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1. 发明授权

US08053563B2 YKL-40 monoclonal authority 有权
标题翻译： YKL-40单克隆抗体
公开(公告)号：US08053563B2
公开(公告)日：2011-11-08
申请号：US11817244
申请日：2006-02-16
申请人： Richard Bonnichsen , Paul Price
发明人： Richard Bonnichsen , Paul Price
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C07K2317/73
摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
摘要翻译：本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是成功治愈的先决条件。本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

2. 发明申请

US20090175870A1 YKL-40 MONOCLONAL AUTHORITY 有权
标题翻译： YKL-40单克隆抗体
公开(公告)号：US20090175870A1
公开(公告)日：2009-07-09
申请号：US11817244
申请日：2006-02-16
申请人： Richard Bonnichsen , Paul Price
发明人： Richard Bonnichsen , Paul Price
IPC分类号： A61K39/395 , C07K16/18 , C07K5/00 , C07K7/00 , C12N5/06 , A61K38/08
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C07K2317/73
摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
摘要翻译：本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是成功治愈的先决条件。本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

3. 发明授权

US08673301B2 YKL-40 monoclonal antibody 有权
标题翻译： YKL-40单克隆抗体
公开(公告)号：US08673301B2
公开(公告)日：2014-03-18
申请号：US13290803
申请日：2011-12-02
申请人： Richard Bonnichsen , Paul Price
发明人： Richard Bonnichsen , Paul Price
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C07K2317/73
摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
摘要翻译：本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是成功治愈的先决条件。本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

4. 发明申请

US20120149882A1 YKL-40 MONOCLONAL ANTIBODY 有权
标题翻译： YKL-40单克隆抗体
公开(公告)号：US20120149882A1
公开(公告)日：2012-06-14
申请号：US13290803
申请日：2011-12-02
申请人： Richard Bonnichsen , Paul Price
发明人： Richard Bonnichsen , Paul Price
IPC分类号： C07K16/40
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C07K2317/73
摘要： The present invention relates to monoclonal anti-human YKL-antibodies which are capable to modulate biological processes in which YKL-40 plays a prominent role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.
摘要翻译：本发明涉及能够调节其中YKL-40起突出作用的生物学过程的单克隆抗人YKL-抗体。抑制细胞，特别是癌细胞的生长和/或诱导细胞凋亡。本发明还涉及包含所述抗体的药物组合物，并且使用所述抗体和/或药物组合物来治疗疾病，其中抑制细胞生长，细胞分裂，细胞外基质的重塑，转移和/或由细胞凋亡引起的细胞死亡的诱导是成功治愈的先决条件。本发明的抗体能够通过与YKL-40上的特异性表位结合而在上述方法中抑制YKL-40的生物学功能。

5. 发明授权

US4300423A Apparatus for severing and separating cup-shaped object supports 失效
标题翻译：用于切断和分离杯形物体支架的装置
公开(公告)号：US4300423A
公开(公告)日：1981-11-17
申请号：US91196
申请日：1979-11-07
申请人： Paul Price
发明人： Paul Price
IPC分类号： B01L99/00 , B26D1/547 , B26D3/00 , B01L11/00
CPC分类号： B01L99/00 , B26D1/547 , Y10T83/2216 , Y10T83/222 , Y10T83/6544 , Y10T83/6614 , Y10T83/7587
摘要： For the purposes of severing and separating a plurality of cup-shaped object supports (2) of plastic material, which are interconnectedly arranged on a support plate (1), use is made of a method wherein the support plate (1) is first put into a gripping device (4) and secured therein. Subsequently a severing device (5) which is displaceable in the plane of the support plate (1) is set in motion to sever the cup-shaped object supports by means of a saw blade (14). The object supports (2) fall into the respectively associated glass reagent vessels (20) by way of distributor passages (18) which lead downwardly in a truncated pyramid configuration, which reagent vessels can be pushed into position below the distributor block (17) in a container carrier (19). The method according to the invention replaces the conventional operations of severing and separating the object supports (2) by a shears.
摘要翻译：为了切断和分离互连地布置在支撑板（1）上的多个塑料材料的杯形物体支撑件（2）的目的，使用其中首先放置支撑板（1）的方法进入夹紧装置（4）并固定在其中。随后，在支撑板（1）的平面中可移位的切断装置（5）被运动以通过锯片（14）切断杯形物体支撑件。物体支撑件（2）通过分配器通道（18）落入分别关联的玻璃试剂容器（20）中，分配器通道（18）以截锥形结构向下引导，该试剂容器可以被推入分配器块（17）下方的位置容器托架（19）。根据本发明的方法取代了用剪切机切断和分离物体支撑件（2）的常规操作。

