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1. 发明授权

US5303621A Clamping device for a defined clamping of workpieces 失效
标题翻译：用于定义工件夹紧的夹紧装置
公开(公告)号：US5303621A
公开(公告)日：1994-04-19
申请号：US716670
申请日：1991-06-17
申请人： Bernhard Horlitz , Reiner Glomb , Peter Maresch , Ralf Wagner
发明人： Bernhard Horlitz , Reiner Glomb , Peter Maresch , Ralf Wagner
IPC分类号： B21D43/00 , B23B5/12 , B23B13/02 , B23Q1/00 , B23Q1/76
CPC分类号： B23B5/12 , Y10T82/10 , Y10T82/2527
摘要： A clamping device is furnished, in particular for peeling machines for metallic bars (21) and tubes. The clamping device clamps the workpieces in a defined way at a preselected position (99) and independent of the diameter of the workpieces. The clamping device includes means for synchronization (64-69) of the motion of the clamping rollers (31, 32). The clamping position of the bar to be clamped can be varied by an adjustment device. The means for synchronization (64-69) of the clamping motion transfer a preselectable part of the clamping force, which is furnished such that the means for synchronization are held free from play via preclamping, during in all clamping phases. This eliminates vibrations of the bar (21) together with the clamping means (31, 62; 32, 63) or any undesired shifting of the clamping position.
摘要翻译：装有夹紧装置，特别是用于金属棒（21）和管子的剥皮机。夹紧装置将工件以限定的方式夹紧在预选位置（99）处，并且与工件的直径无关。夹紧装置包括用于夹紧辊（31,32）的运动同步（64-69）的装置。要夹紧的杆的夹紧位置可以通过调节装置来改变。夹持运动的同步装置（64-69）传递夹紧力的预选部分，其在所有夹紧阶段期间被设置为使得用于同步的装置通过预夹紧保持不发挥作用。这消除了杆（21）与夹紧装置（31,62; 32,63）的振动或夹紧位置的任何不希望的移动。

2. 发明授权

US5255581A Peeling machine 失效
标题翻译：剥皮机
公开(公告)号：US5255581A
公开(公告)日：1993-10-26
申请号：US716650
申请日：1991-06-17
申请人： Reiner Glomb , Peter Maresch , Ralf Wagner
发明人： Reiner Glomb , Peter Maresch , Ralf Wagner
IPC分类号： B23B5/12 , B23Q1/00
CPC分类号： B23B5/12 , B23Q1/0063 , Y10T29/4561 , Y10T82/2527 , Y10T82/2529
摘要： A peeling machine (1) includes individual device groups (2, 5, 63, 7) which can be centered and clamped at guide rails (23, 24). The guide rails also furnish a particular sliding possibility for a selective moving apart of individual device groups (2, 5, 63). This allows for maintenance, inspection, and repair of the device groups, which are made accessible by moving the individual device groups apart without any heavy equipment. The device groups, which are not to be separated during the pulling apart of the peeling machine at the guide rails, are connected to each other (64, 65) such that the peeling machine can be separated and subdivided at the desired location. The guide rails extend parallel to the rotation axis (62) of the cutter head (26) of the peeling machine and can be quickly bolted and released.
摘要翻译：剥皮机（1）包括可以在导轨（23,24）处于中心并夹紧的单独的装置组（2,5,63,7）。导轨还为各个设备组（2,5,63）的选择性移动分开提供特定的滑动可能性。这允许对设备组进行维护，检查和维修，通过将各个设备组分开，无需任何重型设备就可以进行访问。在剥离机在导轨的拉开期间不分离的装置组彼此连接（64,65），使得剥皮机可以在期望的位置分离和细分。导轨平行于剥皮机的刀头（26）的旋转轴线（62）延伸，并且可以快速地螺栓连接并释放。

