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1. 发明授权

US08858961B2 Compositions containing alpha-2-adrenergic agonist components 有权
标题翻译：含有α-2-肾上腺素能激动剂组分的组合物
公开(公告)号：US08858961B2
公开(公告)日：2014-10-14
申请号：US12482783
申请日：2009-06-11
申请人： Richard S. Graham , Peter G. Bakhit , Orest Olejnik
发明人： Richard S. Graham , Peter G. Bakhit , Orest Olejnik
IPC分类号： A61K9/00 , A61K31/715 , A61K31/498 , A61K31/734 , A61K31/716 , A61K47/32 , A61K31/78 , A61K47/38
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/498 , A61K31/715 , A61K31/716 , A61K31/734 , A61K31/78 , A61K47/02 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.
摘要翻译：可用于改善α-2-肾上腺素能激动剂组分的有效性的组合物包括载体组分，α-2-肾上腺素能激动剂组分，有助于增溶α-2-肾上腺素能激动剂组分的溶解度增强组分。在一个实施方案中，α-2-肾上腺素能激动剂组分包括α-2-肾上腺素能激动剂。在另一个实施方案中，增溶溶解成分包括羧甲基纤维素。

2. 发明申请

US20090312337A1 COMPOSITIONS CONTAINING ALPHA-2-ADRENERGIC AGONIST COMPONENTS 有权
标题翻译：含有ALPHA-2-ADRENERGIC AGONIST COMPONENTS的组合物
公开(公告)号：US20090312337A1
公开(公告)日：2009-12-17
申请号：US12482783
申请日：2009-06-11
申请人： Richard S. Graham , Peter G. Bakhit , Orest Olejnik
发明人： Richard S. Graham , Peter G. Bakhit , Orest Olejnik
IPC分类号： A61K31/498 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/498 , A61K31/715 , A61K31/716 , A61K31/734 , A61K31/78 , A61K47/02 , A61K47/32 , A61K47/38 , A61K2300/00
摘要： Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.
摘要翻译：可用于改善α-2-肾上腺素能激动剂组分的有效性的组合物包括载体组分，α-2-肾上腺素能激动剂组分，有助于增溶α-2-肾上腺素能激动剂组分的溶解度增强组分。在一个实施方案中，α-2-肾上腺素能激动剂组分包括α-2-肾上腺素能激动剂。在另一个实施方案中，增溶溶解成分包括羧甲基纤维素。

3. 发明授权

US07244768B2 Compositions and methods comprising prostaglandin related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia 失效
标题翻译：包含前列腺素相关化合物和三叶因子家族肽用于治疗青光眼与降低充血的组合物和方法
公开(公告)号：US07244768B2
公开(公告)日：2007-07-17
申请号：US10521367
申请日：2004-08-25
申请人： Peter G. Bakhit , Richard Graham , Orest Olejnik
发明人： Peter G. Bakhit , Richard Graham , Orest Olejnik
IPC分类号： A61K31/165 , A61K31/00
CPC分类号： A61K38/17 , A61K31/557 , A61K31/5575 , A61K31/715 , A61K38/1709 , A61K2300/00
摘要： Compositions, methods, and pharmaceutical products related to prostaglandin-related compounds and trefoil factor family peptides are disclosed herein. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence of hyperemia.
摘要翻译：本文公开了与前列腺素相关化合物和三叶因子家族肽相关的组合物，方法和药物产品。特别感兴趣的是用于治疗青光眼的组合物和方法，其中发生充血发生。

4. 发明授权

US07332526B2 Compositions and methods comprising prostaglandin-related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia 失效
标题翻译：包含前列腺素相关化合物和三叶因子家族肽的组合物和方法用于治疗青光眼，减少充血
公开(公告)号：US07332526B2
公开(公告)日：2008-02-19
申请号：US11761498
申请日：2007-06-12
申请人： Peter G. Bakhit , Richard Graham , Orest Olejnik
发明人： Peter G. Bakhit , Richard Graham , Orest Olejnik
IPC分类号： A01N31/00 , A61K38/00
CPC分类号： A61K38/17 , A61K31/557 , A61K31/5575 , A61K31/715 , A61K38/1709 , A61K2300/00
摘要： Compositions, methods, and pharmaceutical products related to prostaglandin-related compounds and trefoil factor family peptides are disclosed herein. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence of hyperemia.
摘要翻译：本文公开了与前列腺素相关化合物和三叶因子家族肽相关的组合物，方法和药物产品。特别感兴趣的是用于治疗青光眼的组合物和方法，其中发生充血发生。

5. 发明授权

US06984628B2 Ophthalmic compositions comprising trefoil factor family peptides 有权
标题翻译：包含三叶因子家族肽的眼科组合物
公开(公告)号：US06984628B2
公开(公告)日：2006-01-10
申请号：US10621053
申请日：2003-07-15
申请人： Peter G. Bakhit , Orest Olejnik , Richard Graham
发明人： Peter G. Bakhit , Orest Olejnik , Richard Graham
IPC分类号： A61K38/02 , A61K38/17
CPC分类号： A61K36/47 , A61K31/715 , A61K35/30 , A61K36/48 , A61K38/13 , A61K38/1841 , A61K38/22 , A61K2300/00
摘要： This invention relates to compositions comprising trefoil family factor peptides which are useful in preventing or treating dry eye by topical administration of the composition to eye of the patient. One aspect of this invention relates to topical ophthalmic compositions comprising a trefoil factor family peptide, and preferably, a mucoadhesive component, as described herein. Another aspect of this invention relates to the use of these compositions to treat or prevent dry eye in a patient.
摘要翻译：本发明涉及包含三叶片家族因子肽的组合物，其可用于通过将组合物局部施用于患者眼睛来预防或治疗干眼症。本发明的一个方面涉及如本文所述的包含三叶因子家族肽，优选粘膜粘附成分的局部眼用组合物。本发明的另一方面涉及这些组合物在患者体内治疗或预防干眼症的用途。