6. 发明授权

US08455246B2 Serum-free mammalian cell culture medium, and uses thereof 有权
标题翻译：无血清哺乳动物细胞培养基及其用途
公开(公告)号：US08455246B2
公开(公告)日：2013-06-04
申请号：US12463351
申请日：2009-05-08
申请人： Stephen Gorfien , Richard Fike , Glenn Godwin , Joyce Dzimian , David A. Epstein , Dale Gruber , Paul Price
发明人： Stephen Gorfien , Richard Fike , Glenn Godwin , Joyce Dzimian , David A. Epstein , Dale Gruber , Paul Price
IPC分类号： A61K33/32 , A61K33/34 , A01N59/16 , C12N5/00 , C12N5/02 , C12N5/07 , C12N5/10 , C12N11/00 , C12N11/16
CPC分类号： C12N5/0682 , C07K14/61 , C12N5/0037 , C12N5/0043 , C12N5/005 , C12N5/0603 , C12N7/00 , C12N9/2402 , C12N9/2471 , C12N15/85 , C12N2500/14 , C12N2500/16 , C12N2500/22 , C12N2500/24 , C12N2500/32 , C12N2500/34 , C12N2500/35 , C12N2500/38 , C12N2500/74 , C12N2500/76 , C12N2500/90 , C12N2500/95 , C12N2501/90 , C12N2501/91 , C12N2710/10051 , C12Y302/01023
摘要： The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.
摘要翻译：本发明提供了支持哺乳动物细胞，特别是上皮细胞和成纤维细胞的体外培养，特别是悬浮液的细胞培养基制剂，以及使用这些培养基在体外悬浮培养哺乳动物细胞的方法。培养基包含基础培养基和聚阴离子或聚阴离子化合物，优选多磺化或多硫酸化合物，更优选硫酸葡聚糖。本发明还提供化学上定义的，无蛋白质的真核细胞培养基，其包含铁螯合物和锌，其能够支持悬浮培养物中的生长（特别是哺乳动物细胞的高密度生长），从而增加表达水平的培养细胞中的重组蛋白，和/或增加培养细胞中的病毒产生。

7. 发明授权

US08048637B2 Diagnostic composition and method for the detection of a Trichinella infection 有权
标题翻译：用于检测旋毛虫感染的诊断组合物和方法
公开(公告)号：US08048637B2
公开(公告)日：2011-11-01
申请号：US12666027
申请日：2007-06-29
申请人： Patrik Buholzer , Alex Raber , Paul Price , Daniel Zwald , Weldy Bonilla Pinschewer , Roger Marti , Jurg Weidmann , Christoph Stamm
发明人： Patrik Buholzer , Alex Raber , Paul Price , Daniel Zwald , Weldy Bonilla Pinschewer , Roger Marti , Jurg Weidmann , Christoph Stamm
IPC分类号： G01N33/53 , G01N33/532 , G01N33/531 , G01N33/533 , A61K38/00
CPC分类号： G01N33/5308 , C07K14/4354 , G01N33/569 , G01N33/6854 , G01N2333/4353
摘要： A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.
摘要翻译：一种用于检测从被旋毛虫感染的动物或人获得的样品中的抗体的诊断组合物，其包含至少一种含有一系列氨基酸的肽，所述氨基酸形成由感染旋毛虫的猪的血清识别的连续或不连续表位。

