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1. 发明授权

US4522947A Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents 失效
标题翻译：某些用作抗过敏剂的1,3-恶唑并[4,5H]喹啉
公开(公告)号：US4522947A
公开(公告)日：1985-06-11
申请号：US476673
申请日：1983-03-18
申请人： John H. Musser , Richard E. Brown
发明人： John H. Musser , Richard E. Brown
IPC分类号： C07D215/28 , C07D498/04 , A61K31/47
CPC分类号： C07D215/28
摘要： New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl,Z is oxygen, sulfur or nitrogen,X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, andm is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.
摘要翻译：新喹啉化合物及相应的1,2-; 1,3- 和1,4-苯并二嗪，喹啉化合物具有下式：其中R1和R2独立地是氢，低级烷基，卤素，三氟甲基，氨基，低级烷基氨基，低级酰氨基，氰基，芳基，芳基/低级亚烷基，硝基，低级炔基，低级烯基，低级烷基亚磺酰基，低级烷基磺酰基，低级烷酰基，羧基，低级烷氧基，低级烷酰基或低级烯酰基，Y为氧，硫，氮或R 3 N，其中R 3为氢低级烷基，烯基，炔基，芳基，芳烷基，酰基，氨基烷基或羧基烷基，Z是氧，硫或氮，X是氰基，烷氧羰基，羧基，甲酰肟基，四唑基，烷氧基烷基或羧基烷基，m是0或1，可用作药物，特别是用于治疗哮喘，和/或作为制备用于治疗哮喘的化合物的中间体。

2. 发明授权

US4307091A Process for treatment of allergic conditions with benzoxazinediones 失效
标题翻译：用苯并恶嗪酮治疗过敏症状的方法
公开(公告)号：US4307091A
公开(公告)日：1981-12-22
申请号：US149078
申请日：1980-05-12
申请人： Richard E. Brown , Vasil St. Georgiev , Bernard Loev , Robert Mack
发明人： Richard E. Brown , Vasil St. Georgiev , Bernard Loev , Robert Mack
IPC分类号： C07D265/36 , C07D267/14
CPC分类号： C07D265/36 , C07D267/14
摘要： Therapeutic compositions containing as active principle, a benzoxazindione or pharmaceutically-acceptable acid addition salt thereof are useful in the treatment of allergy.
摘要翻译：含有作为活性成分的苯并恶嗪二酮或其药学上可接受的酸加成盐的治疗组合物可用于治疗过敏。

3. 发明授权

US4179513A Indole-2-carboxylic acids to effect CNS depressant activity 失效
标题翻译：吲哚-2-羧酸以影响CNS抑制活性
公开(公告)号：US4179513A
公开(公告)日：1979-12-18
申请号：US895201
申请日：1978-04-10
申请人： Richard E. Brown
发明人： Richard E. Brown
IPC分类号： C07D209/42 , C07D498/04 , A61K31/40
CPC分类号： C07D209/42
摘要： This invention relates to substituted indolobenzoxazepines which act as central nervous system depressants and as such are useful as tranquillizers.
摘要翻译：本发明涉及作为中枢神经系统抑制剂的取代的吲哚并苯并氮杂，因此可用作镇静剂。

4. 发明授权

US4148806A Process for the preparation of indolopyrones 失效
标题翻译：制备吲哚并呋喃的方法
公开(公告)号：US4148806A
公开(公告)日：1979-04-10
申请号：US860504
申请日：1977-12-14
申请人： Richard E. Brown , Paul C. Unangst , Frank Fontsere , Arthur C. Fabian
发明人： Richard E. Brown , Paul C. Unangst , Frank Fontsere , Arthur C. Fabian
IPC分类号： C07D209/36 , C07D491/04 , C07D491/052
CPC分类号： C07D491/04 , C07D209/36
摘要： This invention relates to a novel process for preparing a group of novel substituted indolopyrones.
摘要翻译：本发明涉及制备一组新型取代的吲哚吡酮的新方法。

