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1. 发明授权

US08255048B2 Circuit for controlled commutation of multiplexed electrodes for an active implantable medical device 有权
标题翻译：用于有源可植入医疗装置的多路电极的受控换向电路
公开(公告)号：US08255048B2
公开(公告)日：2012-08-28
申请号：US11965432
申请日：2007-12-27
申请人： Renzo Dal Molin , Alain Ripart
发明人： Renzo Dal Molin , Alain Ripart
IPC分类号： A61N1/00
CPC分类号： A61N1/372 , A61N1/3605 , A61N1/36082 , A61N1/3627
摘要： A circuit for controlled commutation of multiplexed electrodes, for an active implantable medical device. This circuit is located in a lead equipped with multiplexed sensing/pacing electrodes. This circuit decodes a signal generated by a generator, commanding a series of switches, which ensures selective coupling of the various electrodes to the proximal and distal terminals of the generator. This signal is a modulated signal comprising a coded series of logic pulses defining a particular configuration for coupling the lead electrodes to the proximal or distal terminal of the generator. The signal comprises a micropulse, that precedes the coded series of logic pulses and has an amplitude and duration lower than the amplitude and duration of each of the logic pulses. The detection of this micropulse activates, in response, all the circuit switches to an open position over a duration (PHASE 1) at least equal to the duration of reception of the coded series of logic pulses.
摘要翻译：用于有源可植入医疗装置的多路电极的可控换向电路。该电路位于配有多路传感/起搏电极的引线中。该电路解码由发电机产生的信号，指令一系列开关，确保各种电极选择性地耦合到发电机的近端和远端。该信号是包括限定用于将引线电极耦合到发电机的近端或远端的特定配置的一系列逻辑脉冲的调制信号。该信号包括在编码的逻辑脉冲串之前的微脉冲，并且具有低于每个逻辑脉冲的幅度和持续时间的幅度和持续时间。该微脉冲的检测作为响应激活至少等于编码的逻辑脉冲序列的接收持续时间的持续时间（PHASE 1）上的所有电路开关。

2. 发明授权

US09126825B2 Implantable biocompatible component integrating an active sensor for measurement of a physiological parameter, a micro-electromechanical system or an integrated circuit 有权
标题翻译：集成了用于测量生理参数的有源传感器，微机电系统或集成电路的可植入生物相容性部件
公开(公告)号：US09126825B2
公开(公告)日：2015-09-08
申请号：US11860250
申请日：2007-09-24
申请人： Renzo Dal Molin , Alain Ripart
发明人： Renzo Dal Molin , Alain Ripart
IPC分类号： B81B7/00
CPC分类号： B81B7/007 , B81B2201/06
摘要： An implantable biocompatible component (10) integrating an active element of the type of a sensor for the measurement of a physiologic parameter, a micro-electromechanical system and an integrated electronic circuit. This component (10) has a substrate (12) and a lid (22) in silicon or quartz. The substrate (12) integrates the active element (14) and biocompatible metallic pads (16), electrically connected to the active element. The lid (22) encompasses and peripherally closes the substrate in a hermetic manner, level with the face integrating the active element. This component is void of metallic case for insulation between the active element and outside environment, and of insulative feedthrough for electrical connection to the active element. The substrate and lid can be directly welded to each other through their faces in vis-à-vis, or by interpositioning a sealing ring made of a biocompatible material.
摘要翻译：整合了用于测量生理参数的传感器类型的有源元件，微机电系统和集成电子电路的可植入生物相容性部件（10）。该组件（10）具有硅或石英的基板（12）和盖（22）。基板（12）将有源元件（14）和与活性元件电连接的生物相容性金属焊盘（16）集成。盖（22）以密封的方式包围并周边地封闭基板，与集成有源元件的面平齐。该元件在有源元件和外部环境之间绝缘的金属外壳以及用于与有源元件电连接的绝缘馈通无效。基板和盖子可以相对于彼此直接地彼此焊接，或者通过插入由生物相容性材料制成的密封环。