6. 发明授权

US08257730B2 Steroid-containing sustained release intraocular implants and related methods 有权
标题翻译：类固醇持续释放眼内植入物及相关方法
公开(公告)号：US08257730B2
公开(公告)日：2012-09-04
申请号：US11118288
申请日：2005-04-29
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61K9/0092 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.
摘要翻译：生物相容性眼内植入物包括彼此相关的类固醇和聚合物，以促进类固醇进入眼睛大于约两个月的时间。类固醇可以与可生物降解的聚合物基质相关联，例如两种可生物降解聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。植入物可以放置在眼睛中以治疗一种或多种眼睛状况。类固醇从植入物中释放超过约两个月，可能会释放超过几年。

7. 发明授权

US08007828B2 Stabilized biodegradable neurotoxin implants 有权
标题翻译：稳定的生物降解神经毒素植入物
公开(公告)号：US08007828B2
公开(公告)日：2011-08-30
申请号：US12577114
申请日：2009-10-09
申请人： Patrick M. Hughes , Orest Olejnik
发明人： Patrick M. Hughes , Orest Olejnik
IPC分类号： A61K9/14
CPC分类号： A61K9/0024 , A61K9/0051 , A61K9/204 , A61K38/4893
摘要： Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time.
摘要翻译：提供了可生物降解的神经毒素植入物和制造和使用这种植入物的方法。可生物降解的神经毒素植入物包括神经毒素，可生物降解的聚合物组分和酸度调节组分。当植入物位于患者体内时，可生物降解的聚合物组分有效地控制来自植入物的神经毒素的释放。酸性调节组分有效地将植入物的pH保持在期望的范围内，当植入物位于患者体内时，当植入物生物降解时，稳定神经毒素是有效的。在一个实施方案中，植入物包括肉毒杆菌毒素，可生物降解聚合物，以及衍生生物可降解聚合物的单体或包含单体单元的寡聚物，所述单体基本上与衍生可生物降解聚合物的单体相同，或这些单体和低聚物。低聚物和可生物降解的聚合物可以衍生自单一类型的单体。本文公开的植入物可以施用于需要长时间治疗效果的人或动物患者。

8. 发明申请

US20100222587A1 COMPOSITIONS AND METHODS FOR THE INTRAOCULAR TRANSPORT OF THERAPEUTIC AGENTS 有权
标题翻译：治疗药物内分泌运输的组合物和方法
公开(公告)号：US20100222587A1
公开(公告)日：2010-09-02
申请号：US12730102
申请日：2010-03-23
申请人： Patrick M. HUGHES , Orest Olejnik , Joan-En Chang-Lin
发明人： Patrick M. HUGHES , Orest Olejnik , Joan-En Chang-Lin
IPC分类号： C07D403/12
CPC分类号： A61K31/557 , A61K9/0048 , A61K31/498 , A61K31/513 , A61K47/542 , A61K47/549 , A61K47/55 , A61K47/551 , A61K47/64
摘要： Membrane transporter-targeted therapeutic agents and methods of making and using the same.
摘要翻译：膜转运体靶向治疗剂及其制备和使用方法。

9. 发明申请

US20080145407A1 METHODS FOR REDUCING NEOVASCULARIZATION OR EDEMA 审中-公开
标题翻译：减少新生血管或EDEMA的方法
公开(公告)号：US20080145407A1
公开(公告)日：2008-06-19
申请号：US11932373
申请日：2007-10-31
申请人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
发明人： Glenn T. Huang , Thierry Nivaggioli , Lon T. Spada , Hiroshi Sugimoto , Wendy M. Blanda , James N. Chang , Orest Olejnik
IPC分类号： A61F2/16 , A61K31/56 , A61P27/02
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0024 , A61K9/0092 , A61K9/1647 , A61K9/204 , A61K31/5377 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/593 , A61L27/18 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/222 , A61L2300/436 , A61L2300/45 , A61L2300/604 , A61L2430/16 , A61K2300/00 , C08L67/04
摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.
摘要翻译：生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

10. 发明申请

US20080070834A1 Cyclosporin Compositions 有权
标题翻译：环孢菌素组合物
公开(公告)号：US20080070834A1
公开(公告)日：2008-03-20
申请号：US11940652
申请日：2007-11-15
申请人： James Chang , Orest Olejnik , Bruce Firestone
发明人： James Chang , Orest Olejnik , Bruce Firestone
IPC分类号： A61K38/13 , A61P27/02
CPC分类号： A61K47/44 , A61K9/0048 , A61K9/107 , A61K38/13 , Y10S514/912 , Y10S514/975
摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.
摘要翻译：本文公开了包含约0.001％至约0.4％的环孢菌素A，表面活性剂和比重为0.8至0.95的油的组合物。

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