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1. 发明授权

US4503331A Non-circular emission computed tomography 失效
标题翻译：非圆形发射计算机断层扫描
公开(公告)号：US4503331A
公开(公告)日：1985-03-05
申请号：US370425
申请日：1982-04-21
申请人： Richard M. Kovacs, Jr. , Eugene J. Senger , Robert H. Wake
发明人： Richard M. Kovacs, Jr. , Eugene J. Senger , Robert H. Wake
IPC分类号： G01N23/04 , A61B6/02 , A61B6/03 , G01T1/164 , G01T1/166 , G01T1/29 , G01T1/20
CPC分类号： G01T1/1648 , A61B6/037 , G01T1/2985
摘要： A radiation imaging system including a rotatable scintillation detector for non-circular emission computed tomography. The radiation imaging system includes a rotatable scintillation detector and a linearly movable detector stand. With the stand stationary, the scintillation detector is capable of circularly orbiting about the longitudinal axis of the patient for emission computed tomography and with the detector stationary the detector stand may be linearly displaced for whole body scanning with the patient aligned parallel to the detector stand path in an orientation orthogonal to the tomographic orientation. The circular rotational motion is combined with the linear translation such that the detector orbits about a section of the patient in a non-circular path. The path assures a minimum distance between the face of the scintillation detector and the boundary of the patient during the entire tomographic orbit to thereby improve resolution of the tomogram.
摘要翻译：一种辐射成像系统，包括用于非圆形发射计算机断层摄影的可旋转闪烁检测器。放射线成像系统包括可旋转闪烁检测器和线性可移动检测器支架。在立体静止的情况下，闪烁检测器能够围绕患者的纵向轴线循环发射计算机断层摄影，并且随着检测器静止，检测器支架可以线性位移，以使患者平行于检测器支架路径对准整个身体扫描在与断层摄影取向正交的方向上。圆形旋转运动与线性平移组合，使得检测器围绕患者的一部分以非圆形路径运动。所述路径确保在整个断层摄影轨道期间闪烁检测器的面部与患者的边界之间的最小距离，从而提高断层图像的分辨率。

2. 发明授权

US4426578A Support structure for rotatable scintillation detector 失效
标题翻译：可旋转闪烁探测器的支撑结构
公开(公告)号：US4426578A
公开(公告)日：1984-01-17
申请号：US195269
申请日：1980-10-08
申请人： James M. Bradcovich , Robert H. Wake , Richard M. Kovacs, Jr. , Carlos D. Pinkstaff
发明人： James M. Bradcovich , Robert H. Wake , Richard M. Kovacs, Jr. , Carlos D. Pinkstaff
IPC分类号： A61B6/00 , G01T1/164 , G01T1/20
CPC分类号： A61B6/4441 , A61B6/447 , G01T1/1648
摘要： A curved beam apparatus adapted for mounting thereon a scintillation detector. The apparatus comprises a circular C-arm which is balanced with a counterweight at one end and a scintillation detector pivotally mounted by means of a yoke at the other end. The C-arm is mounted in a carrier member which in turn is attached to a base. The carrier member is rotatable about an axis passing through its center. In addition, the C-arm rotates circumferentially along a plane defined by the shape of the C-arm and intersecting said axis. The combination of the rotation of the C-arm and the rotation of the carrier member permits the scintillation detector to be quickly and easily manually positioned to any desired location on an imaginary sphere surrounding a portion of patient to be examined.
摘要翻译：适用于安装闪烁检测器的弯曲光束装置。该装置包括圆形C形臂，其在一端与配重平衡，并且在另一端通过轭架枢转地安装闪烁检测器。 C形臂安装在承载构件中，该承载构件又附接到基座。承载构件可以绕穿过其中心的轴线旋转。此外，C形臂沿着由C形臂的形状限定并与所述轴相交的平面沿周向旋转。 C臂的旋转和载体构件的旋转的组合允许快速且容易地将闪烁检测器手动定位到围绕待检查患者的一部分的假想球上的任何期望位置。

