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1. 发明申请

US20070281971A1 Novel Compound 有权
标题翻译：新型化合物
公开(公告)号：US20070281971A1
公开(公告)日：2007-12-06
申请号：US11672536
申请日：2007-02-08
申请人： Reshma Chudasama , Andrew Kennedy
发明人： Reshma Chudasama , Andrew Kennedy
IPC分类号： A61K31/4709 , C07D401/02
CPC分类号： C07D401/12
摘要： A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof, for use in treating pulmonary disorders.
摘要翻译：联苯-2-基氨基甲酸1- [2-（2-氯-4 - {[（R）-2-羟基-2-（8-羟基-2-氧代-1,2-二氢喹啉-2-基）嘧啶-5-基）乙基氨基]甲基} -5-甲氧基苯基氨基甲酰基）乙基]哌啶-4-基酯或其溶剂合物，用于治疗肺部疾病。

2. 发明授权

US07960551B2 Compound 有权
标题翻译：复合
公开(公告)号：US07960551B2
公开(公告)日：2011-06-14
申请号：US11672536
申请日：2007-02-08
申请人： Reshma Chudasama , Andrew Kennedy
发明人： Reshma Chudasama , Andrew Kennedy
IPC分类号： C07D215/38
CPC分类号： C07D401/12
摘要： A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof, for use in treating pulmonary disorders.
摘要翻译：联苯-2-基氨基甲酸1- [2-（2-氯-4 - {[（R）-2-羟基-2-（8-羟基-2-氧代-1,2-二氢喹啉-2-基）嘧啶-5-基）乙基氨基]甲基} -5-甲氧基苯基氨基甲酰基）乙基]哌啶-4-基酯或其溶剂合物，用于治疗肺部疾病。

3. 发明申请

US20050033605A1 Configuring a semantic network to process health care transactions 审中-公开
标题翻译：配置语义网络来处理医疗交易
公开(公告)号：US20050033605A1
公开(公告)日：2005-02-10
申请号：US10680863
申请日：2003-10-07
申请人： Heather Bergeron , Chris Easton , Andrew Kennedy , James Kennedy , Doug Koen , Eugene Krylov , John Morris , Jayant Pai , Alon Peled , Simone Pringle , John Trustman , Lyubomir Vujisic , Andre Yoshida
发明人： Heather Bergeron , Chris Easton , Andrew Kennedy , James Kennedy , Doug Koen , Eugene Krylov , John Morris , Jayant Pai , Alon Peled , Simone Pringle , John Trustman , Lyubomir Vujisic , Andre Yoshida
IPC分类号： G06F17/27 , G06Q10/00 , G06F17/60
CPC分类号： G06Q10/10 , G06F17/2785 , G06Q30/0601 , G06Q50/22
摘要： The disclosed technology can identify indicia associated with different entity types (e.g., health care companies, health care suppliers, health care practitioners, etc.) that interact within a health care industry, identify one or more relationships (e.g., contractual provisions) that can affect interactions between such entity types, and identify transactions associated with one or more of the interactions. Further, the identified transactions can be organized into one or more transaction sequences. The identified indicia, the one or more identified relationships, and the one or more transaction sequences can then be associated to form a semantic network. An instance of the semantic network can be formed based, at least in part, on a detection of at least one interaction associated with the entities.
摘要翻译：所公开的技术可以识别与在医疗保健行业内相互作用的不同实体类型（例如，医疗保健公司，医疗保健供应商，医疗保健从业人员等）相关联的标记，识别一个或多个关系（例如合同条款）影响此类实体类型之间的交互，并识别与一个或多个交互关联的事务。此外，所识别的事务可以被组织成一个或多个事务序列。所识别的标记，一个或多个所识别的关系以及一个或多个事务序列随后可以被关联以形成语义网络。可以至少部分地基于与实体相关联的至少一个交互的检测来形成语义网络的实例。

4. 发明授权

US4651657A Button orientating apparatus 失效
标题翻译：按钮定位装置
公开(公告)号：US4651657A
公开(公告)日：1987-03-24
申请号：US676984
申请日：1984-04-12
申请人： Andrew Kennedy
发明人： Andrew Kennedy
IPC分类号： D05B3/22
CPC分类号： D05B3/22
摘要： A button support 53 is upwardly biased and is movable along a vertical axis between three positions. Buttons formed with at least two thread holes are orientated by rotary frictional drive means 60 and 61 through effecting relative rotation between the button support 53 and a button 101 which are located by positioning means 13 and 18 positioning a button above the button support. In the lowest position of the button support, the button support is free to rotate about the vertical axis relative to a button 101 located by the positioning means 13 and 18. In an intermediate position the button support together with the button located by the positioning means 13 and 18 are rotatable about the vertical axis. Pins 54 project upwardly from the button support 53 for insertion in the holes of the button so that the button and button support can rotate together. In an upper position, the button support is locked against further rotation so as to provide a support for buttons in the required orientation.
摘要翻译：按钮支撑件53向上偏置并且可沿着三个位置之间的竖直轴线移动。形成有至少两个螺纹孔的按钮由旋转摩擦驱动装置60和61定向，以通过定位装置13和18定位按钮支撑件上方的按钮而定位在按钮支撑件53和按钮101之间的相对旋转。在按钮支撑件的最低位置，按钮支撑件相对于由定位装置13和18定位的按钮101围绕垂直轴线自由旋转。在中间位置，按钮与由定位装置定位的按钮一起支撑 13和18可以围绕垂直轴线旋转。销54从按钮支撑件53向上突出以插入按钮的孔中，使得按钮和按钮支撑件可以一起旋转。在上部位置，按钮支撑件被锁定以防止进一步旋转，以便为所需取向中的按钮提供支撑。