3. 发明授权

US5230266A Rotary-driven tool spindle 失效
标题翻译：旋转驱动工具主轴
公开(公告)号：US5230266A
公开(公告)日：1993-07-27
申请号：US776338
申请日：1992-01-27
申请人： Reiner Glomb , Peter Maresch , Ralf Wagner
发明人： Reiner Glomb , Peter Maresch , Ralf Wagner
IPC分类号： B23B3/26 , B23B19/00 , B23B19/02 , B23B29/034 , B23B29/24 , B23Q11/00 , F16C25/08
CPC分类号： B23B29/03446 , B23B29/24 , B23Q11/0035 , F16C25/08 , Y10T82/2527 , Y10T82/2529
摘要： A rotary driven spindle (6) comprises sliders (14, 64) arranged on its front face, which can be adjusted radially as the spindle (6) rotates. To this end, an adjustment mechanism (21) comprises a device component (8) which rotates with the spindle and which can be moved relative to the spindle in order to adjust the slider (14). The radial centrifugal, frictional and working forces transmitted to the bearing housing (7) by the adjustment mechanism during adjustment of the slider (14) are compensated to a controllable extent by compensation of the centrifugal forces directly between the spindle and the device component (8). The compensation is effected by means of centrifugal weights (16, 66), the centrifugal force of which is deflected into axial forces. In one embodiment, the centrifugal weights (16, 66) penetrate a gap (12, 13) which tapers outward between two front faces (12, 13) of the component and the spindle. The centrifugal forces are converted to axial forces at the inclined surfaces (12, 13) which form the gap. The centrifugal force compensation is preferably arranged in the enclosed region between the bearings (17, 18) of the spindle (6).
摘要翻译：旋转从动主轴（6）包括布置在其前表面上的滑块（14,64），当主轴（6）旋转时可以径向调节。为此，调节机构（21）包括与主轴一起旋转并可相对于主轴移动的装置部件（8），以便调节滑块（14）。在调节滑块（14）期间通过调节机构传递到轴承壳体（7）的径向离心力，摩擦力和作用力通过直接在主轴和装置部件（8）之间的离心力的补偿被补偿到可控程度）。补偿通过离心重物（16,66）进行，其离心力被偏转成轴向力。在一个实施例中，离心重块（16,66）穿过在部件的两个前表面（12,13）和主轴之间向外渐缩的间隙（12,13）。在形成间隙的倾斜表面（12,13）处将离心力转换成轴向力。离心力补偿优选地布置在主轴（6）的轴承（17,18）之间的封闭区域中。

4. 发明授权

US5009136A Turning machine 失效
标题翻译：车床
公开(公告)号：US5009136A
公开(公告)日：1991-04-23
申请号：US447742
申请日：1989-12-08
申请人： Reiner Glomb , Peter Maresch , Ralf Wagner
发明人： Reiner Glomb , Peter Maresch , Ralf Wagner
IPC分类号： B23B5/12 , B23B31/12
CPC分类号： B23B5/12 , B23B31/1276 , Y10T409/305768 , Y10T82/2521 , Y10T82/2527 , Y10T82/2529
摘要： A centerless turning machine for rods. The machine includes a cutter-head mounted at the front end of a rotating hollow shaft, and further includes a plurality of advancing rollers of an infeed device operatively mounted at the inlet end of the turning machine. The turning machine further includes a front guide mechanism and a rear guide mechanism, respectively mounted on opposite sides of the cutter head, and also includes a clamping carriage which is mounted on the outlet side of the turning machine. The rear guide mechanism takes the form of a tubular support which is provided with a flange mounted in the machine housing and which extends into the rotating hollow shaft. The rear guide mechanism has, at its free end, which protrudes into the hollow shaft, three individually spring biased guide elements for the rod. The springs for each individual guide element form a first resilient abutment for each guide element. The movements of the three guide elements are synchronized by a rotatable ring. The rotational position of the ring is prestressed against the housing. Upon a closing movement of the adjustmeent ring, the individual springs are compressed and finally each guide element abuts against a second rigid abutment.
摘要翻译：用于棒的无心转动机。该机器包括安装在旋转空心轴的前端的刀头，还包括可操作地安装在车床的入口端的进给装置的多个前进辊。车削机还包括分别安装在刀头的相对侧上的前引导机构和后引导机构，还包括安装在车床出口侧的夹紧托架。后引导机构呈管状支撑件的形式，该管状支撑件设置有安装在机器壳体中并延伸到旋转中空轴中的凸缘。后引导机构在其自由端处具有突出到中空轴中的三个单独的弹簧偏压引导元件。用于每个单独引导元件的弹簧为每个引导元件形成第一弹性邻接。三个引导元件的移动通过可旋转环同步。环的旋转位置预先抵靠壳体。在调节环的闭合运动时，单个弹簧被压缩，并且最后每个引导元件抵靠第二刚性支座。