3. 发明授权

US5068808A Imager and process 失效
标题翻译：成像仪和过程
公开(公告)号：US5068808A
公开(公告)日：1991-11-26
申请号：US274912
申请日：1988-11-22
申请人： Robert H. Wake
发明人： Robert H. Wake
IPC分类号： G06T15/40
CPC分类号： G06T15/405
摘要： An apparatus and process for the flexible and rapid manipulation of multidimensional data is disclosed. Coordinates ae transformed by the use of a plurality of transform memories, each being addressable by a coordinate of an n-tuple. Each member provides an intermediate value that when added to others provides a transformed coordinate. This eliminates the need for high-speed multipliers. The transform memories are additionally addressable by flags and tags associated with the location, attribute or object of interest. Different transformations take place depending on the values of the flags and tags. This allows flexible manipulation of the data. Z-buffering is done at high speed in parallel with the results being combined in efficient combiner circuits. In addition, this parallel operation permits the transformations themselves to be done in parallel. By adding a selectable adder to the input of the z-buffers, normal z-buffer operation may be selected or a radiographic mode utilizing the entire width of the z-buffer to hold an accumulated intensity may be selected.
摘要翻译：公开了用于灵活和快速操纵多维数据的装置和过程。通过使用多个变换存储器进行坐标变换，每个变换存储器可通过n元组的坐标来寻址。每个成员提供一个中间值，当添加到其他人提供一个转换的坐标。这消除了对高速乘法器的需要。变换存储器可以通过与感兴趣的位置，属性或对象相关联的标志和标签进行寻址。根据标志和标签的值，进行不同的转换。这样可以灵活地操纵数据。 Z缓冲以高速并行完成，结果被组合在有效的组合器电路中。此外，这种并行操作允许并行进行变换本身。通过向z缓冲器的输入添加可选择的加法器，可以选择正常的z缓冲器操作，或者可以选择利用z缓冲器的整个宽度来保持累积强度的射线照相模式。

4. 发明授权

US4223353A Variable persistance video display 失效
标题翻译：可变持续视频显示
公开(公告)号：US4223353A
公开(公告)日：1980-09-16
申请号：US958131
申请日：1978-11-06
申请人： John T. Keller , Robert H. Wake
发明人： John T. Keller , Robert H. Wake
IPC分类号： G01R13/34 , G01T1/164 , H04N5/66
CPC分类号： G01T1/1642 , G01R13/345
摘要： The invention relates to a video display device which includes a memory for storing intensity values for each pixel of the video display. Connected with the memory is a persister which decreases the intensity values as a selectable function of time such that a displayed image will appear to fade. Also connected with the memory is an input for increasing specific intensity values in response to the receipt of input data corresponding to that specific display pixel. The invention further relates to a scintillation camera in combination with the video display device in which input data indicates the occurrence of a radiation caused scintillation at some corresponding coordinate position and in which the rate of image fading is consonant with the rate of data acquisition, whereby a real-time display of the passage of a radioisotope through a patient may be produced.
摘要翻译：本发明涉及一种视频显示设备，其包括用于存储视频显示器的每个像素的强度值的存储器。与存储器连接的是一个持久性能，它将强度值作为可选择的时间功能降低，使得显示的图像将显示为淡出。还与存储器连接的是用于响应于对应于该特定显示像素的输入数据的接收而增加特定强度值的输入。本发明还涉及与视频显示装置组合的闪烁照相机，其中输入数据指示在某个对应的坐标位置发生辐射引起的闪烁，并且其中图像衰落的速率与数据采集的速率相符，由此可以产生通过患者通过放射性同位素的实时显示。

5. 发明授权

US07155274B1 Optical computed tomography scanner for small laboratory animals 有权
标题翻译：用于小型实验室动物的光学计算机断层扫描仪
公开(公告)号：US07155274B1
公开(公告)日：2006-12-26
申请号：US10717969
申请日：2003-11-21
申请人： Robert H. Wake , Brian Hummer , Gary M. Becker , Steve L. Ponder , Vince Magraner
发明人： Robert H. Wake , Brian Hummer , Gary M. Becker , Steve L. Ponder , Vince Magraner
IPC分类号： A61B6/00
CPC分类号： A61B5/0062 , A61B5/0073 , A61B5/415 , A61B2503/40 , B33Y80/00
摘要： An optical CT scanner for small laboratory animals comprises a housing having a vertical through opening through which a test subject is passed through during a scanning session, the housing including a peripheral slot disposed transversely through the perimeter of the opening; a movable horizontal table disposed through the opening, the table being split with a horizontal slot aligned with the peripheral slot; a scanning head rotatable about the opening, the scanning head including a light beam directed toward the peripheral slot, the scanning head including a plurality of collimators directed toward the peripheral slot, the scanning head including a plurality of main photodetectors to detect the light beam after passing through the test subject and the collimators; a perimeter photodetector adapted to provide perimeter data of the test subject during a scanning session; an electrical circuit to amplify and digitize the output from the photodetectors; and a first computer programmed to reconstruct an image of the test subject from the output of the circuit.
摘要翻译：用于小实验室动物的光学CT扫描器包括具有垂直通孔的壳体，扫描期间测试对象通过该垂直通孔穿过，壳体包括横向延伸穿过开口的周边的外围狭槽; 设置在所述开口中的可移动水平台，所述工作台与所述外围槽对准的水平槽分开; 所述扫描头可围绕所述开口旋转，所述扫描头包括指向所述外围槽的光束，所述扫描头包括指向所述外围槽的多个准直器，所述扫描头包括多个主光电检测器，以在通过测试对象和准直器; 适于在扫描会话期间提供测试对象的周边数据的周边光电检测器; 用于放大和数字化来自光电检测器的输出的电路; 以及第一计算机，其被编程为从所述电路的输出重建所述测试对象的图像。