5. 发明申请

US20120220779A1 Novel Processes 审中-公开
标题翻译：新进程
公开(公告)号：US20120220779A1
公开(公告)日：2012-08-30
申请号：US13503867
申请日：2010-11-02
申请人： Claire Frances Crawford , Sandrine Garcia , Jonathan Paul Graham , Sandra Jane Harling , Nicholas Paul Henley , Stephen Andrew Hermitage , John Howard Hutchinson , Trevor Raymond Keel , Andrew Kennedy , Andrew McMurtrie Mason , Mark Simon Scott , Neil Michael Smith , Nicholas Simon Stock , Yuichi Tateno , Leontine Saskia Trouw , Peter Graham Turner , Christopher John Wallis , Robert David Willacy
发明人： Claire Frances Crawford , Sandrine Garcia , Jonathan Paul Graham , Sandra Jane Harling , Nicholas Paul Henley , Stephen Andrew Hermitage , John Howard Hutchinson , Trevor Raymond Keel , Andrew Kennedy , Andrew McMurtrie Mason , Mark Simon Scott , Neil Michael Smith , Nicholas Simon Stock , Yuichi Tateno , Leontine Saskia Trouw , Peter Graham Turner , Christopher John Wallis , Robert David Willacy
IPC分类号： C07D401/14
CPC分类号： C07D403/14
摘要： The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.
摘要翻译：本发明提供了可用于制备5-脂氧合酶活化蛋白（FLAP）抑制剂及其中间体的方法。特别地，制备3- [3-（叔丁基硫烷基）-1- [4-（6-乙氧基 - 吡啶-3-基）苄基] -5-（5-甲基 - 吡啶-2-基 - 甲氧基）-1H-吲哚-2-基] -2,2-二甲基 - 丙酸，3- [3-（叔丁基硫烷基）-1- [4-（6-乙氧基 - 吡啶-2-基）吡啶-3-基）苄基] -5-（5-甲基 - 吡啶-2-基 - 甲氧基）-1H-吲哚-2-基] -2,2-二甲基 - 丙酸酯，以及可用于所述方法的中间体。

6. 发明申请

US20120214858A1 IMIDAMIDE SPHINGOSINE KINASE INHIBITORS 有权
标题翻译：咪嘧啶兴奋剂激酶抑制剂
公开(公告)号：US20120214858A1
公开(公告)日：2012-08-23
申请号：US13390207
申请日：2010-08-16
申请人： Kevin R. Lynch , Timothy L. Macdonald , Thomas P. Mathews , Andrew Kennedy , Yugesh Kharel
发明人： Kevin R. Lynch , Timothy L. Macdonald , Thomas P. Mathews , Andrew Kennedy , Yugesh Kharel
IPC分类号： A61K31/40 , C07D207/16 , A61K31/166 , A61K31/167 , A61K31/16 , A61K31/155 , A61P35/00 , A61P9/00 , A61P11/06 , A61P37/00 , A61P29/00 , A61P43/00 , A61P27/02 , A61P3/10 , A61P19/02 , A61P1/00 , A61P25/00 , A61P11/00 , A61P13/12 , A61P1/16 , C07C257/16
CPC分类号： C07D207/09 , A61K31/155 , A61K31/40 , C07C257/16 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2103/74 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74
摘要： Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
摘要翻译：提供可以抑制鞘氨醇激酶1和鞘氨醇激酶2（SphK1和SphK2）活性的亚胺酰胺（脒）类似物。这些化合物可以预防肿瘤中的血管生成。

7. 发明申请

US20060173672A1 Processing health care transactions using a semantic network 审中-公开
标题翻译：使用语义网络处理医疗保健交易
公开(公告)号：US20060173672A1
公开(公告)日：2006-08-03
申请号：US10681052
申请日：2003-10-07
申请人： Heather Bergeron , Chris Easton , Andrew Kennedy , James Kennedy , Doug Koen , Eugene Krylov , John Morris , Jayant Pai , Alon Peled , Simone Pringle , John Trustman , Lyubomir Vujisic , Andre Yoshida
发明人： Heather Bergeron , Chris Easton , Andrew Kennedy , James Kennedy , Doug Koen , Eugene Krylov , John Morris , Jayant Pai , Alon Peled , Simone Pringle , John Trustman , Lyubomir Vujisic , Andre Yoshida
IPC分类号： G06F17/27
CPC分类号： G06F17/27
摘要： The disclosed technology can execute a sequence of transactions to process a request associated with a health care company and/or other entities interacting in a health care industry. Execution of at least some of the transaction sequence can result in the formation of an instance of a semantic network that can be used to support such processing. The request can correspond to a change in a relationship associated with such entities, where such request corresponds to an electronic document exhibiting a structured natural language format with a fixed context and a fixed grammar.
摘要翻译：所公开的技术可以执行一系列交易以处理与医疗保健公司和/或在医疗保健行业中交互的其他实体相关联的请求。执行至少一些事务序列可以导致形成可用于支持这种处理的语义网络的实例。该请求可以对应于与这种实体相关联的关系的改变，其中这样的请求对应于呈现具有固定上下文和固定语法的结构化自然语言格式的电子文档。

