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1. 发明申请

US20050107388A1 Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain 失效
标题翻译：异恶唑脲衍生物作为治疗疼痛的vr-1受体调节剂
公开(公告)号：US20050107388A1
公开(公告)日：2005-05-19
申请号：US10505358
申请日：2003-03-21
申请人： Rebecca Brown , Victoria Doughty , Gregory Hollingworth , A. Jones , Matthew Lindon , Christopher Moyes , Lauren Rogers
发明人： Rebecca Brown , Victoria Doughty , Gregory Hollingworth , A. Jones , Matthew Lindon , Christopher Moyes , Lauren Rogers
IPC分类号： C07D237/28 , A61K31/427 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/502 , A61K31/506 , A61K31/5377 , A61P1/04 , A61P11/00 , A61P11/06 , A61P13/10 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/04 , A61P25/06 , A61P29/00 , A61P37/02 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/14 , C07D217/16 , C07D217/22 , C07D217/24 , C07D217/26 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/541 , A61K31/496 , A61K31/498 , A61K31/517
CPC分类号： C07D401/12 , C07D215/38 , C07D217/02 , C07D217/08 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents, n is 0-3 and y is an aryl, heteroaryl, carbocyclyl or fused-carbocyclyl group; as VR-1 antagonists for treating conditions or diseases in which pain and/or inflammation predominates; the use of the same for manufacturing medicaments, pharmaceutical compositions comprising them and methods of treatment utilising them.
摘要翻译：本发明提供式（I）化合物; 其中A，B，D和E为C或N的药学上可接受的盐和N-氧化物，条件是一个或多个为N，R 1，R 2， R 3，R 4，R 5和R 6是简单的取代基，n是0-3和 y是芳基，杂芳基，碳环基或稠合碳环基; 作为用于治疗其中疼痛和/或炎症占优势的病症或疾病的VR-1拮抗剂; 使用它们制造药物，包含它们的药物组合物和使用它们的治疗方法。

2. 发明申请

US20060154930A1 Substituted amino heterocycles as vr-1 antagonists for treating pain 审中-公开
公开(公告)号：US20060154930A1
公开(公告)日：2006-07-13
申请号：US10545877
申请日：2004-02-20
申请人： Rebecca Brown , Frank Burkamp , Victoria Doughty , Stephen Fischer , Gregory Hollingworth , A. Jones , Timothy Sparey
发明人： Rebecca Brown , Frank Burkamp , Victoria Doughty , Stephen Fischer , Gregory Hollingworth , A. Jones , Timothy Sparey
IPC分类号： C07D487/04 , A61K31/503
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: in which: one of T1 and T4 is N and the other is C; T2 and T3 are independently N or C(CH2)nR2; X, Y and Z are independently N or C(CH2)nR3; R1 is Ar1 or R1 is C1-6alkyl optionally substituted with one or two groups Ar1; Ar1 is an optionally substituted cyclohexyl, piperidinyl, piperazinyl, morpholinyl, adamantyl, phenyl, naphthyl, a six membered heteroaromatic ring containing one, two or three nitrogen atoms, a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one O or S atom being present, or a nine- or ten-membered bicyclic heteroaromatic ring in which phenyl or a six-membered heteroaromatic ring as defined above is fused to a six- or five-membered heteroaromatic ring as defined above; Ar is an optionally substituted phenyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms or a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, Ar being optionally substituted by one, two or three groups chosen from halogen, CF3, OCF3, C1-6-alkyl, C2-6alkenyl, C2-6alkynyl, nitro, cyano, isonitrile, hydroxy, C1-6alkoxy, C1-6alkylthio, —NR6R7, —CONR6R7, —COH, CO2H, C1-6alkoxycarbonyl, haloC1-4alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, C1-4alkylcarbonyl and a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, optionally substituted by C1-6alkyl, halogen, amino, hydroxy or cyano; or a pharmaceutically acceptable salt thereof as a VR-1 ligand; pharmaceutical compositions comprising it; its use in therapy; use of it in the manufacture of a medicament to treat pain; and methods of treating subjects suffering from pain.

