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1. 发明申请

US20090142292A1 Method For The Mitigation of Symptoms of Dry Eye 审中-公开
标题翻译：减轻干眼症状的方法
公开(公告)号：US20090142292A1
公开(公告)日：2009-06-04
申请号：US12266646
申请日：2008-11-07
申请人： Richard I. Blackwell , Jay F. Kunzler , Daniel M. Ammon, JR. , Joseph C. Salamone
发明人： Richard I. Blackwell , Jay F. Kunzler , Daniel M. Ammon, JR. , Joseph C. Salamone
IPC分类号： A61K31/74 , A61K31/715 , A61P27/02 , A61K31/79 , A61K31/785 , A61K31/765
CPC分类号： G02B1/043 , A61K9/0051
摘要： A method for the mitigation of symptoms of dry eye is disclosed. The method involves at least (a) incorporating one or more non-functionalized polymers having one or more hydrophilic moieties into an ophthalmic device that is a polymerization product of a comonomer mixture comprising: (i) a major amount of a non-silicone-containing hydrophilic monomer; and (ii) an end terminal functionalized surfactant; and (b) inserting the ophthalmic device in the eye of a patient.
摘要翻译：公开了一种减轻干眼症状的方法。该方法至少包括（a）将一种或多种具有一个或多个亲水部分的非官能化聚合物掺入到作为共聚单体混合物的聚合产物的眼科装置中，所述共聚单体混合物包含：（i）主要量的非含硅氧烷亲水单体; 和（ii）末端官能化表面活性剂; 和（b）将眼科装置插入患者的眼睛。

2. 发明授权

US08389597B2 High water content ophthalmic devices 有权
标题翻译：高含水量的眼科装置
公开(公告)号：US08389597B2
公开(公告)日：2013-03-05
申请号：US13370364
申请日：2012-02-10
申请人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
发明人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
IPC分类号： G02B1/04
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译：公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。

3. 发明申请

US20120141408A1 High Water Content Ophthalmic Devices 有权
标题翻译：高含水量眼科装置
公开(公告)号：US20120141408A1
公开(公告)日：2012-06-07
申请号：US13370364
申请日：2012-02-10
申请人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
发明人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
IPC分类号： A61K31/785 , C08F226/10 , A61P27/02 , B05D5/00 , A61K31/79 , C08F220/56 , C08F230/08
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译：公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。

4. 发明授权

US08138290B2 High water content ophthalmic devices 有权
标题翻译：高含水量的眼科装置
公开(公告)号：US08138290B2
公开(公告)日：2012-03-20
申请号：US12350262
申请日：2009-01-08
申请人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
发明人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
IPC分类号： C08F20/00
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译：公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。

5. 发明申请

US20090191256A1 HIGH WATER CONTENT OPHTHALMIC DEVICES 有权
标题翻译：高水含量眼科设备
公开(公告)号：US20090191256A1
公开(公告)日：2009-07-30
申请号：US12350262
申请日：2009-01-08
申请人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
发明人： Richard I. Blackwell , Joseph C. Salamone , Jay F. Kunzler
IPC分类号： A61K9/00 , C08L83/00 , A61P27/02
CPC分类号： G02B1/043
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; (b) a hydrophobic monomer; and (c) a crosslinking agent, wherein the ophthalmic device has an equilibrium water content of at least about 70 weight percent and further wherein the ophthalmic device has an evaporative dehydration barrier layer on the surface thereof. A method for the mitigation of evaporative corneal dehydration employing the high water content ophthalmic device is also disclosed.
摘要翻译：公开了一种眼科装置，其是单体混合物的聚合产物，其包含（a）主要量的非含硅氧烷的亲水性单体; （b）疏水单体; 和（c）交联剂，其中所述眼科装置具有至少约70重量％的平衡水含量，并且其中所述眼科装置在其表面上具有蒸发性脱水阻隔层。还公开了一种使用高含水量眼科装置缓解蒸发角膜脱水的方法。

6. 发明申请

US20100149482A1 CONTACT LENS 审中-公开
标题翻译：隐形眼镜
公开(公告)号：US20100149482A1
公开(公告)日：2010-06-17
申请号：US12333342
申请日：2008-12-12
申请人： Daniel M. Ammon, JR. , Rosa Lee , Richard I. Blackwell
发明人： Daniel M. Ammon, JR. , Rosa Lee , Richard I. Blackwell
IPC分类号： G02C7/04
CPC分类号： G02C7/04 , G02C7/048 , G02C7/049
摘要： Disclosed are silicone-containing contact lenses having an overall additive thickness less than or equal to about 310 μm.
摘要翻译：公开了具有小于或等于约310μm的总添加剂厚度的含硅氧烷的隐形眼镜。

