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    • 10. 发明授权
    • Catheter for treatment of total occlusions and methods for manufacture and use of the catheter
    • 用于治疗全部闭塞的导管以及制造和使用导管的方法
    • US07399291B2
    • 2008-07-15
    • US11291758
    • 2005-12-01
    • Minh VoCory Anderson
    • Minh VoCory Anderson
    • A61F7/12A61F7/00A61M29/00
    • A61M25/0015A61M25/0009A61M25/0043A61M2025/1052
    • A catheter for treatment of chronic total occlusions includes an occlusion breach device, a catheter body made of a temperature-dependent softening, shape-memory, thermoplastic polymer having a first flexible state and a second stiff state. The catheter body has a heat transfer conduit and a conduit for slidably receiving the breach device. A heat-transferring device selectively changes a temperature of the heat transfer conduit to, thereby, change stiffness of the catheter body between the two states. To treat a CTO with the catheter, it is warmed above the glass-transition temperature and below the melting-temperature to make the catheter flexible. The catheter has a shape when inserted at the occlusion site and is cooled to, thereby, stiffen. Breaching of the occlusion is assisted with the stiff catheter. The catheter is removed by warming the polymer. Also provided is a method for manufacturing such a selectively stiffening catheter.
    • 用于治疗慢性完全闭塞的导管包括闭塞突破装置,由温度依赖性软化形状记忆体形成的导管体,具有第一柔性状态和第二僵硬状态的热塑性聚合物。 导管主体具有传热导管和用于可滑动地接收突破装置的导管。 传热装置选择性地改变传热管道的温度,从而改变导管体在两种状态之间的刚度。 为了用导管治疗CTO,将其温度高于玻璃化转变温度并低于熔融温度,以使导管变得柔软。 导管在插入位置时具有形状并被冷却,从而变硬。 使用刚性导管辅助阻塞闭塞。 通过加热聚合物去除导管。 还提供了制造这种选择性加强导管的方法。