5. 发明授权

US07378515B2 Synthetic gagpol genes and their uses 失效
标题翻译：合成gagpol基因及其用途
公开(公告)号：US07378515B2
公开(公告)日：2008-05-27
申请号：US10276482
申请日：2001-05-18
申请人： Ralf Wagner , Markus Graf , Ludwig Deml , Kurt Bieler
发明人： Ralf Wagner , Markus Graf , Ludwig Deml , Kurt Bieler
IPC分类号： C07H21/04
CPC分类号： C12N9/1276 , C07K14/005 , C12N2740/15022 , C12N2740/16222
摘要： The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles. The invention further relates to the generation of packaging cells and vaccines based on the synthetic gag and gagpol genes.
摘要翻译：本发明涉及通过密码子优化优化用于高水平表达的合成gag和gagpol基因及其用于有效产生载体颗粒的用途。本发明还涉及基于合成gag和gagpol基因产生包装细胞和疫苗。

6. 发明授权

US07249919B2 Release device for actuating a clamping device for tools 有权
标题翻译：用于启动工具夹紧装置的释放装置
公开(公告)号：US07249919B2
公开(公告)日：2007-07-31
申请号：US10906713
申请日：2005-03-03
申请人： Albrecht Dawidziak , Heinrich Englert , Hubert Klein , Bernd Martin , Walter Rapp , Ralf Wagner
发明人： Albrecht Dawidziak , Heinrich Englert , Hubert Klein , Bernd Martin , Walter Rapp , Ralf Wagner
IPC分类号： B23C5/26
CPC分类号： B23B31/265 , B23B31/28 , B23B2260/062 , B23B2270/09 , Y10T408/95 , Y10T409/309464
摘要： A release device for actuating a clamping device for tools has at least one release element and a drive drivingly connected to the at least one release element for moving the at least one release element from a rest position into a release position in which a draw bar of the clamping device is moved against a clamping force into a disengaged position. The drive is an electric motor. The axis of the electric motor can be aligned with the axis of the release device but an angled arrangement of the electric motor and of the release device relative to one another is also possible.
摘要翻译：用于致动用于工具的夹紧装置的释放装置具有至少一个释放元件和驱动地连接到所述至少一个释放元件的驱动器，用于将至少一个释放元件从静止位置移动到释放位置，在该释放位置中，夹紧装置抵抗夹紧力移动到脱离位置。驱动器是电动机。电动机的轴线可以与释放装置的轴线对齐，但是电动机和释放装置相对于彼此的倾斜布置也是可能的。

7. 发明授权

US08691533B2 Inducible gene expression 有权
标题翻译：诱导型基因表达
公开(公告)号：US08691533B2
公开(公告)日：2014-04-08
申请号：US11658206
申请日：2005-08-03
申请人： Frank Notka , Ralf Wagner , Diana Hammer
发明人： Frank Notka , Ralf Wagner , Diana Hammer
IPC分类号： C12N5/10 , C12N7/01 , C12N15/00 , C12N15/33 , A61K48/00
CPC分类号： C07K14/005 , A61K48/00 , C12N2740/16322
摘要： The invention relates to vector constructs for an HIV-specific gene therapy. The expression of transgenes is coupled with an infection of the cell with HIV while the transcription of the transgene is controlled by a transcription control region derived from HIV. In addition, the transgene is improved with regard to RNA stability and expression efficiency by modifying the nucleotide sequence.
摘要翻译：本发明涉及用于HIV特异性基因治疗的载体构建体。转基因的表达与HIV感染的细胞相结合，而转基因的转录受来自HIV的转录控制区的控制。此外，通过修饰核苷酸序列，关于RNA稳定性和表达效率，转基因得到改善。