3. 发明申请

US20080148606A1 STABILIZING AND SUPPORT ACCESSORY FOR STILETTO HEELS 审中-公开
标题翻译：稳定和支持附件
公开(公告)号：US20080148606A1
公开(公告)日：2008-06-26
申请号：US11942087
申请日：2007-11-19
申请人： Rebecca Brown , Monica Murphy
发明人： Rebecca Brown , Monica Murphy
IPC分类号： A43B13/22 , A43B21/00
CPC分类号： A43B3/166 , A43C13/00
摘要： A stabilizing and support accessory is provided for a stiletto heel. A base plate, having a surface contact area significantly greater than that of the heel, is mounted underneath the heel by means of a simple, clip-on attachment, such that the attachment can be easily and quickly mounted on a heel for walking over soft or uneven surfaces, and also quickly removed when not needed. A preferred clip-on attachment is formed of a section of spring steel shaped into an upwardly opening, U-shaped clip and a horizontally opening clip integrally extending from one element of the upwardly opening clip. An alternative form, formed primarily of plastic, is attached by a single, horizontally disposed clip gripping the heel. The accessories are sufficiently inexpensive that they may be discarded after use, as after walking on muddy surfaces, for example.
摘要翻译：为高跟鞋提供稳定和支撑配件。具有明显大于脚跟的表面接触面积的基板通过简单的夹紧附件安装在脚后跟下方，使得附件可以容易且快速地安装在脚跟上以用于走过软或不平坦的表面，并且在不需要时也快速移除。优选的夹持附件由弹性钢的一部分形成，形成为向上开口的U形夹子和从向上开启夹子的一个元件整体延伸的水平开启夹子。主要由塑料形成的替代形式通过一个单一的水平设置的夹子夹紧脚跟。附件足够便宜，使用后可能被丢弃，例如在泥泞的表面上行走之后。

4. 发明授权

US07385724B2 Photo manager 失效
标题翻译：照片经理
公开(公告)号：US07385724B2
公开(公告)日：2008-06-10
申请号：US10400036
申请日：2003-03-26
申请人： Rebecca Brown
发明人： Rebecca Brown
IPC分类号： G06F15/00
CPC分类号： G06F15/00 , H04N1/00132 , H04N1/00148 , H04N1/00164 , H04N1/00167 , H04N1/0019 , H04N1/00196 , H04N1/3873 , Y10T428/24802
摘要： A method of photo display comprises electronically selecting at least one photo from a memory and electronically arranging at least one electronic photo sheet template, including arranging the at least one photo on the template, into a manipulable configuration for producing a three-dimensional photo display.
摘要翻译：一种照片显示方法包括从存储器电子地选择至少一张照片，并且电子地排列至少一个电子照片纸模板，包括将模板上的至少一张照片布置成用于产生三维照片显示的可操纵配置。

5. 外观设计

USD806094S1 Display screen or portion thereof with graphical user interface 有权
公开(公告)号：USD806094S1
公开(公告)日：2017-12-26
申请号：US29598245
申请日：2017-03-23
申请人： Edward Maisonneuve , Rebecca Brown
设计人： Edward Maisonneuve , Rebecca Brown