6. 发明授权

US5952664A Laser imaging apparatus using biomedical markers that bind to cancer cells 失效
公开(公告)号：US5952664A
公开(公告)日：1999-09-14
申请号：US8477
申请日：1998-01-16
申请人： Robert H. Wake , Richard J. Grable
发明人： Robert H. Wake , Richard J. Grable
IPC分类号： A61B5/00 , G01J1/58 , G01N21/47 , G01N21/64
CPC分类号： G01N21/6428 , A61B5/0059 , A61B5/0091 , A61B5/4312 , G01N21/4795 , G01N21/645
摘要： A method for collecting data for use in image reconstruction of a tissue being scanned containing cancer cells comprises the steps of providing a source of laser beam; providing a biochemical marker that selectively binds to cancer cells within the tissue; directing the laser beam toward the object being scanned; orbiting the laser beam around the object; providing a plurality of sensors adapted to simultaneously detect the laser beam after passing through the object; and limiting the sensors to detect only the radiation released by the biochemical marker after having been activated by the laser beam.

7. 发明授权

US4197836A Nuclear cardiac blood volume detecting apparatus 失效
标题翻译：核心血容量检测仪
公开(公告)号：US4197836A
公开(公告)日：1980-04-15
申请号：US872069
申请日：1978-01-25
申请人： Henry N. Wagner , Robert H. Wake
发明人： Henry N. Wagner , Robert H. Wake
IPC分类号： A61B5/0275 , A61B5/0456 , A61B6/00 , G01T1/161
CPC分类号： A61B6/4057 , A61B5/02755 , A61B5/0456 , A61B5/7475 , A61B6/4258 , G01T1/161
摘要： A built up image illustrating blood volume in the heart versus time taken over many cardiac cycles is produced by continuously displaying a graph of cumulative data indicating the amount of radioactivity from a tracer in the blood detected in the heart during each of a series of intervals into which the average cardiac period is divided. The parallel lines of a raster scan display correspond respectively to the memory channels. The count stored in a particular memory channel causes the video signal for the corresponding line to be maintained at a binary level for a corresponding time interval thus generating a bar graph in which the length of each bar indicates the amount of radioactivity sensed during the corresponding interval of the cardiac cycle. As each memory channel accumulates radioactivity data with each successive cardiac cycle, each bar displayed in the bar graph lengthens to indicate the cumulative activity until an interpretable curve is obtained.
摘要翻译：通过在一系列间隔期间连续显示表示在心脏中检测到的血液中的示踪剂的放射性量的累积数据的累积数据的图形，生成了心脏中的血容量与许多心动周期摄取的时间的累积图像。平均心脏周期是分开的。光栅扫描显示的平行线分别对应于存储器通道。存储在特定存储器通道中的计数使得对应行的视频信号在相应的时间间隔内保持在二进制水平，从而产生条形图，其中每个条的长度指示在相应间隔期间感测的放射性量的心脏周期。随着每个记忆通道在每个连续的心动周期中累积放射性数据，条形图中显示的每个条都延长以指示累积活动，直到获得可解释的曲线。

8. 发明授权

US4151416A Dynamic uniform flood correction for radioisotope cameras 失效
标题翻译：放射性同位素摄像机的动态均匀洪水校正
公开(公告)号：US4151416A
公开(公告)日：1979-04-24
申请号：US822351
申请日：1977-08-05
申请人： Joseph B. Richey , Robert H. Wake , Henry H. Wilson , Michael C. Cheiky
发明人： Joseph B. Richey , Robert H. Wake , Henry H. Wilson , Michael C. Cheiky
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1642
摘要： The intrinsic nonuniformity of a radioisotope camera having an array of photomultiplier tubes viewing a scintillator crystal assembly is improved by comparing an internally generated correction factor from 1 to n, assigned to a location where a radiation event has been detected, to a random number between 1 and n and then discarding the radiation event datum if the correction factor is less than the random number. Correction factors are first generated by comparing the count at each location with an average minimum count in the presence of a uniform flood source.
摘要翻译：通过将分配到已经检测到辐射事件的位置的内部生成的校正因子从1到n比较到1之间的随机数来改善具有观察闪烁体晶体组件的光电倍增管阵列的放射性同位素照相机的固有不均匀性和n，然后如果校正因子小于随机数，则丢弃辐射事件数据。首先通过将每个位置的计数与均匀洪水源的平均最小计数进行比较来首先产生校正因子。