3. 发明授权

US06556866B2 Active implantable medical device, in particular a pacemaker, defibrillator and/or cardiovertor of the multisite type providing resynchronization of the ventricles 有权
标题翻译：主动植入式医疗装置，特别是起搏器，除颤器和/或多站点类型的心脏转换器，其提供心室的再同步
公开(公告)号：US06556866B2
公开(公告)日：2003-04-29
申请号：US09739614
申请日：2000-12-18
申请人： Renzo Dal Molin , Alain Ripart
发明人： Renzo Dal Molin , Alain Ripart
IPC分类号： A61N1365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： An active implantable medical device, in particular a pacemaker, defibrillator and/or cardiovertor of the multisite type providing resynchronization of the ventricles electrodes are placed in at least two sites, right and left, and are connected to a circuit for the collection of cardiac signals, to detect a depolarization potential. Electrodes also are connected to a stimulation circuit, to apply stimulation pulses to at least some of the sites. The device provides resynchronization of the ventricular contraction, by establishing a delay between the times of application of the respective stimulation pulses on the right ventricle (RV) and left ventricle (LV), determining a parameter (z) representative of the degree of synchronization between ventricles, and varying the delay in the direction of the improvement of the aforesaid representative parameter. The parameter is a bio-impedance measurement.
摘要翻译：主动植入式医疗装置，特别是提供心室电极再同步的多位置类型的起搏器，除颤器和/或心律转换器被放置在左右至少两个位置，并连接到用于收集心脏信号的电路，以检测去极化潜能。电极也连接到刺激电路，以将刺激脉冲施加到至少一些部位。该设备通过在右心室（RV）和左心室（LV）上施加相应的刺激脉冲的时间之间建立延迟来确定表示心室收缩的同步程度的参数（z），从而提供心室收缩的再同步并改变上述代表性参数改进方向上的延迟。该参数是生物阻抗测量。

4. 发明授权

US08214044B2 Telemetry apparatus for communications with an active device implanted in a patient's thoracic region 有权
标题翻译：用于与植入患者胸部区域的主动装置进行通信的遥测装置
公开(公告)号：US08214044B2
公开(公告)日：2012-07-03
申请号：US11469676
申请日：2006-09-01
申请人： Renzo Dal Molin
发明人： Renzo Dal Molin
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A41D13/1281
摘要： Apparatus for telemetry equipment for communication with an active device implanted in the thoracic area of a patient This equipment includes a wave collector (16) essentially sensitive to a magnetic field so as to allow an exchange of signals through magnetic coupling (i.e., an inductive channel) with the implanted device (14). The wave collector is connected to an electronic circuit package (24) for transmission/reception and signal processing of acquired data and programming. The apparatus further comprises a cloth (10) in the form of a vest to be worn by and able to cover at least one part of the patient's anatomy, a support structure (18) for receiving and supporting the wave collector, and adjustable members able to fix the support structure at a chosen location of the cloth, for example, by means of hooking tapes (20) disposed on the support (18) and cooperating surface material on the cloth. Thus, after initial positioning of the wave collector in front of the area where the device is implanted, placement and maintaining of the wave collector will be fixed to that location each time the patient puts the cloth on.
摘要翻译：用于与植入患者胸部区域的有源装置通信的遥测设备的装置该设备包括对磁场基本敏感的波收发器（16），以允许通过磁耦合（即，感应通道）与植入装置（14）。波收发器连接到电子电路封装（24），用于发送/接收和获取的数据和编程的信号处理。该装置还包括一种背心形式的布（10），以便能够覆盖患者解剖结构的至少一部分，并且能够覆盖患者解剖结构的至少一部分，用于接收和支撑波收集器的支撑结构（18）以将支撑结构固定在布的选定位置处，例如通过设置在支撑件（18）上的钩带（20）和布上的配合表面材料。因此，在收集器在植入装置的区域之前的初始定位之后，每当患者将布放置时，波收集器的放置和维持将被固定到该位置。