5. 发明授权

US4013671A Substituted benzopyrano[3,4-c]pyridines and process for their preparation 失效
标题翻译：取代的苯并吡喃（3,4-C）吡啶及其制备方法
公开(公告)号：US4013671A
公开(公告)日：1977-03-22
申请号：US666829
申请日：1976-03-15
申请人： Richard E. Brown , John Shavel, Jr.
发明人： Richard E. Brown , John Shavel, Jr.
IPC分类号： A61K31/535 , C07D491/052 , C07D311/06 , C07D311/76
CPC分类号： C07D491/052 , A61K31/535
摘要： Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##STR1## In the above formula, R.sub.1 R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c] pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

6. 发明授权

US3984546A Substituted benzopyrano [3,4-c]pyridines for the treatment of bronchial asthma 失效
标题翻译：取代的苯并吡喃并[8,3-c {9吡啶用于治疗支气管哮喘
公开(公告)号：US3984546A
公开(公告)日：1976-10-05
申请号：US622547
申请日：1975-10-15
申请人： Richard E. Brown , John Shavel, Jr.
发明人： Richard E. Brown , John Shavel, Jr.
IPC分类号： A61K31/535 , A61K31/54 , A61K31/44 , A61K31/445
CPC分类号： C07D491/052 , A61K31/535 , A61K31/54 , Y10S514/826
摘要： Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.
摘要翻译：公开了具有以下结构式的取代的苯并吡喃并[3,4-c]吡啶：在上式中，R 1和R 2是氢，羟基或具有1至6个碳原子的低级烷氧基; X为氧原子，硫原子，亚甲基或被氢取代的氮原子，1〜6个碳原子的低级烷基或1〜6个碳原子的低级烷酰基。本发明化合物是通过在酸催化剂存在下使R1，R2取代的苯酚与3-乙酯基-4-哌啶酮反应得到中间体R1，R2取代的苯并吡喃并[3,4-c]吡啶。通过用适当取代的烷基卤处理苯并吡喃并[3,4-c]吡啶得到N-氨基烷基苯并吡喃并[3,4-c]吡啶。本发明的化合物可用作治疗支气管哮喘的支气管扩张剂。

7. 发明授权

US3961057A Benzopyrano(3,4-C)pyridine bronchodilators 失效
标题翻译：苯并吡喃（3,4-C）吡啶支气管扩张剂
公开(公告)号：US3961057A
公开(公告)日：1976-06-01
申请号：US538424
申请日：1975-01-03
申请人： Richard E. Brown , John Shavel, Jr.
发明人： Richard E. Brown , John Shavel, Jr.
IPC分类号： A61K31/535
CPC分类号： C07D491/052 , A61K31/535 , Y10S514/826
摘要： Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1##In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.
摘要翻译：公开了具有以下结构式的取代的苯并吡喃并[3,4-c]吡啶：在上式中，R 1和R 2是氢，羟基或具有1至6个碳原子的低级烷氧基; R3是氢或1〜6个碳原子的低级烷基，X是氧原子，硫原子，亚甲基或被氢取代的氮原子，1〜6个碳原子的低级烷基或 1至6个碳原子的低级烷酰基。本发明化合物是通过在酸催化剂存在下使R1，R2取代的苯酚与3-乙酯基-4-哌啶酮反应得到中间体R1，R2取代的苯并吡喃并[3,4-c]吡啶。通过用适当取代的烷基卤处理苯并吡喃并[3,4-c]吡啶得到N-氨基烷基苯并吡喃并[3,4-c]吡啶。本发明的化合物可用作治疗支气管哮喘的支气管扩张剂。

8. 发明授权

US3932466A Substituted 2-amino chromones and process for the preparation thereof 失效
标题翻译：取代的2-氨基色酮及其制备方法
公开(公告)号：US3932466A
公开(公告)日：1976-01-13
申请号：US532417
申请日：1974-12-13
申请人： Richard E. Brown , David M. Lustgarten
发明人： Richard E. Brown , David M. Lustgarten
IPC分类号： C07D311/22 , C07D7/34
CPC分类号： C07D311/22 , Y10S514/826
摘要： This invention relates to substituted 2-amino chromones of the general structure I: ##SPC1##wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 may be hydrogen, hydroxy, lower alkyl or lower alkoxy of 1-6 carbon atoms, halogen such as chloro or bromo, or aryl such as phenyl, and X may be cyano or carboxamido. Two novel procedures for preparing substituted 2-amino chromones having the Formula I, starting with salicylic acid or substituted salicylic acid, are described. The compounds of this invention are active in the prevention of allergic and asthmatic reactions in mammals.
摘要翻译：本发明涉及通用结构I的取代的2-氨基色酮：