9. 发明授权

US07977619B2 Detector array for use in a laser imaging apparatus 有权
标题翻译：用于激光成像设备的检测器阵列
公开(公告)号：US07977619B2
公开(公告)日：2011-07-12
申请号：US09816375
申请日：2001-03-26
申请人： Robert H. Wake , Richard J. Grable
发明人： Robert H. Wake , Richard J. Grable
IPC分类号： A61B10/00 , H01J3/14
CPC分类号： A61B5/0091 , A61B5/0073 , A61B5/4312
摘要： A detector array for use in a laser imaging apparatus, comprises a plurality of housings disposed in an arc around an opening in which an object to be scanned is disposed, each housing including an open front end, a rear end and a longitudinal axis; and a detector disposed within each housing at a distance from the front end, thereby to restrict the field of view of each detector. The housings are adapted to be orbited around the object about an orbit axis. Each detector is adapted to simultaneously detect light exiting from the object within the respective field of view of each detector. A method for collecting light exiting from a object being scanned with a light source is also disclosed.
摘要翻译：一种用于激光成像设备的检测器阵列，包括围绕其中设置待扫描物体的开口设置的弧形的多个壳体，每个壳体包括敞开的前端，后端和纵向轴线; 以及设置在每个壳体内距离前端一定距离的检测器，从而限制每个检测器的视场。壳体适于围绕物体围绕轨道轴线轨道运动。每个检测器适于在每个检测器的相应视场内同时检测从物体出射的光。还公开了一种用于收集从用光源扫描的物体射出的光的方法。

10. 发明授权

US07446875B2 Apparatus and method for acquiring time-resolved measurements utilizing direct digitization of the temporal point spread function of the detected light 失效
标题翻译：用于利用检测到的光的时间点扩展函数的直接数字化获取时间分辨测量的装置和方法
公开(公告)号：US07446875B2
公开(公告)日：2008-11-04
申请号：US11270812
申请日：2005-11-10
申请人： Robert H. Wake , Steven L. Ponder
发明人： Robert H. Wake , Steven L. Ponder
IPC分类号： G01N21/00
CPC分类号： A61B5/0059
摘要： An apparatus for acquiring time-resolved measurements from a sample from optical scanning comprises pulsed laser light directed to the sample; a first detector disposed to detect the light after exiting from the sample, the detected light being in the form of a first temporal point spread function (TPSF); a first amplifier to amplify the first TPSF; a first analog-to-digital converted (ADC) to directly digitize the first TPSF; a first buffer connected to the first ADC; a time-pickoff detector to initiate the first ADC to digitize the first TPSF; a clock burst generator initiated by the time-pickoff detector to provide conversion timing to the first ADC; and a computer programmed to fit the digitized first TPSF to a theoretical curve to extract its amplitude, and attenuation and scattering coefficients.A method for acquiring time-resolved measurements from a sample from optical scanning comprises directing a pulse of light onto a surface of the sample; detecting the light that exits from the sample in the form of a temporal point spread function (TPSF); directly digitizing the TPSF; and extracting a transport scattering coefficient and a absorption coefficient from the digitized TPSF.
摘要翻译：用于从光学扫描的样品获取时间分辨测量的装置包括被引导到样品的脉冲激光; 第一检测器，被设置为检测从样品出射之后的光，检测到的光以第一时间点扩散函数（TPSF）的形式; 用于放大第一TPSF的第一放大器; 第一个模数转换（ADC）直接数字化第一个TPSF; 连接到第一ADC的第一缓冲器; 启动第一ADC以数字化第一TPSF的时间检测器; 由时间检测器发起的时钟脉冲串发生器以向第一ADC提供转换定时; 以及被编程为将数字化的第一TPSF拟合到理论曲线以提取其振幅以及衰减和散射系数的计算机。从光学扫描的样本获取时间分辨测量的方法包括将光脉冲引导到样品的表面上; 以时间点扩散函数（TPSF）的形式检测从样本中退出的光; 直接数字化TPSF; 并从数字化TPSF中提取传输散射系数和吸收系数。

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