5. 发明授权

US06975905B2 Stimulation circuits for a cycle to cycle stimulation threshold capture for an active implantable cardiac device 有权
标题翻译：用于循环的刺激电路以循环用于有源可植入心脏装置的刺激阈值捕获
公开(公告)号：US06975905B2
公开(公告)日：2005-12-13
申请号：US10073095
申请日：2002-02-08
申请人： Pascal Pons , Renzo Dal Molin
发明人： Pascal Pons , Renzo Dal Molin
IPC分类号： A61N1/37 , A61N1/362
CPC分类号： A61N1/3712
摘要： A circuit for delivering a back-up stimulation voltage in a cycle to cycle capture test for an active implantable medical device such as a pacemaker, defibrillator and/or cardiovertor or a multisite device having an enhanced circuit for delivering back-up stimulation pulses. This device comprises a first stimulation stage having: a output capacitor (12); a charging circuit (14) to charge the output capacitor to a first predetermined voltage (V1) for the stimulation that is close to the threshold of effectiveness for the stimulation of the patient; a first switch (18) that is able to connect the output capacitor to a stimulation terminal (16) of the device; a capture test circuit that is able to determine, after delivery of a stimulation, whether the stimulation was effective or if, on the contrary, there was loss of capture; a circuit for readjusting the stimulation voltage according to the result of the capture test; and a circuit able to deliver a backup-stimulation after the capture test if the result of the capture test reveals a loss of capture. The circuit for delivering a backup-stimulation includes an additional capacitor that is maintained charged, and a second switch (34), able to connect the additional capacitor to the aforementioned stimulation terminal (16) of the device to deliver the back-up stimulation pulse.
摘要翻译：一种用于在循环中递送备用刺激电压以循环捕获测试的电路，用于有源植入式医疗装置例如起搏器，除颤器和/或心律转换器或具有用于递送备用刺激脉冲的增强电路的多站点装置。该装置包括：第一刺激级，其具有：输出电容器（12）; 充电电路（14），用于将所述输出电容器充电到所述刺激的第一预定电压（V1），所述第一预定电压接近所述刺激患者的有效性阈值; 第一开关（18），其能够将输出电容器连接到装置的刺激端子（16）; 捕获测试电路，能够在传递刺激后确定刺激是否有效，或者相反，是否存在捕获的损失; 根据捕获测试结果重新调节刺激电压的电路; 以及如果捕获测试的结果显示捕获失败，则能够在捕获测试后提供备份刺激的电路。用于递送备用刺激的电路包括保持充电的附加电容器和能够将附加电容器连接到装置的前述刺激端子（16）的第二开关（34），以传递备用刺激脉冲。

6. 发明授权

US5649965A Protection against electromagnetic perturbations of external origin for a active implantable device 失效
标题翻译：防止有源可植入装置的外部电磁干扰
公开(公告)号：US5649965A
公开(公告)日：1997-07-22
申请号：US577227
申请日：1995-12-22
申请人： Pascal Pons , Renzo Dal Molin
发明人： Pascal Pons , Renzo Dal Molin
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3706
摘要： An active implantable medical device, particularly a cardiac pacemaker or defibrillator, having a protection circuit that is effective against electromagnetic perturbations of external origin. The active implantable device is characterized in that at least all active components of the protection circuit (58, 60, 94, 98) are integrated components in a monolithically integrated microchip (16) including a control signal and circuits to commute selectively signals collected by external electrodes to the device for processing. In particular, the commutation circuits comprise static switches (24, 24', 28, 28', 38, 38', 40, 40', 44, 44', 46, 46', 50, 50', 54), and the control signal is a control voltage (VSUB, VCC) that is greater than the voltage (VPILE) of the battery of the device. The device delivers control logic signals (VDD, VSS) that are less than the battery voltage, and the protection circuit includes a voltage translator circuit (58) to raise, in absolute value, the logic control signal level to a value compatible with the static switches, control voltages and greater than the nominal level of parasitic voltages resulting from electromagnetic perturbations that are susceptible to appear on the static switch connection.
摘要翻译：主动植入医疗装置，特别是心脏起搏器或去纤颤器，具有有效抵抗外部电磁干扰的保护电路。有源可植入装置的特征在于，保护电路（58,60,94,98）的至少所有有源部件是集成组件，其包括单片集成微芯片（16），其包括控制信号和电路，以选择性地选择由外部收集的信号电极到设备进行处理。特别地，换向电路包括静态开关（24,24'，28,28'，38,38'，40,40'，44,44'，46,46'，50,50'，54），并且控制信号是大于设备电池电压（VPILE）的控制电压（VSUB，VCC）。该装置提供小于电池电压的控制逻辑信号（VDD，VSS），并且保护电路包括电压转换器电路（58），以绝对值将逻辑控制信号电平提升到与静态开关，控制电压以及大于电磁干扰产生的寄生电压的标称电平，这些电磁扰动易于出现在静态开关连接上。

