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1. 发明授权

US06580944B1 Method and apparatus for diagnosing sleep breathing disorders while a patient in awake 失效
标题翻译：睡眠呼吸障碍的诊断方法和装置
公开(公告)号：US06580944B1
公开(公告)日：2003-06-17
申请号：US09724402
申请日：2000-11-28
申请人： Richard A. Katz , Michael S. Lawee , Anthony Kiefer Newman
发明人： Richard A. Katz , Michael S. Lawee , Anthony Kiefer Newman
IPC分类号： A61B50472
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/024 , A61B5/0402 , A61B5/05 , A61B5/087 , A61B5/1455
摘要： An apparatus and method for identifying the timing of the onset of and duration of an event characteristic of sleep breathing disorder while a patient is awake. Chaotic processing techniques analyze data concerning a cardio-respiratory function, such as nasal air flow. Excursions of the resulting signal beyond a threshold provide markers for delivering the average repetition rate for such events that is useful in the diagnosis of obstructed sleep apnea and other respiratory dysfunctions.
摘要翻译：一种用于在患者清醒时识别睡眠呼吸障碍特征的事件发作时间和持续时间的装置和方法。混沌处理技术分析有关呼吸功能的数据，如鼻气流量。所产生的信号超出阈值的偏移提供了用于传递用于诊断阻塞性睡眠呼吸暂停和其它呼吸功能障碍的这种事件的平均重复率的标记。

2. 发明授权

US5769084A Method and apparatus for diagnosing sleep breathing disorders 失效
标题翻译：用于诊断睡眠呼吸障碍的方法和装置
公开(公告)号：US5769084A
公开(公告)日：1998-06-23
申请号：US687098
申请日：1996-07-10
申请人： Richard A. Katz , Michael S. Lawee , A. Kief Newman
发明人： Richard A. Katz , Michael S. Lawee , A. Kief Newman
IPC分类号： A61B5/113 , A61B5/0472
CPC分类号： A61B5/4818 , A61B5/113
摘要： An apparatus and method for identifying the timing of the onset of and duion of an event characteristic of sleep breathing disorder. Chaotic processing techniques analyze data concerning one or more cardio-respiratory functions such as nasal air flow, chest wall effort, oxygen saturation, heart rate and heart activity. Excursions of the resulting signal beyond a threshold provide markers for the timing of such an event that is useful in the diagnosis of obstructed sleep apnea and other respiratory dysfunctions.
摘要翻译：一种用于识别睡眠呼吸障碍特征的发作时间和持续时间的装置和方法。混沌处理技术分析关于一种或多种心脏呼吸功能的数据，例如鼻气流量，胸壁力，氧饱和度，心率和心脏活动。所产生的信号超出阈值的偏移提供了用于诊断阻塞性睡眠呼吸暂停和其他呼吸功能障碍的这种事件的时间的标记。

3. 发明授权

US08611190B1 Bio-acoustic wave energy transducer 有权
标题翻译：生物声波能量传感器
公开(公告)号：US08611190B1
公开(公告)日：2013-12-17
申请号：US13246951
申请日：2011-09-28
申请人： Derke R. Hughes , Richard A. Katz , Albert H. Nuttall , John R. Cooley
发明人： Derke R. Hughes , Richard A. Katz , Albert H. Nuttall , John R. Cooley
IPC分类号： H04B3/00 , H04R3/00 , H04R27/04 , H04R17/00
CPC分类号： H04R3/00 , H04R1/2811 , H04R2430/03
摘要： A method and apparatus is taught for a signal processing breakthrough that significantly alleviates the “Curse of Dimensionality” (COD) in the characterization of nonlinear physical systems; namely, the reduction in the number of coefficients used to describe the higher order (i.e., nonlinear) kernels in the Volterra series expansion. The latter technique provides the means to evaluate simultaneously from a wide band excitation, all the inter-modulation products up to a specified order by greatly reducing the number of coefficients in the higher order kernel estimation to a manageable set that can be easily manipulated by current personal computers used to enhance a finite element (FE) model that generates a bio-inspired acoustic transducer model.
摘要翻译：教授了一种信号处理突破的方法和装置，显着减轻了非线性物理系统表征中的“尺寸诅咒”（COD）; 即用于描述Volterra系列扩展中的较高阶（即非线性）内核的系数数目的减少。后一种技术提供了通过大大减少高阶核估计中的系数数目到可容易地由当前流程操纵的可管理集合的同时从宽频带激励，所有调制间产生到所指定的顺序的方法。用于增强生成有吸引力的声换能器模型的有限元（FE）模型的个人计算机。

