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1. 发明授权

US4096264A Certain substituted imidazo [1,2-a] pyridines 失效
标题翻译：某些取代的咪唑并[8,1-a {9 {0]吡啶
公开(公告)号：US4096264A
公开(公告)日：1978-06-20
申请号：US718652
申请日：1976-08-26
申请人： Richard J. Bochis , Peter Kulsa
发明人： Richard J. Bochis , Peter Kulsa
IPC分类号： C07D213/79 , A61K31/435 , A61P33/10 , C07D213/38 , C07D213/42 , C07D213/53 , C07D213/86 , C07D471/04 , A61K31/44 , C07D401/02
CPC分类号： C07D213/42 , C07D213/38 , C07D213/53 , C07D213/86 , C07D471/04
摘要： Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3-position are active anthelmintic agents. The novel compounds are prepared from the appropriate substituted 2-aminopyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.
摘要翻译：某些具有取代氨基的2-或3-位的取代咪唑并[1,2-a]吡啶是活性的驱肠剂。该新化合物由合适的取代的2-氨基吡啶前体制备。还公开了利用所述新型咪唑并[1,2-a]吡啶作为其活性成分用于治疗蠕虫病的组合物。

2. 发明授权

US4250174A 3-Substituted imidazo [1,2-A] pyridines 失效
标题翻译： 3-取代的咪唑并[1,2-A]吡啶
公开(公告)号：US4250174A
公开(公告)日：1981-02-10
申请号：US35367
申请日：1979-05-02
申请人： Richard J. Bochis , Peter Kulsa , Richard L. Tolman
发明人： Richard J. Bochis , Peter Kulsa , Richard L. Tolman
IPC分类号： A61K31/435 , A61P33/10 , C07D471/04 , A61K31/41 , C07D401/02 , C07D403/02
CPC分类号： C07D471/04
摘要： Imidazo pyridines with a carbamate group in the 2-position and a phenylthio, or phenylsulfinyl group in the 6-position are disclosed which also are substituted at the 3-position. The 3-position substituents may be halogen, substituted aminomethyl, acyl, and the like. The compounds are active anthelmintic agents. Compositions and methods for the use of such compounds against helmintic infections are also disclosed.
摘要翻译：公开了2-位氨基甲酸酯基和6-位的苯硫基或苯基亚磺酰基的咪唑并吡啶，其也在3-位取代。 3-位取代基可以是卤素，取代的氨基甲基，酰基等。这些化合物是活性的驱肠剂。还公开了使用这种化合物抵抗疱疹感染的组合物和方法。

3. 发明授权

US4237300A Certain 6-substituted-2-pyridinamines 失效
标题翻译：某些6-取代-2-吡啶胺
公开(公告)号：US4237300A
公开(公告)日：1980-12-02
申请号：US92876
申请日：1979-11-09
申请人： Richard J. Bochis , Peter Kulsa
发明人： Richard J. Bochis , Peter Kulsa
IPC分类号： C07D213/38 , C07D213/42 , C07D213/53 , C07D213/86 , C07D471/04 , C07D213/02
CPC分类号： C07D213/42 , C07D213/38 , C07D213/53 , C07D213/86 , C07D471/04
摘要： Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3-position are active anthelmintic agents. The novel compounds are prepared from the appropriate substituted 2-aminopyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.
摘要翻译：某些具有取代氨基的2-或3-位的取代咪唑并[1,2-a]吡啶是活性的驱肠剂。该新化合物由合适的取代的2-氨基吡啶前体制备。还公开了利用所述新型咪唑并[1,2-a]吡啶作为其活性成分用于治疗蠕虫病的组合物。