9. 发明授权

US08670009B2 Two-sided thermal print sensing 有权
标题翻译：双面热敏打印感应
公开(公告)号：US08670009B2
公开(公告)日：2014-03-11
申请号：US11644262
申请日：2006-12-22
申请人： Dale R. Lyons , Richard E. Brown
发明人： Dale R. Lyons , Richard E. Brown
IPC分类号： B41J3/60
CPC分类号： B41J3/60 , B41J11/009
摘要： An apparatus and method for identifying a type of media installed in a two- or dual-sided thermal printer is provided. In one embodiment, one or more functions of the dual-sided thermal printer may be enabled or disabled depending on the identified media type.
摘要翻译：提供一种用于识别安装在双面或双面热敏打印机中的介质的类型的装置和方法。在一个实施例中，取决于所识别的介质类型，可以启用或禁用双面热敏打印机的一个或多个功能。

10. 发明授权

US4739368A Reader-printer apparatus and method for variable length copying of information on a standard sheet length 失效
标题翻译：用于在标准纸张长度上对信息进行可变长度复印的读取器 - 打印机设备和方法
公开(公告)号：US4739368A
公开(公告)日：1988-04-19
申请号：US853590
申请日：1986-04-18
申请人： Eugene W. Lachut , Francis L. Soucy , Bruce A. Holroyd , Richard E. Brown
发明人： Eugene W. Lachut , Francis L. Soucy , Bruce A. Holroyd , Richard E. Brown
IPC分类号： G03B27/32 , G03B21/11 , G03G15/04 , G03G15/043 , G03G15/22 , G03G15/00
CPC分类号： G03G15/223 , G03B21/118
摘要： A microform reader-printer apparatus includes a viewing screen having ruler-like fiducial marks that are indicative of distance from an edge of an image frame being viewed. The apparatus includes a keyboard permitting the operator to input data to a printer control regarding the portion of the image frame which is desired to be copied by the printer. In the printing mode the portion of the image frame selected for reproduction is printed using an electrophotographic reproduction engine. An electro-static image of the image selected for reproduction is formed on a photoconductive drum by translating a pair of scanning mirrors. Means including a notched bracket movable with the scanning mirror is provided for controlling the "on" time of a projection lamp and/or corona charger so that electrostatic image formation occurs only for the portion of the image frame selected for reproduction. Adjustments to lamp "on" time are also made for different lamp brightness readings, since brighter lamps take a longer time to quench. Means are also provided for controlling lamp brightness in accordance with the exposure requirements of the portion selected for reproduction. The electrostatic image is then developed and transferred to a standard size copy sheet. The copy sheet thus includes only the image area selected for reproduction and clear areas upon which notes or comments may be written.
摘要翻译：微型读取器 - 打印机设备包括具有尺寸基准标记的观察屏幕，其指示与正在观看的图像帧的边缘的距离。该装置包括一个键盘，允许操作者向打印机控制器输入关于期望由打印机复制的图像帧部分的数据。在打印模式中，使用电子照相再现引擎打印选择用于再现的图像帧的部分。通过平移一对扫描反射镜，在感光鼓上形成选择用于再现的图像的静电图像。包括可移动扫描镜的切口支架的装置被设置用于控制投影灯和/或电晕充电器的“接通”时间，使得仅对于用于再现的图像帧的部分进行静电图像形成。对于不同的灯亮度读数，也可对灯“开”时间进行调整，因为更亮的灯需要更长的时间来淬火。还提供了用于根据选择用于再现的部分的曝光要求来控制灯的亮度的装置。然后将静电图像显影并转移到标准尺寸的复印纸上。因此，复印件仅包括选择用于再现的图像区域和可写入注释或注释的清晰区域。

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