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1. 发明授权

US08535703B2 Methods of arthroscopic osteochondral resurfacing 有权
标题翻译：关节镜骨软骨表面重建方法
公开(公告)号：US08535703B2
公开(公告)日：2013-09-17
申请号：US12198843
申请日：2008-08-26
申请人： Reinhold Schmieding , Gerlinde Michel , Stephane Naudin , Hans Linden
发明人： Reinhold Schmieding , Gerlinde Michel , Stephane Naudin , Hans Linden
IPC分类号： A61F2/02 , A61K35/16 , A61K35/14 , A61K35/28
CPC分类号： A61K35/16 , A61K35/28
摘要： Methods of arthroscopic resurfacing of anatomical tissue utilizing a biological component strengthened with glue or similar material. The biological component is selected from the group consisting of blood, blood components, PRP, bone marrow aspirate (BMA) and autologous conditioned plasma (ACP). The biological component/glue composition may be inserted (by injection and/or by employing a biologic resurfacing mold, for example) into, or in the vicinity of, the anatomical tissue. Upon insertion within, or contact with, the anatomical tissue, the biological component/glue composition is designed to coagulate and solidify (or partially solidify) within minutes, to advance healing or tissue growth of the anatomical tissue. The biological component/glue composition may optionally comprise components such as growth factors, antiseptic chemicals and/or antibiotics and/or electrolytes, or hormones or site-specific hybrid proteins, among others.
摘要翻译：使用胶水或类似材料增强生物成分的解剖组织关节镜重建方法。生物成分选自血液，血液成分，PRP，骨髓抽吸物（BMA）和自体条件血浆（ACP）。可以将生物组分/胶组合物（通过注射和/或通过使用生物表面重塑模具）插入到解剖组织中或在其附近。在插入解剖组织内或与解剖组织接触时，生物组分/胶组合物被设计成在几分钟内凝结并固化（或部分固化），以促进解剖组织的愈合或组织生长。生物组分/胶组合物可以任选地包含诸如生长因子，防腐化学品和/或抗生素和/或电解质，或激素或位点特异性杂合蛋白等组分。

2. 发明申请

US20090060974A1 METHODS OF ARTHROSCOPIC OSTEOCHONDRAL RESURFACING 有权
标题翻译：方法治疗骨质疏松性骨质疏松
公开(公告)号：US20090060974A1
公开(公告)日：2009-03-05
申请号：US12198843
申请日：2008-08-26
申请人： Reinhold Schmieding , Gerlinde Michel , Stephane Naudin , Hans Linden
发明人： Reinhold Schmieding , Gerlinde Michel , Stephane Naudin , Hans Linden
IPC分类号： A61K35/14 , A61F2/02 , A61K35/16 , A61P19/00
CPC分类号： A61K35/16 , A61K35/28
摘要： Methods of arthroscopic resurfacing of anatomical tissue utilizing a biological component strengthened with glue or similar material. The biological component is selected from the group consisting of blood, blood components, PRP, bone marrow aspirate (BMA) and autologous conditioned plasma (ACP). The biological component/glue composition may be inserted (by injection and/or by employing a biologic resurfacing mold, for example) into, or in the vicinity of, the anatomical tissue. Upon insertion within, or contact with, the anatomical tissue, the biological component/glue composition is designed to coagulate and solidify (or partially solidify) within minutes, to advance healing or tissue growth of the anatomical tissue. The biological component/glue composition may optionally comprise components such as growth factors, antiseptic chemicals and/or antibiotics and/or electrolytes, or hormones or site-specific hybrid proteins, among others.
摘要翻译：使用胶水或类似材料增强生物成分的解剖组织关节镜重建方法。生物成分选自血液，血液成分，PRP，骨髓抽吸物（BMA）和自体条件血浆（ACP）。可以将生物组分/胶组合物（通过注射和/或通过使用生物表面重塑模具）插入到解剖组织中或在其附近。在插入解剖组织内或与解剖组织接触时，生物组分/胶组合物被设计成在几分钟内凝结并固化（或部分固化），以促进解剖组织的愈合或组织生长。生物组分/胶组合物可以任选地包含诸如生长因子，防腐化学品和/或抗生素和/或电解质，或激素或位点特异性杂合蛋白等组分。