7. 发明申请

US20120263218A1 APPARATUS AND METHOD FOR QUANTIFICATION OF THE DESYNCHRONIZATION BETWEEN THE CLOCKS OF TWO HBC ACTIVE IMPLANTS 有权
标题翻译：用于定量两个HBC活动植入物的时钟之间的分离的装置和方法
公开(公告)号：US20120263218A1
公开(公告)日：2012-10-18
申请号：US13370200
申请日：2012-02-09
申请人： Renzo Dal Molin , Ashutosh Ghildiyal
发明人： Renzo Dal Molin , Ashutosh Ghildiyal
IPC分类号： H04B17/00
CPC分类号： A61N1/37288 , A61N1/37205 , A61N1/3962 , G06F1/06 , G06F1/12 , H04B3/46 , H04B17/00 , H04J3/06 , H04Q1/20
摘要： A method for quantification of the desynchronization between the clocks of two medical devices communicating wirelessly, for example, by HBC signals. The devices are separately clocked by slow clocks (CLK1/32k, CLK2/32k) and include selectively activated fast clocks (CLK1/10M, CLK2/10M). The method comprises: a) on a predetermined transition (T1) of a slow clock, transmission by one device of a synchronization query signal (SYNC) to the other device, b) counting of the pulses of the activated fast clock to detect a predetermined transition (T3) of the first slow clock, then c) transmitting from the other device to the first device a response signal (D1) and d) upon reception of the response signal, computing a temporal shift (OFFSET) according to the result (D1, D2) of the counting of the pulses of the fast clock. Two fast clocks, one on each device, also can be used.
摘要翻译：用于定量通过HBC信号无线通信的两个医疗设备的时钟之间的去同步化的方法。器件分别由慢时钟（CLK1 / 32k，CLK2 / 32k）提供时钟，并包括有选择地激活的快速时钟（CLK1 / 10M，CLK2 / 10M）。该方法包括：a）在慢时钟的预定转换（T1）上，由一个设备向另一个设备发送同步查询信号（SYNC）; b）计数激活的快速时钟的脉冲，以检测预定的转换（T3），然后c）在接收到响应信号时从另一个设备向第一设备发送响应信号（D1）和d），d）根据结果计算时间偏移（OFFSET） D1，D2）对快时钟脉冲的计数。每个设备上有两个快速时钟，也可以使用。

8. 发明授权

US07979112B2 Reconstruction of a surface electrocardiogram based upon an endocardial electrogram 有权
标题翻译：基于心内膜电图重建表面心电图
公开(公告)号：US07979112B2
公开(公告)日：2011-07-12
申请号：US11935334
申请日：2007-11-05
申请人： Renzo Dal Molin , Anissa Bourguiba , Fabienne Porée , Guy Carrault , Alfredo Hernandez , Amar Kachenoura
发明人： Renzo Dal Molin , Anissa Bourguiba , Fabienne Porée , Guy Carrault , Alfredo Hernandez , Amar Kachenoura
IPC分类号： A61B5/0402
CPC分类号： A61N1/3702 , A61B5/04011 , A61B5/0402 , A61B5/04028 , G06K9/0057
摘要： The reconstruction of a surface electrocardiogram based upon an endocardial electrogram. This method includes: (a) acquisition (10) of a plurality of endocardial electrogram signals (EGM) through a plurality of endocardial leads defined based upon endocardial electrodes; (b) calculation (12), by combining the endocardial electrogram (EGM) signals acquired at step (a), of the corresponding endocardial vectogram (VGM); (c) angular resealing (14) of the orthonormalized mark of the endocardial vectogram (VGM) with that of the surface vectocardiogram (VCG); (d) estimation (16), based upon the endocardial vectogram (VGM) calculated at step (b), of a reconstructed surface vectocardiogram (VCGreconstructed), and (e) calculation (18) of the surface electrocardiogram (ECG) corresponding to said reconstructed surface vectocardiogram (VCGreconstructed).
摘要翻译：基于心内膜电图重建表面心电图。该方法包括：（a）通过基于心内膜电极定义的多个心内膜引线获取多个心内膜电图信号（EGM）的（10）; （b）通过组合在步骤（a）中获取的心内膜电图（EGM）信号，相应的心内膜矢量图（VGM）的计算（12）; （c）心内膜矢状图（VGM）的正交标记与表面心动图（VCG）的角度重新密封（14）; （d）基于在步骤（b）计算的心肌向量图（VGM），重建的表面心动图（VCGreconstructed）的估计（16）和（e）对应于所述的表面心电图（ECG）的计算（18）重建表面心肌图（VCGreconstructed）。

