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1. 发明授权

US09615747B2 Method for determining skin glycation 有权
公开(公告)号：US09615747B2
公开(公告)日：2017-04-11
申请号：US13007698
申请日：2011-01-17
申请人： Richard C. Roth , Matthew C. DePauw , Deborah A. O'Toole
发明人： Richard C. Roth , Matthew C. DePauw , Deborah A. O'Toole
IPC分类号： A61B6/00 , A61B5/00 , A61K49/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/0071 , A61B5/0075 , A61B5/443 , A61B5/4836 , A61K49/0004
摘要： A method for the measurement and analysis of skin fluorescence across multiple subjects. The method includes illuminating each subject with an excitation wavelength, detecting a peak fluorescence level within a corresponding emission wavelength range, determining relative levels of skin glycation for each subject, and evaluating the efficacy of a skin treatment based on the relative levels of skin glycation. The method can include ranking and normalizing the peak fluorescence levels for each subject, and the method is suitable for use in placebo-controlled studies of anti-glycation skin therapies.

2. 发明申请

US20110178411A1 METHOD FOR DETERMINING SKIN GLYCATION 有权
标题翻译：用于测定皮肤糖化的方法
公开(公告)号：US20110178411A1
公开(公告)日：2011-07-21
申请号：US13007698
申请日：2011-01-17
申请人： Richard C. Roth , Matthew C. DePauw , Deborah A. O'Toole
发明人： Richard C. Roth , Matthew C. DePauw , Deborah A. O'Toole
IPC分类号： A61B6/00 , A61K49/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/0071 , A61B5/0075 , A61B5/443 , A61B5/4836 , A61K49/0004
摘要： A method for the measurement and analysis of skin fluorescence across multiple subjects. The method includes illuminating each subject with an excitation wavelength, detecting a peak fluorescence level within a corresponding emission wavelength range, determining relative levels of skin glycation for each subject, and evaluating the efficacy of a skin treatment based on the relative levels of skin glycation. The method can include ranking and normalizing the peak fluorescence levels for each subject, and the method is suitable for use in placebo-controlled studies of anti-glycation skin therapies.
摘要翻译：用于测量和分析多个受试者皮肤荧光的方法。该方法包括用激发波长照射每个受试者，检测在相应的发射波长范围内的峰值荧光水平，确定每个受试者的皮肤糖基化的相对水平，以及基于皮肤糖基化的相对水平评估皮肤治疗的功效。该方法可以包括对每个受试者的峰值荧光水平进行排序和归一化，并且该方法适用于抗糖基化皮肤疗法的安慰剂对照研究。

3. 发明授权

US5423041A Coupling rules to an object-oriented program 失效
标题翻译：将规则耦合到面向对象的程序
公开(公告)号：US5423041A
公开(公告)日：1995-06-06
申请号：US590108
申请日：1990-09-28
申请人： Fred H. Burke , Keith O. Carlson , Richard C. Roth
发明人： Fred H. Burke , Keith O. Carlson , Richard C. Roth
IPC分类号： G06F9/06 , G06F9/44 , G06F9/45
CPC分类号： G06F8/315 , G06F9/4438
摘要： A method of coupling rules to a data domain of an object-oriented computer program. During run time, the coupling permits the computer to use rules to directly access user-defined objects for both the matching and the action phases of the inferencing process. Inferencing is implemented with an inference class object and user-defined class object are derived from a working memory element class.
摘要翻译：将规则耦合到面向对象的计算机程序的数据域的方法。在运行时间内，耦合允许计算机使用规则直接访问用户定义的对象，用于推理过程的匹配和动作阶段。推理使用推理类对象实现，用户定义的类对象是从工作内存元素类派生的。

4. 发明授权

US5644770A Coupling rules to an object-oriented program 失效
标题翻译：将规则耦合到面向对象的程序
公开(公告)号：US5644770A
公开(公告)日：1997-07-01
申请号：US400943
申请日：1995-03-08
申请人： Fred H. Burke , Keith O. Carlson , Richard C. Roth
发明人： Fred H. Burke , Keith O. Carlson , Richard C. Roth
IPC分类号： G06F9/06 , G06F9/44
CPC分类号： G06F8/315 , G06F9/4438
摘要： A method of coupling rules to a data domain of an object-oriented computer program. During run time, the coupling permits the computer to use rules to directly access user-defined objects for both the matching and the action phases of the inferencing process, Inferencing is implemented with an inference class object and user-defined class object are derived from a working memory element class.
摘要翻译：将规则耦合到面向对象的计算机程序的数据域的方法。在运行期间，耦合允许计算机使用规则来直接访问用户定义的对象，用于推理过程的匹配和动作阶段。引用使用推理类对象实现，用户定义的类对象从工作记忆元素类。

5. 发明授权

US4057060A Disposable medicinal application apparatus 失效
标题翻译：一次性药用施用装置
公开(公告)号：US4057060A
公开(公告)日：1977-11-08
申请号：US630185
申请日：1975-11-10
申请人： Richard C. Roth
发明人： Richard C. Roth
IPC分类号： A61M3/00 , A61M3/02 , A61M7/02
CPC分类号： A61M3/00 , A61M3/0262
摘要： A disposable medicinal application apparatus for use in the administration of a medicinal fluid comprises sealed flexible bag means at least partially filled with a quantity of the fluid to be applied. The apparatus has a neck piece freely enclosed within the sealed bag means, the neck piece being manipulable against the interior surface of a portion of the bag means and the bag wall being stretched over the neck piece. A separate applicator member has a passage in communication with discharge means. Cooperative locking and lockable means are formed on the applicator member and the neck piece, respectively, to allow the applicator member to be snap-fitted and locked to the neck piece, with the bore of the neck piece and the passage of the applicator member in alignment. A portion of the bag wall is compressed between the exterior surface of the neck piece and the interior surface of the applicator member to form a fluid-tight seal therebetween. A portion of the applicator member comprises means for puncturing the bag wall to allow egress of the medicinal fluid through the aligned bore and passage of the cooperatively locked neck piece and applicator member.
摘要翻译：用于给药液体的一次性药物施用装置包括至少部分填充有待施用流体量的密封柔性袋装置。该装置具有自由地封闭在密封袋装置内的颈部件，该颈部可操纵于袋装置的一部分的内表面，并且袋壁被拉伸在颈部件上。单独的涂抹器构件具有与排出装置连通的通道。合作的锁定和可锁定装置分别形成在涂抹器构件和颈部件上，以允许涂抹器构件卡扣并锁定在颈部件上，颈部件的孔和涂抹器构件的通道对准。袋壁的一部分在颈部件的外表面和涂抹器构件的内表面之间被压缩，以在它们之间形成流体密封的密封。施用器部件的一部分包括用于刺穿袋壁的装置，以允许医用流体通过对准的孔排出并且协同锁定的颈部件和涂抹器构件的通道。

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