7. 发明申请

US20080152540A1 PACKAGING SOLUTIONS 审中-公开
标题翻译：包装解决方案
公开(公告)号：US20080152540A1
公开(公告)日：2008-06-26
申请号：US11615217
申请日：2006-12-22
申请人： Derek A. Schorzman , Richard I. Blackwell , Jay F. Kunzler
发明人： Derek A. Schorzman , Richard I. Blackwell , Jay F. Kunzler
IPC分类号： A61K8/89 , B01J19/00 , C08G63/91
CPC分类号： B65B25/008
摘要： The present invention is directed to new and improved packaging systems for storing cationic ophthalmic devices such as cationic contact lenses and to methods for packaging such cationic ophthalmic devices with solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to a packaging system for storing a cationic ophthalmic device in a solution comprising an effective amount of an anionic polymer. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.
摘要翻译：本发明涉及用于存储阳离子眼科装置如阳离子隐形眼镜的新的和改进的包装系统，以及用于包装这种阳离子眼科装置的方法，其具有提高穿戴期间镜片舒适度的解决方案。特别地，本发明涉及用于将阳离子眼科装置储存在包含有效量的阴离子聚合物的溶液中的包装系统。这种溶液长时间保留在未使用的镜片的表面上，导致在眼睛中持续的表面改性，这可以显着改善首次使用的新鲜透镜的润湿性能，甚至几个镜片插入后几小时，防止干燥和改善润滑性。

8. 发明授权

US07934830B2 High water content silicone hydrogels 有权
标题翻译：高含水硅胶水凝胶
公开(公告)号：US07934830B2
公开(公告)日：2011-05-03
申请号：US12267660
申请日：2008-11-10
申请人： Richard I. Blackwell , Jay F. Kunzler , Amy Jasek
发明人： Richard I. Blackwell , Jay F. Kunzler , Amy Jasek
IPC分类号： G02C7/04
CPC分类号： C08F220/12 , C08F220/02 , C08F222/1006 , C08F230/08 , C08F2220/281 , G02B1/043 , Y10T428/31663 , C08L43/04 , C08L39/06
摘要： Silicone hydrogels formed from a hydrated polymerization product of a monomer mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; and (b) a minor amount of a silicone-containing monomer, wherein the hydrogel has a water content of greater than 50 weight percent are disclosed.
摘要翻译：由单体混合物的水合聚合产物形成的硅氧烷水凝胶包含（a）主要量的非含硅氧烷的亲水单体; 和（b）少量含硅氧烷单体，其中水凝胶的含水量大于50重量％。

9. 发明申请

US20090141234A1 High Water Content Silicone Hydrogels 有权
标题翻译：高含水硅胶水凝胶
公开(公告)号：US20090141234A1
公开(公告)日：2009-06-04
申请号：US12267660
申请日：2008-11-10
申请人： Richard I. Blackwell , Jay F. Kunzler , Amy Jasek
发明人： Richard I. Blackwell , Jay F. Kunzler , Amy Jasek
IPC分类号： G02C7/04 , G02B1/04
CPC分类号： C08F220/12 , C08F220/02 , C08F222/1006 , C08F230/08 , C08F2220/281 , G02B1/043 , Y10T428/31663 , C08L43/04 , C08L39/06
摘要： Silicone hydrogels formed from a hydrated polymerization product of a monomer mixture comprising (a) a major amount of a non-silicone-containing hydrophilic monomer; and (b) a minor amount of a silicone-containing monomer, wherein the hydrogel has a water content of greater than 50 weight percent are disclosed.
摘要翻译：由单体混合物的水合聚合产物形成的硅氧烷水凝胶包含（a）主要量的非含硅氧烷的亲水单体; 和（b）少量含硅氧烷单体，其中水凝胶的含水量大于50重量％。

10. 发明申请

US20090142387A1 Method For Inhibiting Attachment Of Microorganisms To Biomedical Devices 审中-公开
标题翻译：抑制生物医学器械微生物附着的方法
公开(公告)号：US20090142387A1
公开(公告)日：2009-06-04
申请号：US12274378
申请日：2008-11-20
申请人： Richard I. Blackwell , Catherine Scheuer , Joseph C. Salamone
发明人： Richard I. Blackwell , Catherine Scheuer , Joseph C. Salamone
IPC分类号： A61L27/54 , A01N31/02 , A01P1/00
CPC分类号： G02B1/043
摘要： A method for inhibiting adhesion of bacteria to a surface of a biomedical device is disclosed. The method involves at least (a) incorporating one or more non-functionalized polymers having one or more hydrophilic moieties into an ophthalmic device that is a polymerization product of a comonomer mixture comprising: (i) a major amount of a non-silicone-containing hydrophilic monomer; and (ii) an end-terminal functionalized surfactant; and (b) inserting the ophthalmic device in the eye of a patient, wherein the at least one non-functionalized polymer migrates to the surface of the device in a sustained release manner to inhibit adhesion of bacteria to a surface of the biomedical device. Biomedical devices are also disclosed.
摘要翻译：公开了一种抑制细菌对生物医学装置表面粘附的方法。该方法至少包括（a）将一种或多种具有一个或多个亲水部分的非官能化聚合物掺入到作为共聚单体混合物的聚合产物的眼科装置中，所述共聚单体混合物包含：（i）主要量的非含硅氧烷亲水单体; 和（ii）末端官能化表面活性剂; 和（b）将眼科装置插入患者的眼睛中，其中所述至少一种非官能化聚合物以持续释放的方式迁移到所述装置的表面，以抑制细菌粘附到所述生物医学装置的表面。还公开了生物医学装置。

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