4. 发明授权

US06714481B1 System and method for active sonar signal detection and classification 有权
标题翻译：用于主动声纳信号检测和分类的系统和方法
公开(公告)号：US06714481B1
公开(公告)日：2004-03-30
申请号：US10263299
申请日：2002-09-30
申请人： Richard A. Katz , Albert H. Nuttal
发明人： Richard A. Katz , Albert H. Nuttal
IPC分类号： G01S1589
CPC分类号： G01S7/52001
摘要： A sonar system and method are provided to extract and identify information about a particular target illuminated by an active sonar system. The present invention utilizes a Volterra Series Expansion in conjunction with a least squares procedure to estimate channel and target responses, which may be linear or nonlinear. The system estimates the channel and target responses for different orders of the Volterra Series Expansion and then selects the order for which a minimum error is determined with respect to a measured acoustic return signal. The system requires as inputs only the excitation waveform and the measured acoustic return signal.
摘要翻译：提供声纳系统和方法以提取和识别关于由主动声纳系统照明的特定目标的信息。本发明利用Volterra系列扩展结合最小二乘法来估计信道和目标响应，其可以是线性的或非线性的。系统估计Volterra系列扩展的不同阶数的通道和目标响应，然后选择相对于测量的声学返回信号确定最小误差的顺序。该系统仅需要激励波形和测量的声学返回信号作为输入。

5. 发明申请

US20090003134A1 Method and Apparatus for Improved Active Sonar Using Singular Value Decomposition Filtering 失效
标题翻译：使用奇异值分解滤波改进主动声纳的方法和装置
公开(公告)号：US20090003134A1
公开(公告)日：2009-01-01
申请号：US11768361
申请日：2007-06-26
申请人： Albert H. Nuttall , Richard A. Katz
发明人： Albert H. Nuttall , Richard A. Katz
IPC分类号： G01S15/00
CPC分类号： G01S15/101 , G01S15/582
摘要： The invention is a method for improved active sonar using a singular value decomposition filtering and a Volterra-Hermite Basis Expansion to model real active sonar measurements. The fitting model minimizes the sum of the squared errors between a measured channel response, z(t), and model response, y(t), which is a fitted Volterra Series solution. The model requires as input an excitation waveform, x(t), to which is fitted the model response, y(t). A contracted broadband cross-ambiguity function is used to correct the excitation waveform for Doppler and range effects. Once completed, the modeled response can be used to determine the linearity or non-linearity of the channel effects. Appropriate measures can be utilized to reduce these effects on the measured channel response.
摘要翻译：本发明是使用奇异值分解滤波和Volterra-Hermite Basis扩展来改进主动声纳的方法，以模拟实际的主动声纳测量。拟合模型最小化测量的通道响应z（t）和模型响应y（t）之间的平方误差之和，这是一个适合的Volterra系列解决方案。该模型需要作为输入的激励波形x（t），其中拟合模型响应y（t）。使用合同的宽带交叉模糊函数来校正多普勒和范围效应的激励波形。一旦完成，建模的响应可以用于确定通道效应的线性或非线性。可以采用适当的措施来减少对测量的通道响应的影响。