4. 发明授权

US4177274A Substituted imidazo [1,2-a] pyridines 失效
标题翻译：取代的咪唑并[1,2-a]吡啶
公开(公告)号：US4177274A
公开(公告)日：1979-12-04
申请号：US912594
申请日：1978-06-05
申请人： Richard J. Bochis , Peter Kulsa
发明人： Richard J. Bochis , Peter Kulsa
IPC分类号： C07D213/38 , C07D213/42 , C07D213/53 , C07D213/86 , C07D471/04 , A61K31/44
CPC分类号： C07D213/42 , C07D213/38 , C07D213/53 , C07D213/86 , C07D471/04
摘要： Certain novel substituted imidazo [1,2-a] pyridines with a substituted amino group at the 2- or 3-position are active anthelmintic agents. The novel compounds are prepared from the appropriate substituted 2-aminopyridine precursor. Compositions which utilize said novel imidazo [1,2-a] pyridines as the active ingredient thereof for the treatment of helminthiasis are also disclosed.
摘要翻译：某些具有取代氨基的2-或3-位的取代咪唑并[1,2-a]吡啶是活性的驱肠剂。该新化合物由合适的取代的2-氨基吡啶前体制备。还公开了利用所述新型咪唑并[1,2-a]吡啶作为其活性成分用于治疗蠕虫病的组合物。

5. 发明授权

US4590201A 5-amino or substituted amino 1,2,3-triazoles 失效
公开(公告)号：US4590201A
公开(公告)日：1986-05-20
申请号：US576301
申请日：1984-02-02
申请人： Richard J. Bochis , John C. Chabala , Michael H. Fisher
发明人： Richard J. Bochis , John C. Chabala , Michael H. Fisher
IPC分类号： A01N43/36 , A61K31/41 , A61P33/02 , C07C45/42 , C07C45/45 , C07C45/46 , C07C45/63 , C07C45/67 , C07C49/813 , C07C63/70 , C07D249/04 , C07D249/06 , C07F7/18
CPC分类号： C07C247/00 , C07C255/00 , C07C317/00 , C07C323/00 , C07C45/42 , C07C45/45 , C07C45/46 , C07C45/63 , C07C45/673 , C07C49/813 , C07D249/04 , C07D249/06 , C07F7/1852
摘要： Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

6. 发明授权

US4154835A Anthelmintic imidazo [1,2-a] pyridines 失效
标题翻译：驱虫咪唑并{8,12-a {9 {0，吡啶
公开(公告)号：US4154835A
公开(公告)日：1979-05-15
申请号：US841260
申请日：1977-10-12
申请人： Richard J. Bochis
发明人： Richard J. Bochis
IPC分类号： A23K1/16 , A61K31/435 , A61P33/00 , A61P33/10 , C07D213/26 , C07D213/73 , C07D213/78 , C07D213/79 , C07D213/86 , C07D471/04 , A61K31/44
CPC分类号： C07D213/73 , C07D213/26 , C07D213/78 , C07D213/79 , C07D213/86 , C07D471/04
摘要： Novel substituted imidazo [1,2-a] pyridine compounds are disclosed which have a high degree of anthelmintic activity. The compounds are substituted with a carbamate and a halogenated alkene group. Processes for the preparation of such compounds are also disclosed as well as compositions which use the described compounds as active ingredients for the treatment of helminthiasis.
摘要翻译： {PG，1新颖的取代的咪唑并{8,1-a {9 {0吡啶化合物，其具有高度的驱虫活性。化合物被氨基甲酸酯和卤代烯烃基取代。还公开了制备这些化合物的方法以及使用所述化合物作为治疗蠕虫病的活性成分的组合物。

7. 发明授权

US4622330A Antiprotozoal 3-amino or substituted amino pyrazoles 失效
标题翻译：抗原雄激素3-氨基或取代的氨基吡唑
公开(公告)号：US4622330A
公开(公告)日：1986-11-11
申请号：US622337
申请日：1984-06-19
申请人： Richard J. Bochis , Richard A. Dybas , Edward F. Rogers
发明人： Richard J. Bochis , Richard A. Dybas , Edward F. Rogers
IPC分类号： A23K1/16 , C07D231/38 , A01N43/56 , A01N43/78 , C07D231/52 , C07D417/04
CPC分类号： C07D231/38 , A23K20/137
摘要： Novel 3-amino or substituted amino pyrazoles are disclosed as having antiprotozoal and antiparasitic activity in particular anticoccidial activity and are useful for controlling cecal and or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.
摘要翻译：新的3-氨基或取代的氨基吡唑被公开为具有特异抗球虫活性的抗原虫和抗寄生虫活性，并且当以少量施用于动物，特别是通常与动物饲养物混合的家禽时，可用于控制盲肠和/或肠球虫病。

