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1. 发明授权

US08758400B2 Closure system and methods of use 有权
标题翻译：封闭系统和使用方法
公开(公告)号：US08758400B2
公开(公告)日：2014-06-24
申请号：US12941809
申请日：2010-11-08
申请人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
发明人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/0643 , A61B17/1285 , A61B18/148 , A61B2017/00623 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/00986 , A61B2017/081 , A61B2018/00595 , A61B2018/0063
摘要： An apparatus for sealing a passage through tissue communicating with a body lumen is provided. The apparatus includes an elongate member having a proximal end a distal end and a lumen extending from the distal end toward the proximal end defining a longitudinal axis. A plug member is disposed on the distal end and extends distally from the elongate member in a pre-deployed and deployed configuration. The plug member includes a distal port therein in communication with the lumen and has a cross-sectional diameter at a plug proximal end and a plug distal end greater than a cross-sectional diameter of the distal end of the elongate member in the pre-deployed configuration. The apparatus also includes a member extendable distally from the distal port, the member including a proximal end and a distal end.
摘要翻译：提供了一种用于密封通过与体腔连通的组织的通道的装置。所述装置包括细长构件，所述细长构件具有近端，远端和从远端朝向限定纵向轴线的近端延伸的内腔。插塞构件设置在远端上并且以预先展开和展开的构型从细长构件向远侧延伸。插塞构件包括其中与内腔连通的远端端口，并且在插塞近端处具有截面直径，并且塞子远端大于预先部署的细长构件的远端的横截面直径组态。该装置还包括从远端端口向远端延伸的构件，该构件包括近端和远端。

2. 发明授权

US09579091B2 Closure system and methods of use 有权
标题翻译：封闭系统和使用方法
公开(公告)号：US09579091B2
公开(公告)日：2017-02-28
申请号：US11396731
申请日：2006-04-03
申请人： Richard S. Ginn , William N. Aldrich , W. Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony Pantages , Javier Sagastegui , Janina Sagastegui
发明人： Richard S. Ginn , William N. Aldrich , W. Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony Pantages , Javier Sagastegui
IPC分类号： A61B17/08 , A61B17/00 , A61B17/064
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0643 , A61B17/083 , A61B2017/00637 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641
摘要： A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.
摘要翻译：提供封闭系统和使用方法用于密封诸如血管穿刺部位的身体组织中的开口。可以在具有闭合夹的封闭系统中执行关闭身体组织中的开口的方法。该方法可以包括将闭合夹定位在与身体组织中的开口相邻的第一闭合夹具位置中，使得闭合夹的多个尖峰在从开口的中心轴线向外的位置插入到组织中。随后，闭合夹可以被定位在第二闭合夹夹位置中，使得多个钉被向内朝向开口的中心轴线向内拉，以便将开口和每个钉之间的组织拉到一起并关闭开口。

3. 发明授权

US06846319B2 Devices for sealing openings through tissue and apparatus and methods for delivering them 有权
标题翻译：用于通过组织和装置密封开口的装置和用于传送它们的方法
公开(公告)号：US06846319B2
公开(公告)日：2005-01-25
申请号：US09738431
申请日：2000-12-14
申请人： Richard S. Ginn , Stephen M. Salmon , Ronald J. Jabba
发明人： Richard S. Ginn , Stephen M. Salmon , Ronald J. Jabba
IPC分类号： A61B10/00 , A61B17/00 , A61B17/08
CPC分类号： A61B17/0057 , A61B2010/0003 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00898
摘要： An apparatus for sealing a passage through tissue includes an elongate shaft and a cylindrical plug disposed on a distal end of the shaft, the plug including a helical thread on its outer surface. Intestinal submucosa may be secured to the plug, e.g., in a cavity in its distal end, that may be delivered into the passage. Alternatively, the plug may be formed from a bioabsorbable material and may be released from the shaft within the passage. The plug is threaded into the passage, thereby engaging the tissue to seal the passage. The shaft is rotated until it engages a blood vessel within the tissue while monitoring blood flow through the vessel. The shaft is rotated to thread the plug into the passage until blood flow ceases through the vessel, whereupon rotation of the shaft is reversed to back the plug until blood flow through the vessel resumes.
摘要翻译：用于密封通过组织的通道的装置包括细长轴和设置在轴的远端上的圆柱塞，该塞在其外表面上包括螺旋形螺纹。肠粘膜下层可以固定到栓塞，例如在其远端的空腔中，其可以被输送到通道中。或者，插塞可以由生物可吸收材料形成，并且可以在通道内从轴释放。塞子被拧入通道中，从而接合组织以密封通道。旋转轴直到其与组织内的血管接合，同时监测通过血管的血流。轴被旋转以将塞子螺纹连接到通道中，直到血流停止通过血管，由此轴的旋转被反向以回到塞子，直到通过血管的血液流动恢复。

