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    • 5. 发明授权
    • Reciprocating biological filter
    • 往复生物过滤器
    • US06245236B1
    • 2001-06-12
    • US09320438
    • 1999-05-26
    • Robert C. Schenck
    • Robert C. Schenck
    • C02F308
    • C02F3/04Y02W10/15
    • A biological filter for filtering a stream of falling liquid, the filter comprising a body movable between a first and a second position, and a first filter portion coupled to the body such that the first filter portion is positioned under the stream when the body is in the first position. The filter further comprises a second filter portion coupled to the body such that the second filter portion is positioned under the stream when the body is in the second position, wherein the body reciprocates between the first and the second positions when located below the stream of liquid.
    • 一种用于过滤下落液体流的生物过滤器,所述过滤器包括可在第一和第二位置之间移动的主体和联接到所述主体的第一过滤器部分,使得当所述主体处于所述主体时,所述第一过滤器部分位于所述流下方 第一名。 过滤器还包括联接到主体的第二过滤器部分,使得当主体处于第二位置时,第二过滤器部分位于流下方,其中当位于液体流下方时,主体在第一和第二位置之间往复运动 。
    • 6. 发明授权
    • Method of making a porous prothesis with biodegradable coatings
    • 用可生物降解涂层制造多孔假体的方法
    • US5947893A
    • 1999-09-07
    • US241841
    • 1994-05-12
    • C. Mauli AgrawalRobert C. Schenck
    • C. Mauli AgrawalRobert C. Schenck
    • A61F2/00A61F2/30A61F2/36A61L27/04A61L27/18A61L27/56A61F2/04
    • A61F2/30767A61L27/04A61L27/18A61L27/56A61F2/3094A61F2/36A61F2/3662A61F2002/30064A61F2002/30677A61F2002/3611A61F2002/3631A61F2310/0097A61F2310/00976
    • Medical devices, most particularly prosthesis, are defined having at least one porous tissue-mating surface. The tissue-mating surface of the device includes therein a pharmacologically active substance within a biodegradable carrier, such as a polymer or a biodegradable ceramic, such as calcium phosphate. A biodegradable composition of the drug and carrier is impregnated within the pores of the tissue-mating surfaces of the device. The device thereby provides for the long-term release of pharmacologically active substances upon implant. The prosthesis of the present invention provides for enhanced rigid fixation, as pores at the surface of said device provide for bony ingrowth as biodegradable material impregnated therein degrades. Pharmacologically active substances within the biodegradable composition also enhances the rate of bony in-growth where said substances are particularly osteoinductive. The structure of the present device effectively delivers pharmacologically active substances to tissue- (e.g., to bone) mating surfaces as they are positioned directly against the tissue/bone surfaces upon implant. Methods for preparing said prosthesis, as well as methods for facilitating the delivery of a pharmacologically active substance at a tissue (bone) prosthesis are also disclosed.
    • 被定义为具有至少一个多孔组织配合表面的医疗装置,特别是假体。 该装置的组织配合表面在其中包含可生物降解的载体例如聚合物或可生物降解的陶瓷如磷酸钙的药理活性物质。 药物和载体的可生物降解的组合物浸渍在装置的组织配合表面的孔内。 因此,该装置提供植入时药物活性物质的长期释放。 本发明的假体提供了增强的刚性固定,因为在其中浸渍的可生物降解的材料降解时,所述装置的表面处的孔提供骨向内生长。 可生物降解组合物中的药理活性物质还提高了所述物质特别是骨诱导的骨生长速率。 本装置的结构有效地将药理活性物质递送到组织(例如,骨)配合表面,因为它们在植入时直接抵靠组织/骨表面定位。 还公开了用于制备所述假体的方法以及促进药物活性物质在组织(骨)假体递送的方法。