6. 发明授权

US5319608A Method and system for identifying the onset of a turbulent boundary layer induced by a body moving through a fluid medium 失效
标题翻译：用于识别由移动通过流体介质的身体引起的湍流边界层的开始的方法和系统
公开(公告)号：US5319608A
公开(公告)日：1994-06-07
申请号：US117514
申请日：1993-09-02
申请人： Richard A. Katz
发明人： Richard A. Katz
IPC分类号： B64C23/00 , F15D1/12
CPC分类号： F15D1/12 , B64C23/00
摘要： A method of detect the onset of turbulence in connection with a body movinghrough a fluid medium. First, the body is supplied with sensors each for generating a signal suitable for measuring amplitude of pressure fluctuations of the medium proximate a region of said sidewall of the body in at least a region of the body in which turbulence is expected to occur. During a reference stage during which the body moves through the fluid medium when it is known that turbulence is occurring around at least a portion of said body , the sensors each generate reference temporal pressure data representing fluctuations in pressure of the fluid medium around said body. In response to reference temporal pressure data generated by sensors in a turbulence zone at which turbulence is occurring and sensors in a transition zone between the turbulence zone and a laminar flow zone, a method-of-delay phase portrait is generated for each of a progression of selected delay intervals. These operations are repeated during an operational stage, and phase portraits generated during the operational stage are compared to phase portraits in response to the reference temporal pressure data from the transitional zone and the turbulence zone, for corresponding ones of said selected delay intervals,, and a determination of the onset of turbulence is made in response to such comparison.
摘要翻译：检测与移动通过流体介质的物体相关的湍流的发生的方法。首先，向身体提供传感器，每个传感器用于产生适合于在预期发生湍流的身体的至少一个区域中测量靠近身体的所述侧壁的区域的介质的压力波动的幅度的信号。在已知在所述主体的至少一部分周围发生湍流的参考阶段期间，身体移动通过流体介质，传感器每个生成表示围绕所述主体的流体介质的压力波动的参考时间压力数据。响应于在湍流发生的湍流区域中的传感器产生的参考时间压力数据和在湍流区域和层流区域之间的过渡区域中的传感器，生成延迟相位图像的方法的选定延迟间隔。在操作阶段重复这些操作，并且响应于来自过渡区和湍流区的参考时间压力数据，在操作阶段期间产生的相位肖像与相位肖像进行比较，并且对于相应的所述选择的延迟间隔，以及响应于这样的比较来确定湍流的发生。

7. 发明申请

US20110172107A1 ASSAY FOR IDENTIFYING AGENTS THAT MODULATE EPIGENETIC SILENCING, AND AGENTS IDENTIFIED THEREBY 审中-公开
标题翻译：用于识别调节沉默剂的试剂的测定和鉴定的试剂
公开(公告)号：US20110172107A1
公开(公告)日：2011-07-14
申请号：US12736702
申请日：2009-04-30
申请人： Richard A. Katz , Anna Marie Skalka
发明人： Richard A. Katz , Anna Marie Skalka
IPC分类号： C12Q1/68 , C40B30/00 , C12N5/071 , C12N9/78 , C07K14/47 , C12N9/10 , C12N9/00 , C12N9/02
CPC分类号： C12N15/111 , C12N2320/12
摘要： A high throughput RNAi-based assay for identify factors involved in maintaining epigenetic silencing is disclosed. The assay measures reactivation of a silent reporter gene in cells, resulting from RNAi-based knockdown in target mRNA. RNAi-based screening of these silent reporter cells has identified known enzymes that place or remove epigenetic marks on histones, as well as non-enzymatic proteins that function in silencing or in transfer of marks during S-phase. In addition, the screen has been used to identify a number of novel gene products involved in epigenetic silencing, which are also disclosed.
摘要翻译：公开了用于识别维持表观遗传学沉默的因素的高通量RNAi测定。该测定法测定细胞中无声报道基因的再活化，由基于RNAi的靶mRNA敲低引起。这些无声报道细胞的基于RNAi的筛选已经鉴定了在组蛋白中放置或除去表观遗传标记的已知酶，以及在S期期间沉默或转移标记的非酶蛋白质。此外，该屏幕已经用于鉴定参与表观遗传学沉默的许多新的基因产物，这也被公开。

8. 发明授权

US06356816B1 Method and apparatus for reducing drag in marine vessels 失效
标题翻译：减少船舶阻力的方法和装置
公开(公告)号：US06356816B1
公开(公告)日：2002-03-12
申请号：US09663422
申请日：2000-09-15
申请人： Richard A. Katz
发明人： Richard A. Katz
IPC分类号： B64C2300
CPC分类号： B63B1/38 , B63B2001/387 , Y02T70/122
摘要： A system is disclosed that applies non-linear signal processing methods derived from theories of information and non-linear oscillations (chaos) to control the turbulent boundary layer of marine vessels in order to reduce the drag to which the vessels encountered while moving in water. The system uses measurement probes mounted along the hull of a marine vessel to provide detection markers for increase or decrease in the drag based on a prescribed fluid (i.e., air) injection and flow rate in boundary layer. The invention utilizes a differential radius (DR) to determine the minimum entropy for a given flow rate in the boundary layer which defines the optimum condition used by the system for reducing drag.
摘要翻译：公开了一种应用从信息理论和非线性振荡（混沌）导出的非线性信号处理方法来控制海洋船舶的湍流边界层的系统，以便减少在水中移动时遇到的船舶的阻力。该系统使用沿海洋船体的船体安装的测量探针，以提供基于边界层中的规定流体（即空气）喷射和流速来增加或减少阻力的检测标记。本发明利用差分半径（DR）来确定边界层中给定流速的最小熵，其限定了系统用于减少阻力的最佳条件。

