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2. 发明申请

US20140141988A1 Systems And Compositions For Diagnosing Barrett's Esophagus And Methods Of Using The Same 有权
标题翻译：用于诊断巴雷特食管的系统和组成及其使用方法
公开(公告)号：US20140141988A1
公开(公告)日：2014-05-22
申请号：US14005409
申请日：2012-03-15
申请人： Rebecca Jane Thorne , Bruce B. Campbell
发明人： Rebecca Jane Thorne , Bruce B. Campbell
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57407 , C12Q1/6886 , G01N2800/14 , G01N2800/56
摘要： The invention provides a system, composition, and methods of using the systems and compositions for the analysis of a sample from a subject to accurately diagnose, prognose, or classify the subject with certain grades of or susceptibility to Barrett's esophagus. In some embodiments, the system of the present invention comprises a means of detecting and/or quantifying morphological features, the expression of protein, or the expression of nucleic acids in a plurality of cells and correlating that data with a subject's medical history to predict clinical outcome, treatment plans, preventive medicine plans, or effective therapies. In some embodiments, the invention relates to a method of classifying and compiling data taken from a cell sample from a subject analyzing the data, and converting the data from the system into a score by which a pathologist may calculate the likelihood that the subject develops cancer.
摘要翻译：本发明提供了使用系统和组合物来分析来自受试者的样品的系统，组合物和方法，以对Barrett食管的某些等级或易感性准确地诊断，预测或分类受试者。在一些实施方案中，本发明的系统包括检测和/或定量多个细胞中形态特征，蛋白质表达或核酸表达的方法，并将该数据与受试者的病史相关联以预测临床结果，治疗计划，预防医学计划或有效疗法。在一些实施方案中，本发明涉及对来自分析数据的受试者的细胞样品进行分类和编译的数据的方法，以及将来自系统的数据转换成病理学家可以计算受试者发生癌症的可能性的评分。

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