8. 发明授权

US4482545A Isoefrotomycin, process of preparation, pharmaceutical composition and method of using same 失效
标题翻译：异佛霉素，制备方法，药物组合物及其使用方法
公开(公告)号：US4482545A
公开(公告)日：1984-11-13
申请号：US541804
申请日：1983-10-13
申请人： Richard J. Bochis , Ray S. Dewey
发明人： Richard J. Bochis , Ray S. Dewey
IPC分类号： C07H17/04 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7048 , A61P3/00 , A61P31/04 , C07H15/04 , A61K31/71 , C07H3/06
CPC分类号： C07H15/04
摘要： There is disclosed the novel compound isoefrotomycin which is synthesized from efrotomycin as a Michael adduct by treatment with a mixture of polar and nonpolar solvents. Isoefrotomycin is an effective antimicrobial agent and growth promotant in animals.
摘要翻译：公开了通过用极性溶剂和非极性溶剂的混合物处理，从efrotomycin作为迈克尔加合物合成的新型化合物异构霉素。异佛霉素是动物中有效的抗微生物剂和生长促进剂。

9. 发明授权

US5143918A Halomacrolides and derivatives having immunosuppressive activity 失效
标题翻译：具有免疫抑制活性的灭麦芽糖和衍生物
公开(公告)号：US5143918A
公开(公告)日：1992-09-01
申请号：US759747
申请日：1991-09-12
申请人： Richard J. Bochis , Matthew J. Wyvratt, Jr.
发明人： Richard J. Bochis , Matthew J. Wyvratt, Jr.
IPC分类号： C07H19/01
CPC分类号： C07H19/01
摘要： Novel C-3" and C-4" halogen-substituted macrolides of FK-506 type structural Formula I: ##STR1## are described. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases (such as juvenile-onset diabetes melitus, multiple sclerosis and rheumatoid arthritis), infectious diseases and/or the prevention of rejection of foreign organ transplants, e.g. bone marrow and heart transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses such as: psoriasis, atopical dermatitiis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasulitides erythemas, cutaneous eosinophilias, Lupus erythematosus or Alopecia areata.
摘要翻译：描述了FK-506型结构式I的新型C-3“和C-4”卤素取代的大环内酯类。这些大环内酯类免疫抑制剂可用于哺乳动物宿主中用于治疗自身免疫性疾病（如幼年型糖尿病，多发性硬化和类风湿性关节炎），感染性疾病和/或预防外来器官移植排斥反应。骨髓和心脏移植。此外，这些大环内酯类免疫抑制剂可用于局部治疗炎性和过度增生性皮肤病以及免疫介导疾病的皮肤表现，如牛皮癣，特应性皮肤病，接触性皮炎和进一步湿疹性皮肤病，脂溢性皮炎，扁平苔藓，天疱疮，大疱类天疱疮，大疱性表皮松解症，荨麻疹，血管紧张素，血管舒张红斑，皮肤嗜酸粒细胞，红斑狼疮或斑秃。

10. 发明授权

US5064835A Hydroxymacrolide derivatives having immunosuppressive activity 失效
标题翻译：具有免疫抑制活性的羟肟酸衍生物
公开(公告)号：US5064835A
公开(公告)日：1991-11-12
申请号：US486700
申请日：1990-03-01
申请人： Richard J. Bochis , Huyn O. Ok , Matthew J. Wyvratt
发明人： Richard J. Bochis , Huyn O. Ok , Matthew J. Wyvratt
IPC分类号： A61K31/40 , A61K31/445 , A61P17/00 , A61P37/06 , C07D498/18 , C07H19/01
CPC分类号： C07H19/01
摘要： Novel hydroxymacrolide derivatives of the general structural Formula I: ##STR1## have been prepared from (a) suitable precursor(s) by selective reduction of the ketone at C-2. These macrolide immunosuppressants are useful in a human host for the treatment of autoimmune diseases (such as juvenile-onset diabetes melitus, multiple sclerosis and rheumatoid arthritis), infectious diseases and/or the prevention of rejection of foreign organ transplants, e.g. bone marrow and heart transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses such as: psoriasis, atopical dermatitiis, contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis, Lichen planus, Pemphigus, bullous Pemphigoid, Epidermolysis bullosa, urticaria, angioedemas, vasculitides, erythemas, cutaneous eospinphilias, Lupus erythematosus or Alopecia areata.

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