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1. 发明申请

US20110257741A1 IMPLANTS AND METHODS FOR RESHAPING HEART VALVES 审中-公开
标题翻译：用于修复心脏瓣膜的植入物和方法
公开(公告)号：US20110257741A1
公开(公告)日：2011-10-20
申请号：US13088189
申请日：2011-04-15
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian , Michael R. Henson , Richard S. Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian , Michael R. Henson , Richard S. Rhee , Steven C. Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. In certain embodiments, magnetic tissue shaping devices are implanted in tissue adjacent heart valve leaflets. The devices are mutually attractive or repulsive so as to remodel the heart tissue and improve heart valve function. In certain other embodiments, one or more tissue shaping devices including shape memory material are implanted in a patient's body within or on tissue adjacent a heart valve leaflet. The shape memory material can be activated within the patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The shape memory tissue shaping devices are implanted in a first configuration and then activated to remember a second configuration that displaces tissue so as to remodel the heart valve geometry and improve heart valve function. In certain other embodiments, a brace is crimped to the base of a heart valve leaflet to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。在某些实施例中，将磁组织成形装置植入在心脏瓣膜小叶附近的组织中。这些装置是相互吸引或排斥的，以便改造心脏组织并改善心脏瓣膜功能。在某些其他实施例中，包括形状记忆材料的一个或多个组织成形装置植入在心脏瓣膜附近的组织内或组织附近的患者体内。形状记忆材料可以以较少侵入性或非侵入性方式在患者体内被激活，例如通过经皮或外部施加能量到患者身体。形状记忆组织成形装置以第一配置植入，然后被激活以记住置换组织的第二配置，以便改造心脏瓣膜几何形状并改善心脏瓣膜功能。在某些其他实施例中，支架卷曲到心脏瓣膜小叶的底部以支撑小叶并改善瓣膜关闭。

2. 发明授权

US07377941B2 Adjustable cardiac valve implant with selective dimensional adjustment 有权
标题翻译：可调心脏瓣膜植入物，具有选择性尺寸调整
公开(公告)号：US07377941B2
公开(公告)日：2008-05-27
申请号：US11124405
申请日：2005-05-06
申请人： Richard S. Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel M. Shaolian
发明人： Richard S. Rhee , Emanuel Shaoulian , Shahram Moaddeb , Samuel M. Shaolian
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入方式在装置体内调节装置。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

3. 发明申请

US20100081868A1 SHAPE MEMORY DEVICES AND METHODS FOR RESHAPING HEART ANATOMY 审中-公开
标题翻译：形状记忆装置和用于重建心脏解剖的方法
公开(公告)号：US20100081868A1
公开(公告)日：2010-04-01
申请号：US12567532
申请日：2009-09-25
申请人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

4. 发明授权

US07594887B2 Shape memory devices and methods for reshaping heart anatomy 失效
标题翻译：形状记忆装置和重塑心脏解剖的方法
公开(公告)号：US07594887B2
公开(公告)日：2009-09-29
申请号：US11876586
申请日：2007-10-22
申请人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

5. 发明申请

US20080215145A1 CARDIAC VALVE IMPLANT WITH ENERGY ABSORBING MATERIAL 有权
标题翻译：具有能量吸收材料的心脏瓣膜植入物
公开(公告)号：US20080215145A1
公开(公告)日：2008-09-04
申请号：US12032476
申请日：2008-02-15
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施方案中，所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。能量吸收增强材料与所述形状记忆材料热连通。主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸，并且构造成以第一构造植入心脏。身体构件被配置为响应于激活能量从第一配置变换到第二配置。第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。