8. 发明授权

US07573830B2 Integrated programmable device for safety critical applications 有权
标题翻译：用于安全关键应用的集成可编程器件
公开(公告)号：US07573830B2
公开(公告)日：2009-08-11
申请号：US11228882
申请日：2005-09-16
申请人： Ralf Wagner , Bernhard Fuessl , Arthur Kreutzer
发明人： Ralf Wagner , Bernhard Fuessl , Arthur Kreutzer
IPC分类号： H04L12/26 , H04L12/40
CPC分类号： G05B19/0428 , G05B2219/24196
摘要： An integrated programmable device has a plurality of signal inputs (P1, P2, P3) connected to respective ones of a plurality of switching elements (S1, S2, S3). Each switching element (S1, S2, S3) has an associated enable line (E1, E2, E3). A control circuit (15) activates one or more selected signal inputs (P1-P3) in accordance with a channel select signal (16) via these enable lines (E1, E2, E3). Feedback lines (F1, F2, F3) are connected to corresponding enable lines (E1, E2, E3) to a channel feedback indicative of which signal inputs (P1, P2, P3) is enabled. This allows determination whether the enabled signal inputs (P1, P2, P3) correspond to the channel select signal (16) and initiates an exception handling in case of a mismatch. The comparison can be performed by a compare logic circuit (40) or the channel feedback can be stored in a memory (30) accessible by a software program (60), which performs the comparison.
摘要翻译：集成可编程装置具有连接到多个开关元件（S1，S2，S3）中的相应开关元件的多个信号输入（P1，P2，P3）。每个开关元件（S1，S2，S3）具有相关联的使能线（E1，E2，E3）。控制电路（15）经由这些使能线（E1，E2，E3）根据信道选择信号（16）激活一个或多个选择的信号输入（P1-P3）。反馈线（F1，F2，F3）连接到相应的使能线（E1，E2，E3）到指示哪些信号输入（P1，P2，P3）被使能的信道反馈。这允许确定使能的信号输入（P1，P2，P3）是否对应于信道选择信号（16），并且在不匹配的情况下启动异常处理。比较可以由比较逻辑电路（40）执行，或者信道反馈可以被存储在由执行比较的软件程序（60）可访问的存储器（30）中。

9. 发明授权

US07767455B2 Nucleus export reporter system 失效
标题翻译：核出口记者系统
公开(公告)号：US07767455B2
公开(公告)日：2010-08-03
申请号：US10415483
申请日：2001-10-30
申请人： Ralf Wagner , Marcus Graf
发明人： Ralf Wagner , Marcus Graf
IPC分类号： C12N15/00
CPC分类号： C12N15/1051 , C12N15/1075 , C12N15/85 , C12N2840/44 , C12Q1/6897
摘要： The present invention relates to reporter systems for RNA export, methods for searching for molecules which influence RNA export, and a method, based on these methods, for detecting a viral infection.
摘要翻译：本发明涉及用于RNA输出的报告系统，用于搜索影响RNA输出的分子的方法，以及基于这些方法检测病毒感染的方法。

10. 发明授权

US07332588B1 Genome of the HIV-1 inter-subtype (C/B) and use thereof 有权
标题翻译： HIV-1亚型（C / B）的基因组及其用途
公开(公告)号：US07332588B1
公开(公告)日：2008-02-19
申请号：US10130157
申请日：2000-11-16
申请人： Ralf Wagner , Hans Wolf , Marcus Graf
发明人： Ralf Wagner , Hans Wolf , Marcus Graf
IPC分类号： C07H21/04 , C12N15/11 , C12N15/09 , C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： The present invention refers to a polynucleotide comprising the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3 or the fragment or derivative thereof, or a polynucleotide hybridizing with the nucleic acid sequence as depicted in SEQ ID NO:1, 2 or 3. The present invention further refers to polypeptides encoded by the nucleic acid sequence or the fragment or derivative thereof as depicted in SEQ ID NO:1, 2 or 3. The polynucleotides and polypeptides may be used as medicaments, vaccines or diagnostic substances, preferably for the treatment, prevention or diagnostic of HIV infections.
摘要翻译：本发明涉及包含SEQ ID NO：1,2或3所示的核酸序列或其片段或衍生物的多核苷酸，或与SEQ ID NO：1,2所示的核酸序列杂交的多核苷酸本发明还涉及由SEQ ID NO：1,2或3所示的核酸序列或其片段或衍生物编码的多肽。多核苷酸和多肽可用作药物，疫苗或诊断物质，优选用于治疗，预防或诊断HIV感染。

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