3. 发明授权

US09486317B2 Method of arthroscopic osteochondral resurfacing using PRP strengthened with fibrin glue 有权
标题翻译：使用纤维蛋白胶增强PRP的关节镜骨软骨表面重建方法
公开(公告)号：US09486317B2
公开(公告)日：2016-11-08
申请号：US12198836
申请日：2008-08-26
申请人： Giuseppe Milano , Gerlinde Michel , Stephane Naudin , Hans Linden , Reinhold Schmieding
发明人： Giuseppe Milano , Gerlinde Michel , Stephane Naudin , Hans Linden , Reinhold Schmieding
IPC分类号： A61F2/02 , A61K35/16 , A61K35/14 , A61K35/28 , A61F2/30 , A61B17/00 , A61B17/56
CPC分类号： A61F2/30756 , A61B17/00491 , A61B2017/00495 , A61B2017/564 , A61F2002/30757 , A61F2002/30761 , A61F2310/00377
摘要： Methods of arthroscopic resurfacing of a joint utilizing a biological component strengthened with fibrin glue. The biological component is selected from the group consisting of PRP, bone marrow aspirate (BMA) and autologous conditioned plasma (ACP). The biological component/fibrin glue composition may be inserted (by injection or by employing a biologic resurfacing mold, for example) into a transosseous tunnel in the vicinity of the defect to be repaired. Upon insertion at the defect site, the biological component/fibrin glue composition is designed to coagulate and solidify within few minutes, to advance the healing of the damaged tissue and tissue growth. The biological component/fibrin glue composition may optionally comprise components such as growth factors, antiseptic chemicals and/or antibiotics and/or electrolytes, or hormones or site-specific hybrid proteins, among others.
摘要翻译：使用纤维蛋白胶增强的生物成分的关节镜关节镜重建方法。生物成分选自PRP，骨髓抽吸物（BMA）和自体条件血浆（ACP）。可以将生物成分/纤维蛋白胶组合物插入（例如通过注射或通过使用生物表面重塑模具）到要修复的缺陷附近的骨质隧道中。在插入缺损部位时，生物组分/纤维蛋白胶组合物设计成在几分钟内凝结固化，以促进受损组织的愈合和组织生长。生物组分/纤维蛋白胶组合物可以任选地包含诸如生长因子，防腐化学品和/或抗生素和/或电解质，或激素或位点特异性杂交蛋白等组分。

4. 发明申请

US20090062870A1 METHOD OF ARTHROSCOPIC OSTEOCHONDRAL RESURFACING USING PRP STRENGTHENED WITH FIBRIN GLUE 有权
标题翻译：使用加强纤维蛋白凝胶的PRP治疗骨质疏松性骨质疏松症的方法
公开(公告)号：US20090062870A1
公开(公告)日：2009-03-05
申请号：US12198836
申请日：2008-08-26
申请人： Giuseppe Milano , Gerlinde Michel , Stephane Naudin , Hans Linden , Reinhold Schmieding
发明人： Giuseppe Milano , Gerlinde Michel , Stephane Naudin , Hans Linden , Reinhold Schmieding
IPC分类号： A61F5/00 , A61B19/00
CPC分类号： A61F2/30756 , A61B17/00491 , A61B2017/00495 , A61B2017/564 , A61F2002/30757 , A61F2002/30761 , A61F2310/00377
摘要： Methods of arthroscopic resurfacing of a joint utilizing a biological component strengthened with fibrin glue. The biological component is selected from the group consisting of PRP, bone marrow aspirate (BMA) and autologous conditioned plasma (ACP). The biological component/fibrin glue composition may be inserted (by injection or by employing a biologic resurfacing mold, for example) into a transosseous tunnel in the vicinity of the defect to be repaired. Upon insertion at the defect site, the biological component/fibrin glue composition is designed to coagulate and solidify within few minutes, to advance the healing of the damaged tissue and tissue growth. The biological component/fibrin glue composition may optionally comprise components such as growth factors, antiseptic chemicals and/or antibiotics and/or electrolytes, or hormones or site-specific hybrid proteins, among others.
摘要翻译：使用纤维蛋白胶增强的生物成分的关节镜关节镜重建方法。生物成分选自PRP，骨髓抽吸物（BMA）和自体条件血浆（ACP）。可以将生物成分/纤维蛋白胶组合物插入（例如通过注射或通过使用生物表面重塑模具）到要修复的缺陷附近的骨质隧道中。在插入缺损部位时，生物组分/纤维蛋白胶组合物设计成在几分钟内凝结固化，以促进受损组织的愈合和组织生长。生物组分/纤维蛋白胶组合物可以任选地包含诸如生长因子，防腐化学品和/或抗生素和/或电解质，或激素或位点特异性杂交蛋白等组分。