6. 发明授权

US07361190B2 Adjustable cardiac valve implant with coupling mechanism 有权
标题翻译：可调节心脏瓣膜植入物与联接机构
公开(公告)号：US07361190B2
公开(公告)日：2008-04-22
申请号：US11123851
申请日：2005-05-06
申请人： Emanuel Shaoulian , Samuel M. Shaolian , Shahram Moaddeb
发明人： Emanuel Shaoulian , Samuel M. Shaolian , Shahram Moaddeb
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a tubular member configured to be attached to or near a cardiac valve annulus. The tubular member includes a receptacle end and an insert end configured to couple with the receptacle end of the tubular member such that the tubular member substantially forms a shape of a ring. The insert end is configured to move with respect to the receptacle end to change a circumference of the ring.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，这些装置包括构造成附接到心脏瓣膜环上或附近的管状构件。管状构件包括容置端和插入端，所述插入端构造成与管状构件的容置端相连，使得管状构件基本上形成环的形状。插入端构造成相对于插座端移动以改变环的圆周。

7. 发明授权

US07285087B2 Shape memory devices and methods for reshaping heart anatomy 有权
标题翻译：形状记忆装置和重塑心脏解剖的方法
公开(公告)号：US07285087B2
公开(公告)日：2007-10-23
申请号：US11142078
申请日：2005-05-31
申请人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Samuel M. Shaolian , Emanuel Shaoulian , Richard Rhee , Steven C. Anderson
IPC分类号： A61F2/00
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译：提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。形状记忆元件具有原始形状和至少一种存储器形状。当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。元件然后被激活以从原始形状转换到至少一个存储器形状之一。元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。

8. 发明申请

US20110257740A1 SELECTIVELY ADJUSTABLE CARDIAC VALVE IMPLANTS 审中-公开
标题翻译：选择性可调节的心脏瓣膜植入物
公开(公告)号：US20110257740A1
公开(公告)日：2011-10-20
申请号：US13079429
申请日：2011-04-04
申请人： Emanuel Shaoulian , Shahram Moaddeb , Samuel M. Shaolian
发明人： Emanuel Shaoulian , Shahram Moaddeb , Samuel M. Shaolian
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a first body member including a first shape memory material configured to transform the annuloplasty ring from a first configuration having a first size of a dimension to a second configuration having a second size of the dimension. The second size is less than said first size in septal lateral distance. The devices also include a second body member including a second shape memory material configured to transform the annuloplasty ring from the second configuration to a third configuration having a third size of the dimension, wherein the second size is less than the third size in septal lateral distance.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，所述装置包括第一主体构件，所述第一主体构件包括第一形状记忆材料，所述第一形状记忆材料构造成将瓣膜成形术环从具有尺寸的第一尺寸的第一构型转换成具有尺寸的第二尺寸的第二构型。第二尺寸小于所述第一尺寸在间隔侧向距离。所述装置还包括第二主体构件，所述第二主体构件包括第二形状记忆材料，所述第二形状记忆材料构造成将瓣膜成形术环从第二构型转换成具有尺寸的第三尺寸的第三构型，其中第二尺寸小于第三尺寸的间隔横向距离。

9. 发明授权

US07722668B2 Cardiac valve implant with energy absorbing material 有权
标题翻译：带能量吸收材料的心脏瓣膜植入物
公开(公告)号：US07722668B2
公开(公告)日：2010-05-25
申请号：US12032476
申请日：2008-02-15
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian
IPC分类号： A61F2/06
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施方案中，所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。能量吸收增强材料与所述形状记忆材料热连通。主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸，并且构造成以第一构造植入心脏。身体构件被配置为响应于激活能量从第一配置变换到第二配置。第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。

10. 发明授权

US07510577B2 Adjustable cardiac valve implant with ferromagnetic material 有权
标题翻译：可调心脏瓣膜植入物与铁磁材料
公开(公告)号：US07510577B2
公开(公告)日：2009-03-31
申请号：US11124408
申请日：2005-05-06
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a ferromagnetic shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration. The body member is configured to be implanted into a heart so as to reinforce a cardiac valve annulus in the first configuration. The body member is configured to transform from the first configuration to the second configuration in vivo in response to a magnetic field. The body member in the second configuration is configured to reduce a size of the cardiac valve annulus.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括包括铁磁形状记忆材料的主体构件。主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸。身体构件被配置成植入心脏中，以便在第一构型中加强心脏瓣膜环。身体构件被配置为响应于磁场在体内从第一配置转变为第二配置。第二构造中的本体构件被构造成减小心脏瓣膜环的尺寸。

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