6. 发明授权

US08598980B2 Biometrics with mental/physical state determination methods and systems 有权
标题翻译：具有精神/身体状态确定方法和系统的生物识别技术
公开(公告)号：US08598980B2
公开(公告)日：2013-12-03
申请号：US12838964
申请日：2010-07-19
申请人： Scott Charles Evans , Rebecca Brown , Michael Tin-Lung Chan , Rahul Bhotika , Srinivas Chukka , David W. Hagan , Ken R. Turner
发明人： Scott Charles Evans , Rebecca Brown , Michael Tin-Lung Chan , Rahul Bhotika , Srinivas Chukka , David W. Hagan , Ken R. Turner
IPC分类号： G05B19/00 , B60R25/00
CPC分类号： G06F21/32 , G07C9/00158
摘要： Methods and systems for determining whether a particular individual is to be granted, among other things, access to information, access to a particular room or other space, or permission to perform a given act or transaction are disclosed. For example, disclosed is an exemplary method that includes performing multiple biometrics tests on the individual to retrieve multiple biometrics test results, performing at least a first data fusion operation on the multiple biometrics test results to determine an identity result, performing at least one biological state test to determine one or more biological state test results of the individual, and conditionally granting authority to the individual based on the identity result and the one or more biological state results.
摘要翻译：公开了用于确定特定个人是否被授予的方法和系统，其中包括访问信息，访问特定房间或其他空间，或者允许执行给定的行为或交易。例如，所公开的是一种示例性方法，其包括对个体执行多个生物测定测试以检索多个生物测定结果，对多个生物特征测试结果执行至少第一数据融合操作以确定身份结果，执行至少一个生物学状态测试以确定个体的一种或多种生物状态测试结果，并且基于身份结果和一种或多种生物状态结果有条件地授予个人权力。

7. 发明申请

US20060111631A1 System, apparatus and method for forensic facial approximation 失效
标题翻译：用于法医面部近似的系统，装置和方法
公开(公告)号：US20060111631A1
公开(公告)日：2006-05-25
申请号：US10992433
申请日：2004-11-19
申请人： Timothy Kelliher , Peter Tu , Wesley Turner , Rebecca Brown , Michael Taister , Kevin Miller
发明人： Timothy Kelliher , Peter Tu , Wesley Turner , Rebecca Brown , Michael Taister , Kevin Miller
IPC分类号： A61B5/05
CPC分类号： G06T7/0012 , G06T5/50 , G06T7/30 , G06T2200/04 , G06T2207/10028 , G06T2207/10072 , G06T2207/30008
摘要： A system, method and apparatus for performing a facial approximation is described. The system includes an acquisition subsystem and a facial approximation algorithm. The method includes the steps of acquiring models of known skulls and a model of a questioned skull, comparing the models of the known skulls with the model of the questioned skull, and removing variation in the facial structure of the questioned skull due to skeletal variation between the known skulls and the questioned skull. The apparatus includes a bony structure software component, a bony structure warping software component, and a soft tissue software component.
摘要翻译：描述用于执行面部近似的系统，方法和装置。该系统包括采集子系统和面部近似算法。该方法包括以下步骤：获取已知头骨的模型和被询问的头骨的模型，将已知头骨的模型与被询问的头骨的模型进行比较，以及消除由于骨骼变化引起的被问问的头骨的面部结构的变化已知的头骨和被问问的头骨。该装置包括骨结构软件组件，骨结构翘曲软件组件和软组织软件组件。

8. 外观设计

USD872735S1 Display screen or portion thereof with graphical user interface 有权
公开(公告)号：USD872735S1
公开(公告)日：2020-01-14
申请号：US29598247
申请日：2017-03-23
申请人： Edward Maisonneuve , Rebecca Brown
设计人： Edward Maisonneuve , Rebecca Brown
摘要： This patent document contains copyrightable computer software elements including but not limited to screen displays and other copyrightable subject matter. The following notice shall apply to these elements: Copyright©2017 Rebecca Brown, All Rights Reserved. A portion of the disclosure of this patent document contains material to which a claim for copyright is made. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, as long as the above Copyright Notice remains legible on all copies. The copyright owner reserves all other national and international copyright rights.
The FIGURE is a front view of a display screen or portion thereof with graphical user interface.
The portions showing a display screen or portion thereof having a grey tone overlay form no part of the claimed design. All text elements shown in broken lines likewise form no part of the claimed design. The white background in the drawing is disclaimed.