8. 发明申请

US20100190182A1 DIAGNOSTIC COMPOSITION AND METHOD FOR THE DETECTION OF A TRICHINELLA INFECTION 有权
标题翻译：诊断组合物和检测TRICHINELLA感染的方法
公开(公告)号：US20100190182A1
公开(公告)日：2010-07-29
申请号：US12666027
申请日：2007-06-29
申请人： Patrik Buholzer , Alex Raber , Paul Price , Daniel Zwald , Weldy Bonilla Pinschewer , Roger Marti , Jurg Weidmann , Christoph Stamm
发明人： Patrik Buholzer , Alex Raber , Paul Price , Daniel Zwald , Weldy Bonilla Pinschewer , Roger Marti , Jurg Weidmann , Christoph Stamm
IPC分类号： G01N33/53 , C07K2/00
CPC分类号： G01N33/5308 , C07K14/4354 , G01N33/569 , G01N33/6854 , G01N2333/4353
摘要： A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.
摘要翻译：一种用于检测从被旋毛虫感染的动物或人获得的样品中的抗体的诊断组合物，其包含至少一种含有一系列氨基酸的肽，所述氨基酸形成由感染旋毛虫的猪的血清识别的连续或不连续表位。

9. 发明授权

US07103860B2 Verification of embedded test structures in circuit designs 有权
公开(公告)号：US07103860B2
公开(公告)日：2006-09-05
申请号：US10349452
申请日：2003-01-23
申请人： Paul Price , Jean-François Côté , Ajit Kumar Verma
发明人： Paul Price , Jean-François Côté , Ajit Kumar Verma
IPC分类号： G06F17/50
CPC分类号： G01R31/318314 , G01R31/318307 , G01R31/318357 , G06F17/5022
摘要： A program product for use in generating test benches for verifying test structures embedded in a circuit, comprises a verification specification processor for parsing a verification specification containing test specifications for selected test structures and a test bench generator for each of one or more types of embedded test structures, each test bench generator being operable to process a test structure specification of a test structure of a corresponding test structure type and generate a test bench using data contained in said test specifications of said verification specification, data contained in said test structure specification and data contained in a test connection specification.

10. 发明申请

US20060148074A1 Serum-free mammalian cell culture medium, and uses thereof 有权
公开(公告)号：US20060148074A1
公开(公告)日：2006-07-06
申请号：US11151647
申请日：2005-06-14
申请人： Stephen Gorfien , Richard Fike , Glenn Godwin , Joyce Dzimian , David Epstein , Dale Gruber , Don McClure , Paul Price
发明人： Stephen Gorfien , Richard Fike , Glenn Godwin , Joyce Dzimian , David Epstein , Dale Gruber , Don McClure , Paul Price
IPC分类号： C12N5/06
CPC分类号： C12N5/0682 , C07K14/61 , C12N5/0037 , C12N5/0043 , C12N5/005 , C12N5/0603 , C12N7/00 , C12N9/2402 , C12N9/2471 , C12N15/85 , C12N2500/14 , C12N2500/16 , C12N2500/22 , C12N2500/24 , C12N2500/32 , C12N2500/34 , C12N2500/35 , C12N2500/38 , C12N2500/74 , C12N2500/76 , C12N2500/90 , C12N2500/95 , C12N2501/90 , C12N2501/91 , C12N2710/10051 , C12Y302/01023
摘要： The present invention provides a cell culture medium formulation that supports the in vitro cultivation, particularly in suspension, of mammalian cells, particularly epithelial cells and fibroblast cells, and methods for cultivating mammalian cells in suspension in vitro using these media. The media comprise a basal medium and a polyanionic or polyanionic compound, preferably a polysulfonated or polysulfated compound, and more preferably dextran sulfate. The present invention also provides chemically defined, protein-free eukaryotic cell culture media comprising an iron chelate and zinc, which is capable of supporting the growth (and particularly the high-density growth of mammalian cells) in suspension culture, increasing the level of expression of recombinant protein in cultured cells, and/or increasing virus production in cultured cells.

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