4. 发明申请

US20110106148A1 CLOSURE SYSTEM AND METHODS OF USE 有权
标题翻译：封闭系统及其使用方法
公开(公告)号：US20110106148A1
公开(公告)日：2011-05-05
申请号：US12941809
申请日：2010-11-08
申请人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
发明人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
IPC分类号： A61B17/00
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/0643 , A61B17/1285 , A61B18/148 , A61B2017/00623 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/00986 , A61B2017/081 , A61B2018/00595 , A61B2018/0063
摘要： A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.
摘要翻译：提供封闭系统和使用方法用于密封诸如血管穿刺部位的身体组织中的开口。可以在具有闭合夹的封闭系统中执行关闭身体组织中的开口的方法。该方法可以包括将闭合夹定位在与身体组织中的开口相邻的第一闭合夹具位置中，使得闭合夹的多个尖峰在从开口的中心轴线向外的位置插入到组织中。随后，闭合夹可以被定位在第二闭合夹夹位置中，使得多个钉被向内朝向开口的中心轴线向内拉，以便将开口和每个钉之间的组织拉到一起并关闭开口。

5. 发明授权

US07828817B2 Apparatus and methods for delivering a closure device 有权
标题翻译：用于传送闭合装置的装置和方法
公开(公告)号：US07828817B2
公开(公告)日：2010-11-09
申请号：US11198811
申请日：2005-08-04
申请人： W. Martin Belef , William N. Aldrich , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony Pantages , Javier Sagastegui
发明人： W. Martin Belef , William N. Aldrich , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony Pantages , Javier Sagastegui
IPC分类号： A61B17/08
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/128 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641
摘要： An apparatus for delivering a clip to close an opening through tissue includes a sheath and a carrier assembly including a clip therein that is slidable on the sheath. An actuator assembly is connectable to the sheath, and telescoping actuator members extend from the handle that are connectable to the carrier assembly for advancing the carrier assembly along the sheath. An obturator on the actuator assembly includes splines that may be deployed beyond a distal end of the sheath, and expanded to a transverse expanded configuration for positioning the sheath before deploying the clip. The actuator members include cooperating detents that selectively release the actuator members as the carrier assembly reaches predetermined positions along the sheath for deploying the clip from the carrier assembly, and that collapse the splines to allow removal of the apparatus after deploying the clip.
摘要翻译：用于递送夹子以封闭通过组织的开口的装置包括护套和载体组件，其包括可在护套上滑动的夹子。致动器组件可连接到护套，并且可伸缩的致动器构件从手柄延伸，所述手柄可连接到托架组件，用于沿着护套推进托架组件。致动器组件上的密封件包括可以部署在鞘的远端之外的花键，并且在展开夹子之前扩展成横向扩展构型以定位护套。致动器构件包括配合的棘爪，当托架组件沿着护套到达预定位置时，选择性地释放致动器构件，用于将夹子从承载器组件展开，并且在使用夹子之后使花键折叠以允许移除装置。