5. 发明申请

US20090043318A1 APPLICATOR FOR SUTURE/BUTTON CONSTRUCT 有权
标题翻译：应用者/按钮构造
公开(公告)号：US20090043318A1
公开(公告)日：2009-02-12
申请号：US12167922
申请日：2008-07-03
申请人： Gerlinde Michel , Benedikt Bodinger , Karen L. Gallen , Stephane Naudin
发明人： Gerlinde Michel , Benedikt Bodinger , Karen L. Gallen , Stephane Naudin
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0419
摘要： A technique for joint repair employing a suture/button construct and an applicator designed to securely engage a button of the suture/button construct. The button of the suture/button construct securely engages the shaft of the applicator. The suture from the button may be wrapped around a securing device (for example, a rod or bolt) located on or within the handle. The applicator with the secured button is introduced into the tissue (for example, soft tissue or a bone tunnel) and the button is passed through the tissue.
摘要翻译：一种采用缝合/纽扣结构和施用设计用于牢固地接合缝线/按钮结构的按钮的联合修复技术。缝合/按钮结构的按钮牢固地接合敷贴器的轴。来自按钮的缝合线可以缠绕在位于手柄上或手柄内的固定装置（例如，杆或螺栓）上。将具有固定按钮的施用器引入组织（例如，软组织或骨隧道）中，并且按钮通过组织。

6. 发明授权

US08348960B2 Applicator for suture/button construct 有权
标题翻译：缝合器/按钮结构的敷料器
公开(公告)号：US08348960B2
公开(公告)日：2013-01-08
申请号：US12167922
申请日：2008-07-03
申请人： Gerlinde Michel , Benedikt Bodinger , Karen L. Gallen , Stephane Naudin
发明人： Gerlinde Michel , Benedikt Bodinger , Karen L. Gallen , Stephane Naudin
IPC分类号： A61B17/10
CPC分类号： A61B17/0401 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0419
摘要： A technique for joint repair employing a suture/button construct and an applicator designed to securely engage a button of the suture/button construct. The button of the suture/button construct securely engages the shaft of the applicator. The suture from the button may be wrapped around a securing device (for example, a rod or bolt) located on or within the handle. The applicator with the secured button is introduced into the tissue (for example, soft tissue or a bone tunnel) and the button is passed through the tissue.
摘要翻译：一种采用缝合/纽扣结构和施用设计用于牢固地接合缝线/按钮结构的按钮的联合修复技术。缝合/按钮结构的按钮牢固地接合敷贴器的轴。来自按钮的缝合线可以缠绕在位于手柄上或手柄内的固定装置（例如，杆或螺栓）上。将具有固定按钮的施用器引入组织（例如，软组织或骨隧道）中，并且按钮通过组织。

7. 发明申请

US20080166421A1 METHOD OF SURGICAL TREATMENT USING AUTOLOGOUS CONDITIONED PLASMA 有权
标题翻译：使用自动等离子体的手术治疗方法
公开(公告)号：US20080166421A1
公开(公告)日：2008-07-10
申请号：US11963554
申请日：2007-12-21
申请人： Michael Buhr , Werner Siekmann , Stephane Naudin
发明人： Michael Buhr , Werner Siekmann , Stephane Naudin
IPC分类号： A61K35/16
CPC分类号： A61K35/18 , A61M1/0281 , A61M1/029 , A61M2202/0415
摘要： A method of providing autologous conditioned plasma (ACP) for treatment of connective tissue injuries. The method comprises the steps of: (i) providing an apparatus comprising a centrifuge and a double syringe, the double syringe including an inner syringe body and an outer syringe body; (ii) drawing autologous blood into the outer syringe body; (iii) subjecting the autologous blood to at least one centrifugation step to obtain an autologous conditioned plasma (ACP); (iv) removing, with the inner syringe body, at least a portion of autologous conditioned plasma (ACP) from the outer syringe body; and (v) inject ACP for treatment of various cartilage or tendon damage or diseases.
摘要翻译：提供自体条件血浆（ACP）治疗结缔组织损伤的方法。该方法包括以下步骤：（i）提供包括离心机和双注射器的装置，所述双注射器包括内注射器主体和外注射器主体; （ii）将自体血液吸入外部注射器体内; （iii）使自体血液进行至少一个离心步骤以获得自体条件血浆（ACP）; （iv）用所述内注射器主体从所述外注射器主体移除至少一部分自体条件等离子体（ACP）; 和（v）注射ACP治疗各种软骨或肌腱损伤或疾病。

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