8. 发明申请

US20050033583A1 Processing transactions using a structured natural language 审中-公开
标题翻译：使用结构化自然语言处理事务
公开(公告)号：US20050033583A1
公开(公告)日：2005-02-10
申请号：US10656909
申请日：2003-09-05
申请人： Heather Bergeron , Chris Easton , Kunjan Jhaveri , Andrew Kennedy , James Kennedy , Jayant Pai , Alon Peled , Simone Pringle , Benjamin Sprecher , John Trustman
发明人： Heather Bergeron , Chris Easton , Kunjan Jhaveri , Andrew Kennedy , James Kennedy , Jayant Pai , Alon Peled , Simone Pringle , Benjamin Sprecher , John Trustman
IPC分类号： G06F17/27 , G06Q10/00 , G10L11/00
CPC分类号： G06Q10/10 , G06F17/2785
摘要： The disclosed technology can identify indicia associated with different entity types that interact within an industry, identify one or more relationships (e.g., contractual provisions) that can affect interactions between such entity types, and identify transactions associated with one or more of the interactions. Further, the identified transactions can be organized into one or more transaction sequences. The identified indicia, the one or more identified relationships, and the one or more transaction sequences can then be associated to form a semantic network. An instance of the semantic network can be formed in response to the execution of at least some of the transaction sequence and can serve, at least in part, as the basis for processing requests associated with the entities. The requests can correspond to interactions associated with the entities and may be represented in a natural language format, exhibiting a fixed context and a fixed grammar.
摘要翻译：所公开的技术可以识别与在行业内交互的不同实体类型相关联的标记，识别可影响这些实体类型之间的交互的一个或多个关系（例如，合同规定），以及识别与一个或多个交互相关联的交易。此外，所识别的事务可以被组织成一个或多个事务序列。所识别的标记，一个或多个所识别的关系以及一个或多个事务序列随后可以被关联以形成语义网络。语义网络的实例可以响应于至少一些交易序列的执行形成，并且可以至少部分地用作处理与实体相关联的请求的基础。请求可以对应于与实体相关联的交互，并且可以以自然语言格式表示，表现出固定的上下文和固定语法。

9. 发明授权

US09421177B2 Imidamide sphingosine kinase inhibitors 有权
标题翻译：亚胺酰胺鞘氨醇激酶抑制剂
公开(公告)号：US09421177B2
公开(公告)日：2016-08-23
申请号：US13390207
申请日：2010-08-16
申请人： Kevin R. Lynch , Timothy L. Macdonald , Thomas P. Mathews , Andrew Kennedy , Yugesh Kharel
发明人： Kevin R. Lynch , Timothy L. Macdonald , Thomas P. Mathews , Andrew Kennedy , Yugesh Kharel
IPC分类号： C07D207/09 , A61K31/155 , C07C257/16
CPC分类号： C07D207/09 , A61K31/155 , A61K31/40 , C07C257/16 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2103/74 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74
摘要： Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
摘要翻译：提供可以抑制鞘氨醇激酶1和鞘氨醇激酶2（SphK1和SphK2）活性的亚胺酰胺（脒）类似物。这些化合物可以预防肿瘤中的血管生成。

10. 发明授权

US06803464B2 Process for the preparation of pyrazine compounds 失效
标题翻译：吡嗪化合物的制备方法
公开(公告)号：US06803464B2
公开(公告)日：2004-10-12
申请号：US10275457
申请日：2002-11-05
申请人： Dean David Edney , Andrew Kennedy
发明人： Dean David Edney , Andrew Kennedy
IPC分类号： C07D24100
CPC分类号： C07C257/14 , C07D241/20
摘要： The present invention relates to a process for the preparation of both the phenyl pyrazine derivative 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine and an intermediate in the synthesis of 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine, 2-{[Cyano-(2,3,5-trichlorophenyl)-methyl]-amino}-acetamidine or a salt thereof.
摘要翻译：本发明涉及一种制备苯基吡嗪衍生物2,6-二氨基-3-（2,3,5-三氯苯基）吡嗪和合成2,6-二氨基-3-（ 2,3,5-三氯苯基）吡嗪，2 - {[氰基 - （2,3,5-三氯苯基） - 甲基] - 氨基} - 乙脒或其盐。

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