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1. 发明申请

US20080219616A1 All Polymer Optical Waveguide Sensor 失效
标题翻译：所有聚合物光波导传感器
公开(公告)号：US20080219616A1
公开(公告)日：2008-09-11
申请号：US12089939
申请日：2006-10-10
申请人： Reinhold Wimberger-Friedl , Gert T Hooft , Christiane De Witz
发明人： Reinhold Wimberger-Friedl , Gert T Hooft , Christiane De Witz
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , G01N21/648
摘要： The present invention is directed to an evanescent field induced optical sensor of a transparent polymer substrate coated with a thin transparent polymer waveguide for use as biosensor for detecting biological molecules, wherein the transparent polymer waveguide has a thickness of ≧0.10 μm and ≦0.50 μm and a refractive index nD of 1.39 to 1.79, said transparent polymer waveguide has a coupling grating recess structure for enhancing the coupling of the light wave into said transparent polymer waveguide, the lower surface of said transparent polymer waveguide contacts the transparent polymer substrate, said transparent polymer substrate has a refractive index n of 1.29 to 1.69, wherein the material of said transparent polymer waveguide and said transparent poly-mer substrate is selected such that the difference of the refractive index ΔnD of said transparent polymer waveguide and said transparent polymer substrate is at least Δ n 0.1, the outer upper surface of said polymer waveguide possess specific binding compounds to detect at least one specific chemical and/or biochemical substance or the outer upper surface of said polymer waveguide is covered with a thin noble metal layer.
摘要翻译：本发明涉及涂覆有用作检测生物分子的生物传感器的薄透明聚合物波导的透明聚合物基质的消逝场感应光学传感器，其中透明聚合物波导的厚度>0.10μm和<= 0.50 所述透明聚合物波导具有用于增强所述光波耦合到所述透明聚合物波导中的耦合光栅凹槽结构，所述透明聚合物的下表面波导与透明聚合物基板接触，所述透明聚合物基材的折射率n为1.29至1.69，其中所述透明聚合物波导和所述透明聚合物基板的材料选择为使得折射率差异Deltan < 所述透明聚合物波导和所述透明聚合物基底的D i至少为Δn0.1，外部上部sur 所述聚合物波导的表面具有特异性结合化合物以检测至少一种特定化学和/或生物化学物质，或者所述聚合物波导的外部上表面被薄的贵金属层覆盖。

2. 发明授权

US07558446B2 All polymer optical waveguide sensor 失效
标题翻译：所有聚合物光波导传感器
公开(公告)号：US07558446B2
公开(公告)日：2009-07-07
申请号：US12089939
申请日：2006-10-10
申请人： Reinhold Wimberger-Friedl , Gert 'T Hooft , Christiane De Witz
发明人： Reinhold Wimberger-Friedl , Gert 'T Hooft , Christiane De Witz
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , G01N21/648
摘要： The present invention is directed to an evanescent field induced optical sensor of a transparent polymer substrate coated with a thin transparent polymer waveguide for use as biosensor for detecting biological molecules, wherein the transparent polymer waveguide has a thickness of ≧0.10 μm and ≦0.50 μm and a refractive index nD of 1.39 to 1.79, said transparent polymer waveguide has a coupling grating recess structure for enhancing the coupling of the light wave into said transparent polymer waveguide, the lower surface of said transparent polymer waveguide contacts the transparent polymer substrate, said transparent polymer substrate has a refractive index n of 1.29 to 1.69, wherein the material of said transparent polymer waveguide and said transparent polymer substrate is selected such that the difference of the refractive index ΔnD of said transparent polymer waveguide and said transparent polymer substrate is at least Δ n 0.1, the outer upper surface of said polymer waveguide possess specific binding compounds to detect at least one specific chemical and/or biochemical substance or the outer upper surface of said polymer waveguide is covered with a thin noble metal layer.
摘要翻译：本发明涉及涂覆有用作检测生物分子的生物传感器的薄透明聚合物波导的透明聚合物基质的消逝场感应光学传感器，其中透明聚合物波导的厚度>0.10μm和<= 0.50 所述透明聚合物波导具有用于增强所述光波与所述透明聚合物波导耦合的耦合光栅凹槽结构，所述透明聚合物波导的下表面与透明聚合物基底接触，所述透明聚合物波导透明聚合物基材的折射率n为1.29〜1.69，其中所述透明聚合物波导和所述透明聚合物基材的材料选择为使得所述透明聚合物波导和所述透明聚合物基材的折射率DeltanD的差异至少为 Δn0.1，所述聚合物的外部上表面 veguide具有特异性结合化合物以检测至少一种特定化学和/或生物化学物质，或者所述聚合物波导的外部上表面被薄的贵金属层覆盖。