6. 发明授权

US06942674B2 Apparatus and methods for delivering a closure device 有权
公开(公告)号：US06942674B2
公开(公告)日：2005-09-13
申请号：US10081723
申请日：2002-02-21
申请人： W. Martin Belef , William N. Aldrich , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony Pantages , Javier Sagastegui
发明人： W. Martin Belef , William N. Aldrich , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony Pantages , Javier Sagastegui
IPC分类号： A61B17/00 , A61B17/064 , A61B17/08 , A61B17/128 , A61B19/00 , A61B17/10
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/128 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641
摘要： An apparatus for delivering a clip to close an opening through tissue includes a sheath and a carrier assembly including a clip therein that is slidable on the sheath. An actuator assembly is connectable to the sheath, and telescoping actuator members extend from the handle that are connectable to the carrier assembly for advancing the carrier assembly along the sheath. An obturator on the actuator assembly includes splines that may be deployed beyond a distal end of the sheath, and expanded to a transverse expanded configuration for positioning the sheath before deploying the clip. The actuator members include cooperating detents that selectively release the actuator members as the carrier assembly reaches predetermined positions along the sheath for deploying the clip from the carrier assembly, and that collapse the splines to allow removal of the apparatus after deploying the clip.

7. 发明授权

US5443457A Tracking tip for a short lumen rapid exchange catheter 失效
标题翻译：短管快速交换导管的跟踪尖端
公开(公告)号：US5443457A
公开(公告)日：1995-08-22
申请号：US201101
申请日：1994-02-24
申请人： Richard S. Ginn , Stephen M. Salmon
发明人： Richard S. Ginn , Stephen M. Salmon
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02
CPC分类号： A61M25/0102 , A61M25/0068 , A61M2025/0063 , A61M2025/0183 , A61M25/008
摘要： A catheter system includes a catheter sheath and a flexible working shaft within a working lumen of the sheath. The sheath includes a monorail-type guidewire lumen at its distal end, and a stiffening member is provided adjacent a side port of the monorail guidewire lumen to inhibit prolapse of the catheter as it is introduced past a bend or curve over a guidewire. In a first embodiment, the stiffening member may be secured directly within a working lumen of the catheter body. In a second embodiment, the stiffening member may be attached to a distal end of the working shaft, typically an imaging core.
摘要翻译：导管系统包括在护套的工作腔内的导管鞘和柔性工作轴。护套在其远端包括单轨型导丝管腔，并且在单轨导丝管腔的侧端附近设置加强构件，以在导管穿过导丝线的弯曲或曲线时抑制导管的脱垂。在第一实施例中，加强构件可以直接固定在导管主体的工作腔内。在第二实施例中，加强构件可以附接到工作轴的远端，通常是成像芯。

8. 发明授权

US06663655B2 Apparatus and methods for sealing vascular punctures 失效
标题翻译：用于密封血管穿刺的装置和方法
公开(公告)号：US06663655B2
公开(公告)日：2003-12-16
申请号：US09866548
申请日：2001-05-25
申请人： Richard S. Ginn , Stephen M. Salmon
发明人： Richard S. Ginn , Stephen M. Salmon
IPC分类号： A61B1708
CPC分类号： A61B17/0057 , A61B2010/0003 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00898
摘要： An apparatus for sealing a passage through tissue includes a bioabsorbable body disposed on a distal end of a handle device. The plug member includes a helical thread on its outer surface and the plug member and handle device include cooperating lumens communicating with a distal port. A sealing member is disposed within the plug member lumen. An obturator is inserted through the lumens until its distal tip extends beyond the plug member, the distal tip including a bleed back port. The plug member is threaded into a passage towards a blood vessel until the bleed back indicator identifies the location of the vessel with respect to the plug member. The plug member is released from the handle device, the handle device and obturator are withdrawn, and the sealing member seals the lumen. The plug member is left within the passage to seal the passage until the tissue heals.
摘要翻译：用于密封通过组织的通道的装置包括设置在手柄装置的远端上的生物可吸收体。插塞构件在其外表面上包括螺旋形螺纹，并且插塞构件和手柄装置包括与远端端口连通的配合腔。密封构件设置在塞构件内腔内。通过腔管插入一个闭孔器，直到其远端尖端延伸超出插塞部件，远侧末端包括一个排出口。塞子构件被拧入到血管的通道中，直到排泄指示器识别血管相对于塞子构件的位置。塞子构件从手柄装置释放，手柄装置和闭塞器被抽出，并且密封构件密封内腔。插塞构件留在通道内以密封通道，直到组织愈合。

