugent , Richard Storer , Richard Joseph Pye , Colin Richard Dorgan
IPC分类号： A61K31/675 , C07D307/79 , A61K31/343 , C07D209/08 , A61K31/4045 , C07D277/66 , A61K31/428 , C07D235/04 , A61K31/4184 , C07D263/58 , A61K31/423 , C07D413/02 , A61K31/5377 , C07F9/653 , A61K31/573 , A61K31/58 , A61P21/00
CPC分类号： A61K31/573 , A61K31/423 , A61K45/06 , C07D263/58 , A61K2300/00
摘要： Combinations comprising (or consisting essentially of) one or more compounds of formula (1) with one or more ancillary agents, to processes for preparing the combinations, and to various therapeutic uses of the combinations. Also provided are pharmaceutical compositions containing the combinations as well as a method of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia using the combinations.
摘要翻译：包含（或基本上由）一种或多种式（1）化合物与一种或多种辅助试剂组合的组合，以及组合的各种治疗用途。还提供了含有组合的药物组合物以及使用这些组合治疗杜氏肌营养不良症，贝克肌营养不良症或恶病质的方法。

10. 发明申请

US20100279974A1 Nucleosides With Non-Natural Bases as Anti-Viral Agents 审中-公开
标题翻译：非天然碱作为抗病毒剂的核苷
公开(公告)号：US20100279974A1
公开(公告)日：2010-11-04
申请号：US11885898
申请日：2006-03-09
申请人： Claire Pierra , Jean-Francois Griffon , Richard Storer , Gilles Gosselin
发明人： Claire Pierra , Jean-Francois Griffon , Richard Storer , Gilles Gosselin
IPC分类号： A61K31/70 , C07H19/23 , C07H19/048 , C07H19/12 , A61P31/12
CPC分类号： A61K31/706 , C07H19/04
摘要： A method and composition for treating a host infected with flavivirus, pestivirus or hepacivirus comprising administering an effective flavivirus, pestivirus or hepacivirus treatment amount of a described base-modified nucleoside or a pharmaceutically acceptable salt or prodrug thereof, is provided.
摘要翻译：提供用于治疗感染黄病毒，瘟病毒或肝炎病毒的宿主的方法和组合物，其包括施用有效的黄病毒，瘟病毒或肝炎病毒处理量的所述碱基修饰的核苷或其药学上可接受的盐或前药。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式