9. 发明申请

US20070135423A1 E-fluoro-4-(pyridin-2-yl)-piperidine-1-carboxamide derivatives and related compounds which modulate the function of the vanilloid-1 receptor (vr1) for the treatment of pain 审中-公开
标题翻译： E-fluor-4-（吡啶-2-基） - 哌啶-1-甲酰胺衍生物和调节香草素-1受体（vr1）功能的相关化合物用于治疗疼痛
公开(公告)号：US20070135423A1
公开(公告)日：2007-06-14
申请号：US10577585
申请日：2004-10-27
申请人： Tracy Bayliss , Rebecca Brown , Frank Burkamp , Brian Jones , Joseph Neduvelil
发明人： Tracy Bayliss , Rebecca Brown , Frank Burkamp , Brian Jones , Joseph Neduvelil
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/454 , C07D417/02 , C07D413/02 , C07D401/02
CPC分类号： C07D451/04 , C07D401/04
摘要： Compounds of formula (I): wherein: A1 is phenyl, a six-membered aromatic heterocycle containing one, two or three nitrogen atoms, or a five-membered aromatic heterocycle containing up to four heteroatoms chosen from O, N and S, at most one heteroatom being O or S; A2 is phenyl, a six-membered aromatic heterocycle containing one, two or three nitrogen atoms, or a five-membered aromatic heterocycle containing up to four heteroatoms chosen from O, N and S, at most one heteroatom being O or S; L is a bond or C1-6alkylene; R1 and R2 independently chosen from hydrogen and C1-6alkyl or R1 and R2 may, together, form a methylene or ethylene bridge; W is halogen, C1-6alkyl, haloC1-6alkyl, C1-6alkoxy or haloC1-6alkoxy; X is O, S or NR3 or X, together with the atom to which it is attached, and Y, form an unsaturated five-membered ring together with A2; Y is a bond, C1-4alkylene, NH or NH(CH2)1-3; or a pharmaceutically acceptable salt thereof; other substituents are defined in claim 1; which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).
摘要翻译：式（I）化合物：其中：A 1是苯基，含有一个，两个或三个氮原子的六元芳族杂环，或含有至多四个选自以下的杂原子的五元芳族杂环： O，N和S，最多一个杂原子是O或S; A 2是苯基，含有一个，两个或三个氮原子的六元芳族杂环，或含有至多四个选自O，N和S的杂原子的五元芳族杂环，最多一个杂原子是O或S; L是键或C 1-6 - 亚烷基; R 1和R 2独立地选自氢和C 1-6烷基或R 1和R 2 > 2可以一起形成亚甲基或乙烯桥; W是卤素，C 1-6烷基，卤代C 1-6烷基，C 1-6 - 烷氧基或卤代C 1-6 烷氧基; X是O，S或NR 3或X，连同其所连接的原子，Y与A 2形成不饱和五元环; Y是一个键，C 1-4亚烷基，NH或NH（CH 2 CH 2）1-3。或其药学上可接受的盐; 其它取代基如权利要求1中所定义; 其可用作治疗化合物，特别是用于治疗通过调节香草素-1受体（VR1）的功能而改善的疼痛和其它病症。

10. 发明申请

US20060171571A1 Systems and methods for quality-based fusion of multiple biometrics for authentication 审中-公开
标题翻译：用于认证的多个生物识别技术的质量融合的系统和方法
公开(公告)号：US20060171571A1
公开(公告)日：2006-08-03
申请号：US11205515
申请日：2005-08-17
申请人： Michael Chan , Rebecca Brown , Wesley Turner , Timothy Kelliher , Ronald Sutton , Mark Cavanagh
发明人： Michael Chan , Rebecca Brown , Wesley Turner , Timothy Kelliher , Ronald Sutton , Mark Cavanagh
IPC分类号： G06K9/00
摘要： An authentication system incorporates pluralilty of fused biometric modalities which are combined with quality indicia of the biometric samples. Fusion processing maps individual modality data along with one or more quality measurements to a fused score for purposes of making an authentication decision.
摘要翻译：认证系统包含与生物特征样本的质量标记组合的多个融合生物特征模式。融合处理将个体模态数据连同一个或多个质量测量结合在一起，以便进行认证决定。

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