9. 发明授权

US5935114A Rapid exchange delivery catheter 失效
标题翻译：快速交换导管
公开(公告)号：US5935114A
公开(公告)日：1999-08-10
申请号：US762468
申请日：1996-12-09
申请人： Yue-Teh Jang , Richard S. Ginn , Stephen M. Salmon
发明人： Yue-Teh Jang , Richard S. Ginn , Stephen M. Salmon
IPC分类号： A61M25/00 , A61B17/22 , A61B19/00 , A61F2/06 , A61F2/84 , A61M25/01 , A61M29/02 , A61M5/00
CPC分类号： A61M25/0169 , A61F2/958 , A61B2017/22051 , A61B2090/3782 , A61M2025/0183 , A61M2025/0681 , A61M25/104
摘要： A catheter exchange member is provided for reducing exchange time when replacing one catheter (or similar device) with another in the vascular anatomy of a patient. The catheter exchange member includes a tubular body having a proximal and a distal end and a central lumen. A tapered fixture having a distal port and a proximal opening which is larger than the distal port is attached to the tubular body at the distal port. An elongate shaft is attached to and extends proximally from either the tapered fixture or the tubular body. The exchange member is preferably used within a conventional guiding catheter where the tubular body is advanced through a distal end of the guiding catheter and into the coronary artery while the tapered fixture remains in the guiding catheter. This configuration allows various therapeutic and diagnostic devices to be stored within the guiding catheter just proximal to the tapered fixture. One of the devices can be placed within the coronary artery by simply advancing it through the tapered fixture which channels the device into the tubular body and into the coronary artery. The device may be replaced with another by simply removing it and advancing the second device into the tapered fixture and into the coronary artery
摘要翻译：提供了一种导管更换构件，用于在将患者的血管解剖结构中的另一导管（或类似装置）替换为另一导管时减少交换时间。导管更换构件包括具有近端和远端以及中心腔的管状体。具有远端口和大于远端口的近端开口的锥形固定件在远端口处附接到管状体。细长轴连接到锥形夹具或管状体的近侧并从其延伸。交换构件优选地用在传统的导向导管内，其中管状体前进通过导向导管的远端并进入冠状动脉，同时锥形夹具保持在引导导管中。这种配置允许各种治疗和诊断装置被存储在紧邻锥形固定装置的引导导管内。其中一个装置可以通过简单地将其推进通过锥形固定器而放置在冠状动脉内，该锥形夹具将装置引导到管状体中并进入冠状动脉。该装置可以通过简单地将其移除并将第二装置推入锥形固定装置并进入冠状动脉来替换

10. 发明授权

US09492148B2 Apparatus and methods for sealing vascular punctures 有权
公开(公告)号：US09492148B2
公开(公告)日：2016-11-15
申请号：US10734929
申请日：2003-12-12
申请人： Richard S. Ginn , Stephen M. Salmon
发明人： Richard S. Ginn , Stephen M. Salmon
IPC分类号： A61B17/00 , A61B10/00
CPC分类号： A61B17/0057 , A61B2010/0003 , A61B2017/00004 , A61B2017/00637 , A61B2017/00654 , A61B2017/00672 , A61B2017/00898
摘要： An apparatus for sealing a passage through tissue includes a bioabsorbable body disposed on a distal end of a handle device. The plug member includes a helical thread on its outer surface and the plug member and handle device include cooperating lumens communicating with a distal port. A sealing member is disposed within the plug member lumen. An obturator is inserted through the lumens until its distal tip extends beyond the plug member, the distal tip including a bleed back port. The plug member is threaded into a passage towards a blood vessel until the bleed back indicator identifies the location of the vessel with respect to the plug member. The plug member is released from the handle device, the handle device and obturator are withdrawn, and the sealing member seals the lumen. The plug member is left within the passage to seal the passage until the tissue heals.

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