9. 发明授权

US5359663A Method and system for suppressing noise induced in a fluid medium by a body moving therethrough 失效
标题翻译：通过移动通过其的身体抑制流体介质中引起的噪声的方法和系统
公开(公告)号：US5359663A
公开(公告)日：1994-10-25
申请号：US117513
申请日：1993-09-02
申请人： Richard A. Katz
发明人： Richard A. Katz
IPC分类号： G10K11/178 , G10K11/16
CPC分类号： G10K11/178 , G10K2210/127 , G10K2210/3048 , G10K2210/3229
摘要： A method of detecting the onset of turbulence in connection with a body mng through a fluid medium and reducing turbulence noise in acoustic sensor systems carried thereby. First, the body is supplied with sensors each for generating a signal suitable for measuring amplitude of pressure fluctuations of the medium proximate a region of said sidewall of the body in at least a region of the body in which turbulence is expected to occur. During a reference stage during which the body moves through the fluid medium when it is known that turbulence is occurring around at least a portion of said body, the sensors each generate reference temporal pressure data representing fluctuations in pressure of the fluid medium around said body. In response to reference temporal pressure data generated by sensors in a turbulence zone at which turbulence is occurring and sensors in a transition zone between the turbulence zone and a laminar flow zone, method-of-delay phase portraits are generated for a progression of selected delay intervals. During an operational stage, the signals from the sensors are filtered to generate a portion representing the turbulence due to motion of the body through the medium and a portion representing signals from external acoustic signal sources, and the turbulence signal portion is used to generate signals of appropriate phase which are injected into the medium to reduce the turbulence noise signals.
摘要翻译：检测与通过流体介质移动的物体相关的湍流的发生并降低由此携带的声学传感器系统中的湍流噪声的方法。首先，向身体提供传感器，每个传感器用于产生适合于在预期发生湍流的身体的至少一个区域中测量靠近身体的所述侧壁的区域的介质的压力波动的幅度的信号。在已知在所述主体的至少一部分周围发生湍流的参考阶段期间，身体移动通过流体介质，传感器每个生成表示围绕所述主体的流体介质的压力波动的参考时间压力数据。响应于在湍流发生的湍流区域中的传感器产生的参考时间压力数据和在湍流区域和层流区域之间的过渡区域中的传感器，产生延迟相位画像以用于所选延迟的进展间隔在操作阶段期间，来自传感器的信号被过滤以产生表示由身体通过介质的运动引起的湍流的部分和表示来自外部声信号源的信号的部分，并且湍流信号部分用于产生适当的相位注入到介质中以减少湍流噪声信号。

10. 发明授权

US07929375B2 Method and apparatus for improved active sonar using singular value decomposition filtering 失效
标题翻译：使用奇异值分解滤波改进主动声纳的方法和装置
公开(公告)号：US07929375B2
公开(公告)日：2011-04-19
申请号：US11768361
申请日：2007-06-26
申请人： Albert H. Nuttall , Richard A. Katz
发明人： Albert H. Nuttall , Richard A. Katz
IPC分类号： G01S15/00
CPC分类号： G01S15/101 , G01S15/582
摘要： The invention is a method for improved active sonar using a singular value decomposition filtering and a Volterra-Hermite Basis Expansion to model real active sonar measurements. The fitting model minimizes the sum of the squared errors between a measured channel response, z(t), and model response, y(t), which is a fitted Volterra Series solution. The model requires as input an excitation waveform, x(t), to which is fitted the model response, y(t). A contracted broadband cross-ambiguity function is used to correct the excitation waveform for Doppler and range effects. Once completed, the modeled response can be used to determine the linearity or non-linearity of the channel effects. Appropriate measures can be utilized to reduce these effects on the measured channel response.
摘要翻译：本发明是使用奇异值分解滤波和Volterra-Hermite Basis扩展来改进主动声纳的方法，以模拟实际的主动声纳测量。拟合模型最小化测量的通道响应z（t）和模型响应y（t）之间的平方误差之和，这是一个适合的Volterra系列解决方案。该模型需要作为输入的激励波形x（t），其中拟合模型响应y（t）。使用合同的宽带交叉模糊函数来校正多普勒和范围效应的激励波形。一旦完成，建模的响应可以用于确定通道效应的线性或非线性。可以采用适当的措施来减少对测量的通道响应的影响。

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