3. 发明申请

US20080257071A1 Microfluidic Device with Porous Membrane and an Unbranched Channel 审中-公开
标题翻译：具有多孔膜和非支化通道的微流控器件
公开(公告)号：US20080257071A1
公开(公告)日：2008-10-23
申请号：US12094849
申请日：2006-11-16
申请人： Reinhold Wimberger-Friedl , Christiane De Witz
发明人： Reinhold Wimberger-Friedl , Christiane De Witz
IPC分类号： G01N1/00
CPC分类号： B01L3/5027 , B01D2313/086 , B01L3/502753 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0887
摘要： The invention relates to a microfluidic device for detection of a substance in a sample fluid, and to a cartridge for performing a biological assay, containing such a device. The microfluidic device comprises two housing parts (52, 54) with a porous membrane (50) there between. Each housing part has recesses, or channel parts, (56-1, 56-2, 56-n, 58-1, 58-2, 58-n) that are connected via a recess of the opposite housing part, and through the membrane (50), such that an unbranched channel is defined for the sample fluid. At one or more of the positions where the channel crosses the membrane (50), a spot (48-1, 48-2, 48-n) with an immobilized indicator substance is present, to which a target substance in the sample fluid may bind. An advantage of the present device is that in principle all of the sample fluid passes each spot. Hence there is no need to recirculate and/or mix the sample fluid, as is the case in devices with parallel flow-through paths for the fluid. The device will therefore be simpler, and give a more reliable detection result.
摘要翻译：本发明涉及用于检测样品流体中的物质的微流体装置和用于进行包含这种装置的生物测定的盒。微流体装置包括两个在其间具有多孔膜（50）的壳体部分（52,54）。每个壳体部分具有经由相对的壳体部分的凹部连接的凹部或通道部分（56-1,56-2,66-n，58-1,58-2,58-n），并且通过膜（50），使得为样品流体定义未分支的通道。在通道穿过膜（50）的一个或多个位置处，存在具有固定的指示物质的斑点（48-1,48-2,48-n），样品流体中的目标物质可以绑定本装置的优点在于，原则上所有样品流体都通过每个点。因此，不需要再循环和/或混合样品流体，如同用于流体的平行流通路径的装置的情况。因此，该装置将更简单，并且给出更可靠的检测结果。

4. 发明申请

US20070053051A1 Micro-mechanical thermo structure and method for manufacturing such micro-mechanical structure 失效
标题翻译：微机械热结构及其制造方法
公开(公告)号：US20070053051A1
公开(公告)日：2007-03-08
申请号：US10539388
申请日：2003-11-20
申请人： Dirk Broer , Grietje Mol , Christiane De Witz
发明人： Dirk Broer , Grietje Mol , Christiane De Witz
IPC分类号： G02F1/01
CPC分类号： B29C37/0053 , B29C33/42 , B29C43/021 , B29C2035/0827 , B29L2011/0016 , B29L2031/756 , B81B3/0035 , B81B2201/047 , B81C2201/034
摘要： The invention relates to a micro-mechanical thermal structure for modulating a light beam and a method for manufacturing such a structure. The micro-mechanical structure comprises two layers of material with different thermal expansion coefficients in a first direction and a second direction respectively, in which the first direction is transverse to the second direction and the two layers comprise an oriented polymer and the director of the molecules of the oriented polymer of the first layer is transverse to the director of the molecules of the oriented polymer of the second layer. An array of such micro-mechanical structures may form a thermo-optical modulator for modulating light. The method comprises a step of providing a mold with an orientation-inducing layer to obtain a molecular orientation in a mono-meric state of liquid crystalline monomers and a step of fixing the molecular orientation by photo-polymerization.
摘要翻译：本发明涉及用于调制光束的微机械热结构及其制造方法。微机械结构包括在第一方向和第二方向上分别具有不同热膨胀系数的两层材料，其中第一方向横向于第二方向，并且两层包括取向聚合物和分子的导向体的第一层的取向聚合物横向于第二层的取向聚合物的分子的导向体。这种微机械结构的阵列可以形成用于调制光的热光调制器。该方法包括提供具有取向诱导层以获得液晶单体的单体状态的分子取向的模具和通过光聚合固定分子取向的步骤的步骤。

5. 发明申请

US20060187383A1 Method of manufacturing a reflector and liquid crystal display device including such a reflector 审中-公开
标题翻译：制造反射器的方法和包括这种反射器的液晶显示装置
公开(公告)号：US20060187383A1
公开(公告)日：2006-08-24
申请号：US10564327
申请日：2004-07-15
申请人： Dirk Broer , Christiane De Witz , Ties Van Bommel
发明人： Dirk Broer , Christiane De Witz , Ties Van Bommel
IPC分类号： G02F1/1335
CPC分类号： G02B5/0215 , G02B5/0221 , G02B5/0268 , G02B5/0284 , G02B5/0289 , G02F1/133555 , G03F7/0007 , G03F7/001 , G03F7/30 , G03F7/36 , G03F7/40 , G03F7/405
摘要： The invention relates to a method for manufacturing a diffusive reflector (450) for a reflective or transflective Liquid Crystal Display (400). The reflector comprises a surface (452) that is structured by means of a photo-embossing process. Herein, a layer (100) of a mixture is provided including a photo-diffusible monomer (102), which may be transported through the layer under the influence of selectively applied irradiation. A layer relief is thus formed, which is preferably developed further at an elevated temperature. The layer is fixed and stabilized by means of a cross-linking step, preferably including thermally induced and/or photo-induced polymerization. In a final step, the polymer relieved surface thus formed is provided with a reflective material (154).
摘要翻译：本发明涉及一种制造用于反射或半透反射液晶显示器（400）的扩散反射器（450）的方法。反射器包括通过光压印工艺构造的表面（452）。这里，提供了包含可光扩散单体（102）的混合物层（100），其可以在选择性照射的影响下被输送通过该层。因此形成了层状浮雕，其优选在升高的温度下进一步显影。该层通过交联步骤固定和稳定，优选包括热诱导和/或光诱导的聚合。在最终步骤中，由此形成的聚合物缓和表面设置有反射材料（154）。

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