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    • 1. 发明申请
    • Medicaments for Treating Barrett's Eesophagus
    • 药物治疗巴雷特的食管
    • US20070270501A1
    • 2007-11-22
    • US10588567
    • 2005-02-18
    • Rebecca FitzgeraldChih-Long Chang
    • Rebecca FitzgeraldChih-Long Chang
    • A61K31/045A61K31/07A61P17/02
    • A61K31/11A61K31/121
    • The present invention relates to the use of a retinoic acid antagonist in the manufacture of a medicament for the treatment or prevention of Barrett's oesophagus (Barrett's mucosa). Furthermore, the invention relates to use of a retinoic acid antagonist in the manufacture of a medicament for the treatment or prevention of ectopic development of columnar epithelium, use of such an antagonist in the conversion of columnar epithelium to squamous epithelium, in the induction or maintenance of squamous epithelium, and in the reduction of proliferation of ectopic columnar epithelium. Preferably the retinoic acid antagonist is an aldehyde dehydrogenase inhibitor such as a competitive inhibitor. Preferably the antagonist is citral.
    • 本发明涉及视黄酸拮抗剂在制备用于治疗或预防巴雷特氏食道(Barrett's mucosa)的药物中的用途。 此外,本发明涉及视黄酸拮抗剂在制造用于治疗或预防柱状上皮的异位发育的药物中的用途,在诱导或维持中使用这种拮抗剂将柱状上皮转化成鳞状上皮 的鳞状上皮细胞,以及异位柱状上皮的增殖减少。 优选地,视黄酸拮抗剂是醛脱氢酶抑制剂,例如竞争性抑制剂。 优选地,拮抗剂是柠檬醛。
    • 8. 发明申请
    • Method for designing wiring topology for electromigration avoidance and fabrication method of integrate circuits including said method
    • 用于设计电迁移避免的布线拓扑的方法和包括所述方法的集成电路的制造方法
    • US20120060137A1
    • 2012-03-08
    • US12926505
    • 2010-11-23
    • Jiang Hui-RuChang Hua-YuChih-Long Chang
    • Jiang Hui-RuChang Hua-YuChih-Long Chang
    • G06F17/50
    • G06F17/5077G06F2217/82
    • A method for designing wiring topology for electromigration avoidance, which is composed of multiple sources, multiple sinks and multiple wires, is disclosed. The steps of said method to get an optimal topology includes: 1. calculating the length of all the wires to choose one of the wires with the shortest length as a feasible wire, 2. deciding a capacity of the feasible wire, 3. deciding the capacities of the other wire according to the capacity of the feasible wire, a flow of the source of the feasible wire and a flow of the sink of the feasible wire, 4. comparing the length of the other wires to select another feasible wire, 5. repeating said steps until finding all feasible wires for constructing a feasible topology, 6. creating a flow network according to the feasible topology, 7. iteratively checking if a negative cycle exists in the flow network and removing it until no more negative cycles.
    • 公开了一种用于设计电迁移避免的布线拓扑的方法,该方法由多个源,多个汇和多个线组成。 所述获得最佳拓扑的方法的步骤包括:1.计算所有电线的长度,选择最短长度的导线之一作为可行电线,2.确定可行电线的容量,3.确定 根据可行线的容量,可行线的流量和可行线的汇流量,另一条线的容量,4.比较其他线的长度以选择另一条可行的线,5 重复所述步骤,直到找到用于构建可行拓扑的所有可行的线路,6.根据可行拓扑创建流网络,7.迭代地检查流网络中是否存在负循环并将其移除直到没有更多的负循环。