9. 发明申请

US20100249626A1 DISCRIMINATING BETWEEN TACHYCARDIAS OF VENTRICULAR ORIGIN AND SUPRA ENTRICULAR ORIGIN, METHODS AND APPARATUS 有权
标题翻译：鉴别静脉原始EN EN EN EN AND AND AND US US US US US US US US US US US US US US US US US US US US US US
公开(公告)号：US20100249626A1
公开(公告)日：2010-09-30
申请号：US12412808
申请日：2009-03-27
申请人： Jinane El Arab , Renzo Dal Molin , Christine Henry , Paola Bouchet , Remi Dubois , Gerard Dreyfus
发明人： Jinane El Arab , Renzo Dal Molin , Christine Henry , Paola Bouchet , Remi Dubois , Gerard Dreyfus
IPC分类号： A61B5/0464
CPC分类号： G06K9/00557 , A61B5/04011 , A61B5/0464 , A61B5/7264 , A61B5/7267 , A61N1/3622 , A61N1/3962
摘要： An active medical device able to discriminate between tachycardias of ventricular origin and of supra-ventricular origin. Two distinct temporal components (UnipV, BipV) are obtained corresponding to two EGM signals of ventricular electrograms. The diagnosis operates in at least two-dimensional space to determine, from the variations of one temporal component as a function of the other temporal component, a 2D characteristic representative of a heart beat and, this, for a reference beat collected in Sinus Rhythm (SR) in the absence of tachycardia episodes, and for a heart beat in Tachycardia. The discrimination of the tachycardia type, VT or SVT, is then realized by a classifier operating a comparison of the two current and reference 2D characteristics.
摘要翻译：一种能够区分心室起搏的心动过速和超心室起源的活跃的医疗装置。对应于心室电图的两个EGM信号获得两个不同的时间分量（UnipV，BipV）。诊断操作在至少二维空间中，以从作为另一个时间分量的函数的一个时间分量的变化确定代表心跳的2D特征，并且对于在窦性节律中收集的参考节拍（ SR），无心动过速，心动过速时心跳。然后通过操作两个电流和参考2D特征的比较的分类器来实现对心动过速类型VT或SVT的区分。

10. 发明授权

US07663451B2 RF telemetry for an active medical device such as an implant or programmer for an implant 有权
标题翻译：用于有源医疗设备的RF遥测，例如用于植入物的植入物或编程器
公开(公告)号：US07663451B2
公开(公告)日：2010-02-16
申请号：US11757252
申请日：2007-06-01
申请人： Renzo Dal Molin
发明人： Renzo Dal Molin
IPC分类号： A61N1/08 , A61N1/16 , H03H9/70 , H03H9/54
CPC分类号： A61N1/37276 , A61N1/37223 , H03H9/175
摘要： RF telemetry for an active medical device such as active implant or programmer for such implant. The device includes at least one RF antenna (14), and at least one RF telemetry transmitter/receiver (44) with, for coupling to the antenna, an associated band rejection filter (54). The band rejection filter (54) comprises at least one volume acoustic wave BAW resonator (40) of the SMR type with insulation by Bragg acoustic reflector (42). The device can be a multi-band device comprising a plurality of RF transmitters/receivers (12, 44) operating in respective distinct bands of frequencies such as the 402˜405-MHz, 863˜870-MHz, 902˜928-MHz and 2.4-GHz bands or by UWB transmission.
摘要翻译：用于有源医疗设备的RF遥测，例如用于这种植入物的有源植入物或编程器。该设备包括至少一个RF天线（14）和至少一个RF遥测发射机/接收机（44），其具有用于耦合到天线的相关联的带阻滤波器（54）。带阻滤波器（54）包括具有由布拉格声反射器（42）绝缘的SMR型的至少一个体积声波BAW谐振器（40）。该设备可以是多频带设备，其包括多个RF发射器/接收器（12,44），其操作在各种不同的频带，例如402〜405MHz，863〜870MHz，902〜928MHz，以及 2.4GHz频带或通过UWB传输。

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